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  • Journal of the International Neuropsychological Society, Volume 14, Issue 6
  • November 2008, pp. 967-979

fMRI activation during a language task in adolescents with ASD

  • DOI:
  • Published online: 27 October 2008

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by language and communication impairments, social impairments, and repetitive behaviors or restricted interests. Previous studies of semantic functions have found differences in semantic processing and differences in the activation of the language network in adults with ASD compared to controls. The goal of this study is to examine semantic functions in adolescents with ASD compared to typically developing adolescents. We utilized fMRI with a reading version of a response-naming task to investigate activation in 12 right-handed adolescent boys with ASD and 12 typically developing boys. Both groups performed the task at ceiling levels. Boys with ASD had significantly stronger activation than controls in Broca's area, which was less left lateralized in ASD individuals. Controls had a significant correlation between frontal and temporal language area activation in the left hemisphere, whereas ASD adolescents did not. Direct group comparisons revealed additional regions activated in the ASD group relative to the control group. These results suggest differences in semantic organization, approaches to the semantic task, or efficiency in semantic processing in ASD adolescents relative to typically developing adolescents. (JINS, 2008, 14, 967–979.)

Corresponding author
Correspondence and reprint requests to: Tracey Knaus Ph.D., Department of Anatomy & Neurobiology, Boston University School of Medicine, 715 Albany Street L-814, Boston, MA 02118. E-mail:
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

F. Abell , M. Krams , J. Ashburner , R. Passingham , K. Friston , R. Frackowiak , F. Happé , C. Frith , & U. Frith (1999). The neuroanatomy of autism: A voxel-based whole brain analysis of structural scans. Neuroreport, 10, 16471651.

N. Barnea-Goraly , H. Kwon , V. Menon , S. Eliez , L. Lotspeich , & A.L. Reiss (2004). White matter structure in autism: Preliminary evidence from diffusion tensor imaging. Biological Psychiatry, 55, 323326.

H.K. Blumenfeld , J.R. Booth , & D.D. Burman (2006). Differential prefrontal-temporal neural correlates of semantic processing in children. Brain and Language, 99, 226235.

N. Boddaert , P. Belin , N. Chabane , J.B. Poline , C. Barthélemy , M.C. Mouren-Simeoni , F. Brunelle , Y. Samson , & M. Zilbovicius (2003). Perception of complex sounds: Abnormal pattern of cortical activation in autism. American Journal of Psychiatry, 160, 20572060.

N. Boddaert , N. Chabane , P. Belin , M. Bourgeois , V. Royer , C. Barthélemy , M.C. Mouren-Simeoni , A. Philippe , F. Brunelle , Y. Samson , & M. Zilbovicius (2004). Perception of complex sounds in autism: Abnormal auditory cortical processing in children. American Journal of Psychiatry, 161, 21172120.

S. Bookheimer (2002). Functional MRI of language: New approaches to understanding the cortical organization of semantic processing. Annual Review of Neuroscience, 25, 151188.

S.Y. Bookheimer (2000). Methodological issues in pediatric neuroimaging. Mental Retardation and Developmental Disabilities Research Reviews, 6, 161165.

S.Y. Bookheimer , T.A. Zeffiro , T. Blaxton , B.A. Malow , W.D. Gaillard , S. Sato , C. Kufta , P. Fedio , & W.H. Theodore (1997). A direct comparison of PET activation and electrocortical stimulation mapping for language localization. Neurology, 48, 10561065.

E. Courchesne , C.M. Karns , H.R. Davis , R. Ziccardi , R.A. Carper , Z.D. Tigue , H.J. Chisum , P. Moses , K. Pierce , C. Lord , A.J. Lincoln , S. Pizzo , L. Schreibman , R.H. Haas , N.A. Akshoomoff , & R.Y. Courchesne (2001). Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study. Neurology, 57, 245254.

R.W. Cox & A. Jesmanowicz (1999). Real-time 3D image registration for functional MRI. Magnetic Resonance in Medicine, 42, 10141018.

L. de Fossé , S.M. Hodge , N. Makris , D.N. Kennedy , V.S. Caviness Jr., L. McGrath , S. Steele , D.A. Ziegler , M.R. Herbert , J.A. Frazier , H. Tager-Flusberg , & G.J. Harris (2004). Language-association cortex asymmetry in autism and specific language impairment. Annals of Neurology, 56, 757766.

S.D. Forman , J.D. Cohen , M. Fitzgerald , W.F. Eddy , M.A. Mintun , & D.C. Noll (1995). Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold. Magnetic Resonance in Medicine, 33, 636647.

A.L. Foundas (2001). The anatomical basis of language. Topics in Language Disorders, 21, 119.

M.S. Gaffrey , N.M. Kleinhaus , F. Haist , N. Akshoomoff , A. Campbell , E. Courchesne , & R.-A. Müller (2007). A typical participation of visual cortex during word processing in autism: An fMRI study of semantic decision. Neuropsychologia, 45, 16721684.

W.D. Gaillard , B.C. Sachs , J.R. Whitnah , Z. Ahmad , L.M. Balsamo , J.R. Petrella , S.H. Braniecki , C.M. McKinney , K. Hunter , B. Xu , & C.B. Grandin (2003). Developmental aspects of language processing: fMRI of verbal fluency in children and adults. Human Brain Mapping, 18, 176185.

H. Gervais , P. Belin , N. Boddaert , M. Leboyer , A. Coez , I. Sfaello , C. Barthélemy , F. Brunelle , Y. Samson , & M. Zilbovicius (2004). Abnormal cortical voice processing in autism. Nature Neuroscience, 7, 801802.

G.J. Harris , C.F. Chabris , J. Clark , T. Urban , I. Aharon , S. Steele , L. McGrath , K. Condouris , & H. Tager-Flusberg (2006). Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging. Brain and Cognition, 61, 5468.

M.R. Herbert , G.J. Harris , K.T. Adrien , D.A. Ziegler , N. Makris , D.N. Kennedy , N.T. Lange , C.F. Chabris , A. Bakardjiev , J. Hodgson , M. Takeoka , H. Tager-Flusberg , & V.S. Caviness Jr. (2002). Abnormal asymmetry in language association cortex in autism. Annals of Neurology, 52, 588596.

M.R. Herbert , D.A. Ziegler , C.K. Deutsch , L.M. O'Brien , D.N. Kennedy , P.A. Filipek , A.I. Bakardjiev , J. Hodgson , M. Takeoka , N. Makris , & V.S. Caviness Jr. (2005). Brain asymmetries in autism and developmental language disorder: A nested whole-brain analysis. Brain, 128, 213226.

S.K. Holland , E. Plante , A.W. Byars , R.H. Strawsburg , V.J. Schmithorst , & W.S. Ball Jr. (2001). Normal fMRI brain activation patterns in children performing a verb generation task. Neuroimage, 14, 837843.

M.A. Just , V.L. Cherkassky , T.A. Keller , & N.J. Minshew (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity. Brain, 127, 18111821.

Y. Kamio , D. Robins , E. Kelley , B. Swainson , & D. Fein (2007). Atypical lexical/semantic processing in high-functioning autism spectrum disorders without early language delay. Journal of Autism & Developmental Disorders, 37, 11161122.

R.K. Kana , T.A. Keller , V.L. Cherkassky , N.J. Minshew , & M.A. Just (2006). Sentence comprehension in autism: Thinking in pictures with decreased functional connectivity. Brain, 129, 24842493.

T.A. Knaus , A.M. Bollich , D.M. Corey , L.C. Lemen , & A.L. Foundas (2004). Sex-linked differences in the anatomy of perisylvian language cortex: A volumetric MRI study of gray-matter volumes. Neuropsychology, 18, 738747.

T.A. Knaus , A.M. Bollich , D.M. Corey , L.C. Lemen , & A.L. Foundas (2006). Variability in perisylvian brain anatomy in healthy adults. Brain and Language, 97, 219232.

T.A. Knaus , D.M. Corey , A.M. Bollich , L.C. Lemen , & A.L. Foundas (2007). Anatomical asymmetries of anterior perisylvian speech-language regions. Cortex, 43, 499510.

C. Lord , S. Risi , L. Lambrecht , E.H. Cook , B.L. Lenventhal , P.S. DiLavore , A. Pickles , & M. Rutter (2000). The autism diagnostic observation schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205223.

C. Lord , M. Rutter , & A. Le Couteur (1994). Autism diagnostic interview—revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659685.

G.M. McAlonan , V. Cheung , C. Cheung , J. Suckling , G.Y. Lam , K.S. Tai , L. Yip , D.G.M. Murphy , & S.E. Chua (2005). Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. Brain, 128, 268276.

L. Mottron , K. Morasse , & S. Belleville (2001). A study of memory functioning in individuals with autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 253260.

R.-A. Müller , M.E. Behen , R.D. Rothermel , D.C. Chugani , O. Muzik , T.J. Mangner , & H.T. Chugani (1999). Brain mapping of language and auditory perception in high-functioning autistic adults: A PET study. Journal of Autism and Developmental Disorders, 29, 1931.

R.-A. Müller , D.C. Chugani , M.E. Behen , R.D. Rothermel , O. Muzik , P.K. Chakraborty , & H.T. Chugani (1998). Impairment of dentato-thalamo-cortical pathway in autistic men: Language activation data from positron emission tomography. Neuroscience Letters, 245, 14.

J.M. Piro (1998). Handedness and intelligence: Patterns of hand preference in gifted and nongifted children. Developmental Neuropsychology, 14, 619630.

B.L. Schlaggar , T.T. Brown , H.M. Lugar , K.M. Visscher , F.M. Miezin , & S.E. Petersen (2002). Functional neuroanatomical differences between adults and school-age children in the processing of single words. Science, 296, 14761479.

J.P. Szaflarski , S.K. Holland , V.J. Schmithorst , & A.W. Byars (2006). fMRI study of language lateralization in children and adults. Human Brain Mapping, 27, 202212.

H. Tager-Flusberg , R. Joseph , & S. Folstein (2001). Current directions in research on autism. Mental Retardation and Developmental Disabilities, 7, 2129.

M. Toichi & Y. Kamio (2001). Verbal association for simple common words in high-functioning autism. Journal of Autism & Developmental Disorders, 31, 483490.

M. Toichi & Y. Kamio (2002). Long-term memory and levels-of-processing in autism. Neuropsychologia, 40, 964969.

M. Toichi & Y. Kamio (2003). Long-term memory in high-functioning autism: Controversy on episodic memory in autism reconsidered. Journal of Autism & Developmental Disorders, 33, 151161.

M. Vigneau , V. Beaucousin , P.Y. Hervé , H. Duffau , F. Crivello , O. Houdé , B. Mazoyer , & N. Tzourio-Mazoyer (2006). Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing. Neuroimage, 30, 14141432.

A.G. Wood , A.S. Harvey , R.M. Wellard , D.F. Abbott , V. Anderson , M. Kean , M.M. Saling , & G.D. Jackson (2004). Language cortex activation in normal children. Neurology, 63, 10351044.

K.J. Worsley , C.H. Liao , J. Aston , V. Petre , G.H. Duncan , F. Morales , & A.C. Evans (2002). A general statistical analysis for fMRI data. Neuroimage, 15, 115.

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