Skip to main content
×
Home
    • Aa
    • Aa

Regional atrophy of the corpus callosum in dementia

  • BRADLEY J. HALLAM (a1) (a2), WARREN S. BROWN (a1), CHRIS ROSS (a1), J. GALEN BUCKWALTER (a1) (a3), ERIN D. BIGLER (a4) (a5), JOANN T. TSCHANZ (a6), MARIA C. NORTON (a6), KATHLEEN A. WELSH-BOHMER (a7) and JOHN C.S. BREITNER (a8)...
Abstract

The regional distribution of degeneration of the corpus callosum (CC) in dementia is not yet clear. This study compared regional CC size in participants (n = 179) from the Cache County Memory and Aging Study. Participants represented a range of cognitive function: Alzheimer's disease (AD), vascular dementia (VaD), mild ambiguous (MA–cognitive problems, but not severe enough for diagnosis of dementia), and healthy older adults. CC outlines obtained from midsagittal magnetic resonance images were divided into 99 equally spaced widths. Factor analysis of these callosal widths identified 10 callosal regions. Multivariate analysis of variance revealed significant group differences for anterior and posterior callosal regions. Post-hoc pairwise comparisons of CC regions in patient groups as compared to the control group (controlling for age) revealed trends toward smaller anterior and posterior regions, but not all were statistically significant. As compared to controls, significantly smaller anterior and posterior CC regions were found in the AD group; significantly smaller anterior CC regions in the VaD group; but no significant CC regional differences in the MA group. Findings suggest that dementia-related CC atrophy occurs primarily in the anterior and posterior portions. (JINS, 2008, 14, 414–423.)

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Regional atrophy of the corpus callosum in dementia
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Regional atrophy of the corpus callosum in dementia
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Regional atrophy of the corpus callosum in dementia
      Available formats
      ×
Copyright
Corresponding author
Correspondence and reprint requests to: Warren S. Brown, Ph.D., The Travis Research Institute, 180 N. Oakland Ave., Pasadena, CA 91101. E-mail: wsbrown@fuller.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

Badaruddin, D.H., Andrews, G.L., Bölte, S., Schilmoeller, K.J., Schilmoeller, G., Paul, L.K., & Brown, W.S. (2007). Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry and Human Development, 38, 287302.

Bentler, P.M. & Yuan, K.H. (1996). Test of linear trend in eigenvalues of a covariance matrix with application to data analysis. British Journal of Mathematical and Statistical Psychology, 49, 299312.

Biegon, A., Eberling, J.L., Richardson, B.C., Ross, M.S., Wong, S.T.S., Reed, B.R., & Jagust, W.J. (1994). Human corpus callosum in aging and Alzheimer's disease: A magnetic resonance imaging study. Neurobiology of Aging, 15, 393397.

Binetti, G., Magni, E., Padovani, A., Cappa, S.F., Bianchetti, A., & Trabucchi, M. (1996). Executive dysfunction in early Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 60, 9193.

Braak, H. & Braak, E. (1991). Neuropathological staging of Alzheimer's related changes. Acta Neuropathology, 82, 239259.

Breitner, J.C.S., Wyse, B.W., Anthony, J.C., Welsh-Bohmer, K.A., Steffens, D.C., Norton, M.C., Tschanz, J.T., Plassman, B.L., Meyer, M.R., Skoog, I., & Khachaturian, A. (1999). APOE-E4 count predicts age when prevalence of AD increases, then declines: The Cache County study. Neurology, 53, 321331.

Brown, W.S. & Paul, L.K. (2000). Psychosocial deficits in agenesis of the corpus callosum with normal intelligence. Cognitive Neuropsychiatry, 5, 135157.

Brun, A. & Englund, E. (2002). Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading. Histopathology, 41, 37.

Clarke, J.M., Lufkin, R.B., & Zaidel, E. (1993). Corpus callosum morphometry and dichotic listening performance: Individual differences in functional interhemispheric inhibition? Neuropsychologia, 31, 547557.

Cowell, P.E., Allen, L.S., Kertesz, A., Zalatimo, N.S., & Denenberg, V.H. (1994). Human corpus callosum: A stable mathematical model of regional neuroanatomy. Brain and Cognition, 25, 5266.

Cuenod, C.A., Denys, A., Michot, J.L., Jehenson, P., Forette, F., Kaplan, D., Syrota, A., & Boller, F. (1993). Amygdala atrophy in Alzheimer's disease. An in vivo magnetic resonance imaging study. Archives of Neurology, 50, 941945.

Cummings, J.L. (1998). Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology, 51(S1), S2S17.

De Lacoste, M., Kirkpatrick, J., & Ross, E. (1985). Topography of the human corpus callosum. Journal of Neuropathology and Experimental Neurology, 44, 578591.

Denenberg, V.H., Cowell, P.E., Fitch, R.H., Kertesz, A., & Kenner, G.H. (1991a). Corpus callosum: Multiple parameter measurements in rodents and humans. Physiology & Behavior, 49, 433437.

Denenberg, V.H., Kertesz, A., & Cowell, P.E. (1991b). A factor analysis of the human's corpus callosum. Brain Research, 548, 126132.

Erkinjuntti, T., Lee, D.H., Gao, F., Steenhuis, R., Eliasziw, M., Fry, R., Merskey, H., & Hachinski, V.C. (1993). Temporal lobe atrophy on magnetic resonance imaging in the diagnosis of early Alzheimer's disease. Archives of Neurology, 50, 305310.

Folstein, M., Folstein, S., & McHugh, P.R. (1975). Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.

Hampel, H., Teipel, S.J., Alexander, G.E., Horwitz, B., Teichberg, D., Schapiro, M.B., & Rapoport, S.I. (1998). Corpus callosum atrophy is a possible indicator of region- and celltype-specific neuronal degeneration in Alzheimer disease: A magnetic resonance imaging analysis. Archives of Neurology, 55, 193198.

Janowsky, J.S., Kaye, J.A., & Carper, R.A. (1996). Atrophy of the corpus callosum in Alzheimer's disease versus healthy aging. The American Geriatrics Society, 44, 798803.

Jellinger, K.A. (1998). The neuropathological diagnosis of Alzheimer's disease. Journal of Neural Transmission. Supplemental, 53, 97118.

Jobst, K.A., Smith, A.D., Szatmari, M., Esiri, M.E., Jaskowski, A., Hindley, N., McDonald, B., & Molyneux, A.J. (1994). Rapidly progressing atrophy of medial temporal lobe in Alzheimer disease. Lancet, 343, 829830.

Jorm, A.F. (1994). A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Development and cross-validation. Psychological Medicine, 24, 145153.

Kaufer, D.I., Miller, B.L., Itti, L., Fairbanks, L.A., Li, J., Fishman, J., Kushi, J., & Cummings, J.L. (1997). Midline cerebral morphometry distinguishes rontotemporal dementia and Alzheimer's disease. Neurology, 48, 978985.

Kesslak, J.P., Nalcioglu, O., & Cotman, C.W. (1991). Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease. Neurology, 41, 5154.

Killiany, R.J., Moss, M.B., Albert, M.S., Sandor, T., Tieman, J., & Jolesz, F. (1993). Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. Archives of Neurology, 50, 949954.

Lyoo, I.K., Satlin, A., Lee, C.K., & Renshaw, P.F. (1997). Regional atrophy of the corpus callosum in subjects with Alzheimer's disease and multi-infarct dementia. Psychiatric Research: Neuroimaging Section, 74, 6372.

McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939944.

Murphy, D.G., DeCarli, C.D., Daly, E., Gillette, J.A., McIntosh, A.R., Haxby, J.V., Teichberg, D., Schapiro, M.B., Rapoport, S.I., & Horwitz, B. (1993). Volumetric magnetic resonance imaging in men with dementia of the Alzheimer type: Correlations with disease severity. Biological Psychiatry, 34, 619621.

Murray, C., Viehman, A., & Lippa, C.F. (2006). The corpus callosum in Pick's disease, Alzheimer's disease, and amyotrophic lateral sclerosis: Gliosis implies possible clinical consequence. American Journal of Alzheimer's Disease and Other Disorders, 21, 3743.

Peters, M., Oeltze, S., Seminowicz, D., Steinmetz, H., Koeneke, S., & Jancke, L. (2002). Divisions of the corpus callosum into subregions. Brain and Cognition, 50, 6272.

Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194.

Petersen, R.C. & O'Brien, J. (2006). Mild Cognitive Impairment should be considered for DSM-V. Journal of Geriatric Psychiatry and Neurology, 19, 147154.

Peterson, B.S., Feineigle, P.A., Staib, L.H., & Gore, J.C. (2001). Automated measurement of latent morphological features in the human corpus callosum. Human Brain Mapping, 12, 232245.

Pozzilli, C., Bastianello, S., Padovani, A., Passafiume, D., Millefiorini, E., Bozzao, L., & Fieschi, C. (1991). Anterior corpus callosum atrophy and verbal fluency in multiple sclerosis. Cortex, 27, 441445.

Scott, S.A., DeKosky, S.T., & Scheff, S.W. (1991). Volumetric atrophy of the amygdale in Alzheimer's disease: Quantitative serial reconstruction. Neurology, 41, 351356.

Shear, P.K., Sullivan, E.V., Mathalon, D.H., Lim, K.O., Davis, L.F., Yesavage, J.A., Tinklenberg, J.R., & Pfefferbaum, A. (1995). Longitudinal volumetric computed tomographic analysis of regional brain changes in normal aging and Alzheimer's disease. Archives of Neurology, 52, 392402.

Storandt, M., Grant, E.A., Miller, J.P., & Morris, J.C. (2006). Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI. Neurology, 67, 467473.

Tabert, M.H., Manly, J.J., Liu, X., Pelton, G.H., Rosenblum, S., Jacobs, M., Zamora, D., Goodkind, M., Bell, K., Stern, Y., & Devanand, D.P. (2006). Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Archives of General Psychiatry, 63, 916924.

Teipel, S.J., Bayer, W., Alexander, G.E., Bokde, A.L.W., Zebuhr, Y., Teichberg, D., Muller-Spahn, F., Schapiro, M.B., Moller, H.J., Rapoport, S.I., & Hampel, H. (2003). Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer's disease in relation to dementia severity: Evidence from early neocortical degeneration. Neurobiology of Aging, 24, 8594.

Teipel, S.J., Hampel, H., Alexander, G.E., Schapiro, M.B., Horwitz, B., Teichberg, D., Daley, E., Hippius, H., Moller, H.J., & Rapoport, S.I. (1998). Dissociation between corpus callosum atrophy and white matter pathology in Alzheimer's disease. Neurology, 51, 13811385.

Teipel, S.J., Hampel, H., Pietrini, P., Alexander, G.E., Horwitz, B., Daley, E., Moller, H., Schapiro, M.B., & Rapoport, S.I. (1999). Region-specific corpus callosum atrophy correlates with the regional pattern of cortical glucose metabolism in Alzheimer disease. Archives of Neurology, 56, 467473.

Thomann, P.A., Wustenberg, T., Pantel, J., Essig, M., & Schroder, J. (2006). Structural changes of the corpus callosum in mild cognitive impairment and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 21, 215220.

Tschanz, J.T., Corcoran, C., Skoog, I., Khachaturian, A.S., Herrick, J., Hayden, K.M., Welsh-Bohmer, K.A., Calvert, T., Norton, M.C., Zandi, P., & Breitner, J.C.S. on behalf of the Cache County Study Group. (2004). Dementia: The leading predictor of death after age 85. The Cache County Study. Neurology, 62, 115662.

Vermersch, P., Scheltens, P., Barkhof, F., Steinling, M., & Leys, D. (1993). Evidence for atrophy of the corpus callosum in Alzheimer's disease. European Neurology, 34, 8386.

Wang, H. & Su, M.Y. (2006). Regional pattern of increased water diffusivity in hippocampus and corpus callosum in Mild Cognitive Impairment. Dementia and Geriatric Cognitive Disorders, 22, 223229.

Welsh, K.A., Butters, N., Mohs, R.C., Beekly, D., Edland, S., Fillenbaum, G., & Heyman, A. (1994). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological b attery. Neurology, 44, 609614.

Whitehouse, P.J., Price, D.L., Clark, A.W., Coyle, J.T., & DeLong, M.R. (1981). Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis. Annals of Neurology, 10, 122126.

Wiltshire, K., Foster, S., Kaye, J.A., Small, B.J., & Camicioli, R. (2005). Corpus callosum in neurodegenerative diseases: Findings in Parkinson's disease. Dementia and Geriatric Cognitive Disorders, 20, 345351.

Witelson, S.F. (1985). The brain connection: The corpus callosum is larger in left-handers. Science, 229, 665668.

Yamanouchi, H., Sugiura, S., & Shimada, H. (1990). Loss of nerve fibres in the corpus callosum of progressive subcortical vascular encephalopathy. Journal of Neurology, 237, 3941.

Yamauchi, H., Fukuyama, H., Harada, K., Nabatame, H., Ogawa, M., Ouchi, Y., Kimura, J., & Konishi, J. (1993). Callosal atrophy parallels decreased cortical oxygen metabolism and neuropsychological impairment in Alzheimer's disease. Archives of Neurology, 50, 10701074.

Yamauchi, H., Fukuyama, H., Nagahama, Y., Katsumi, Y., Dong, Y., Hayashi, T., Konishi, J., & Kimura, J. (1998). Atrophy of the corpus callosum, cortical hypometabolism, and cognitive impairment in corticobasal degeneration. Archives of Neurology, 55, 609614.

Yamauchi, H., Fukuyama, H., Nagahama, Y., Katsumi, Y., Dong, Y., Konishi, J., & Kimura, J. (1997). Atrophy of the corpus callosum, cognitive impairment, and cortical hypometabolism in progressive supranuclear palsy. Annals of Neurology, 41, 606614.

Yamauchi, H., Fukuyama, H., Nagahama, Y., Katsumi, Y., Hayashi, T., Oyanagi, C., Konishi, J., & Shio, H. (2000). Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 69, 623629.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 40 *
Loading metrics...

Abstract views

Total abstract views: 127 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 28th May 2017. This data will be updated every 24 hours.