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NIH Toolbox Cognitive Battery (NIHTB-CB): The NIHTB Pattern Comparison Processing Speed Test

  • Noelle E. Carlozzi (a1), David S. Tulsky (a2) (a3), Nancy D. Chiaravalloti (a4), Jennifer L. Beaumont (a5), Sandra Weintraub (a6), Kevin Conway (a7) and Richard C. Gershon (a5)...


The NIH Toolbox (NIHTB) Pattern Comparison Processing Speed Test was developed to assess processing speed within the NIHTB for the Assessment of Neurological Behavior and Function Cognition Battery (NIHTB-CB). This study highlights validation data collected in adults ages 18–85 on this measure and reports descriptive data, test–retest reliability, construct validity, and preliminary work creating a composite index of processing speed. Results indicated good test–retest reliability. There was also evidence for both convergent and discriminant validity; the Pattern Comparison Processing Speed Test demonstrated moderate significant correlations with other processing speed tests (i.e., WAIS-IV Coding, Symbol Search and Processing Speed Index), small significant correlations with measures of working memory (i.e., WAIS-IV Letter-Number Sequencing and PASAT), and non-significant correlations with a test of vocabulary comprehension (i.e., PPVT-IV). Finally, analyses comparing and combining scores on the NIHTB Pattern Comparison Processing Speed Test with other measures of simple reaction time from the NIHTB-CB indicated that a Processing Speed Composite score performed better than any test examined in isolation. The NIHTB Pattern Comparison Processing Speed Test exhibits several strengths: it is appropriate for use across the lifespan (ages, 3–85 years), it is short and easy to administer, and it has high construct validity. (JINS, 2014, 20, 1–12)


Corresponding author

Correspondence and reprint requests to: Noelle E. Carlozzi, Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, Building 14, 2800 Plymouth Road, Ann Arbor, Michigan 48109-2800. E-mail:


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Dr. Carlozzi is funded by NIH grants R03NS065194, R01NR013658, R01NS077946, U01NS056975. She was previously funded by contracts H133B090024, B6237R, H133G070138, H133A070037-08A and a grant from the NJ Department of Health and Senior Services.
Dr. Tulsky is funded by NIH contracts H133B090024, H133N060022, H133G070138, B6237R, cooperative agreement U01AR057929, and grant, R01HD054659. He has received consultant fees from the Institute for Rehabilitation and Research, Frazier Rehabilitation Institute/Jewish Hospital, Craig Hospital, and Casa Colina Centers for Rehabilitation.
Dr. Chiaravalloti is funded by the National Multiple Sclerosis Society (NMSS; PP1952), the National Institutes of Health (NIH; R01NR013658; R01AG032088), the National Institute on Disability and Rehabilitation Research (NIDRR: H133A120030) the New Jersey Commission on Spinal Cord Injury Research (CSCR13IRG018) and the New Jersey Commission on Brain Injury Research (CBIR12IRG004 to support research unrelated to this project.
Ms. Beaumont served as a consultant for NorthShore University HealthSystem,, and Georgia Gastroenterology Group PC. She received funding for travel as an invited speaker at the North American Neuroendocrine Tumor Symposium.
Dr. Weintraub is funded by NIH grants # R01DC008552, P30AG013854, and the Ken and Ruth Davee Foundation and conducts clinical neuropsychological evaluations (35% effort) for which her academic-based practice clinic bills. She serves on the editorial board of Dementia & Neuropsychologia and advisory boards of the Turkish Journal of Neurology and Alzheimer’s and Dementia.
Dr. Conway reports no disclosures.
Dr. Gershon has received personal compensation for activities as a speaker and consultant with Sylvan Learning, Rockman, and the American Board of Podiatric Surgery. He has several grants awarded by NIH: N01-AG-6-0007, 1U5AR057943-01, HHSN260200600007, 1U01DK082342-01, AG-260-06-01, HD05469, NINDS: U01 NS 056 975 02, NHLBI K23: K23HL085766 NIA; 1RC2AG036498-01; NIDRR: H133B090024, OppNet: N01-AG-6-0007.
Disclaimer: The views and opinions expressed in this report are those of the authors and should not be construed to represent the views of NIH or any of the sponsoring organizations, agencies, or the U.S. government.
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