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  • Journal of the International Neuropsychological Society, Volume 19, Issue 3
  • March 2013, pp. 349-354

White Matter Microstructural Integrity and Executive Function in Parkinson's Disease

  • Catherine Gallagher (a1) (a2), Brian Bell (a1) (a2), Barbara Bendlin (a3), Matthew Palotti (a1) (a2), Ozioma Okonkwo (a3), Aparna Sodhi (a3), Rachel Wong (a1) (a2), Laura Buyan-Dent (a2), Sterling Johnson (a1) (a3), Auriel Wilette (a3), Sandra Harding (a3), Nancy Ninman (a2), Erik Kastman (a3) and Andrew Alexander (a4) (a5)
  • DOI:
  • Published online: 15 January 2013

Recent studies suggest that white matter abnormalities contribute to both motor and non-motor symptoms of Parkinson's disease. The present study was designed to investigate the degree to which diffusion tensor magnetic resonance imaging (DTI) indices are related to executive function in Parkinson's patients. We used tract-based spatial statistics to compare DTI data from 15 patients to 15 healthy, age- and education-matched controls. We then extracted mean values of fractional anisotropy (FA) and mean diffusivity (MD) within an a priori frontal mask. Executive function composite Z scores were regressed against these DTI indices, age, and total intracranial volume. In Parkinson's patients, FA was related to executive composite scores, and both indices were related to Stroop interference scores. We conclude that white matter microstructural abnormalities contribute to cognitive deficits in Parkinson's disease. Further work is needed to determine whether these white matter changes reflect the pathological process or a clinically important comorbidity. (JINS, 2013, 19, 1–6)

Corresponding author
Correspondence and reprint requests to: Catherine Gallagher, 7211 MFCB, 1685 Highland Avenue, Madison, WI 53705-2281. E-mail:
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G.E. Alexander , M.R. DeLong , P.L. Strick (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357381. doi:10.1146/

N.I. Bohnen , R.L. Albin (2011). White matter lesions in Parkinson disease. Nature Reviews Neurology, 7(4), 229236. doi:10.1038/nrneurol.2011.21

H. Braak , K. Del Tredici , H. Bratzke , J. Hamm-Clement , D. Sandmann-Keil , U. Rub (2002). Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). Journal of Neurology, 249(Suppl 3), III/15.

S.M. de la Monte , S.E. Wells , T. Hedley-Whyte , J.H. Growdon (1989). Neuropathological distinction between Parkinson's dementia and Parkinson's plus Alzheimer's disease. Annals of Neurology, 26(3), 309320. doi:10.1002/ana.410260302

W.R. Gibb , A.J. Lees (1988). The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry, 51(6), 745752.

C.J. Golden (1975). The measurement of creativity by the Stroop Color and Word Test. Journal of Personality Assessment, 39(5), 502506. doi:10.1207/s15327752jpa3905_9

M.M. Hoehn , M.D. Yahr (1967). Parkinsonism: Onset, progression and mortality. Neurology, 17(5), 427442.

H. Matsui , K. Nishinaka , M. Oda , H. Niikawa , K. Komatsu , T. Kubori , F. Udaka (2007). Wisconsin Card Sorting Test in Parkinson's disease: Diffusion tensor imaging. Acta Neurologica Scandinavica, 116(2), 108112. doi:10.1111/j.1600-0404.2006.00795.x

D. Muslimovic , B. Post , J.D. Speelman , B. Schmand (2005). Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology, 65(8), 12391245. doi:10.1212/01.wnl.0000180516.69442.95

A.M. Paolo , B.N. Axelrod , A.I. Troster , K.T. Blackwell , W.C. Koller (1996). Utility of a Wisconsin Card Sorting Test short form in persons with Alzheimer's and Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 18(6), 892897. doi:10.1080/01688639608408310

C.L. Rae , M.M. Correia , E. Altena , L.E. Hughes , R.A. Barker , J.B. Rowe (2012). White matter pathology in Parkinson's disease: The effect of imaging protocol differences and relevance to executive function. Neuroimage, 62(3), 16751684. doi:10.1016/j.neuroimage.2012.06.012

M.A. Sager , B. Hermann , A. La Rue (2005). Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer's Prevention. Journal of Geriatric Psychiatry and Neurology, 18(4), 245249. doi:10.1177/0891988705281882

P. Scheltens , F. Barkhof , D. Leys , J.P. Pruvo , J.J. Nauta , P. Vermersch , J. Valk (1993). A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. Journal of the Neurological Sciences, 114(1), 712.

D.T. Stuss , D. Floden , M.P. Alexander , B. Levine , D. Katz (2001). Stroop performance in focal lesion patients: Dissociation of processes and frontal lobe lesion location. Neuropsychologia, 39(8), 771786.

S.M. Smith , M. Jenkinson , H. Johansen-Berg , D. Rueckert , T.E. Nichols , C.E. Mackay , T.E. Behrens (2006). Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. Neuroimage, 31(4), 14871505. doi:10.1016/j.neuroimage.2006.02.024

S.M. Smith , T.E. Nichols (2009). Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage, 44(1), 8398. doi:10.1016/j.neuroimage.2008.03.061

W. Zhan , G.A. Kang , G.A. Glass , Y. Zhang , C. Shirley , R. Millin , N. Schuff (2012). Regional alterations of brain microstructure in parkinson's disease using diffusion tensor imaging. Movement Disorders, 27(1), 9097. doi:10.1002/mds.23917

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Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
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