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Hippocampal volume and declarative memory function in combat-related PTSD

  • STEVEN H. WOODWARD (a1), DANNY G. KALOUPEK (a2) (a3), LAURA J. GRANDE (a4), WENDY K. STEGMAN (a5), CATHERINE J. KUTTER (a6), LORAINE LESKIN (a7), REBECCA PRESTEL (a2), MARIE SCHAER (a8) (a9), ALLAN L. REISS (a10) and STEPHAN ELIEZ (a8)...
Abstract
Abstract

The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed. (JINS, 2009, 15, 830–839.)

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Corresponding author
*Correspondence and reprint requests to: Steven H. Woodward, Ph.D., Dissemination and Training Division, National Center for PTSD, Mail Code 334 PTSD, VA Palo Alto HCS, 3801 Miranda Avenue, Palo Alto, CA 94304. E-mail: steve.woodward@va.gov
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Andreasen N., Flaum M., Swayze V.N., O’Leary D., Alliger R., Cohen G., et al. . (1993). Intelligence and brain structure in normal individuals. American Journal of Psychiatry, 150, 130–134.
Beck A.T., Ward C.H., Mendelson M., Mock J., & Erbaugh J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561–571.
Bilkey D.K. (2007). Space and context in the temporal cortex. Hippocampus, 17(9), 813–825.
Blake D., Weathers F., Nagy L., Kaloupek D., Klauminzer G., Charney D., et al. . (2000). Clinician-Administered PTSD Scale (CAPS) instructional manual: National Center for PTSD.
Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Charney D.S., & Keane T.M. (1997). Clinician-Administered PTSD Scale for DSM-IV: Current and Lifetime Version: Boston: Behavioral Science Division, Boston VA Medical Center/Neurosciences Division, West Haven VA Medical Center.
Bonne O., Vythilingam M., Inagaki M., Wood S., Neumeister A., Nugent A.C., et al. . (2008). Reduced posterior hippocampal volume in posttraumatic stress disorder. Journal of Clinical Psychiatry, 69(7), 1087–1091.
Bossini L., Tavanti M., Calossi S., Lombardelli A., Polizzotto N.R., Galli R., et al. . (2008). Magnetic resonance imaging volumes of the hippocampus in drug-naive patients with post-traumatic stress disorder without comorbidity conditions. Journal of Psychiatric Research, 42(9), 752–762.
Brandt J. (1991). The Hopkins Verbal Learning Test: Development of a new memory test with six equivalent forms. Clinical Neuropsychology, 5, 125–142.
Bremner J.D., Randall P., Scott T.M., Bronen R.A., Seibyl J.P., Southwick S.M., et al. . (1995). MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. American Journal of Psychiatry, 152(7), 973–981.
Bremner J.D., Randall P., Vermetten E., Staib L., Bronen R.A., Mazure C., et al. . (1997). Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse–a preliminary report. Biological Psychiatry, 41(1), 23–32.
Bremner J.D., Vythilingam M., Vermetten E., Southwick S.M., McGlashan T., Nazeer A., et al. . (2003). MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. American Journal of Psychiatry, 160(5), 924–932.
Brewin C.R., Kleiner J.S., Vasterling J.J., & Field A.P. (2007). Memory for emotionally neutral information in posttraumatic stress disorder: A meta-analytic investigation. Journal of Abnormal Psychology, 116(3), 448–463.
Coburn-Litvak P.S., Tata D.A., Gorby H.E., McCloskey D.P., Richardson G., & Anderson B.J. (2004). Chronic corticosterone affects brain weight, and mitochondrial, but not glial volume fraction in hippocampal area CA3. Neuroscience, 124(2), 429–438.
Convit A., de Leon M.J., Tarshish C., De Santi S., Kluger A., Rusinek H., & George A.E. (1995). Hippocampal volume losses in minimally impaired elderly. Lancet, 345(8944), 266.
Dale A.M., Fischl B., & Sereno M.I. (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage, 9(2), 179–194.
Desikan R.S., Segonne F., Fischl B., Quinn B.T., Dickerson B.C., Blacker D., et al. . (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage, 31(3), 968–980.
First M.B., Spitzer M.B., Gibbon M., & Williams J.B.W. (1995). Structured clinical interview for DSM-IV axis II personality disorders – patient (SCID-I/P), Version 2.0. New York: New York State Psychiatric Institute.
Fischl B., & Dale A.M. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Science of the USA, 97(20), 11050–11055.
Fischl B., Sereno M.I., & Dale A.M. (1999). Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage, 9(2), 195–207.
Fischl B., Sereno M.I., Tootell R.B., & Dale A.M. (1999). High-resolution intersubject averaging and a coordinate system for the cortical surface. Human Brain Mapping, 8(4), 272–284.
Fischl B., van der Kouwe A., Destrieux C., Halgren E., Segonne F., Salat D.H., et al. . (2004). Automatically parcellating the human cerebral cortex. Cerebral Cortex, 14(1), 11–22.
Fortin M., Voss P., Lord C., Lassonde M., Pruessner J., Saint-Amour D., et al. . (2008). Wayfinding in the blind: Larger hippocampal volume and supranormal spatial navigation. Brain, 131(Pt. 11), 2995–3005.
Gilbertson M.W., Williston S.K., Paulus L.A., Lasko N.B., Gurvits T.V., Shenton M.E., et al. . (2007). Configural cue performance in identical twins discordant for posttraumatic stress disorder: Theoretical implications for the role of hippocampal function. Biological Psychiatry, 62(5), 513–520.
Golier J.A., Harvey P.D., Legge J., & Yehuda R. (2006). Memory performance in older trauma survivors: Implications for the longitudinal course of PTSD. Annals of the New York Academy of Science, 1071, 54–66.
Gould E., & Tanapat P. (1999). Stress and hippocampal neurogenesis. Biological Psychiatry, 46(11), 1472–1479.
Gurvits T.V., Shenton M.E., Hokama H., Ohta H., Lasko N.B., Gilbertson M.W., et al. . (1996). Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry, 40(11), 1091–1099.
Han X., Jovicich J., Salat D., van der Kouwe A., Quinn B., Czanner S., et al. . (2006). Reliability of MRI-derived measurements of human cerebral cortical thickness: The effects of field strength, scanner upgrade and manufacturer. Neuroimage, 32(1), 180–194.
Harris G.J., Jaffin S.K., Hodge S.M., Kennedy D., Caviness V.S., Marinkovic K., et al. . (2008). Frontal white matter and cingulum diffusion tensor imaging deficits in alcoholism. Alcohol Clinical Experimental Research, 32(6), 1001–1013.
Karl A., Schaefer M., Malta L.S., Dorfel D., Rohleder N., & Werner A. (2006). A meta-analysis of structural brain abnormalities in PTSD. Neuroscience and Biobehavior Review, 30(7), 1004–031.
Kates W.R., Abrams M.T., Kaufmann W.E., Breiter S.N., & Reiss A.L. (1997). Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Research, 75(1), 31–48.
Keane T.M., Caddell J.M., & Taylor K.L. (1988). Mississippi Scale for Combat-Related Posttraumatic Stress Disorder: Three studies in reliability and validity. Journal of Consulting and Clinical Psychology, 56(1), 85–90.
Keane T.M., Fairbank J.A., Caddell J.M., Zimering R.T., Taylor K.L., & Mora C.A. (1989). Clinical evaluation of a measure to assess combat exposure. Psychological Assessment, 1(1), 53–55.
Kirschbaum C., Wolf O.T., May M., Wippich W., & Hellhammer D.H. (1996). Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sciences, 58(17), 1475–1483.
Laakso M.P., Soininen H., Partanen K., Helkala E.L., Hartikainen P., Vainio P., et al. . (1995). Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer’s disease: Correlation with memory functions. Journal of Neural Transmission, Parkinson’s Disease and Dementia Section, 9(1), 73–86.
Lang S., Kroll A., Lipinski S.J., Wessa M., Ridder S., Christmann C., et al. . (2009). Context conditioning and extinction in humans: Differential contribution of the hippocampus, amygdala and prefrontal cortex. European Journal of Neuroscience, 29(4), 823–832.
Marquis S., Moore M.M., Howieson D.B., Sexton G., Payami H., Kaye J.A., & Camicioli R. (2002). Independent predictors of cognitive decline in healthy elderly persons. Archives of Neurology, 59(4), 601–606.
McEwen B.S., & Magarinos A.M. (1997). Stress effects on morphology and function of the hippocampus. Annals of the New York Academy of Science, 821, 271–284.
McNally R.J. (1998). Experimental approaches to cognitive abnormality in posttraumatic stress disorder. Clinical Psychology Review, 18(8), 971–982.
Metzger L.J., Orr S.P., Lasko N.B., McNally R.J., & Pitman R.K. (1997). Seeking the source of emotional Stroop interference effects in PTSD: A study of P3s to traumatic words. Integrative Physiological and Behavioral Science, 32(1), 43–51.
Nakano T., Wenner M., Inagaki M., Kugaya A., Akechi T., Matsuoka Y., et al. . (2002). Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors. American Journal of Psychiatry, 159(12), 2087–2093.
Osterrieth P.A. (1944). Le test de copie d’ude figure complex: Contribution a l’edtude de la perception et de la memoire. Archives de Psycholgie, 30, 286–340.
Pavic L., Gregurek R., Rados M., Brkljacic B., Brajkovic L., Simetin-Pavic I., et al. . (2007). Smaller right hippocampus in war veterans with posttraumatic stress disorder. Psychiatry Research, 154(2), 191–198.
Pederson C.L., Maurer S.H., Kaminski P.L., Zander K.A., Peters C.M., Stokes-Crowe L.A., & Osborn R.E. (2004). Hippocampal volume and memory performance in a community-based sample of women with posttraumatic stress disorder secondary to child abuse. Journal of Traumatic Stress, 17(1), 37–40.
Psychological Corporation (1997). Wechsler Adult Intelligence Scale, Third Revision. San Antonio, TX: Harcourt Brace.
Reiss A.L., Hennessey J.G., Rubin M., Beach L., Abrams M.T., Warsofsky I.S., et al. . (1998). Reliability and validity of an algorithm for fuzzy tissue segmentation of MRI. Journal of Computer Assisted Tomography, 22(3), 471–479.
Rey A. (1941). L’examen psychologique dans les cas d’enchphalopathie traumatique. Archives de Psycholgie, 28, 286–340.
Samuelson K.W., Neylan T.C., Metzler T.J., Lenoci M., Rothlind J., Henn-Haase C., et al. . (2006). Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse. Neuropsychology, 20(6), 716–726.
Sapolsky R.M. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57(10), 925–935.
Selzer M.L. (1971). The Michigan alcoholism screening test: The quest for a new diagnostic instrument. American Journal of Psychiatry, 127(12), 1653–1658.
Shin L.M., Shin P.S., Heckers S., Krangel T.S., Macklin M.L., Orr S.P., et al. . (2004). Hippocampal function in posttraumatic stress disorder. Hippocampus, 14(3), 292–300.
Simic G., Kostovic I., Winblad B., & Bogdanovic N. (1997). Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer’s disease. Journal of Comparative Neurology, 379(4), 482–494.
Soininen H.S., Partanen K., Pitkanen A., Vainio P., Hanninen T., Hallikainen M., et al. . (1994). Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: Correlation to visual and verbal memory. Neurology, 44(9), 1660–1668.
Spreen O., & Strauss E. (1991). A compendium of neuropsychological tests: Administration, norms and commentary. New York: Oxford University Press.
Stein M.B., Koverola C., Hanna C., Torchia M.G., & McClarty B. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine, 27(4), 951–959.
Talairach J., & Tournoux P. (1988). Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical.
Tata D.A., Marciano V.A., & Anderson B.J. (2006). Synapse loss from chronically elevated glucocorticoids: Relationship to neuropil volume and cell number in hippocampal area CA3. Journal of Comparative Neurology, 498(3), 363–374.
Tischler L., Brand S.R., Stavitsky K., Labinsky E., Newmark R., Grossman R., et al. . (2006). The relationship between hippocampal volume and declarative memory in a population of combat veterans with and without PTSD. Annals of the New York Academy of Science, 1071, 405–409.
Vasterling J.J., Proctor S.P., Amoroso P., Kane R., Heeren T., & White R.F. (2006). Neuropsychological outcomes of army personnel following deployment to the Iraq war. JAMA, 296(5), 519–529.
Vythilingam M., Blair K.S., McCaffrey D., Scaramozza M., Jones M., Nakic M., et al. . (2007). Biased emotional attention in post-traumatic stress disorder: A help as well as a hindrance? Psychological Medicine, 37(10), 1445–1455.
Vythilingam M., Luckenbaugh D.A., Lam T., Morgan C.A. 3rd, Lipschitz D., Charney D.S., et al. . (2005). Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder. Psychiatry Research, 139(2), 89–99.
Wais P.E. (2008). fMRI signals associated with memory strength in the medial temporal lobes: A meta-analysis. Neuropsychologia.
Wechsler D. (1997). Wechsler Memory Scale-Third Edition: Administration and scoring manual. San Antonio, TX: The Psychological Corporation.
Woodward S.H., Kaloupek D.G., Streeter C.C., Kimble M.O., Reiss A.L., Eliez S., et al. . (2007). Brain, skull, and CSF volumes in adult posttraumatic stress disorder. Journal of Traumatic Stress, 20, 763–774.
Woodward S.H., Kaloupek D.G., Streeter C.C., Kimble M.O., Reiss A.L., Eliez S., et al. . (2006a). Hippocampal volume, PTSD, and alcoholism in combat veterans. American Journal of Psychiatry, 163(4), 674–681.
Woodward S.H., Kaloupek D.G., Streeter C.C., Martinez C., Schaer M., & Eliez S. (2006b). Decreased anterior cingulate volume in combat-related PTSD. Biological Psychiatry, 59(7), 582–587.
Woodward S.H., Schaer M., Kaloupek D.G., Cediel L., & Eliez S. (in press). Cerebral cortical volume is globally and regionally smaller in combat-related posttraumatic stress disorder. Archives of General Psychiatry.
Yehuda R., Golier J.A., Tischler L., Harvey P.D., Newmark R., Yang R.K., & Buchsbaum M.S. (2007). Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: Relation to risk and resilience factors. Journal of Psychiatric Research, 41(5), 435–445.
Yehuda R., Golier J.A., Tischler L., Stavitsky K., & Harvey P.D. (2005). Learning and memory in aging combat veterans with PTSD. Journal of Clinical Experimental Neuropsychology, 27(4), 504–515.
Zimmerman M.E., Pan J.W., Hetherington H.P., Katz M.J., Verghese J., Buschke H., Derby C.A., & Lipton R.B. (2008). Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. Neurology, 70(18), 1594–1600.
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