Skip to main content
×
Home
    • Aa
    • Aa

A large-scale retrospective study of closing-in behavior in Alzheimer’s disease

  • ELISABETTA AMBRON (a1) (a2), ROBERT D. MCINTOSH (a1), FRANCESCA ALLARIA (a3) and SERGIO DELLA SALA (a1) (a4)
Abstract
Abstract

The frequency and characteristics of closing-in behavior (CIB) were examined in 797 patients with Alzheimer’s disease (AD), 132 of whom were followed up longitudinally. The frequency of CIB increased with the complexity of the graphic copying task and with the severity of Alzheimer’s disease. Regression analyses suggested that attentional deficits are critical factors for the appearance of CIB, but that visuospatial impairments also play an important role in the emergence of severe forms of CIB. (JINS, 2009, 15, 787–792.)

Copyright
Corresponding author
*Correspondence and reprint requests to: Robert D. McIntosh, Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ. E-mail: r.d.mcintosh@ed.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

E. Ambron , F. Allaria , R.D. McIntosh , & S Della Sala . (2009a). Closing-in behaviour in fronto-temporal dementia. Journal of Neurology epub Feb 25 2009.

E. Ambron , R.D. McIntosh , & S Della Sala . (2009b). Animal magnetism: Evidence for an attraction account of closing-in behaviour in pre-school children. Cortex, 45, 278284.

E. Brazzelli , E. Capitani , S. Della Sala , H. Spinnler , & M Zuffi . (1994). A neuropsychological instrument adding to the description of patients with suspected cortical dementia: The Milan overall dementia assessment. Journal of Neurology, Neurosurgery and Psychiatry, 57, 15101517.

M. Conson , S. Salzano , V. Manzo , D. Grossi , & L Trojano . (2009). Closing-in without severe drawing disorders: The “fatal” consequences of pathological attraction. Cortex, 45, 285292.

G Gainotti ., (1972). A qualitative study of the closing-in symptom in normal children and in brain-damaged patients. Neuropsychologia, 10, 429436.

G. Gainotti , V. Parlato , D. Monteleone , & S Carlomagno . (1992). Neuropsychological markers of dementia on visual-spatial tasks: A comparison between Alzheimer’s type and vascular forms of dementia. Journal of Clinical and Experimental Neuropsychology, 14, 239252.

J.C. Kwon , S.J. Kang , B.H. Lee , J. Chin , K.M. Heilman , & D.L Na . (2002). Manual approach during hand gesture imitation. Archives of Neurology, 59, 14681475.

B.H. Lee , J. Chin , S.J. Kang , E.J. Kim , K.C. Park , & D.L Na . (2004). Mechanism of the closing-in phenomenon in a figure coping task in Alzheimer’s disease patients. Neurocase, 10, 393397.

R.D. McIntosh , E. Ambron , & S Della Sala . (2008). Evidence for an attraction account of closing-in behaviour. Cognitive Neuropsychology, 25, 376394.

G. McKhann , D. Drachman , M. Folstein , R. Katzman , D. Price , & E.M Stadlan . (1984). Clinical diagnosis of Alzeimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939944.

B.A. Ober , W.J. Jagust , E. Koss , D.C. Delis , & R.P Friedland . (1991). Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 13, 752772.

H. Spinnler , & S Della Sala . (1988). The role of clinical neuropsychology in the neurological diagnosis of Alzheimer’s disease. Journal of Neurology, 235, 258271.

L. Trojano , D. Grossi , & T Flash . (2009). Cognitive neuroscience of drawing: Contributions of neuropsychological, experimental and neurofunctional studies. Cortex, 45, 269277.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 13 *
Loading metrics...

Abstract views

Total abstract views: 77 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 25th September 2017. This data will be updated every 24 hours.