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The Relationship between Negative Symptoms and Both Emotion Management and Non-social Cognition in Schizophrenia Spectrum Disorders

Published online by Cambridge University Press:  21 December 2020

Caitlin O. B. Yolland Open the ORCID record for Caitlin O. B. Yolland [Opens in a new window] ,
Sean P. Carruthers ,
Wei Lin Toh ,
Erica Neill ,
Philip J. Sumner ,
Elizabeth H. X. Thomas Open the ORCID record for Elizabeth H. X. Thomas [Opens in a new window] ,
Eric J. Tan Open the ORCID record for Eric J. Tan [Opens in a new window] ,
Caroline Gurvich Open the ORCID record for Caroline Gurvich [Opens in a new window] ,
Andrea Phillipou  and
Tamsyn E. Van Rheenen
...Show all authors
Caitlin O. B. Yolland*
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia
Sean P. Carruthers
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Carlton, Victoria, Australia
Wei Lin Toh
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia
Erica Neill
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia Department of Psychiatry, University of Melbourne, Parkville, Australia
Philip J. Sumner
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia
Elizabeth H. X. Thomas
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Monash Alfred Psychiatry Research Centre, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia
Eric J. Tan
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia
Caroline Gurvich
Affiliation:
Monash Alfred Psychiatry Research Centre, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia
Andrea Phillipou
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia Department of Psychiatry, University of Melbourne, Parkville, Australia
Tamsyn E. Van Rheenen
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Carlton, Victoria, Australia
Susan L. Rossell
Affiliation:
Centre for Mental Health, Swinburne University of Technology, Hawthorn, Victoria, Australia Department of Psychiatry, St Vincent’s Hospital, Melbourne, Australia
*
*Correspondence and reprint requests to: Caitlin O. B. Yolland, Centre for Mental Health, Swinburne University, PO Box 218, Hawthorn, Victoria 3122, Australia. E-mail: cyolland@swin.edu.au
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Abstract

Objective:

There is ongoing debate regarding the relationship between clinical symptoms and cognition in schizophrenia spectrum disorders (SSD). The present study aimed to explore the potential relationships between symptoms, with an emphasis on negative symptoms, and social and non-social cognition.

Method:

Hierarchical cluster analysis with k-means optimisation was conducted to characterise clinical subgroups using the Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms in n = 130 SSD participants. Emergent clusters were compared on the MATRICS Consensus Cognitive Battery, which measures non-social cognition and emotion management as well as demographic and clinical variables. Spearman’s correlations were then used to investigate potential relationships between specific negative symptoms and emotion management and non-social cognition.

Results:

Four distinct clinical subgroups were identified: 1. high hallucinations, 2. mixed symptoms, 3. high negative symptoms, and 4. relatively asymptomatic. The high negative symptom subgroup was found to have significantly poorer emotion management than the high hallucination and relatively asymptomatic subgroups. No further differences between subgroups were observed. Correlation analyses revealed avolition-apathy and anhedonia-asociality were negatively correlated with emotion management, but not non-social cognition. Affective flattening and alogia were not associated with either emotion management or non-social cognition.

Conclusions:

The present study identified associations between negative symptoms and emotion management within social cognition, but no domains of non-social cognition. This relationship may be specific to motivation, anhedonia and apathy, but not expressive deficits. This suggests that targeted interventions for social cognition may also result in parallel improvement in some specific negative symptoms.

Keywords

SchizophreniaCognitionNegative SymptomsCluster analysisPsychosisSchizoaffective disorder

Information

Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 9 , October 2021 , pp. 916 - 928
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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References

REFERENCES

Addington, J., Addington, D., & Maticka-Tyndale, E. (1991). Cognitive functioning and positive and negative symptoms in schizophrenia. Schizophrenia Research, 5, 123–134.CrossRefGoogle Scholar
Ahmed, A.O., Strauss, G.P., Buchanan, R.W., Kirkpatrick, B., & Carpenter, W.T. (2018). Schizophrenia heterogeneity revisited: clinical, cognitive, and psychosocial correlates of statistically-derived negative symptoms subgroups. Journal of Psychiatric Research, 97, 8–15. doi: 10.1016/j.jpsychires.2017.11.004 CrossRefGoogle ScholarPubMed
Altamura, A.C., Caletti, E., Paoli, R.A., Cigliobianco, M., Zugno, E., Grillo, P., … Zago, S. (2015). Correlation between neuropsychological and social cognition measures and symptom dimensions in schizophrenic patients. Psychiatry Research, 230(2), 172–180. doi: 10.1016/j.psychres.2015.08.034 CrossRefGoogle ScholarPubMed
Andreasen, N.C. (1984a). The scale for the assessment of negative symptoms (SANS). Rinsho Seishin Igaku, 13, 999–1010.Google Scholar
Andreasen, N.C. (1984b). Scale for the assessment of positive symptoms (SAPS). Group, 17(2), 173–180.Google Scholar
August, S.M., Kiwanuka, J.N., McMahon, R.P., & Gold, J.M. (2012). The MATRICS Consensus Cognitive Battery (MCCB): clinical and cognitive correlates. Schizophrenia Research, 134(1), 76–82. doi: 10.1016/j.schres.2011.10.015 CrossRefGoogle ScholarPubMed
Bagney, A., Dompablo, M., Santabarbara, J., Moreno-Ortega, M., Lobo, A., Jimenez-Arriero, M.A., … Rodriguez-Jimenez, R. (2015). Are negative symptoms really related to cognition in schizophrenia? Psychiatry Research, 230(2), 377–382. doi: 10.1016/j.psychres.2015.09.022 CrossRefGoogle ScholarPubMed
Bell, M.D., Corbera, S., Johannesen, J.K., Fiszdon, J.M., & Wexler, B.E. (2013). Social cognitive impairments and negative symptoms in schizophrenia: are there subtypes with distinct functional correlates? Schizophrenia Bulletin, 39(1), 186–196. doi: 10.1093/schbul/sbr125 CrossRefGoogle ScholarPubMed
Bismark, A.W., Thomas, M.L., Tarasenko, M., Shiluk, A.L., Rackelmann, S.Y., Young, J.W., & Light, G.A. (2018). Relationship between effortful motivation and neurocognition in schizophrenia. Schizophrenia Research, 193, 69–76. doi: 10.1016/j.schres.2017.06.042 CrossRefGoogle Scholar
Bobes, J., Arango, C., Garcia-Garcia, M., Rejas, J., & Group, C.S.C. (2010). Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: findings from the CLAMORS study. The Journal of Clinical Psychiatry, 71(3), 280–286. doi: 10.4088/JCP.08m04250yel CrossRefGoogle ScholarPubMed
Bryce, S.D., Rossell, S.L., Lee, S.J., Lawrence, R.J., Tan, E.J., Carruthers, S.P., & Ponsford, J.L. (2018). Neurocognitive and self-efficacy benefits of cognitive remediation in schizophrenia: a randomized controlled trial. Journal of the International Neuropsychological Society, 24(6), 549–562. doi: 10.1017/S1355617717001369 CrossRefGoogle ScholarPubMed
Carruthers, S.P., Gurvich, C.T., Meyer, D., Australian Schizophrenia Research Bank, Bousman, C., Everall, I.P., … Rossell, S.L. (2019). Exploring heterogeneity on the wisconsin card sorting test in schizophrenia spectrum disorders: a cluster analytical investigation. Journal of the International Neuropsychological Society, 25(7), 750–760. doi: 10.1017/S1355617719000420 CrossRefGoogle ScholarPubMed
Carruthers, S.P., Van Rheenen, T.E., Gurvich, C., Sumner, P.J., & Rossell, S.L. (2019). Characterising the structure of cognitive hetereogenity in schizophrenia spectrum disorder: a systematic review and narrative synthesis. Neuroscience & Biobehavioral Reviews, 107, 252–278. doi: 10.1016/j.neubiorev.2019.09.006 CrossRefGoogle Scholar
Chan, Y.H. (2005). Biostatistics 304. Cluster analysis. Singapore Medical Journal, 46(4), 153–159.Google ScholarPubMed
Choi, K.H., Wykes, T., & Kurtz, M.M. (2013). Adjunctive pharmacotherapy for cognitive deficits in schizophrenia: meta-analytical investigation of efficacy. British Journal of Psychiatry, 203(3), 172–178. doi: 10.1192/bjp.bp.111.107359 CrossRefGoogle Scholar
Clatworthy, J., Buick, D., Hankins, M., Weinman, J., & Horne, R. (2005). The use and reporting of cluster analysis in health psychology: a review. British Journal of Health Psychology, 10(Pt 3), 329–358. doi: 10.1348/135910705X25697 CrossRefGoogle ScholarPubMed
Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences (2nd ed.). New York, NY: Lawrence Erlbaum Associates.Google Scholar
Couture, S.M., Granholm, E.L., & Fish, S.C. (2011). A path model investigation of neurocognition, theory of mind, social competence, negative symptoms and real-world functioning in schizophrenia. Schizophrenia Research, 125(2–3), 152–160. doi: 10.1016/j.schres.2010.09.020 CrossRefGoogle Scholar
Dean, O., Giorlando, F., & Berk, M. (2011). N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. Journal of Psychiatry & Neuroscience, 36(2), 78–86. doi: 10.1503/jpn.100057 CrossRefGoogle ScholarPubMed
Dennis, M., Francis, D.J., Cirino, P.T., Schachar, R., Barnes, M.A., & Fletcher, J.M. (2009). Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. Journal of the International Neuropsychological Society, 15(3), 331–343. doi: 10.1017/S1355617709090481 CrossRefGoogle Scholar
DeTore, N.R., Mueser, K.T., & McGurk, S.R. (2018). What does the managing emotions branch of the MSCEIT add to the MATRICS consensus cognitive battery? Schizophrenia Research, 197, 414–420. doi: 10.1016/j.schres.2018.02.018 CrossRefGoogle ScholarPubMed
Dibben, C.R., Rice, C., Laws, K., & McKenna, P.J. (2009). Is executive impairment associated with schizophrenic syndromes? A meta-analysis. Psychological Medicine, 39(3), 381–392. doi: 10.1017/S0033291708003887 CrossRefGoogle ScholarPubMed
Dollfus, S., Everitt, B., Ribeyre, J.M., Assouly-Besse, F., Sharp, C., & Petit, M. (1996). Identifying subtypes of schizophrenia by cluster analyses. Schizophrenia Bulletin, 22(3), 545–555. doi: 10.1093/schbul/22.3.545 CrossRefGoogle ScholarPubMed
Dominguez, M. d. G., Viechtbauer, W., Simons, C. J., van Os, J., & Krabbendam, L. (2009). Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations. Psychological Bulletin, 135(1), 157–171. doi: 10.1037/a0014415 CrossRefGoogle Scholar
Eack, S.M., Greeno, C.G., Pogue-Geile, M.F., Newhill, C.E., Hogarty, G.E., & Keshavan, M.S. (2010). Assessing social-cognitive deficits in schizophrenia with the Mayer-Salovey-Caruso Emotional Intelligence Test. Schizophrenia Bulletin, 36(2), 370–380. doi: 10.1093/schbul/sbn091 CrossRefGoogle ScholarPubMed
Fanning, J.R., Bell, M.D., & Fiszdon, J.M. (2012). Is it possible to have impaired neurocognition but good social cognition in schizophrenia? Schizophrenia Research, 135(1–3), 68–71. doi: 10.1016/j.schres.2011.12.009 CrossRefGoogle ScholarPubMed
Fett, A.K., Viechtbauer, W., Dominguez, M.D., Penn, D.L., van Os, J., & Krabbendam, L. (2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neuroscience & Biobehavioral Reviews, 35(3), 573–588. doi: 10.1016/j.neubiorev.2010.07.001 CrossRefGoogle ScholarPubMed
First, M.B., Spitzer, R.L., Gibbon, M., & Williams, J.B.W. (1995). Structured clinical interview for DSM-IV axis I disorders-patient edition (SCID-I/P, Version 2.0). New York: Biometrics Research Department, New York State Psychiatric Institute, p. 722.Google Scholar
Fusar-Poli, P., Papanastasiou, E., Stahl, D., Rocchetti, M., Carpenter, W., Shergill, S., & McGuire, P. (2015). Treatments of negative symptoms in schizophrenia: meta-analysis of 168 randomized placebo-controlled trials. Schizophrenia Bulletin, 41(4), 892–899. doi: 10.1093/schbul/sbu170 CrossRefGoogle ScholarPubMed
Gold, J.M. (2004). Cognitive deficits as treatment targets in schizophrenia. Schizophrenia Research, 72(1), 21–28. doi: 10.1016/j.schres.2004.09.008 CrossRefGoogle Scholar
Gonzalez-Ortega, I., de Los Mozos, V., Echeburua, E., Mezo, M., Besga, A., Ruiz de Azua, S., … Gonzalez-Pinto, A. (2013). Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis. Psychiatry Research, 206(1), 8–16. doi: 10.1016/j.psychres.2012.08.025 CrossRefGoogle ScholarPubMed
Greenwood, K.E., Landau, S., & Wykes, T. (2005). Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy. Schizophrenia Bulletin, 31(4), 910–921. doi: 10.1093/schbul/sbi035 CrossRefGoogle ScholarPubMed
Greenwood, K.E., Morris, R., Sigmundsson, T., Landau, S., & Wykes, T. (2008). Executive functioning in schizophrenia and the relationship with symptom profile and chronicity. Journal of the International Neuropsychological Society, 14(5), 782–792. doi: 10.1017/S1355617708081198 CrossRefGoogle ScholarPubMed
Grove, W.M., Zald, D.H., Lebow, B.S., Snitz, B.E., & Nelson, C. (2000). Clinical versus mechanical prediction: a meta-analysis. Psychological Assessment, 12(1), 19–30. doi: 10.1037/1040-3590.12.1.19 CrossRefGoogle ScholarPubMed
Halverson, T.F., Orleans-Pobee, M., Merritt, C., Sheeran, P., Fett, A.K., & Penn, D.L. (2019). Pathways to functional outcomes in schizophrenia spectrum disorders: meta-analysis of social cognitive and neurocognitive predictors. Neuroscience & Biobehavioral Reviews, 105, 212–219. doi: 10.1016/j.neubiorev.2019.07.020 CrossRefGoogle ScholarPubMed
Harvey, P.D., Koren, D., Reichenberg, A., & Bowie, C.R. (2006). Negative symptoms and cognitive deficits: what is the nature of their relationship? Schizophrenia Bulletin, 32(2), 250–258. doi: 10.1093/schbul/sbj011 CrossRefGoogle ScholarPubMed
Harvey, P.D. & Strassnig, M. (2012). Predicting the severity of everyday functional disability in people with schizophrenia: cognitive deficits, functional capacity, symptoms, and health status. World Psychiatry, 11(2), 73–79.CrossRefGoogle ScholarPubMed
Huang, M., Huang, Y., Yu, L., Hu, J., Chen, J., Jin, P., … Xu, Y. (2016). Relationship between negative symptoms and neurocognitive functions in adolescent and adult patients with first-episode schizophrenia. BMC Psychiatry, 16(1), 344. doi: 10.1186/s12888-016-1052-x CrossRefGoogle ScholarPubMed
Hughes, C., Kumari, V., Soni, W., Das, M., Binneman, B., Sonia, D., … Sharma, T. (2002). Longitudinal study of symptoms and cognitive function in chronic schizophrenia. Schizophrenia Research, 59(2–3), 137–146.CrossRefGoogle Scholar
Kay, S.R., Fiszbein, A., & Opler, L.A. (1987). The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophrenia Bulletin, 13(2), 261–261.CrossRefGoogle Scholar
Keefe, R.S.E. & Harvey, P.D. (2012). Cognitive impairment in schizophrenia, In Geyer, M.A. & Gross, G. (Eds.), Novel Antischizophrenia Treatments (pp. 11–37). Berlin, Heidelberg: Springer Berlin Heidelberg.CrossRefGoogle Scholar
Kern, R.S., Nuechterlein, K.H., Green, M.F., Baade, L.E., Fenton, W.S., Gold, J.M., … Marder, S.R. (2008). The MATRICS consensus cognitive battery, part 2: co-norming and standardization. American Journal of Psychiatry, 165(2), 214–220. doi: 10.1176/appi.ajp.2007.07010043 CrossRefGoogle ScholarPubMed
Khoury, B., Lecomte, T., Gaudiano, B.A., & Paquin, K. (2013). Mindfulness interventions for psychosis: a meta-analysis. Schizophrenia Research, 150(1), 176–184. doi: 10.1016/j.schres.2013.07.055 CrossRefGoogle ScholarPubMed
Konstantakopoulos, G., Ploumpidis, D., Oulis, P., Patrikelis, P., Soumani, A., Papadimitriou, G.N., & Politis, A.M. (2011). Apathy, cognitive deficits and functional impairment in schizophrenia. Schizophrenia Research, 133(1–3), 193–198. doi: 10.1016/j.schres.2011.07.003 CrossRefGoogle Scholar
Landis, J.R. & Koch, G.G. (1977). The measurement of observer agreement for catagorical data. Biometrics, 33(1), 159–174.CrossRefGoogle Scholar
Lee, S. & Lee, D.K. (2018). What is the proper way to apply the multiple comparison test? Korean Journal of Anesthesiology, 71(5), 353–360. doi: 10.4097/kja.d.18.00242 CrossRefGoogle ScholarPubMed
Lehoux, C., Gobeil, M.H., Lefèbvre, A.A., Maziade, M., & Roy, M.A. (2009). The five-factor structure of the PANSS: a critical review of its consistency across studies. Clinical Schizophrenia & Related Psychoses, 3(2), 103–110. doi: 10.3371/CSRP.3.2.5 CrossRefGoogle Scholar
Liemburg, E., Castelein, S., Stewart, R., van der Gaag, M., Aleman, A., Knegtering, H., & Genetic Risk and Outcome of Psychosis (GROUP) Investigators. (2013). Two subdomains of negative symptoms in psychotic disorders: established and confirmed in two large cohorts. Journal of Psychiatric Research, 47(6), 718–725. doi: 10.1016/j.jpsychires.2013.01.024 CrossRefGoogle ScholarPubMed
Lin, C.H., Huang, C.L., Chang, Y.C., Chen, P.W., Lin, C.Y., Tsai, G.E., & Lane, H.Y. (2013). Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia. Schizophrenia Research, 146(1–3), 231–237. doi: 10.1016/j.schres.2013.02.009 CrossRefGoogle ScholarPubMed
Louise, S., Fitzpatrick, M., Strauss, C., Rossell, S.L., & Thomas, N. (2018). Mindfulness- and acceptance-based interventions for psychosis: our current understanding and a meta-analysis. Schizophrenia Research, 192, 57–63. doi: 10.1016/j.schres.2017.05.023 CrossRefGoogle ScholarPubMed
MacCann, C., Matthews, G., Zeidner, M., & Roberts, R.D. (2003). Psychological assessment of emotional intelligence: a review of self-report and performance-based testing. International Journal of Organizational Analysis, 11(3), 247–274.CrossRefGoogle Scholar
MacCann, C. & Roberts, R.D. (2008). New paradigms for assessing emotional intelligence: theory and data. Emotion, 8(4), 540–551. doi: 10.1037/a0012746 CrossRefGoogle ScholarPubMed
Marder, S.R. & Galderisi, S. (2017). The current conceptualization of negative symptoms in schizophrenia. World Psychiatry, 16, 14–24.CrossRefGoogle Scholar
Mayer, J.D., Salovey, P., & Caruso, D.R. (2002). Mayer-Salovey-Caruso emotional intelligence test (MSCEIT) user’s manual. Toronto, Ontario, Canada: MHS Publishers.Google Scholar
Mayer, J.D., Salovey, P., Caruso, D.R., & Sitarenios, G. (2003). Measuring emotional intelligence with the MSCEIT V2.0. Emotion, 3(1), 97–105. doi: 10.1037/1528-3542.3.1.97 CrossRefGoogle ScholarPubMed
Mehta, U.M., Thirthalli, J., Subbakrishna, D.K., Gangadhar, B.N., Eack, S.M., & Keshavan, M.S. (2013). Social and neuro-cognition as distinct cognitive factors in schizophrenia: a systematic review. Schizophrenia Research, 148(1–3), 3–11. doi: 10.1016/j.schres.2013.05.009 CrossRefGoogle ScholarPubMed
Mohr, P.E., Cheng, C.M., Claxton, K., Conley, R.R., Feldman, J.J., Hargreaves, W.A., … Neumann, P.J. (2004). The heterogeneity of schizophrenia in disease states. Schizophrenia Research, 71(1), 83–95. doi: 10.1016/j.schres.2003.11.008 CrossRefGoogle ScholarPubMed
Nuechterlein, K.H., Green, M.F., Kern, R.S., Baade, L.E., Barch, D.M., Cohen, J.D., … Marder, S.R. (2008). The MATRICS consensus cognitive battery, part 1: test selection, reliability, and validity. The American Journal of Psychiatry, 165(2), 203–213. doi: 10.1176/appi.ajp.2007.07010042 CrossRefGoogle ScholarPubMed
Orchard, B., MacCann, C., Schulze, R., Matthews, G., Zeidner, M., & Roberts, R.D. (2009). New Directions and Alternative Approaches to the Measurement of Emotional Intelligence. In Parker, J., Saklofske, D., & Stough, C. (Eds.), Assessing Emotional Intelligence. The Springer Series on Human Exceptionality (pp. 321–344). Boston, MA: Springer. doi: 10.1007/978-0-387-88370-0_17 CrossRefGoogle Scholar
Palmer, B.R., Gignac, G., Manocha, R., & Stough, C. (2005). A psychometric evaluation of the Mayer–Salovey–Caruso Emotional Intelligence Test Version 2.0. Intelligence, 33(3), 285–305. doi: 10.1016/j.intell.2004.11.003 CrossRefGoogle Scholar
Pelletier-Baldelli, A. & Holt, D.J. (2020). Are negative symptoms merely the “Real World” consequences of deficits in social cognition? Schizophrenia Bulletin, 46(2), 236–241. doi: 10.1093/schbul/sbz095 CrossRefGoogle ScholarPubMed
Penn, D.L., Sanna, L.J., & Roberts, D.L. (2008). Social cognition in schizophrenia: an overview. Schizophrenia Bulletin, 34(3), 408–411. doi: 10.1093/schbul/sbn014 CrossRefGoogle ScholarPubMed
Rabinowitz, J., Levine, S.Z., Garibaldi, G., Bugarski-Kirola, D., Berardo, C.G., & Kapur, S. (2012). Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data. Schizophrenia Research, 137(1–3), 147–150. doi: 10.1016/j.schres.2012.01.015 CrossRefGoogle ScholarPubMed
Reser, M.P., Slikboer, R., & Rossell, S.L. (2019). A systematic review of factors that influence the efficacy of cognitive remediation therapy in schizophrenia. Australian & New Zealand Journal of Psychiatry, 53(7), 624–641. doi: 10.1177/0004867419853348 CrossRefGoogle Scholar
Roberts, R.D., Schulze, R., & MacCann, C. (2008). The measurement of emotional intelligence: a decade of progress. The Sage Handbook of Personality Theory and Assessment, 2, 461–482.Google Scholar
Rodriguez-Jimenez, R., Bagney, A., Mezquita, L., Martinez-Gras, I., Sanchez-Morla, E.M., Mesa, N., … PARG. (2013). Cognition and the five-factor model of the positive and negative syndrome scale in schizophrenia. Schizophrenia Research, 143(1), 77–83. doi: 10.1016/j.schres.2012.10.020 CrossRefGoogle Scholar
Rossell, S.L., Francis, P.S., Galletly, C., Harris, A., Siskind, D., Berk, M., … Castle, D.J. (2016). N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms. BMC Psychiatry, 16(1), 320. doi: 10.1186/s12888-016-1030-3 CrossRefGoogle ScholarPubMed
Savla, G.N., Vella, L., Armstrong, C.C., Penn, D.L., & Twamley, E.W. (2013). Deficits in domains of social cognition in schizophrenia: a meta-analysis of the empirical evidence. Schizophrenia Bulletin, 39(5), 979–992. doi: 10.1093/schbul/sbs080 CrossRefGoogle ScholarPubMed
Schonlau, M. (2004). Visualizing non-hierarchical and hierarchical cluster analyses with clustergrams. Computational Statistics, 19(1), 95–111. doi: 10.1007/BF02915278 CrossRefGoogle Scholar
Sergi, M.J., Rassovsky, Y., Widmark, C., Reist, C., Erhart, S., Braff, D.L., … Green, M.F. (2007). Social cognition in schizophrenia: relationships with neurocognition and negative symptoms. Schizophrenia Research, 90(1–3), 316–324. doi: 10.1016/j.schres.2006.09.028 CrossRefGoogle ScholarPubMed
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., … Dunbar, G.C. (1998). The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry, 59(Suppl. 20), 22–33.Google ScholarPubMed
Strassnig, M.T., Bowie, C., Pinkham, A.E., Penn, D., Twamley, E.W., Patterson, T.L., & Harvey, P.D. (2018). Which levels of cognitive impairments and negative symptoms are related to functional deficits in schizophrenia? Journal of Psychiatric Research, 104, 124–129. doi: 10.1016/j.jpsychires.2018.06.018 CrossRefGoogle Scholar
Strassnig, M.T., Raykov, T., O’Gorman, C., Bowie, C.R., Sabbag, S., Durand, D., … Harvey, P.D. (2015). Determinants of different aspects of everyday outcome in schizophrenia: the roles of negative symptoms, cognition, and functional capacity. Schizophrenia Research, 165(1), 76–82. doi: 10.1016/j.schres.2015.03.033 CrossRefGoogle Scholar
Strauss, G.P., Ahmed, A.O., Young, J.W., & Kirkpatrick, B. (2019). Reconsidering the latent structure of negative symptoms in schizophrenia: a review of evidence supporting the 5 consensus domains. Schizophrenia Bulletin, 45(4), 725–729. doi: 10.1093/schbul/sby169 CrossRefGoogle ScholarPubMed
Strauss, G.P., Esfahlani, F.Z., Galderisi, S., Mucci, A., Rossi, A., Bucci, P., … Sayama, H. (2019). Network analysis reveals the latent structure of negative symptoms in schizophrenia. Schizophrenia Bulletin, 45(5), 1033–1041. doi: 10.1093/schbul/sby133 CrossRefGoogle Scholar
Strauss, G.P., Esfahlani, F.Z., Kirkpatrick, B., Allen, D.N., Gold, J.M., Visser, K.F., & Sayama, H. (2019). Network analysis reveals which negative symptom domains are most central in Schizophrenia vs Bipolar Disorder. Schizophrenia Bulletin, 45(6), 1319–1330. doi: 10.1093/schbul/sby168 CrossRefGoogle ScholarPubMed
Strauss, G.P., Horan, W.P., Kirkpatrick, B., Fischer, B.A., Keller, W.R., Miski, P., … Carpenter, W.T., Jr. (2013). Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome. Journal of Psychiatric Research, 47(6), 783–790. doi: 10.1016/j.jpsychires.2013.01.015 CrossRefGoogle ScholarPubMed
Tan, E.J. & Rossell, S.L. (2014). Building a neurocognitive profile of thought disorder in schizophrenia using a standardized test battery. Schizophrenia Research, 152(1), 242–245. doi: 10.1016/j.schres.2013.11.001 CrossRefGoogle ScholarPubMed
Tan, E.J. & Rossell, S.L. (2017). Formal thought disorder and neurocognition in schizophrenia: the question of individual mechanisms. Schizophrenia Research, 190, 189–190. doi: 10.1016/j.schres.2017.03.039 CrossRefGoogle ScholarPubMed
Tan, E.J., Thomas, N., & Rossell, S.L. (2014). Speech disturbances and quality of life in schizophrenia: differential impacts on functioning and life satisfaction. Comprehensive Psychiatry, 55(3), 693–698. doi: 10.1016/j.comppsych.2013.10.016 CrossRefGoogle ScholarPubMed
Tanaka, T., Tomotake, M., Ueoka, Y., Kaneda, Y., Taniguchi, K., Nakataki, M., … Ohmori, T. (2012). Clinical correlates associated with cognitive dysfunction in people with schizophrenia. Psychiatry and Clinical Neurosciences, 66(6), 491–498. doi: 10.1111/j.1440-1819.2012.02390.x CrossRefGoogle ScholarPubMed
Teigset, C.M., Mohn, C., Brunborg, C., Juuhl-Langseth, M., Holmen, A., & Rund, B.R. (2018). Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? Journal of Child Psychology and Psychiatry, 59(9), 1012–1023. doi: 10.1111/jcpp.12896 CrossRefGoogle ScholarPubMed
van der Gaag, M., Cuijpers, A., Hoffman, T., Remijsen, M., Hijman, R., de Haan, L., … Wiersma, D. (2006). The five-factor model of the Positive and Negative Syndrome Scale I: confirmatory factor analysis fails to confirm 25 published five-factor solutions. Schizophrenia Research, 85(1–3), 273–279. doi: 10.1016/j.schres.2006.04.001 CrossRefGoogle ScholarPubMed
van Hooren, S., Versmissen, D., Janssen, I., Myin-Germeys, I., a Campo, J., Mengelers, R., … Krabbendam, L. (2008). Social cognition and neurocognition as independent domains in psychosis. Schizophrenia Research, 103(1–3), 257–265. doi: 10.1016/j.schres.2008.02.022 CrossRefGoogle ScholarPubMed
Van Rheenen, T.E., Ganella, E.P., Bauer, I.E., & Bartholomeusz, C.F. (2019). Characterization of social cognitive deficits on the schizophrenia-bipolar disorder spectrum: an overview of current evidence. In Lewandowski, K. E. & Moustafa, A. A. (Eds.), Social Cognition in Psychosis (pp. 1–36). Amsterdam: Elsevier. doi: 10.1016/C2017-0-03061-6 Google Scholar
Van Rheenen, T.E., Lewandowski, K.E., Tan, E.J., Ospina, L.H., Ongur, D., Neill, E., … Burdick, K.E. (2017). Characterizing cognitive heterogeneity on the schizophrenia-bipolar disorder spectrum. Psychological Medicine, 47(10), 1848–1864. doi: 10.1017/S0033291717000307 CrossRefGoogle ScholarPubMed
Ventura, J., Hellemann, G.S., Thames, A.D., Koellner, V., & Nuechterlein, K.H. (2009). Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophrenia Research, 113(2–3), 189–199. doi: 10.1016/j.schres.2009.03.035 CrossRefGoogle ScholarPubMed
Ventura, J., Wood, R.C., & Hellemann, G.S. (2013). Symptom domains and neurocognitive functioning can help differentiate social cognitive processes in schizophrenia: a meta-analysis. Schizophrenia Bulletin, 39(1), 102–111. doi: 10.1093/schbul/sbr067 CrossRefGoogle ScholarPubMed
Wechsler, D. (2001). Wechsler Test of Adult Reading: WTAR. San Antonio, TX: Psychological Corpration.Google Scholar
Yolland, C.O.B., Hanratty, D., Neill, E., Rossell, S.L., Berk, M., Dean, O.M., … Siskind, D. (2019). Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia. Australian & New Zealand Journal of Psychiatry, 54, 0004867419893439. doi: 10.1177/0004867419893439 Google ScholarPubMed
Yolland, C.O.B., Phillipou, A., Castle, D.J., Neill, E., Hughes, M.E., Galletly, C., … Rossell, S.L. (2018). Improvement of cognitive function in schizophrenia with N-acetylcysteine: a theoretical review. Nutritional Neuroscience, 23, 1–10. doi: 10.1080/1028415X.2018.1478766 Google ScholarPubMed
Zhang, Z., Murtagh, F., Van Poucke, S., Lin, S., & Lan, P. (2017). Hierarchical cluster analysis in clinical research with heterogeneous study population: highlighting its visualization with R. Annals of Translational Medicine, 5(4), 75. doi: 10.21037/atm.2017.02.05 CrossRefGoogle ScholarPubMed
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