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Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer’s disease

Published online by Cambridge University Press:  11 December 2009

SHARON X. XIE ,
DAVID J. LIBON ,
XINGMEI WANG ,
LAUREN MASSIMO ,
PEACHIE MOORE ,
LUISA VESELY ,
ALEA KHAN ,
ANJAN CHATTERJEE ,
H. BRANCH COSLETT  and
HOWARD I. HURTIG
...Show all authors
SHARON X. XIE*
Affiliation:
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
DAVID J. LIBON
Affiliation:
Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania
XINGMEI WANG
Affiliation:
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
LAUREN MASSIMO
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
PEACHIE MOORE
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
LUISA VESELY
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
ALEA KHAN
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
ANJAN CHATTERJEE
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
H. BRANCH COSLETT
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
HOWARD I. HURTIG
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
TSAO-WEI LIANG
Affiliation:
Department of Neurology, Thomas Jefferson Medical College, Philadelphia, Pennsylvania
MURRAY GROSSMAN
Affiliation:
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
*
*Correspondence and reprint requests to: Sharon X. Xie, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 618 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021. E-mail: sxie@mail.med.upenn.edu
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Abstract

The longitudinal assessment of episodic and semantic memory was obtained from 236 patients diagnosed with Alzheimer’s disease (AD, n = 128) and with frontotemporal lobar degeneration (FTLD, n = 108), including patients with a social comportment/dysexecutive (SOC/EXEC) disorder, progressive nonfluent aphasia (PNFA), semantic dementia (SemD), and corticobasal syndrome (CBS). At the initial assessment, AD patients obtained a lower score on the delayed free recall test than other patients. Longitudinal analyses for delayed free recall found converging performance, with all patients reaching the same level of impairment as AD patients. On the initial evaluation for delayed recognition, AD patients also obtained lower scores than other groups. Longitudinal analyses for delayed recognition test performance found that AD patients consistently produced lower scores than other groups and no convergence between AD and other dementia groups was seen. For semantic memory, there were no initial between-group differences. However, longitudinal analyses for semantic memory revealed group differences over illness duration, with worse performance for SemD versus AD, PNFA, SOC/EXEC, and CBS patients. These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype. (JINS, 2010, 16, 278–286.)

Keywords

Frontotemporal lobar dementiaLongitudinal analysisNeuropsychological assessmentEpisodic memorySemantic memoryPick’s disease
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 2 , March 2010 , pp. 278 - 286
Copyright
Copyright © The International Neuropsychological Society 2009

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