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Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition

Published online by Cambridge University Press:  18 February 2016

Martina Ly ,
Nagesh Adluru ,
Daniel J. Destiche ,
Sharon Y. Lu ,
Jennifer M. Oh ,
Siobhan M. Hoscheidt ,
Andrew L. Alexander ,
Ozioma C. Okonkwo ,
Howard A. Rowley  and
Mark A. Sager
...Show all authors
Martina Ly
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin
Nagesh Adluru
Affiliation:
Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin
Daniel J. Destiche
Affiliation:
Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin
Sharon Y. Lu
Affiliation:
Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin
Jennifer M. Oh
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Siobhan M. Hoscheidt
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Andrew L. Alexander
Affiliation:
Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Ozioma C. Okonkwo
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Howard A. Rowley
Affiliation:
Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Mark A. Sager
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Sterling C. Johnson
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
Barbara B. Bendlin*
Affiliation:
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
*
Correspondence and reprint requests to: Barbara B. Bendlin, Department of Medicine and Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792. E-mail: bbb@medicine.wisc.edu
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Abstract

Objectives: The purpose of this study was to assess whether age-related differences in white matter microstructure are associated with altered task-related connectivity during episodic recognition. Methods: Using functional magnetic resonance imaging and diffusion tensor imaging from 282 cognitively healthy middle-to-late aged adults enrolled in the Wisconsin Registry for Alzheimer’s Prevention, we investigated whether fractional anisotropy (FA) within white matter regions known to decline with age was associated with task-related connectivity within the recognition network. Results: There was a positive relationship between fornix FA and memory performance, both of which negatively correlated with age. Psychophysiological interaction analyses revealed that higher fornix FA was associated with increased task-related connectivity amongst the hippocampus, caudate, precuneus, middle occipital gyrus, and middle frontal gyrus. In addition, better task performance was associated with increased task-related connectivity between the posterior cingulate gyrus, middle frontal gyrus, cuneus, and hippocampus. Conclusions: The findings indicate that age has a negative effect on white matter microstructure, which in turn has a negative impact on memory performance. However, fornix microstructure did not significantly mediate the effect of age on performance. Of interest, dynamic functional connectivity was associated with better memory performance. The results of the psychophysiological interaction analysis further revealed that alterations in fornix microstructure explain–at least in part–connectivity among cortical regions in the recognition memory network. Our results may further elucidate the relationship between structural connectivity, neural function, and cognition. (JINS, 2016, 22, 191–204)

Keywords

AgingTask-related functional connectivityfMRIgPPIFractional anisotropyEpisodic recognition

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Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 22 , Special Issue 2: Human Brain Connectivity in the Modern Era: Relevance to Understanding Health and Disease , February 2016 , pp. 191 - 204
Copyright
Copyright © The International Neuropsychological Society 2016 

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