Skip to main content
×
Home
    • Aa
    • Aa

Deficits in the automatic activation of religious concepts in patients with Parkinson’s disease

  • PAUL M. BUTLER (a1) (a2), PATRICK MCNAMARA (a1) (a2) and RAYMON DURSO (a1) (a2)
Abstract
Abstract

Religion is central to the lives of billions of people worldwide. To probe processing dynamics of religious cognition and its potential brain correlates, we used a novel priming procedure to assess the integrity of religious and control semantic networks in patients with Parkinson’s disease (PD) and controls. Priming for control, but not religious, concepts was intact in PD patients. Patients with left-onset (right-forebrain disease) evidenced severe impairment activating religious concepts. We next modeled the priming performance with modified cable equations. These analyses suggested that deficient performance of PD patients on activation of religious concepts was due to a change in the time constants governing gain and rate of decay of activation in these semantic networks. These modeling results are consistent with dopaminergic dysfunction in right-sided striatal-prefrontal networks. We conclude that right striatal-prefrontal dopaminergic networks support activation of complex religious concepts but not equally complex and related control concepts. (JINS, 2010, 16, 252–261.)

Copyright
Corresponding author
*Correspondence and reprint requests to: Paul M. Butler, Boston University School of Medicine, Department of Neurology, 72 East Concord Street, Robinson Building, 5th Floor, Room 528, Boston, MA 02118. E-mail: pmbutler@bu.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A.J. Angwin , H.J. Chenery , D.A. Copland , W.L. Arnott , R. Grattan , B.E. Murdoch , (2006). Priming of semantic features in Parkinson’s disease. Brain and Language, 99, 218219.

W.L. Arnott , H.J. Chenery , B.E. Murdoch , & P.A Silburn . (2001). Semantic priming in Parkinson’s disease: Evidence for delayed spreading activation. Journal of Clinical and Experimental Neuropsychology, 23, 502519.

K. Asanuma , C. Tang , Y. Ma , V. Dhawan , P. Mattis , C. Edwards , (2006). Network modulation in the treatment of Parkinson’s disease. Brain, 129(Pt 10), 26672678.

N.P. Azari , J. Nickel , G. Wunderlich , M. Niedeggen , H. Hefter , L. Tellmann , (2001). Neural correlates of religious experience. European Journal of Neuroscience, 13, 16491652.

M. Beauregard , & V Paquette . (2006). Neural correlates of a mystical experience in Carmelite nuns. Neuroscience Letters, 405, 186190.

V. Boulenger , L. Mechtouff , S. Thobois , E. Broussolle , M. Jeannerod , & T.A Nazir . (2008). Word processing in Parkinson’s disease is impaired for action verbs but not for concrete nouns. Neuropsychologia, 46, 743756.

M Coltheart . (1981). The MRC psycholinguistic database. Journal of Experimental Psychology, 33, 497505.

L.S. Colzato , W.P. van den Wildenberg , & B Hommel . (2008). Losing the big picture: How religion may control visual attention. PloS ONE, 3, e3679.

D.A. Copland , K.L. McMahon , P.A. Silburn , & G.I de Zubicaray . (2009). Dopaminergic Neuromodulation of semantic processing: A 4-t fMRI study with Levodopa. Cerebral Cortex, 19, 26512658.

W. Dauer , & S Przedborski . (2003). Parkinson’s disease: Mechanisms and models. Neuron, 39, 889909.

O. Devinsky , & G Lai . (2008). Spirituality and religion in epilepsy. Epilepsy & Behavior, 12, 636643.

P.T. Francis , & E.K Perry . (2007). Cholinergic and other neurotransmitter mechanisms in Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies. Movement Disorders, 22(Suppl. 17), S351S357.

N Geschwind . (1983). Interictal behavioral changes in epilepsy. Epilepsia, 24(Suppl. 1), S23S30.

R.L. Gorsuch , & S.E McPherson . (1989). Intrinsic/extrinsic measurement I/E Revised and single item scales. Journal for the Scientific Study of Religion, 28, 348354.

D.E. Hall , K.G. Meador , & H.G Koenig . (2008). Measuring religiousness in health research: Review and critique. Journal of Religious Health, 47, 134163.

S. Han , L. Mao , X. Gu , Y. Zhu , J. Ge , & Y. Ma (2008). Neural consequences of religious belief on self-referential processing. Social Neuroscience, 3, 115.

M. Inzlicht , I. McGregor , J.B. Hirsh , & K Nash . (2009). Neural markers of religious conviction. Psychological Science, 20, 385392.

D. Kapogiannis , A.K. Barbey , M. Su , G. Zamboni , F. Krueger , & J Grafman . (2009). Cognitive and neural foundations of religious belief. Proceedings of the National Academy of Science of the United States of America, 106, 48764881.

H.K. Koenig , M.E. McCullough , & D.B Larson . (2001). Handbook of Religion and Health. New York: Oxford.

P.F. Lovibond , & S.H Lovibond . (1995). The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research and Therapy, 33, 335343.

P. McNamara , J. Andresen , & J Gellard . (2003). Religion of religiosity and scores on fluency tests to subjective reports of health in older individuals. International Journal of the Psychology of Religion, 13, 259271.

P. McNamara , R. Durso , & A Brown . (2006). Religiosity in patients with Parkinson’s disease. Neuropsychiatric Disease and Treatment, 2, 341348.

A. Mengelberg , & R.J Siegert . (2003). Is theory-of-mind impaired in Parkinson’s disease? Cognitive Neuropsychiatry, 8, 191209.

W. Milberg , R. McGlinchey-Berroth , K.M. Duncan , & J.A Higgin . (1999). Alterations in the dynamics of semantic activation in Alzheimer’s disease: Evidence for the gain/decay hypothesis of a disorder of semantic memory. Journal of the International Neuropsychological Society, 5, 641658.

A. Newberg , M. Pourdehnad , A. Alavi , & E d’Aquili . (2003). Cerebral blood flow during meditative prayer: Preliminary findings and methodological issues. Perceptual and Motor Skills, 97, 625630.

J. Saltzman , E. Strauss , M. Hunter , & S Archibald . (2000). Theory of mind and executive functions in normal aging and Parkinson’s disease. Journal of the International Neuropsychological Society, 6, 781788.

U. Schjødt , H. Stødkilde-Jørgensen , A.W. Geertz , & A Roepstorff . (2008). Rewarding prayers. Neuroscience Letters, 443, 165168.

A.W. Toga , & P.M Thompson . (2003). Mapping brain asymmetry. Nature Reviews Neuroscience, 4, 3748.

J Wenger . (2004). The automatic activation of religious concepts: Implications for religious orientations. International Journal of the Psychology of Religion, 14:109123.

E. Winner , H. Brownell , F. Happé , A. Blum , & D Pincus . (1998). Distinguishing lies from jokes: Theory of mind deficits and discourse interpretation in right hemisphere brain-damaged patients. Brain and Language, 62, 89106.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 5
Total number of PDF views: 12 *
Loading metrics...

Abstract views

Total abstract views: 111 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 27th March 2017. This data will be updated every 24 hours.