Skip to main content
×
Home

Coordinated and circumlocutory semantic naming errors are related to anterolateral temporal lobes in mild AD, amnestic mild cognitive impairment, and normal aging

  • MARCIO LUIZ FIGUEREDO BALTHAZAR (a1) (a2), CLARISSA LIN YASUDA (a2), FABRÍCIO RAMOS SILVESTRE PEREIRA (a2), FELIPE PAULO GUAZZI BERGO (a2), FERNANDO CENDES (a2) and BENITO PEREIRA DAMASCENO (a1)...
Abstract
Abstract

Naming difficulties are characteristic of Alzheimer’s disease (AD) and, to a lesser extent, of amnestic mild cognitive impairment (aMCI) patients. The association of naming impairment with anterior temporal lobe (ATL) atrophy in Semantic Dementia (SD) could be a tip of the iceberg effect, in which case the atrophy is a marker of more generalized temporal lobe pathology. Alternatively, it could reflect the existence of a functional gradient within the temporal lobes, wherein more anterior regions provide the basis for greater specificity of representation. We tested these two hypotheses in a study of 15 subjects with mild AD, 17 with aMCI, and 16 aged control subjects and showed that coordinate and circumlocutory semantic error production on the Boston Naming Test was weakly correlated with ATL gray matter density, as determined by voxel-based morphometry. Additionally, we investigated whether these errors were benefited by phonemic cues, and similarly to SD, our AD patients had small improvement. Because there is minimal gradient of temporal lobe atrophy in AD or MCI, and, therefore, no basis for a tip of the iceberg effect, these findings support the theory of a modest functional gradient in the temporal lobes, with the ATLs being involved in the naming of more specific objects. (JINS, 2010, 16, 1099–1107.)

Copyright
Corresponding author
*Correspondence and reprint requests to: Marcio L.F. Balthazar, Department of Neurology, Medical School, University of Campinas (UNICAMP), Postcode: 13083-970, Campinas-SP, Brazil. Email: mbalth@gmail.com
References
Hide All
Adlam A.L., Bozeat S., Arnold R., Watson P., & Hodges J.R. (2006). Semantic knowledge in mild cognitive impairment and mild Alzheimer’s disease. Cortex, 42, 675684.
Albert M.S., Heller H.S., & Milberg W. (1988). Changes in naming ability with age. Psychology and Aging, 3, 173178.
Alexopoulos G.S., Abrams R.C., Young R.C., & Shamoian C.A. (1988). Cornell scale for depression in dementia. Biological Psychiatry, 23, 271284.
Ashburner J. (2009). Computational anatomy with the SPM software. Magnetic Resonance Imaging, 27, 11631174.
Ashburner J., & Friston K.J. (2005). Unified segmentation. Neuroimage, 26, 839851.
Ashburner J., & Friston K.J. (2009). Computing average shaped tissue probability templates. Neuroimage, 45, 333341.
Balthazar M.L., Cendes F., & Damasceno B.P. (2008). Semantic error patterns on the Boston Naming Test in normal aging, amnestic mild cognitive impairment, and mild Alzheimer’s disease: Is there semantic disruption? Neuropsychology, 22, 703709.
Bergougnian L., Chupin M., Czechowska Y., Kinkingnehun S., Lemogne C., Le Bastard G., et al. . (2009). Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression? Neuroimage, 45, 2937.
Bright P., Moss H.E., Stamatakis E.A., & Tyller L.K. (2005). The anatomy of object processing: The role of anteromedial temporal cortex. The Quarterly Journal of ExperimentalL Psychology, 58B, 361377.
Brucki S.M., Nitrini R., Caramelli P., Bertolucci P.H., & Okamoto I.H. (2003). [Suggestions for utilization of the mini-mental state examination in Brazil]. Arquivos de Neuropsiquiatria, 61, 777781.
Carthery-Goulart M.T., Areza-Fegyveres R., Schultz R.R., Okamoto I., Caramelli P., Bertolucci P.H., et al. . (2007). [Brazilian version of the Cornell depression scale in dementia]. Arquivos de Neuropsiquiatria, 65, 912915.
Chertkow H., & Bub D. (1990). Semantic memory loss in dementia of Alzheimer’s type. What do various measures measure? Brain, 113, 397417.
Christensen A.-L. (1979). Luria’s neuropsychological investigation (2nd ed.). Copenhagen: Munksgaard.
Cummings J.L. (2000). Cognitive and behavioral heterogeneity in Alzheimer’s disease: Seeking the neurobiological basis. Neurobiology of Aging, 21, 845861.
Damasio A.R. (1989). The brain binds entities and events by multiregional activation from convergence zones. Neural Computation, 1, 123132.
Dudas R.B., Clague F., Thompson S.A., Graham K.S., & Hodges J.R. (2005). Episodic and semantic memory in mild cognitive impairment. Neuropsychologia, 43, 12661276.
Faust M.E., Balota D.A., & Multhaup K.S. (2004). Phonological blocking during picture naming in dementia of the Alzheimer type. Neuropsychology, 18, 526536.
Folstein M.F., Folstein S.E., & McHugh P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Galton C.J., Patterson K., Graham K., Lambon-Ralph M.A., Williams G., Antoun N., et al. . (2001). Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology, 57, 216225.
Garrard P., Lambon Ralph M.A., Patterson K., Pratt K.H., & Hodges J.R. (2005). Semantic feature knowledge and picture naming in dementia of Alzheimer’s type: A new approach. Brain and Language, 93, 7994.
Grossman M., McMillan C., Moore P., Ding L., Glosser G., Work M., et al. . (2004). What’s in a name: Voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer’s disease, frontotemporal dementia and corticobasal degeneration. Brain, 127, 628649.
Hodges J.R., Patterson K., Oxbury S., & Funnell E. (1992). Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain, 115, 17831806.
Hodges J.R., & Patterson K. (1995). Is semantic memory consistently impaired early in the course of Alzheimer’s disease? Neuroanatomical and diagnostic implications. Neuropsychologia, 33, 441459.
Kaplan E.F., Goodglass H., & Weintraub S. (1983). The Boston naming test (2nd ed.). Philadelphia: Lea & Febiger.
Jefferies E., Patterson K., & Lambon Ralph M.A. (2008). Deficits of knowledge versus executive control in semantic cognition: Insights from cued naming. Neuropsychologia, 46, 649658.
LaBarge E., Edwards D., & Knesevich J.W. (1986). Performance of normal elderly on the Boston Naming Test. Brain and Language, 27, 380384.
Lambon Ralph M.A., & Patterson K. (2008). Generalization and differentiation in semantic memory: Insights from semantic dementia. Annals of New York Academy of Sciences, 1124, 6176.
Lukatela K., Malloy P., Jenkins M., & Cohen R. (1998). The naming deficit in early Alzheimer’s and vascular dementia. Neuropsychology, 12, 565572.
Lu L.H., Crosson B., Nadeau S.L., Heilman K.M., Gonzales-Rothi L.J., Raimer A., et al. . (2002). Category specific naming deficits for objects and actions: Semantic attributes and grammatical role hypotheses. Neuropyschologia, 40, 16081621.
Martin A., & Chao L.L. (2001). Semantic memory and the brain: Structure and processes. Current Opinion in Neurobiology, 11, 194201.
McKhann G., Drachman D., Folstein M., Katzman R., Price D., & Stadlan E.M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939944.
Mesulam M.M., Rogalsky E., Wieneke C., Cobia D., Rademaker A., Thompson C., et al. . (2009). Neurology of anomia in the semantic variant of primary progressive aphasia. Brain, 132, 25532565.
Morris J. (1993). The clinical dementia rating (CDR): Current version and scoring rules. Neurology, 43, 24122414.
Mummery C.J., Patterson K., Price C.J., Ashburner J., Frackowiak R.S., & Hodges J.R. (2000). A voxel-based morphometry study of semantic dementia: Relationship between temporal lobe atrophy and semantic memory. Annals of Neurology, 47, 3645.
Olson I.R., Plotzker A., & Ezzyat Y. (2007). The Enigmatic temporal pole: A review of findings on social and emotional processing. Brain, 130, 17181731.
Patterson K., Nestor P.J., & Rogers T.T. (2007). Where do you know what you know? The representation of semantic knowledge in the human brain. Nature Reviews Neuroscience, 8, 976987.
Ratcliff G. (1979). Spatial thought, mental rotation and the right cerebral hemisphere. Neuropsychologia, 17, 4954.
Rey A. (1964). [Clinical examination in psychology]. Paris: Press Universitaire de France.
Rogers S.L., & Friedman R.B. (2008). The underlying mechanisms of semantic memory loss in Alzheimer’s disease and semantic dementia. Neuropsychologia, 46, 1221.
Rorden C., & Brett M. (2000). Stereotaxic display of brain lesions. Behavioural Neurology, 12, 191200.
Rorden C., Bonilha L., & Nichols T.E. (2007). Rank-order versus mean based statistics for neuroimaging. Neuroimage, 35, 15311537.
Rorden C., Fridriksson J., & Karnath H.O. (2009). An evaluation of traditional and novel tools for lesion behavior mapping. Neuroimage, 44, 13551362.
Salmon D.P., Butters N., & Chan A.S. (1999). The deterioration of semantic memory in Alzheimer’s disease. Canadian Journal of Experimental Psychology, 53, 108117.
Schwartz M.F., Kimberg D.Y., Walker G.M., Faseyitan O., Brecher A., Dell G.S., et al. . (2009). Anterior temporal involvement in semantic word retrieval: Voxel-based lesion-symptom mapping evidence from aphasia. Brain, 132, 34113427.
Simmons W.K., & Barsalou L.W. (2003). The similarity-in-topography principle: Reconciling theories of conceptual deficits. Cognitive Neuropsychology, 3, 451486.
Simmons W.K., Reddish M., Bellgowan P.S., & Martin A. (2010). The selectivity and functional connectivity of the anterior temporal lobes. Cerebral Cortex, 20, 813825.
Snowden J.S., Goulding P.J., & Neary D. (1989). Semantic dementia: A form of circumscribed temporal atrophy. Behavioural Neurology, 2, 167182.
Venneri A., McGeown W.J., Hietanen H.M., Guerrini C., Ellis A.W., & Shanks M.F. (2008). The anatomical bases of semantic retrieval deficits in early Alzheimer’s disease. Neuropsychologia, 46, 497510.
Wechsler D. (1987). Wechsler memory scale - Revised. San Antonio, TX: The Psychological Corporation.
Winblad B., Palmer K., Kivipelto M., Jelic V., Fratiglioni I., Wahlund L.O., et al. . (2004). Mild cognitive impairment-beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240246.
Whitwell J.L., Avula R., Senjem M.L., Kantarci K., Weigand S.D., Samiklogu H.A., et al. . (2010). Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology, 74, 12791287.
Zec R.F., Markwell S.J., Burkett N.R., & Larsen D.L. (2005). A longitudinal study of confrontation naming in the “normal” elderly. Journal of International Neuropsychological Society, 11, 716726.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 4
Total number of PDF views: 25 *
Loading metrics...

Abstract views

Total abstract views: 168 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 20th November 2017. This data will be updated every 24 hours.