Skip to main content Accesibility Help
×
×
Home

Diminished Risk-Aversion After Right DLPFC Stimulation: Effects of rTMS on a Risky Ball Throwing Task

  • Jaan Tulviste (a1) and Talis Bachmann (a2)
Abstract

Objectives: Several studies on human risk taking and risk aversion have reported the involvement of the dorsolateral prefrontal cortex (DLPFC). Yet, current knowledge of the neural mechanisms of risk-related decision making is not conclusive, mainly relying on studies using non-motor tasks. Here we examine how modulation of DLPFC activity by repetitive transcranial magnetic stimulation (rTMS) affects risk-taking behavior during a motor response task. Methods: One-Hertz rTMS to the right DLPFC was applied to monitor risk-taking and risk-aversion performance during a goal-directed risky task with motor response. Healthy participants were instructed to aim for a high score by throwing a ball as close to the ceiling as possible, while avoiding touching the ceiling with the ball. Results: One-Hertz rTMS stimulation to the right DLPFC significantly increased the frequency of ceiling hits, compared to Sham-stimulation. Conclusions: Our results suggest that the right DLPFC is a valid target for manipulating risky behavior in tasks with a motor-response. Following rTMS stimulation participants' preference shifts toward immediate awards, while becoming significantly less sensitive to potential negative consequences. The results confirm that the right DLPFC is involved in impulse control in goal-directed executive tasks. (JINS, 2019, 25, 72–78)

Copyright
Corresponding author
Correspondence and reprint requests to: Jaan Tulviste, Institute of Psychology, University of Tartu, Näituse 2, Tartu, Estonia. E-mail: jaant@ut.ee
References
Hide All
Beam, W., Borckardt, J.J., Reeves, S.T., & George, M.S. (2009). An efficient and accurate new method for locating the F3 position for prefrontal TMS applications. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 2(1), 5054.
Bechara, A., Damasio, A.R., Damasio, H., & Anderson, S.W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition, 50(1–3), 715.
Boschin, E.A., Mars, R.B., & Buckley, M.J. (2017). Transcranial magnetic stimulation to dorsolateral prefrontal cortex affects conflict-induced behavioral adaptation in a Wisconsin Card Sorting Test analogue. Neuropsychologia, 94, 3643.
Briggs, G.G., & Nebes, R.D. (1975). Patterns of hand preference in a student population. Cortex, 11(3), 230238.
Camus, M., Halelamien, N., Plassmann, H., Shimojo, S., O’Doherty, J., Camerer, C., & Rangel, A. (2009). Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex decreases valuations during food choices. European Journal of Neuroscience, 30(10), 19801988.
Carver, C.S., & White, T.L. (1994). Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS scales. Journal of Personality and Social Psychology, 67(2), 319.
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E.M., Hallett, M., & Cohen, L.G. (1997). Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology, 48, 13981403.
Cheng, G.L., & Lee, T.M. (2016). Altering risky decision-making: Influence of impulsivity on the neuromodulation of prefrontal cortex. Social Neuroscience, 11(4), 353364.
Curtis, C.E., & D’Esposito, M. (2003). Persistent activity in the prefrontal cortex during working memory. Trends in Cognitive Sciences, 7(9), 415423.
Duecker, F., & Sack, A.T. (2015). Rethinking the role of sham TMS. Frontiers in Psychology, 6, 210.
Fellows, L.K., & Farah, M.J. (2003). Ventromedial frontal cortex mediates affective shifting in humans: Evidence from a reversal learning paradigm. Brain, 126(8), 18301837.
Fitzgerald, P.B., Fountain, S., & Daskalakis, Z.J. (2006). A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition. Clinical Neurophysiology, 117(12), 25842596.
Fuster, J.M. (1991). The prefrontal cortex and its relation to behavior. Progress in Brain Research, 87, 201211.
Fuster, J.M. (1997). The prefrontal cortex-anatomy physiology, and neuropsychology of the frontal lobe. Philadelphia: Lippincott-Raven.
Gable, P.A., Neal, L.B., & Threadgill, A.H. (2018). Regulatory behavior and frontal activity: Considering the role of revised‐BIS in relative right frontal asymmetry. Psychophysiology, 55(1). doi:1111/psyp.12910
Gorini, A., Lucchiari, C., Russell-Edu, W., & Pravettoni, G. (2014). Modulation of risky choices in recently abstinent dependent cocaine users: A transcranial direct-current stimulation study. Frontiers in Human Neuroscience, 8, 661. doi:10.3389/fnhum.2014.00661
Harro, J., & Oreland, L. (2016). The role of MAO in personality and drug use. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 69, 101111.
Hutcherson, C.A., Plassmann, H., Gross, J.J., & Rangel, A. (2012). Cognitive regulation during decision making shifts behavioral control between ventromedial and dorsolateral prefrontal value systems. Journal of Neuroscience, 32(39), 1354313554.
Knoch, D., Gianotti, L.R., Pascual-Leone, A., Treyer, V., Regard, M., Hohmann, M., & Brugger, P. (2006). Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior. Journal of Neuroscience, 26(24), 64696472.
Lisanby, S.H., Gutman, D., Luber, B., Schroeder, C., & Sackeim, H.A. (2001). Sham TMS: Intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials. Biological Psychiatry, 49(5), 460463.
Liu, P., & Feng, T. (2017). The overlapping brain region accounting for the relationship between procrastination and impulsivity: A voxel-based morphometry study. Neuroscience, 360, 917.
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., & Robbins, T. (2002). Decision‐making processes following damage to the prefrontal cortex. Brain, 125(3), 624639.
Miller, E.K., & Cohen, J.D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24(1), 167202.
Otsa, M., Paaver, M., Harro, J., & Bachmann, T. (2016). A biomarker of risk-prone behavioral phenotype correlates with winning in a game of skill. Journal of Psychophysiology, 30, 155164.
Pascual-Leone, A., & Hallett, M. (1994). Induction of errors in a delayed response task by repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex. Neuroreport, 5(18), 2517.
Pochon, J.B., Levy, R., Poline, J.B., Crozier, S., Lehéricy, S., Pillon, B., … Dubois, B. (2001). The role of dorsolateral prefrontal cortex in the preparation of forthcoming actions: An fMRI study. Cerebral Cortex, 11(3), 260266.
Pripfl, J., Neumann, R., Köhler, U., & Lamm, C. (2013). Effects of transcranial direct current stimulation on risky decision making are mediated by ‘hot’and ‘cold’decisions, personality, and hemisphere. European Journal of Neuroscience, 38(12), 37783785.
Rao, H., Korczykowski, M., Pluta, J., Hoang, A., & Detre, J.A. (2008). Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART). NeuroImage, 42(2), 902910.
Reckless, G.E., Bolstad, I., Nakstad, P.H., Andreassen, O.A., & Jensen, J. (2013). Motivation alters response bias and neural activation patterns in a perceptual decision-making task. Neuroscience, 238, 135147.
Romero, J.R., Anschel, D., Sparing, R., Gangitano, M., & Pascual-Leone, A. (2002). Subthreshold low frequency repetitive transcranial magnetic stimulation selectively decreases facilitation in the motor cortex. Clinical Neurophysiology, 113(1), 101107.
Ruff, C.C., Driver, J., & Bestmann, S. (2009). Combining TMS and fMRI: From ‘virtual lesions’ to functional-network accounts of cognition. Cortex, 45(9), 10431049.
Sela, T., Kilim, A., & Lavidor, M. (2012). Transcranial alternating current stimulation increases risk-taking behavior in the balloon analog risk task. Frontiers in Neuroscience, 6, 22. doi:10.3389/fnins.2012.00022
Silvanto, J., & Pascual-Leone, A. (2008). State-dependency of transcranial magnetic stimulation. Brain Topography, 21(1), 1.
Stuss, D.T., & Alexander, M.P. (2007). Is there a dysexecutive syndrome?. Philosophical Transactions of the Royal Society B: Biological Sciences, 362(1481), 901915.
Stuss, D.T. (2011). Functions of the frontal lobes: Relation to executive functions. Journal of the International Neuropsychological Society, 17(5), 759765.
Tulviste, J., Goldberg, E., Podell, K., & Bachmann, T. (2016). Effects of repetitive transcranial magnetic stimulation on non-veridical decision making. Acta Neurobiologiae Experimentalis, 76(3), 182191.
Wassermann, E.M. (1998). Risk and safety of repetitive transcranial magnetic stimulation: Report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5–7, 1996. Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 108(1), 116.
Wassermann, E.M., & Lisanby, S.H. (2001). Therapeutic application of repetitive transcranial magnetic stimulation: A review. Clinical Neurophysiology, 112(8), 13671377.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed