Skip to main content
    • Aa
    • Aa

Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure

  • ESTHER YUET YING LAU (a1), GAIL A. ESKES (a2) (a3) (a4), DEBRA L. MORRISON (a4) (a5), MALGORZATA RAJDA (a2) (a5) and KATHLEEN F. SPURR (a6)...

Obstructive sleep apnea (OSA) is characterized by disrupted breathing and hypoxemia during sleep, daytime sleepiness, and changes in cognition and mood. One important question is regarding the reversibility of cognitive deficits after treatment with continuous positive airway pressure (CPAP). Here, we report the outcomes of CPAP treatment as measured by tests of attention and executive function. Thirty-seven individuals with moderate to severe OSA and compliant on CPAP treatment were studied with working memory tasks, neuropsychological testing, and overnight polysomnographic sleep study and compared to 27 healthy controls. CPAP improved the respiratory disturbance index, minimum and mean oxygen saturation (SpO2), subjective sleep quality, and daytime sleepiness ratings compared to pre-treatment values. In terms of current neurocognitive function, treated individuals with OSA performed at a comparable level to controls on basic working memory storage functions but still showed a significant reduction on tests of working memory requiring the central executive. The OSA group also performed worse on neuropsychological measures of complex attention, executive function, and psychomotor speed. While CPAP is an effective treatment for OSA in terms of ameliorating breathing disruption and oxygen desaturation during sleep, as well as daytime sleepiness, some cognitive deficits may be more resistant to treatment. (JINS, 2010, 16, 1077–1088.)

Corresponding author
*Correspondence and reprint requests to: Esther Yuet Ying Lau, Add: K641, Knowles Building, Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong. E-mail:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

R. Grunstein (2005). Continuous positive airway pressure treatment for obstructive sleep apnea-hypopnea syndrome. In M.H. Kryger , T. Roth & W.C. Dement (Eds.), Principles and practice of sleep medicine (4th ed., pp. 10661080). Philadelphia: Elsevier Saunders.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 10
Total number of PDF views: 52 *
Loading metrics...

Abstract views

Total abstract views: 366 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd September 2017. This data will be updated every 24 hours.