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The impact of HIV-associated neuropsychological impairment on everyday functioning

  • ROBERT K. HEATON (a1) (a2), THOMAS D. MARCOTTE (a1), MONICA RIVERA MINDT (a3), JOSEPH SADEK (a1), DAVID J. MOORE (a4), HEATHER BENTLEY (a1), J. ALLEN MCCUTCHAN (a1), CARLA REICKS (a1), IGOR GRANT (a1) (a2) and THE HNRC GROUP...
Abstract

HIV-1 infection can be associated with neuropsychological (NP) deficits ranging from subtle to severe. The purpose of this study was to evaluate the functional, or “real-world” impact of HIV-associated NP impairment in a group of 267 HIV-infected participants. All participants received comprehensive NP, neuromedical, and standardized functional evaluations that included laboratory measures of shopping, cooking, financial management, medication management and vocational abilities. Compared to NP-normal participants, those with NP impairment performed significantly worse on all laboratory measures of everyday functioning. Multivariate analyses revealed that the NP ability domains of Abstraction/Executive Function, Learning, Attention/Working Memory and Verbal abilities most strongly and consistently predicted failures on the functional battery. Both NP impairment and impairment on the functional battery were significantly associated with subjective experiences of cognitive difficulties, as well as unemployment and increased dependence in activities of daily living; multivariate prediction models that also considered depressed mood and biological measures of disease progression revealed that impairment on the functional battery and depression were the only unique predictors of all three indicators of “real-world” functioning. The current results add to growing evidence concerning the clinical significance of HIV-associated NP impairment. Objective, laboratory based functional measures, such as those used here, may compliment NP testing in future studies directed at understanding the impact on life quality of central nervous system disorders and their treatments. Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons.NOTE: Dr. Erin D. Bigler served as action editor during the course of this review. (JINS, 2004, 10, 317–331.)

Copyright
© 2004 The International Neuropsychological Society
Corresponding author
Reprint requests to: Robert K. Heaton, University of California, Department of Psychiatry (0603-G), 9500 Gilman Drive, La Jolla, CA 92093-0603.
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Albert, S.M., Marder, K.M., Dooneief, G., Bell, K., Sano, M., Todak, G., & Stern, Y. (1995). Neuropsychologic impairment in early HIV infection: A risk factor for work disability. Archives of Neurology, 52, 525–530.
Albert, S.M., Weber, C.M., Todak, G., Polanco, C., Clouse, R., McElhiney, M., Rabkin, J., & Marder, K. (1999). An observed performance test of medication management ability in HIV: Relation to neuropsychological status and medication outcomes. AIDS and Behavior, 3, 121–128.
American Academy of Neurology AIDS Task Force. (1991). Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection. Neurology, 41, 778–785.
Baldessarini, R.J., Finklestein, S., & Arana, G.W. (1983). The predictive power of diagnostic tests and the effect of prevalence of illness. Archives of General Psychiatry, 40, 569–573.
Benedict, R.H.B, Mezhir, J.J., Walsh, K., & Hewitt, R.G. (2000). Impact of human immunodeficiency virus Type-1-associated cognitive dysfunction on activities of daily living and quality of life. Archives of Clinical Neuropsychology, 15, 529–534.
Butters, N., Grant, I., Haxby, J., Judd, L.L., Martin, A., McClelland, J., Pequegnat, W., Schacter, D., & Stover, E. (1990). Assessment of AIDS-related cognitive changes: Recommendations of the NIMH Workshop on Neuropsychological Assessment Approaches. Journal of Clinical and Experimental Neuropsychology, 12, 963–978.
Diehr, M.C., Heaton, R.K., Miller, W., & Grant, I. (1998). The Paced Auditory Serial Addition Task (PASAT): Norms for age, education, and ethnicity. Assessment, 5, 375–387.
Gladsjo, J.A., Schuman, C.C., Evans, J.D., Peavy, G.M., Miller, S.W., & Heaton, R.K. (1999). Norms for letter and category fluency: Demographic corrections for age, education, and ethnicity. Assessment, 6, 147–178.
Grant, I., Atkinson, J.H., Hesselink, J.R., Kennedy, C.J., Richman, D.D., Spector, S.A., & McCutchan, J.A. (1987). Evidence for early central nervous system involvement in the acquired immunodeficiency syndrome (AIDS) and other human immunodeficiency virus (HIV) infections. Annals of Internal Medicine, 107, 828–836.
Heaton, R.K., Grant, I., Anthony, W.Z., & Lehman, R.A.W. (1981). A comparison of clinical and automated interpretation of the Halstead-Reitan battery. Journal of Clinical Neuropsychology, 3, 121–141.
Heaton, R.K., Grant, I., Butters, N., White, D.A., Kirson, D., Atkinson, J.H., McCutchan, J.A., Taylor, M.J., Kelly, M.D., Ellis, R.J., Wolfson, T., Velin, R., Marcotte, T.D., Hesselink, J.R., Jernigan, T.L., Chandler, J., Wallace, M., Abramson, I., & the HNRC Group. (1995). The HNRC 500—Neuropsychology of HIV infection at different disease stages. Journal of the International Neuropsychological Society, 1, 231–251.
Heaton, R.K., Marcotte, T.D., White, D.A., Ross, D., Meredith, K., Taylor, M.J., Kaplan, R., & Grant, I. (1996). Nature and vocational significance of neuropsychological impairment associated with HIV infection. Clinical Neuropsychologist, 10, 1–14.
Heaton, R.K. & Pendleton, M.G. (1981). Use of neuropsychological tests to predict adult patients' everyday functioning. Journal of Consulting and Clinical Psychology, 49, 807–821.
Heaton, R.K., Velin, R.A., McCutchan, J.A., Gulevich, S.J., Atkinson, J.H., Wallace, M.R., Godfrey, H., Kirson, D., Grant, I., & the HNRC Group. (1994b). Neuropsychological impairment in human immunodeficiency virus-infection: Implications for employment. Psychosomatic Medicine, 56, 8–17.
Hinkin, C.H., Castellon, S.A., Durvasula, R.S., Hardy, D.J., Lam, M.N., Mason, K.I., Thrasher, D., Goetz, M.B., & Stefaniak, M. (2002). Medication adherence among HIV+ adults: Effects of cognitive dysfunction and regimen complexity. Neurology, 59, 1944–1950.
Hinkin, C.H., Hardy, D.J., Mason, K.I., Castellon, S.A., Durvasula, R.S., Lam, M.N., & Stefaniak, M. (2004). Medication adherence in HIV-infected adults: Effect of patient age, cognitive status, and substance abuse. AIDS, 18(S1), S19–S25
Jernigan, T.L., Archibald, S., Hesselink, J.R., Atkinson, J.H., Velin, R.A., McCutchan, J.A., Chandler, J., Grant, I., & the HNRC Group. (1993). Magnetic resonance imaging morphometric analysis of cerebral volume loss in human immunodeficiency virus infection. Archives of Neurology, 50, 250–255.
Lawton, M.P. & Brody, E.M. (1969). Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist, 9, 179–186.
Lowenstein, D.A., Duara, R., Rubert, M.P., & Arguelles, T. (1995). Neuropsychological test performance and prediction of functional capacities among Spanish-speakers and English-speaking patients with dementia. Archives of Clinical Neuropsychology, 10, 75–88.
Salthouse, T.A. (1994). Age-related differences in basic cognitive processes: Implications for work. Experimental Aging Research, 20, 249–255.
Schiffito, G., Kieburtz, K., McDermott, M.P., McArthur, J., Marder, K., Sacktor, N., Palumbo, D., Selnes, O., Stern, Y., Epstein, L., & Albert, S. (2001). Clinical trials in HIV-associated cognitive impairment: Cognitive and functional outcomes. Neurology, 56, 415–418.
Stout, J.C., Ellis, R.J., Jernigan, T.L., Archibald, S.L., Abramson, I., Wolfson, T., McCutchan, J.A., Wallace, M.R., Atkinson, J.H., Grant, I., & the HNRC Group. (1998). Progressive cerebral volume loss in human immunodeficiency virus infection: A longitudinal volumetric magnetic resonance imaging study. Archives of Neurology, 55, 161–168.
Temkin, N.R., Heaton, R.K., Grant, I., & Dikmen, S.S. (1999). Detecting significant change in neuropsychological test performance: A comparison of four models. Journal of the International Neuropsychological Society, 5, 357–369.
Woods, S.P., Weinborn, M., & Lovejoy, D.W. (2003). Are classification accuracy statistics underused in neuropsychological research?Journal of Clinical and Experimental Neuropsychology, 25, 431–439.
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Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
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