Skip to main content
×
×
Home

New Yes/No Recognition Memory Analysis on the California Verbal Learning Test-3: Clinical Utility in Alzheimer’s and Huntington’s Disease

  • Lisa V. Graves (a1) (a2), Heather M. Holden (a1) (a2), Emily J. Van Etten (a3), Lisa Delano-Wood (a1) (a4) (a5), Mark W. Bondi (a1) (a4) (a5), David P. Salmon (a1) (a6), Jody Corey-Bloom (a1) (a6), Dean C. Delis (a1) (a5) and Paul E. Gilbert (a1) (a2)...
Abstract

Objectives: The third edition of the California Verbal Learning Test (CVLT-3) includes a new index termed List A versus Novel/Unrelated recognition discriminability (RD) on the Yes/No Recognition trial. Whereas the Total RD index incorporates false positive (FP) errors associated with all distractors (including List B and semantically related items), the new List A versus Novel/Unrelated RD index incorporates only FP errors associated with novel, semantically unrelated distractors. Thus, in minimizing levels of source and semantic interference, the List A versus Novel/Unrelated RD index may yield purer assessments of yes/no recognition memory independent of vulnerability to source memory difficulties or semantic confusion, both of which are often seen in individuals with primarily frontal-system dysfunction (e.g., early Huntington’s disease [HD]). Methods: We compared the performance of individuals with Alzheimer’s disease (AD) and HD in mild and moderate stages of dementia on CVLT-3 indices of Total RD and List A versus Novel/Unrelated RD. Results: Although AD and HD subgroups exhibited deficits on both RD indices relative to healthy comparison groups, those with HD generally outperformed those with AD, and group differences were more robust on List A versus Novel/Unrelated RD than on Total RD. Conclusions: Our findings highlight the clinical utility of the new CVLT-3 List A versus Novel/Unrelated RD index, which (a) maximally assesses yes/no recognition memory independent of source and semantic interference; and (b) provides a greater differentiation between individuals whose memory disorder is primarily at the encoding/storage level (e.g., as in AD) versus at the retrieval level (e.g., as in early HD). (JINS, 2018, 24, 833–841)

Copyright
Corresponding author
Correspondence and reprint requests to: Paul E. Gilbert, SDSU/UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA, 92120. E-mail: pgilbert@mail.sdsu.edu
References
Hide All
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990). Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Progress in Brain Research, 85, 119146.
Baldo, J. V., Delis, D., Kramer, J., & Shimamura, A. P. (2002). Memory performance on the California Verbal Learning Test-II: Findings from patients with focal frontal lesions. Journal of the International Neuropsychological Society, 8, 539546.
Blumenfeld, R. S., & Ranganath, C. (2007). Prefrontal cortex and long-term memory encoding: An integrative review of findings from neuropsychology and neuroimaging. Neuroscientist, 13(3), 280291.
Braak, H., & Braak, E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica, 82, 239259.
Budson, A. E., & Kowall, N. W. (2013). Handbook of Alzheimer’s disease and other dementias. Hoboken, NJ: Wiley-Blackwell.
Butters, N., Wolfe, J., Granholm, E., & Martone, M. (1986). An assessment of verbal recall, recognition and fluency abilities in patients with Huntington’s disease. Cortex, 22, 1132.
Butters, N., Wolfe, J., Martone, M., Granholm, E., & Cermak, L. S. (1985). Memory disorders associated with Huntington’s disease: Verbal recall, verbal recognition, and procedural memory. Neuropsychologia, 23, 729743.
Crosson, B., Benefield, H., Cato, M. A., Sadek, J. R., Moore, A. B., Wierenga, C. E., & Briggs, R. W. (2003). Left and right basal ganglia and frontal activity during language generation: Contributions to lexical, semantic, and phonological processes. Journal of the International Neuropsychological Society, 9, 10611077.
Cummings, J. L. (1993). Frontal-subcortical circuits and human behavior. Archives of Neurology, 50, 873880.
Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1987). California Verbal Learning Test. San Antonio, TX: The Psychological Corporation.
Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (2000). California Verbal Learning Test–II (Second Edition, San Antonio, TX: The Psychological Corporation.
Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (2017). California Verbal Learning Test–3 (Third Edition, San Antonio, TX: The Psychological Corporation.
Delis, D. C., Massman, P. J., Butters, N., Salmon, D. P., Cermak, L. S., & Kramer, J. H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychological Assessment, 3, 1926.
Delis, D. C., Wetter, S. R., Jacobson, M. W., Peavy, G., Hamilton, J., Gongvatana, A., & Salmon, D. P. (2005). Recall discriminability: Utility of a new CVLT-II measure in the differential diagnosis of dementia. Journal of the International Neuropsychological Society, 11(6), 708715.
Fine, E. M., Delis, D. C., Wetter, S. R., Jacobson, M. W., Hamilton, J. M., Peavy, G., & Salmon, D. P. (2008). Identifying the “source” of recognition memory deficits in patients with Huntington’s disease or Alzheimer’s disease: Evidence from the CVLT-II. Journal of Clinical and Experimental Neuropsychology, 30(4), 463470.
Graves, L. V., Holden, H. M., Woods, S. P., Delano-Wood, L., Bondi, M., Salmon, D. P., & Gilbert, P. E. (2017). Total recognition discriminability in Huntington’s and Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 39(2), 120130.
Hodges, J. R., Salmon, D. P., & Butters, N. (1990). Differential impairment of semantic and episodic memory in Alzheimer’s and Huntington’s diseases: A controlled prospective study. Journal of Neurology, Neurosurgery, and Psychiatry, 53(12), 10891095.
Huntington Study Group. (1996). Unified Huntington’s disease rating scale: Reliability and consistency. Movement Disorders, 11, 136142.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984). Alzheimer’s disease: Cell-specific pathology isolates the hippocampal formation. Science, 225, 11681170.
Jurica, P. J., Leitten, S., & Mattis, S. (2001). Dementia Rating Scale-2: Professional manual. Lutz, FL: Psychological Assessment Resources.
Kramer, J. H., Delis, D. C., Blusewicz, M. J., Brandt, J., Ober, B. A., & Strauss, M. (1988). Verbal memory errors in Alzheimer’s and Huntington’s dementias. Developmental Neuropsychology, 4, 115.
Kramer, J. H., Levin, B. E., Brandt, J., & Delis, D. C. (1989). Differentiation of Alzheimer’s, Huntington’s, and Parkinson’s disease patients on the basis of verbal learning characteristics. Neurology, 3, 111120.
Lundervold, A. J., Reinvang, I., & Lundervold, A. (1994). Characteristic patterns of verbal memory function in patients with Huntington’s disease. Scandinavian Journal of Psychology, 35(1), 3847.
Macmillan, N. A., & Creelman, D. C. (1991). Detection theory: A user’s guide. New York: Cambridge University Press.
Martone, M., Butters, N., Payne, M., Becker, J. T., & Sax, D. S. (1984). Dissociations between skill learning and verbal recognition in amnesia and dementia. Archives of Neurology, 41, 965970.
Massman, P. J., Delis, D. C., Butters, N., Levin, B. E., & Salmon, D. P. (1990). Are all subcortical dementias alike? Verbal learning and memory in Parkinson’s and Huntington’s disease patients. Journal of Clinical and Experimental Neuropsychology, 12(5), 729744.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS–ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology, 34, 939944.
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R. Jr., Kawas, C. H., & Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup. Alzheimer’s & Dementia, 7(3), 263269.
Montoya, A., Pelletier, M., Menear, M., Duplessis, E., Richer, F., & Lepage, M. (2006). Episodic memory impairment in Huntington’s disease: A meta-analysis. Neuropsychologia, 44, 19841994.
Moss, M. B., Albert, M. S., Butters, N., & Payne, M. (1986). Differential patterns of memory loss among patients with Alzheimer’s disease, Huntington’s disease, and alcoholic Korsakoff’s syndrome. Archives of Neurology, 43, 239246.
Salmon, D. P., & Bondi, M. W. (2009). Neuropsychological assessment of dementia. Annual Review of Psychology, 60, 257282.
Salmon, D. P., & Filoteo, J. V. (2007). Neuropsychology of cortical versus subcortical dementia syndromes. Seminars in Neurology, 27, 721.
Troster, A. I., Butters, N., Salmon, D. P., Cullum, C. M., Jacobs, D., Brandt, J., & White, R. R. (1993). The diagnostic utility of savings scores: Differentiating Alzheimer’s and Huntington’s diseases with the logical memory and visual reproduction tests. Journal of Clinical and Experimental Neuropsychology, 15, 773788.
Tulving, E., Kapur, S., Craik, F. I., Moscovitch, M., & Houle, S. (1994). Hemispheric encoding/retrieval asymmetry in episodic memory: Positron emission tomography findings. Proceedings of the National Academy of Sciences of the United States of America, 91, 20162020.
Vonsattel, J. P. (2000). Neuropathology of Huntington’s disease. NeuroScience News, 3, 4553.
Vonsattel, J., Myers, R., Stevens, T. J., Ferrante, R. J., Bird, E. D., & Richardson, E. P. (1985). Neuropathological classification of Huntington’s disease. Journal of Neuropathology and Experimental Neurology, 44, 559577.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed