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INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia–CORRECTED VERSION

Published online by Cambridge University Press:  28 July 2009

TERESA TORRALVA ,
MARÍA ROCA ,
EZEQUIEL GLEICHGERRCHT ,
PABLO LÓPEZ  and
FACUNDO MANES
TERESA TORRALVA*
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
MARÍA ROCA
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
EZEQUIEL GLEICHGERRCHT
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina
PABLO LÓPEZ
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
FACUNDO MANES
Affiliation:
Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina Institute of Neurosciences Favaloro University, Buenos Aires, Argentina
*
*Correspondence and reprint requests to: Teresa Torralva, Instituto de Neurología Cognitiva (INECO), Castex 3293 (1425), Buenos Aires, Argentina. E-mail: ttorralva@neurologiacognitiva.org
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Abstract

Although several brief sensitive screening tools are available to detect cognitive dysfunction, few have been developed to quickly assess executive functioning (EF) per se. We designed a new brief tool to evaluate EF in neurodegenerative diseases. Patients with an established diagnosis of behavioral variant frontotemporal dementia (bvFTD; n = 22), Alzheimer disease (AD; n = 25), and controls (n = 26) were assessed with a cognitive screening test, the INECO Frontal Screening (IFS), and EF tests. Clinical Dementia Rating Scale (CDR) scores were obtained for all patients. Internal consistency of the IFS was very good (Cronbach’s alpha = .80). IFS total (out of 30 points) was 27.4 (SD = 1.6) for controls, 15.6 (SD = 4.2) for bvFTD, and 20.1 (SD = 4.7) for AD. Using a cutoff of 25 points, sensitivity of the IFS was 96.2%, and specificity 91.5% in differentiating controls from patients with dementia. The IFS correlated significantly with the CDR and executive tasks. The IFS total discriminated controls from demented patients, and bvFTD from AD. IFS is a brief, sensitive, and specific tool for the detection of executive dysfunction associated with neurodegenerative diseases. The IFS may be helpful in the differential diagnosis of FTD and AD. (JINS, 2009, 15, 777–786.)

Keywords

NeuropsychologyCognitionDysexecutionFrontotemporal dementiaAlzheimer diseaseDifferential diagnosis

Information

Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 5 , September 2009 , pp. 777 - 786
Copyright
Copyright © The International Neuropsychological Society 2009

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