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Marine harmful algal blooms, human health and wellbeing: challenges and opportunities in the 21st century

  • Elisa Berdalet (a1), Lora E. Fleming (a2), Richard Gowen (a3) (a4), Keith Davidson (a4), Philipp Hess (a5), Lorraine C. Backer (a6), Stephanie K. Moore (a7), Porter Hoagland (a8) and Henrik Enevoldsen (a9)...
Abstract

Microalgal blooms are a natural part of the seasonal cycle of photosynthetic organisms in marine ecosystems. They are key components of the structure and dynamics of the oceans and thus sustain the benefits that humans obtain from these aquatic environments. However, some microalgal blooms can cause harm to humans and other organisms. These harmful algal blooms (HABs) have direct impacts on human health and negative influences on human wellbeing, mainly through their consequences to coastal ecosystem services (fisheries, tourism and recreation) and other marine organisms and environments. HABs are natural phenomena, but these events can be favoured by anthropogenic pressures in coastal areas. Global warming and associated changes in the oceans could affect HAB occurrences and toxicity as well, although forecasting the possible trends is still speculative and requires intensive multidisciplinary research. At the beginning of the 21st century, with expanding human populations, particularly in coastal and developing countries, mitigating HABs impacts on human health and wellbeing is becoming a more pressing public health need. The available tools to address this global challenge include maintaining intensive, multidisciplinary and collaborative scientific research, and strengthening the coordination with stakeholders, policymakers and the general public. Here we provide an overview of different aspects of the HABs phenomena, an important element of the intrinsic links between oceans and human health and wellbeing.

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Corresponding author
Correspondence should be addressed to: E. Berdalet, Institut de Ciències del Mar (CSIC), Passeig Marítim de la Barceloneta, 37-49, 08003 Barcelona, Catalonia, Spain email: berdalet@icm.csic.es
References
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Aasen, J.A.B., Espenes, A., Miles, C.O., Samdal, I.A., Hess, P. and Aune, T. (2011) Combined oral toxicity of azaspiracid-1 and yessotoxin in female NMRI mice. Toxicon 57, 909917.
Adams, J.A., Seaton, D.D., Buchanan, J.B. and Longbottom, M.R. (1968) Biological observations associated with the toxic phytoplankton bloom off the East Coast. Nature 220, 2425.
Aligizaki, K., Katikou, P., Milandri, A. and Diogène, J. (2011) Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art. Toxicon 57, 390399.
Aligizaki, K., Katikou, P., Nikolaidis, G. and Panou, A. (2008) First episode of shellfish contamination by palytoxin-like compounds from Ostreopsis species (Aegean Sea, Greece). Toxicon 51, 418427.
Alonso, E., Otero, P., Vale, C., Alfonso, A., Antelo, A., Giménez-Llort, L., Chabaud, L., Guillou, C. and Botana, L.M. (2013) Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: ß-Amyloid and neuronal marker improvement. Current Alzheimer Research 10, 279289.
Alonso, E., Vale, C., Vieytes, M.R., Laferla, F.M., Gimenez-Llort, L. and Botana, L.M. (2011a) 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular A beta and hyperphosphorylated tau in vitro. Neurochemistry International 59, 10561065.
Alonso, E., Vale, C., Vieytes, M.R., Laferla, F.M., Gimenez-Llort, L. and Botana, L.M. (2011b) The cholinergic antagonist gymnodimine improves a beta and tau neuropathology in an in vitro model of Alzheimer disease. Cellula Physiology and Biochemistry 27, 783794.
Àlvarez, J., Pedrol, A., Parrón, I., Goxencia, J., de Torres, M., Manzanera, M., Planas, C., Cosculluela, G. and López, A. (2005) Brote Epidémico de sintomatología irritativa en Sant Andreu de Llavaneres: ¿el origen está en el mar? In Proceedings of the XXIII Reunión de la Sociedad Española de Epidemiología, Las Palmas de Gran Canaria, Spain. Gaceta Sanitaria 19 Supplement 1, 3139.
Amzil, Z., Sibat, M., Chomérat, N., Grossel, H., Marco-Miralles, F., Lemee, R., Nézan, E. and Séchet, V. (2012) Ovatoxin-a and palytoxin accumulation in seafood in relation to Ostreopsis cf. ovata blooms on the French Mediterranean coast. Marine Drugs 10, 477496.
Amzil, Z., Sibat, M., Royer, F. and Savar, V. (2008) First report on azaspiracid and yessotoxin groups detection in French shellfish. Toxicon 52, 3948.
Anderson, C.R., Siegel, D.A., Kudela, R.M. and Brzezinski, M.A. (2009) Empirical models of toxigenic Pseudo-nitzschia blooms: potential use as a remote detection tool in the Santa Barbara Channel. Harmful Algae 8, 478492.
Anderson, D.M., Cembella, A.D. and Hallegraeff, G.M. (2012) Progress in understanding harmful algal blooms: paradigm shifts and new technologies for research, monitoring, and management. Annual Review of Marine Science 4, 143176.
Anderson, D.M., Glibert, P.M. and Burkholder, J.M. (2002) Harmful algal blooms and eutrophication: nutrient sources, composition, and consequences. Estuaries 25, 704726.
Anderson, D.M., Keafer, B.A., Geyer, W.R., Signell, R.P. and Loder, T.C. (2005a) Toxic Alexandrium blooms in the western Gulf of Maine: the plume advection hypothesis revisited. Limnology and Oceanography 50, 328345.
Anderson, D.M. and McCarthy, S. (2012) Red tides and harmful algal blooms: impacts on desalination operations. Muscat Oman: Middle East Desalination Research Center (Report).
Anderson, D.M., Stock, C.A., Keafer, B.A., Nelson, A.B., McGillicuddy, D.J., Keller, M., Thompson, B., Matrai, P.A. and Martin, J. (2005b) Alexandrium fundyense cyst dynamics in the Gulf of Maine. Deep-Sea Research II 52, 25222542.
Anderson, D.M., Sullivan, J.J. and Reguera, B. (1989) Paralytic shellfish poisoning in northwest Spain: the toxicity of the dinoflagellate Gymnodinium catenatum. Toxicon 27, 665674.
Arin, L., Guillén, J., Segura-Noguera, M. and Estrada, M. (2013) Open sea hydrographic forcing nutrient and phytoplankton dynamics in a Mediterranean coastal ecosystem. Estuarine Coastal and Shelf Science 133, 116128.
Aune, A., Espenes, A., Aasen, J.A.B., Quilliam, M.A., Hess, P. and Larsen, S. (2012) Study of possible combined toxic effects of azaspiracid-1 and okadaic acid in mice via the oral route. Toxicon 60, 895906.
Ayres, P. (1975) Mussel poisoning in Britain with special reference to paralytic shellfish poisoning. Review of cases reported 1814–1968. Environmental Health 83, 261265.
Azanza, R.V. (1999) Seafood poisoning from harmful algal blooms in coastal areas (abstract only). IOC-SOA International Workshop on Coastal Megacities: Challenges of Growing Urbanisation of the World's Coastal Areas Intergovernmental Oceanographic Commission Workshop (Hangzhou, People's Republic of China 27–30 September 1999) UNESCO. Report, 166.
Azanza, R.V. and Taylor, F.J.R. (2001) Are Pyrodinium blooms in the Southeast Asian region recurring and spreading? A view at the end of the millennium. Ambio 30, 356364.
Bachvaroff, T.R., Adolf, J.E., Squier, A.H., Harvey, H.R. and Place, A.R. (2008) Characterization and quantification of karlotoxins by liquid chromatography-mass spectrometry. Harmful Algae 7, 473484.
Backer, L.C., Fleming, L.E., Rowan, A., Cheng, Y.-S., Benson, J., Pierce, R.H., Zaias, J., Bean, J., Bossart, G.D., Johnson, D., Quimbo, R. and Baden, D.G. (2003) Recreational exposure to aerosolized brevetoxins during Florida red tide events. Harmful Algae 2, 1928.
Backer, L.C., Kirkpatrick, B., Fleming, L.E., Cheng, Y.S., Pierce, R., Bean, J.A., Clark, R., Johnson, D., Wanner, A., Tamer, R. and Baden, D. (2005) Occupational exposure to aerosolized brevetoxins during Florida red tide events: impacts on a healthy worker population. Environmental Health Perspectives 113, 644649.
Backer, L.C. and Moore, S.K. (2011) Harmful algal blooms: future threats in a warmer world. In El Nemr, A. (ed.) Environmental pollution and its relation to climate change. New York, NY: Nova Science Publishers, pp. 495561.
Baden, D.G. and Trainer, V.L. (1993) Mode of action of toxins of seafood poisoning. In Falconer, I. (ed.) Algal toxins in seafood and drinking water. New York, NY: Academic Press, pp. 4974.
Bagnis, R., Kuberski, T. and Laugeir, S. (1979) Clinical observations on 3009 cases of ciguatera (fish poisoning) in the South Pacific. American Journal of Tropical Medicicne and Hygiene 28, 10671073.
Baron, A.W., Steeg, R., Morris, C.M., Blain, P.G. and Judge, S.J. (2011) Motor activity is a sensitive behavioural biomarker of low level exposure to the shellfish toxin, domoic acid, in male and female rats. Toxicology 290, 122.
Barroso García, P., Rueda de la Puerta, P., Parron Carreno, T., Marín Martínez, P. and Enriquez, J.G. (2008) Brote con sintomas respiratorios en la provincia de Almería por una posible exposicion a microalgas toxicas. Gaceta Sanitaria 22, 578584.
Bates, S.S., Bird, C.J., de Freitas, A.S.W., Foxall, R., Gilgan, M., Hanic, L.A., Johnson, G.R., McCulloch, A.W., Odense, P., Pocklingtonm, R., Quilliam, M.A., Sim, P.G., Smith, J.C., Subba Rao, D.V., Todd, E.C.D., Walter, J.A. and Wright, J.L.C. (1989) Pennate diatom Nitzschia pungens as the primary source of domoic acid, a toxin in shellfish from eastern Prince Edward Island, Canada. Canadian Journal of Fisheries and Aquatic Sciences 46, 12031215.
Bauer, M., Hoagland, P., Leschine, T.M., Blount, B.G., Pomeroy, C.M., Lampl, L.L., Scherer, C.W., Ayres, D.L., Tester, P.A., Sengco, M.R., Sellner, K.G. and Schumacker, J. (2009) The importance of human dimensions research in managing harmful algal blooms. Frontiers in Ecology and the Environment 8, 7583.
Bean, J.A., Fleming, L.E., Kirkpatrick, B., Backer, L.C., Nierenberg, K., Reich, A., Cheng, Y.S., Wanner, A., Benson, J., Naar, J., Pierce, R., Abraham, W.M., Kirkpatrick, G., Hollenbeck, J., Zaias, J., Mendes, E. and Baden, D.G. (2011) Florida red tide toxins (brevetoxins) and longitudinal respiratory effects in asthmatics. Harmful Algae 10, 744748.
Beardall, J. and Raven, J.A. (2004) The potential effects of global climate change on microalgal photosynthesis, growth and ecology. Phycologia 43, 2641.
Beaugrand, G., Edwards, M. and Legendre, L. (2010) Marine biodiversity, ecosystem functioning, and carbon cycles. Proceedings of the National Academy of Sciences USA 107, 1012010124.
Berdalet, E., Vila, M. and Abós-Herràndiz, R. (2015) Expansion of the benthic dinoflagellate Ostreopsis with climate change: health risks assessment and policy strategies for management. Harmful Algal Blooms and Climate Change Scientific Symposium. Göteborg, Sweden, 19–22 May 2015. https://pices.int/meetings/international_symposia/2015/2015-HAB/scope.aspx
Bernard, S., Kudela, R.M. and Velo-Suárez, L. (2014) Developing global capabilities for the observation and prediction of harmful algal blooms. In Djavidnia, S., Cheung, V., Ott, M. and Seeyave, S. (eds) Oceans and society: blue planet. Cambridge Scholars Publishing, Chapter 6.
Bindoff, N.L., Willebrand, J., Artale, V., Cazenave, A., Gregory, J., Gulev, S., Hanawa, K., Le Quéré, C., Levitus, S., Nojiri, Y., Shum, C.K., Talley, L.D. and Unnikrishnan, A. (2007) Observations: oceanic climate change and sea level. In Solomon, S., Qin, D., Manning, M., Chen, Z., Marquis, M., Averyt, K.B., Tignor, M., Miller, H.L. (eds) Climate change 2007: the physical science basis contribution of working group I to the fourth assessment report of the intergovernmental panel on climate change. Cambridge: Cambridge University Press, pp. 385432.
Biré, R., Trotereau, S., Lemée, R., Delpont, C., Chabot, B., Aumond, Y. and Krys, S. (2013) Occurrence of palytoxins in marine organisms from different trophic levels of the French Mediterranean coast harvested in 2009. Harmful Algae 28, 1022.
Black, E.A., Whyte, J.N.C., Bagshaw, J.W. and Ginther, N.G. (1991) The effects of Heterosigma akashiwo on juvenile Oncorhynchus tshawytscha and its implications for fish culture. Journal of Applied Ichthyology 7, 168175.
Blanco, J., Correa, J., Muñíz, S., Mariño, C., Martín, H. and Arévalo, F. (2013) Evaluación del impacto de los métodos y niveles utilizados para el control de toxinas en el mejillón. Revista Galega dos Recursos Mariños 3, 155.
Blanco, J., Moroño, A. and Fernández, M.L. (2005) Toxic episodes in shellfish produced by lipophilic phycotoxins: an overview. Galician Journal of Marine Resources 1, 70.
Blossom, H.A., Andersen, N.G., Rasmusse, S.A. and Hansen, P.J. (2014) Stability of the intra- and extracellular toxins of Prymnesium parvum using a microalgal bioassay. Harmful Algae 32, 1121.
Boni, L., Mancini, L., Milandri, A., Poletti, R., Pompei, M. and Viviani, R. (1992) First cases of diarrhetic shellfish poisoning in the Northern Adriatic Sea. In Vollenweider, R.A., Marchetti, R. and Viviani, R. (eds) Marine coastal eutrophication. Amsterdam: Elsevier, pp. 419426.
Borkman, D.G. and Smayda, T. (2009) Multidecadal (1959–1997) changes in Skeletonema abundance and seasonal bloom patterns in Narragansett Bay, Rhode Island, USA. Journal of Sea Research 61, 8494.
Bossart, G.D., Baden, D.G., Ewing, R.Y. and Wright, S.D. (2002) Manatees and brevetoxicosis. In Pfeiffer, C. (ed.) Molecular and cell biology of marine mammals. Melbourne, FL: Krieger Publishing Co., pp. 205212.
Bradley, W.G., Borenstein, A.R., Nelson, L.M., Codd, G.A., Rosen, B.H., Stommel, E.W. and Cox, P.A. (2013) Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases? Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14, 325333.
Brand, L.E., Pablo, J., Compton, A., Hammerschlag, N. and Mash, D.C. (2010) Cyanobacterial blooms and the occurrence of the neurotoxin, beta-N-methylamino-L-alanine (BMAA), in South Florida aquatic food webs. Harmful Algae 9, 620635.
Bravo, I., Vila, M., Casabianca, S., Rodríguez, F., Rial, P., Riobó, P. and Penna, A. (2012) Life cycle stages of the benthic palytoxin-producing dinoflagellate Ostreopsis cf. ovata (Dinophyceae). Harmful Algae 18, 2434.
Brescianini, C., Grillo, C., Melchiorre, N., Bertolotto, R., Ferrari, A., Vivaldi, B., Icardi, G., Gramaccioni, L., Funari, E. and Scardala, S. (2006) Ostreopsis ovata algal blooms affecting human health in Genova, Italy, 2005 and 2006. Euro Surveillance 11, E060907.
Bricelj, V.M. and Lonsdale, D.J. (1997) Aureococcus anophagefferens: causes and ecological consequences of brown tides in U.S. mid-Atlantic coastal waters. Limnology and Oceanography 42, 10231038.
Brissard, C., Herrenknecht, C., Séchet, V., Hervé, F., Pisapia, F., Harcouet, J., Lémée, R., Chomérat, N., Hess, P. and Amzil, Z. (2014) Complex toxin profile of French Mediterranean Ostreopsis cf. ovata strains, seafood accumulation and ovatoxins prepurification. Marine Drugs 12, 28512876.
Brissard, C., Hervé, F., Sibat, M., Séchet, V., Hess, P., Amzil, Z. and Herrenknecht, C. (2015) Characterization of ovatoxin-h, a new ovatoxin analog, and evaluation of chromatographic columns for ovatoxin analysis and purification. Journal of Chromatography A 1388, 87101.
Brown, C.W., Green, D., Hickey, B.M., Jacobs, J.M., Lanerolle, L.W.J., Moore, S., Schwab, D.J., Trainer, V.L., Trtanj, J., Turner, E., Wood, R.J. and Wynne, T.T. (2012) Towards operational forecasts of algal blooms and pathogens. In Morain, S.A. and Budge, A.M. (eds) Environmental tracking for public health surveillance, 1st edn.Leiden: CRC Press, pp. 345368.
Bruno, D.W., Dear, D. and Seaton, D.D. (1989) Mortality associated with phytoplankton blooms among farmed Atlantic salmon, Salmo salar L. in Scotland. Aquaculture 78, 217222.
Bruslé, J. (1997) Ciguatera fish poisoning – a review. Sanitary and economic aspects. Paris: Les éditions INSERM, 147 pp.
Campbell, K., McNamee, S.E., Huet, A.C., Delahaut, P., Vilarino, N., Botana, L.M., Poli, M. and Elliott, C.T. (2014) Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish. Analytical and Bioanalytical Chemistry 406, 68676881.
Campbell, L., Henrichs, D.W., Olson, R.J. and Sosik, H.M. (2013) Continuous automated imaging-in-flow cytometry for detection and early warning of Karenia brevis blooms in the Gulf of Mexico. Environmental Science and Pollution Research 20, 68966902.
Campbell, L., Olson, R.J., Sosik, H.M., Abraham, A., Henrichs, D.W., Hyatt, C.J. and Buskey, E.J. (2010) First harmful Dinophysis (Dinophyceae, Dinophysiales) bloom in the U.S. is revealed by automated imaging flow cytometry. Journal of Phycology 46, 6675.
Caron, D.A., Gurnee, M.-E., Seubert, E., Howard, M.D.A., Darjany, L., Schnetzer, A., Cetinic, I., Filteau, G., Lauri, P., Jones, B. and Trussell, S. (2010) Harmful algae and their potential impacts on desalination operations off southern California. Water Research 44, 385416.
Casabianca, S., Casabianca, A., Riobó, P., Franco, J.M., Vila, M. and Penna, A. (2013) Quantification of the toxic dinoflagellate Ostreopsis spp. by qPCR assay in marine aerosol. Environmental Science and Technology 47, 37883795.
Chateau-Degat, M.L., Chinain, M., Cerf, N., Gingras, S., Hubert, B. and Dewailly, E. (2005) Sea water temperature, Gambierdiscus spp. variability and incidence of ciguatera poisoning in French Polynesia. Harmful Algae 4, 10531062.
Chateau-Degat, M.L., Chinain, M., Darius, H.T., Dewailly, E. and Mallet, H.P. (2009) Epidemiological surveillance of ciguatera in French Polynesia. Bulletin Epidémiologique Hebdomadaire Thématique 48–50, 522525.
Chinain, M., Darius, H.T., Ung, A., Cruchet, P., Wang, Z., Ponton, D., Laurent, D. and Pauillac, S. (2010a) Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture. Toxicon 56, 739750.
Chinain, M., Darius, H.T., Ung, A., Fouc, M.T., Revel, T., Cruchet, P., Pauillac, S. and Laurent, D. (2010b) Ciguatera risk management in French Polynesia: the case study of Raivavae Island (Australes Archipelago). Toxicon 56, 674690.
Ciminiello, P., Dell'Aversano, C., Dello Iacovo, E., Fattorusso, E., Forino, M., Grauso, L., Tartaglione, L., Guerrini, F. and Pistocchi, R. (2010) Complex palytoxin-like profile of Ostreopsis ovata. Identification of four new ovatoxins by high-resolution liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 24, 27352744.
Ciminiello, P., Dell'Aversano, C., Dello Iacovo, E., Fattorusso, E., Forino, M. and Tartaglione, L. (2011) LC-MS of palytoxin and its analogues: state of the art and future perspectives. Toxicon 57, 376389.
Ciminiello, P., Dell'Aversano, C., Dello Iacovo, E., Fattorusso, E., Forino, M. and Tartaglione, L. (2014) First finding of Ostreopsis cf. ovata toxins in marine aerosols. Environmental Science and Technology 48, 35323540.
Ciminiello, P., Dell'Aversano, C., Dello Iacovo, E., Fattorusso, E., Forino, M., Tartaglione, L., Yasumoto, T., Battocchi, C., Giacobbe, M., Amorim, A. and Penna, A. (2013) Investigation of toxin profile of Mediterranean and Atlantic strains of Ostreopsis cf. siamensis (Dinophyceae) by liquid chromatography–high resolution mass spectrometry. Harmful Algae 23, 1927.
Ciminiello, P., Dell'Aversano, C. and Forino, M. (2015) Chemistry of palytoxin and its analogues. In Botana, L. and Alfonso, A. (eds) Phycotoxins: chemistry and biochemistry. Hoboken, NY: Wiley-Blackwell, pp. 85111.
Coulson, J.C., Potts, G.R., Deans, I.R. and Fraser, S.M. (1968) Mortality of shags and other sea birds caused by paralytic shellfish poisoning. Nature 220, 2324.
Cox, P.A., Banack, S.A., Murch, S.J., Rasmussen, U., Tien, G., Bidigare, R.R., Metcalf, J.S., Morrison, L.F., Codd, G.A. and Bergman, B. (2005) Diverse taxa of cyanobacteria produce β-N-methylamino-l-alanine, a neurotoxic amino acid. Proceedings of the National Academy of Sciences USA 102, 50745078.
Dahl, E. and Tangen, K. (1990) Gyrodinium aureolum bloom along the Norwegian coast in 1988. In Granéli, E., Sundstrøm, B., Edler, L. and Anderson, D.M. (eds) Toxic marine phytoplankton. Amsterdam: Elsevier, pp. 123127.
Dahl, E. and Tangen, K. (1993) 25 years experience with Gyrodinium aureolum in Norwegian waters. In Smayda, T.J. and Shimizu, Y. (eds) Toxic phytoplankton blooms in the sea. New York, NY: Elsevier, pp. 1521.
Daigo, K. (1959) Constituents of Chondria armata. III. Constitution of domoic acid. Journal of the Pharmaceutical Society of Japan. Yakugaku Zasshi 79, 360364. [In Japanese, with English abstract]
Dale, B., Edwards, M. and Reid, P.C. (2006) Climate change and harmful algae blooms. In Granéli, E. and Turner, J.T. (eds) Ecology of harmful algae. Ecological studies No. 189. Heidelberg: Springer-Verlag, pp. 367378.
Davidson, K. (2014) The challenges of incorporating realistic simulations of marine protists in biogeochemically based mathematical models. Acta Protozoologica 53, 129138.
Davidson, K. and Bresnan, E. (2009) Shellfish toxicity in UK waters: a threat to human health? Environmental Health 8 Supplement 1, S12.
Davidson, K., Gowen, R.J., Harrison, P.J., Fleming, L., Hoagland, P. and Moschonas, G. (2014) Anthropogenic nutrients and harmful algae in coastal waters. Journal of Environmental Management 146, 206216.
Davidson, K., Gowen, R.J., Tett, P., Bresnan, E., Harrison, P.J., McKinney, A., Milligan, S., Mills, D.K., Silke, J. and Crooks, A.-M. (2012) Harmful algal blooms: how strong is the evidence that nutrient ratios and forms influence their occurrence? Estuarine Coastal and Shelf Science 115, 399413.
Davidson, K., Miller, P.I., Wilding, T., Shutler, J., Bresnan, E., Kennington, K. and Swan, S. (2009) A large and prolonged bloom of Karenia mikimotoi in Scottish waters in 2006. Harmful Algae 8, 349361.
Davidson, K., Tett, P. and Gowen, R. (2011) Harmful algal blooms. In Hester, R.E. and Harrison, R.M. (eds) Marine pollution and human health. Issues in environmental science and technology, no. 33. Cambridge: Royal Society of Chemistry, pp. 95127.
Deeds, J.R., Landsberg, J.H., Etheridge, S.M., Pitcher, G.C. and Longan, S.W. (2008) Non-traditional vectors for paralytic shellfish poisoning. Marine Drugs 6, 308348.
Deeds, J.R. and Schwartz, M.D. (2010) Human risk associated with palytoxin exposure. Toxicon 56, 150162.
DeGrasse, S.L. and Martinez-Diaz, K. (2012) Biotoxin control programmes in North, Central and South American countries. In Cabado, A.G. and Vieites, J.M. (eds) New trends in marine and freshwater toxins: food safety concerns. New York, NY: Nova Science Publishers.
Dewailly, E., Chateau-Degat, M.L. and Suhas, E. (2008) Fish consumption and health in French Polynesia. Asian Pacific Journal of Clinical Nutrition 17, 8693.
Dixon, M.B., Falconet, C., Ho, L., Chow, C.W.K., O'Neill, B.K. and Newcombe, G. (2011a) Removal of cyanobacterial metabolites by nanofiltration from two treated waters. Journal of Hazardous Materials 188, 288295.
Dixon, M.B., Richard, Y., Ho, L., Chow, C.W.K., O'Neill, B.K. and Newcombe, G. (2011b) A coagulation-powdered activated carbon-ultrafiltration–multiple barrier approach for removing toxins from two Australian cyanobacterial blooms. Journal of Hazardous Materials 186, 15531559.
Dobson, A. and Carper, R. (1993) Biodiversity. Lancet 342, 10961099.
Durando, P., Ansaldi, F., Oreste, P., Moscatelli, P., Marensi, L., Grillo, C., Gasparini, R., Icardi, G. and the Collaborative Group for the Ligurian Syndromic Algal Surveillance (2007) Ostreopsis ovata and human health: epidemiological and clinical features of respiratory syndrome outbreaks from a two-year syndromic surveillance, 2005–2006, in north-west Italy. Eurosurveillance 12, 14.
Edwards, M., Johns, D.G., Leterme, S.C., Svendsen, E. and Richardson, A.J. (2006) Regional climate change and harmful algal blooms in the northeast Atlantic. Limnology and Oceanography 51, 820829.
Edwards, M., Reid, P.C. and Planque, B. (2001) Long-term and regional variability of phytoplankton biomass in the Northeast Atlantic (1960–1995). ICES Journal of Marine Science 58, 3949.
EFSA Panel on Contaminants in the Food Chain (CONTAM) (2009) Scientific opinion on marine biotoxins in shellfish – Palytoxin group. EFSA Journal 7. doi: 10.2903/j.efsa.2009.1393.
Elbrächter, M. and Qi, Y.Z. (1998) Aspects of Noctiluca (Dinophyceaea) population dynamics. In Anderson, D.M., Cembella, A.D. and Hallegraeff, G.M. (eds) Physiological ecology of harmful algal blooms. Heidelberg: Springer- Verlag, pp. 133153.
Endo, M., Sakai, T. and Kuroki, A. (1985) Histological and histochemical changes in the gills of the yellowtail Seriola quinqueradiata exposed to the Raphidophycean flagellate Chattonella marina. Marine Biology 87, 193197.
Epelboin, L., Pérignon, A., Hossen, V., Vincent, R., Krys, S. and Caumes, E. (2014) Two clusters of ciguatera fish poisoning in Paris, France, related to tropical fish imported from the French Caribbean by travelers. Journal of Travel Medicine 21, 397402.
Epstein, P. and Rapport, D.J. (1996) Changing coastal marine environments and human health. Ecosystem Health 2, 166176.
Epstein, P.R. (2001) Climate change and emerging infectious diseases. Microbes and Infection 3, 747754.
Estrada, M., Sánchez, F.J. and Fraga, S. (1984) Gymnodinium catenatum (Graham) en las rías gallegas (NO de España). Investigación Pesquera 48, 3140.
European Commission (2011) Commission Regulation (EU) No 15/2011 of 10 January 2011 amending Regulation (EC) No 2074/2005 as regards recognised testing methods for detecting marine biotoxins in live bivalve molluscs. Official Journal L6, 3–6. Available online: http://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex:32011R0015 (accessed 4 November 2015).
Falconer, I. (1998) Algal toxins and human health. In Hrub, J. (ed.) The handbook of environmental chemistry. Berlin: Springer-Verlag, pp. 5382.
FAO (2006) State of world aquaculture, 2006. FAO Fisheries Technical Report Paper No. 500. Rome: Inland Water and Aquaculture Service. Fishery Resources Division, FAO Fisheries Department.
Fehling, J., Davidson, K., Bolch, C.J. and Bates, S.S. (2004) Growth and domoic acid production by Pseudo-nitzschia seriata (Bacillariophyceae) under phosphate and silicate limitation. Journal of Phycology 40, 674683.
Ferrando, R. (1984) Álvar Núñez Cabeza de Vaca, Naufragios y Comentarios, Volume 16. Madrid: Historia, 318 pp.
Fistarol, G.O., Legrand, C. and Granéli, E. (2003) Allelopathic effect of Prymnesium parvum on a natural plankton community. Marine Ecology Progress Series 255, 115125.
Fleming, L.E., Backer, L. and Rowan, A. (2002) The epidemiology of human illnesses associated with harmful algal blooms. In Baden, D. and Adams, D. (eds) Neurotoxicology handbook, Vol. 1. Totowa, NJ: Humana Press, pp. 363381.
Fleming, L.E., Kirkpatrick, B., Backer, L.C., Bean, J.A., Wanner, A., Dalpra, D., Tamer, R., Zaias, J., Cheng, Y.S., Pierces, R., Naar, J., Abraham, W., Clark, R., Zhou, Y., Henry, M.S., Johnson, D., Van de Bogart, G., Bossart, G.D., Harrington, M. and Baden, D.G. (2005) Initial evaluation of the effects of aerosolized Florida red tide toxins (brevetoxins) in persons with asthma. Environmental Health Perspectives 113–5, 650657.
Fleming, L.E., Kirkpatrick, B., Backer, L.C., Bean, J.A., Wanner, A., Reich, A., Zaias, J., Cheng, Y.S., Pierce, R., Naar, J., Abraham, W.M. and Baden, D.G. (2006) Aerosolized red tide toxins (Brevetoxins) and asthma. Chest 131, 187194.
Fleming, L.E., Kirkpatrick, B., Backer, L.C., Walsh, C.J., Nierenberg, K., Clark, J., Reich, A., Hollenbeck, J., Benson, J., Cheng, Y.S., Naar, J., Pierce, R., Bourdelais, A.J., Abraham, W.M., Kirkpatrick, G., Zaias, J., Wanner, A., Mendes, E., Shalat, S., Hoagland, P., Stephan, W., Bean, J., Watkins, S., Clarke, T., Byrne, M. and Baden, D.G. (2011) Review of Florida red tide and human health effects. Harmful Algae 20, 224233.
Fleming, L.E., McDonough, N., Austen, M., Mee, L., Moore, M., Hess, P., Depledge, M.H., White, M., Philippart, K., Bradbrook, P. and Smalley, A. (2014) Oceans and human health: a rising tide of challenges and opportunities for Europe. Marine Environment Research 99, 1619.
Flewelling, L.J., Naar, J.P., Abbott, J.P., Baden, D.G., Barros, N.B., Bossart, G.D., Bottein, M-Y.D., Hammond, D.G., Haubold, E.M., Heil, C.A., Henry, M.S., Jacocks, H.M., Leighfield, T.A., Pierce, R.H., Pitchford, T.D., Rommel, S.A., Scott, P.S., Steidinger, K.A., Truby, E.W., Van Dolah, F.M. and Landsberg, J.H. (2005) Brevetoxicosis: Red tides and marine mammal mortalities. Nature (London) 435, 755756.
Fonda-Umani, S., Beran, A., Parlato, S., Virgilio, D., Zollet, T., De Olazabal, A., Lazzarini, B. and Cabrini, M. (2004) Noctiluca scintillans Macartney in the Northern Adriatic Sea: long-term dynamics, relationships with temperature and eutrophication, and role in the food web. Journal of Plankton Research 26, 545561.
Fraga, S. and Sánchez, F.J. (1985) Toxic and potentially toxic dinoflagellates found in Galician Rías (NW Spain). In Anderson, D.M., White, A.W. and Baden, D.G. (eds) Toxic dinoflagellates. Proceedings of the Third International Conference on Toxic Dinoflagellates, New Brunswick, Canada 8–12 June 1985. New York: Elsevier, pp. 5154.
Freudenthal, A.R. (1990) Public health aspects of ciguatera poisoning contracted on tropical vacations by North American tourists. In Graneli, E., Sundstrom, B., Edler, L. and Anderson, D.M. (eds) Toxic marine phytoplankton. New York, NY: Elsevier, pp. 463468.
Friedman, M.A., Fleming, L.E., Fernandez, M., Bienfang, P., Schrank, K., Dickey, R., Bottein, M.Y., Backer, L., Ayyar, R., Weisman, R., Watkins, S., Granade, R. and Reich, A. (2008) Ciguatera fish poisoning: treatment, prevention and management. Marine Drugs 6, 456479.
Fritz, S., Scholes, R.J., Obersteiner, M., Bouma, J. and Reyers, B. (2008) A conceptual framework for assessing the benefits of a global earth observation system of systems. IEEE Systems Journal 2, 338348.
Frolov, S., Kudela, R.M. and Bellingham, J.G. (2013) Monitoring of harmful algal blooms in the era of diminishing resources: a case study of the US west coast. Harmful Algae 21–22, 112.
Fu, F.-X., Tatters, A.O. and Hutchins, D.A. (2012) Global change and the future of algal blooms in the ocean. Marine Ecology Progress Series 470, 207233.
Fukuyo, Y., Imai, I., Kodama, M. and Tamai, K. (2002) Red tides and harmful algal blooms in Japan. In Taylor, F.J. and Trainer, V.L. (eds) Harmful algal blooms in the PICES region of the North Pacific. PICES Scientific Report No. 23. Sidney, BC: North Pacific Marine Science Organization (PICES), pp. 720.
Fux, E., Biré, R. and Hess, P. (2009) Comparative accumulation and composition of lipophilic marine biotoxins in passive samplers and in mussels (M. edulis) on the West Coast of Ireland. Harmful Algae 8, 523537.
Gaines, G. and Taylor, F.J.R. (1985) An exploratory analysis of PSP patterns in British Columbia. In Anderson, D.M., White, A.W. and Baden, D.G. (eds) Toxic dinoflagellates. Proceedings of the Third International Conference on Toxic Dinoflagellates, New Brunswick, Canada 8–12 June 1985. New York, NY: Elsevier Science, pp. 439444.
Gallitelli, M., Ungaro, N., Addante, L.M., Silver, N.G. and Sabbà, C. (2005) Respiratory illness as a reaction to tropical algal blooms occurring in a temperate climate. Journal of the American Medical Association 293, 25992600.
Gentien, P. (1998) Bloom dynamics and ecophysiology of the Gymnodinium mikimotoi species complex. In Anderson, D.A., Cembella, A.D. and Hallegraeff, G.M. (eds) Physiological ecology of harmful algae blooms. Berlin: Springer, pp. 155173.
GEOHAB (2001) Glibert, P. and Pitcher, G. (eds) Global ecology and oceanography of harmful algal blooms, science plan. Baltimore and Paris: SCOR and IOC, 87 pp.
GEOHAB (2005) Pitcher, G., Moita, T., Trainer, V., Kudela, R., Figueiras, F.G. and Probyn, T. (eds) Global ecology and oceanography of harmful algal blooms, GEOHAB Core Research Project: HABs in upwelling systems. Paris and Baltimore: IOC and SCOR, 82 pp.
GEOHAB (2006) Glibert, P. (ed.) Global ecology and oceanography of harmful algal blooms, harmful algal blooms in eutrophic systems. Paris and Baltimore: IOC and SCOR, 74 pp.
GEOHAB (2008) Gentien, P., Reguera, B., Yamazaki, H., Fernand, L., Berdalet, E. and Raine, R. (eds) Global ecology and oceanography of harmful algal blooms, GEOHAB Core Research Project: HABs in Stratified Systems. Paris and Newark, DE: IOC and SCOR, 59 pp.
GEOHAB (2010) Furuya, K., Glibert, P.M., Zhou, M. and Raine, R. (eds) Global ecology and oceanography of harmful algal blooms, harmful algal blooms in Asia. Paris and Newark, DE: IOC and SCOR, 68 pp.
GEOHAB (2011) McGillicuddy, D.J. Jr., Glibert, P.M., Berdalet, E., Edwards, C., Francks, P. and Ross, O. (eds) GEOHAB modelling: a workshop report. Paris and Newark, DE: IOC and SCOR, 85 pp.
GEOHAB (2012) Berdalet, E., Tester, P.A. and Zingone, A. (eds) Global Ecology and Oceanography of Harmful Algal Blooms, GEOHAB Core Research Project: HABs in Benthic Systems. Paris and Newark: SCOR and IOC of UNESCO, 64 pp.
GEOHAB (2014) Berdalet, E., Bernard, S., Burford, M.A., Enevoldsen, H., Kudela, R., Magnien, R., Roy, S., Tester, P., Urban, E. and Usup, G. (eds) Global ecology and oceanography of harmful algal blooms: synthesis open science meeting. Paris and Newark, DE: IOC and SCOR, 78 pp.
GESAMP (2001) Global Environment Outlook 3, EARTH SCAN, Past, present and future perspectives. Protecting the oceans from land-based activities. Land-based sources and activities affecting the quality and uses of the marine, coastal and associated freshwater environment. GESAMP Reports and Studies No. 71. Nairobi: United Nations Environment Programme.
Gingold, D.B., Strickland, M.J. and Hess, J.J. (2014) Ciguatera fish poisoning and climate change: analysis of the National Poison Center data in the United States, 2001–2011. Environmental Health Perspectives 122, 580586.
Gobler, C.J., Berry, D.L., Anderson, O.R., Burson, A., Koch, F., Rodgers, B.S., Moore, L.K., Goleski, J.A., Allam, B., Bowser, P., Tang, Y.Z. and Nuzzi, R. (2008) Characterization, dynamics, and ecological impacts of harmful Cochlodinium polykrikoides blooms on eastern Long Island, NY, USA. Harmful Algae 7, 293307.
Golubic, S., Abed, R.M.M., Palińska, K., Pauillac, S., Chinain, M. and Laurent, D. (2010) Marine toxic cyanobacteria: diversity, environmental responses and hazards. Toxicon 56, 836841.
Gowen, R.J., Tett, P., Bresnan, E., Davidson, K., McKinney, A., Harrison, P.J., Milligan, S., Mills, D.K., Silke, J. and Crooks, A.-M. (2012) Anthropogenic nutrient enrichment and blooms of harmful micro-algae. Oceanography and Marine Biology: An Annual Review 50, 65126.
Granéli, E. and Hansen, P.J. (2006) Allelopathy in harmful algae: a mechanism to compete for resources? In Granéli, E. and Turner, J.T. (eds) Ecology of harmful algae. Berlin: Springer Verlag, pp. 189201.
Greenfield, D., Marin, R. III, Doucette, G.J., Mikulski, C., Jones, K., Jensen, S., Roman, B., Alvarado, N., Feldman, J. and Scholin, C.A. (2008) Field applications of the second generation environmental sample processor (ESP) for remote detection of harmful algae: 2006–2007. Limnology and Oceanography: Methods 6, 667679.
Haamer, J., Andersson, P.-O., Lindahl, O., Lange, S., Li, X.P. and Edebo, L. (1990) Geographic and seasonal variation of okadic acid content in farmed mussels, Mytilus edulis Linnaeus, 1758, along the Swedish west coast. Journal of Shellfish Research 9, 103108.
Hai, D.-N., Lam, N.-N. and Dippner, J. (2010) Development of Phaeocystis globosa blooms in the upwelling waters of the South Central coast of Viet Nam. Journal of Marine Systems 83, 253261.
Hall, A. and Frame, E.R. (2010) Evidence of domoic acid exposure in harbour seals from Scotland: a potential factor in the decline in abundance? Harmful Algae 9, 489493.
Hallegraeff, G.M. (1993) A review of harmful algal blooms and their apparent global increase. Phycologia 32, 7999.
Hallegraeff, G.M. (2010) Ocean climate change, phytoplankton community responses, and harmful algal blooms: a formidable predictive challenge. Journal of Phycology 46, 220253.
Hallegraeff, G.M. and Bolch, C.J. (1992) Transport of diatom and dinoflagellate resting spores in ships’ ballast water: implications for plankton biogeography and aquaculture. Journal of Plankton Research 14, 10671084.
Hays, G.C., Richardson, A.J. and Robinson, C. (2005) Climate change and marine plankton. Trends in Ecology and Evolution 20, 337344.
He, R., McGillicuddy, D.J., Keafer, B.A. and Anderson, D.M. (2008) Historic 2005 toxic bloom of Alexandrium fundyense in the western Gulf of Maine: 2. Coupled Biophysical Numerical Modeling. Journal of Geophysical Research–Oceans 113, C07040.
Hess, P. (2002) Use of LC-MS testing to identify lipophilic toxins, to establish local trends and interspecies differences and to test the comparability of LC-MS testing with the mouse bioassay: an example from the Irish biotoxin monitoring programme 2001. In Villalba, A., Reguera, B., Romalde, J.L. and Beiras, R. (eds) Fourth International Conference on Molluscan Shellfish Safety, 4–8 June, 2002. Santiago de Compostela: IOC of UNESCO, pp. 5766.
Hess, P. (2010) Requirements for screening and confirmatory methods for the detection and quantification of marine biotoxins in end-product and official control. Analytical and Bioanalytical Chemistry 397, 16831694.
Hess, P. (2012) Phytoplankton and biotoxin monitoring programmes for the safe exploitation of shellfish in Europe. In Cabado, A.G. and Vieites, J.M. (eds) New trends in marine and freshwater toxins: food safety concerns. New York, NY: Nova Science Publishers, pp. 305314.
Hess, P., Abadie, E., Herve, F., Berteaux, T., Sechet, V., Araoz, R., Molgo, J., Zakarian, A., Sibat, M., Rundberget, T., Miles, C.O. and Amzil, Z. (2013) Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon. Toxicon 75, 1626.
Hess, P., Amzil, Z., Belin, C., Compere, C., Lassus, P. and Menesguen, A. (2012) Evolution of European monitoring systems for shellfish toxins – an increased need for the surveillance of phytoplankton. In Pagou, K.A. and Hallegraeff, G.M. (eds) Proceedings of the 14th International Conference on Harmful Algae, 1–5 November 2010, Hersonissos, Crete. Copenhagen: International Society for the Study of Harmful Algae and IOC of UNESCO, pp. 288291.
Hess, P., Grune, B., Anderson, D.B., Aune, T., Botana, L.M., Caricato, P., van Egmond, H.P., Halder, M., Hall, S., Lawrence, J.F., Moffat, C., Poletti, R., Richmond, J., Rossini, G.P., Seamer, C. and Serratosa Vilageliu, J. (2006) Three Rs approaches in marine biotoxin testing – the report and recommendations of a joint ECVAM/DG SANCO workshop (ECVAM Workshop 55). Alternatives to Laboratory Animals (ATLA) 34, 193224.
Hess, P., McCarron, P., Krock, B., Kilcoyne, J. and Miles, C.O. (2014) Azaspiracids: chemistry, biosynthesis, metabolism and detection. In Botana, L. (ed.) Seafood and freshwater toxins. pharmacology, physiology and detection, 3rd edn.Boca Raton, FL: CRC Press, pp. 799821.
Heymann, D.L. (2004) Control of communicable diseases manual, 18th edn.Washington, DC: American Public Health Association.
Higman, W.A., Stone, D.M. and Lewis, J.M. (2001) Sequence comparisons of toxic and non-toxic Alexandrium tamarense (Dinophyceae) isolates from UK waters. Phycologia 40, 256262.
Hinder, S.L., Hays, G.C., Edwards, M., Roberts, E.C., Walne, A.W. and Gravenor, M.B. (2012) Changes in marine dinoflagellate and diatom abundance under climate change. Nature Climate Change 2, 271275.
Hiolski, E.M., Preston, S.K., Frame, E.R., Myers, M.S., Bammler, T.K., Beyer, R.P., Farin, F.M., Wilkerson, H.-W., Smith, D.R., Marcinek, D.J. and Lefebvre, K.A. (2014) Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquatic Toxicology 155, 151159.
Hoagland, P., Anderson, D.M., Kaoru, Y. and White, A.W. (2002) The economic effects of harmful algal blooms in the United States: estimates, assessment issues, and information needs. Estuaries 25, 677695.
Hoagland, P., Jin, D., Beet, A., Kirkpatrick, B., Reich, A., Ullman, S., Fleming, L.E. and Kirkpatrick, G. (2014) The human health effects of Florida Red Tide (FRT) blooms: an expanded analysis. Environment International 68, 144153.
Hoagland, P., Jin, D., Polansky, L.Y., Kirkpatrick, B., Kirkpatrick, G., Fleming, L.E., Reich, A., Watkins, S.M., Ullmann, S.G. and Backer, L.C. (2009) The costs of respiratory illnesses arising from Florida Gulf Coast Karenia brevis blooms. Environmental Heath Perspectives 117, 12391243.
Hoagland, P. and Scatasta, S. (2006) The economic effects of harmful algal blooms. In Granéli, E. and Turner, J.T. (eds) Ecology of harmful algae. New York, NY: Springer-Verlag, pp. 391402.
Hu, C. and He, M.-X. (2008) Origin and offshore extent of floating algae in Olympic sailing area. Eos Transactions American Geosciences Union, 302303.
ICES (2006) Report of the ICES-IOC Working Group on Harmful Algal Bloom Dynamics (WGHABD), 3–6 April 2006, Gdynia, Poland. ICES CM 2006/OCC:04. 47 pp.
ICES (2015) Report of the International Council for the Exploration of the Sea – IOC Working Group on Harmful Algal Bloom Dynamics (WGHABD), 28 April–2 May 2014, Haarlem, the Netherlands. ICES CM 2014/SSGHIE: 12, 87 pp.
Illoul, H., Rodríguez, F., Vila, M., Adjas, N., Aït Younes, A., Bournissa, M., Koroghli, A., Marouf, N., Rabia, S. and Ameur, F.L.K. (2012) The genus Ostreopsis along the Algerian coastal waters (SW Mediterranean Sea) associated with a human respiratory intoxication episode. Cryptogamie, Algologie 33, 209216.
Imai, I., Shimada, H., Shinada, A., Baba, K., Kanamori, M., Sato, M., Kuwahara, Y., Miyoshi, K., Tada, M., Hirano, K., Miyazono, A. and Itakura, S. (2014) Prediction of toxic algal bloom occurrences and adaptation to toxic blooms to minimize economic loss to the scallop aquaculture industry in Hokkaido, Japan. In Trainer, V.L. and Yoshida, T. (eds) Proceedings of the workshop on economic impacts of harmful algal blooms on fisheries and aquaculture. PICES Scientific Report No. 47. Sidney, BC: North Pacific Marine Science Organization (PICES), 85 pp.
IPCC (2008) Climate change 2007 – impacts, adaptation and vulnerability. Working Group II contribution to the Fourth Assessment Report of the IPCC Intergovernmental Panel on Climate Change. Available at: http://www.ipcc.ch/ (last accessed 16 January 2010).
Jackson, J.J., Stivala, C.E., Iorga, B.I., Molgo, J. and Zakarian, A. (2012) Stability of cyclic imine toxins: interconversion of pinnatoxin amino ketone and pinnatoxin A in aqueous media. Journal of Organic Chemistry 77, 1043510440.
Jauffrais, T., Kilcoyne, J., Séchet, V., Herrenknecht, C., Truquet, P., Hervé, F., Bérard, J.B., Nulty, C., Taylor, S., Tillmann, U., Miles, C.O. and Hess, P. (2012) Production and isolation of azaspiracid-1 and-2 from Azadinium spinosum culture in pilot scale photobioreactors. Marine Drugs 10, 13601382.
Jessup, D.A., Miller, M.A., Ryan, J.P., Nevins, H.M., Kerkering, H.A., Mekebri, A., Crane, D.B., Johnson, T.A. and Kudela, R.M. (2009) Mass stranding of marine birds caused by a surfactant-producing red tide. PLoS ONE 4, e4550.
Jiang, L., Eriksson, J., Lage, S., Jonasson, S., Shams, S., Mehine, M., Ilag, L.L. and Rasmussen, U. (2014a) Diatoms: a novel source for the neurotoxin BMAA in aquatic environments. PLoS ONE 9, e84578.
Jiang, S.S., Kuwano, K., Ishikawa, N., Yano, M., Takatani, T. and Arakawa, O. (2014b) Production of domoic acid by laboratory culture of the red alga Chondria armata. Toxicon 92, 15.
Jin, D., Thunberg, E. and Hoagland, P. (2008) Economic impact of the 2005 red tide event on commercial shellfish fisheries in New England. Ocean and Coastal Management 51, 420429.
Johnson, R.C., Zhou, Y., Statler, K., Thomas, J., Cox, F., Hall, S. and Barr, J.R. (2009) Quantification of saxitoxin and neosaxitoxin in human urine utilizing isotope dilution tandem mass spectrometry. Journal of Analytical Toxicology 33, 814.
Kaartvedt, S., Johnsen, T.M., Aksens, D.L., Lie, U. and Svendsen, H. (1991) Occurrence of the toxic phytoflagellate Prymnesium parvum and associated fish mortality in a Norwegian fjord system. Canadian Journal of Fisheries and Aquatic Science 48, 23162323.
Kat, M. (1983) Diarrhetic mussel poisoning in the Netherlands related to the dinoflagellate Dinophysis acuminata. Antonie van Leeuwenhoek 49, 417427.
Kibler, S.R., Tester, P.A., Kunkel, K., Moore, S.K. and Litaker, R.W. (2015) Effects of ocean warming on growth and distribution of dinoflagellates associated with ciguatera fish poisoning in the Caribbean. Ecological Modelling 316, 194210.
Kilcoyne, J., Jauffrais, T., Twiner, M.J., Doucette, G.J., Aasen, J.A.B., Sosa, S., Krock, B., Séchet, V., Nulty, C., Salas, R., Clarke, D., Geraghty, J., Duffy, C., Foley, B., John, U., Quilliam, M.A., McCarron, P., Miles, C.O., Silke, J., Cembella, A., Tillmann, U. and Hess, P. (2014) Azaspiracids – toxicological evaluation, test methods and the source organisms (ASTOX II). Final Project Report. Galway: Marine Institute.
Kilcoyne, J., Keogh, A., Clancy, G., LeBlanc, P., Burton, I.W., Quilliam, M.A., Hess, P. and Miles, C.O. (2012) Improved isolation procedure for Azaspiracids from shellfish, structural elucidation of azaspiracid-6, and stability studies. Journal of Agricultural and Food Chemistry 60, 24472455.
Kim, C.S., Lee, S.G., Lee, C.K., Kim, H.G. and Jung, J. (1999) Reactive oxygen species as causative agents in the ichthyotoxicity of the red tide dinoflagellate Cochlodinium polykrikoides. Journal of Plankton Research 21, 21052115.
Kim, H.G. (2006) Mitigation and controls of HABs. In Granéli, E. and Turner, J.T. (eds) Ecology of harmful algae. Ecological Studies, Vol. 189. Berlin: Springer-Verlag, pp. 327338.
Kim, H.-J., Miller, A.J., McGowan, J. and Carter, M.L. (2009) Coastal phytoplankton blooms in the Southern California Bight. Progress in Oceanography 82, 137147.
Kirkpatrick, B., Bean, J.A., Fleming, L.E., Kirkpatrick, G., Grief, L., Nierenberg, K., Reich, A., Watkins, S. and Naar, J. (2010) Gastrointestinal emergency room admissions and Florida red tide blooms. Harmful Algae 9, 8286.
Kirkpatrick, B., Fleming, L.E., Squicciarini, D., Backer, L.C., Clark, R.C., Abraham, W., Benson, J., Cheng, Y.S., Johnson, D., Pierce, R., Zaias, J., Bossart, G.D. and Baden, D.G. (2004) Literature review of Florida red tide: implications for human health effects. Harmful Algae 3, 99115.
Klontz, K.C., Abraham, A., Plakas, S.M. and Dickey, R.W. (2009) Mussel-associated azaspiracid intoxication in the United States. Annals of Internal Medicine 150, 361361.
Koike, K., Sato, S., Yamaji, M., Nagahama, Y., Kotaki, Y., Ogata, T. and Kodama, M. (1998) Occurrence of okadaic acid-producing Prorocentrum lima on the Sanriku coast, northern Japan. Toxicon 36, 20392042.
Kremp, A., Godhe, A., Egardt, J., Dupond, S., Suikkanen, S., Casabianca, S. and Penna, A. (2012) Intraspecific variability in the response of bloom-forming marine microalgae to changed climate conditions. Ecology and Evolution 2, 21952207.
Kudela, R.M. and Gobler, C.J. (2012) Harmful dinoflagellate blooms caused by Cochodinium sp. Global expansion and ecological strategies facilitating bloom formation. Harmful Algae 14, 7186.
Lancelot, C., Billen, G., Sournia, A., Weisse, T., Colijn, F., Veldhuis, M.J.W., Davies, A. and Wassman, P. (1987) Phaeocystis blooms and nutrient enrichment in the continental coastal zones of the North Sea. Ambio 16, 3846.
Lancelot, C. and Mathot, S. (1987) Dynamics of a Phaeocystis-dominated spring bloom in Belgian coastal waters. I. Phytoplanktonic activities and related parameters. Marine Ecology Progress Series 37, 239249.
Landsberg, J. (2002) The effects of harmful algal blooms on aquatic organisms. Reviews in Fisheries Science 10, 113390.
Landsberg, J.H., Hall, S., Johannessen, J.N., White, K.D., Conrad, S.M., Abbott, J.P., Felwelling, L.J., Richardson, R.W., Dickey, R.W., Jester, E.L.E., Etheridge, S.M., Deeds, J.R., Van Dolah, F.M., Leighfield, T.A., Zou, Y., Beaudry, C.G., Benner, R.A., Rogers, P.L., Scott, P.S., Kawabata, K., Wolny, J.L. and Steidinger, K.A. (2006) Saxitoxin puffer fish poisoning in the United States, with the First Report of Pyrodinium bahamense as the putative toxin source. Environmental Health Perspective 114, 15021507.
Lane, J.Q., Raimondi, P.T. and Kudela, R.M. (2009) Development of a logistic regression model for the prediction of toxigenic Pseudo-nitzschia blooms in Monterey Bay, California. Marine Ecology Progress Series 383, 3751.
Lange, W.R., Snyder, F.R. and Fudala, P.J. (1992) Travel and ciguatera fish poisoning. Archives of Internal Medicine 152, 20492053.
Larkin, S. and Adams, C. (2007) Harmful algal blooms and coastal business: economic consequences in Florida. Society and Natural Resources 20, 849859.
Lassus, P., Bardouil, M., Truquet, I., Le Baut, C. and Pierre, M.J. (1985) Dinophysis acuminata distribution and toxicity along the Southern Brittany coast (France): correlation with hydrological parameters. In Anderson, D.M., White, A.W. and Baden, D.G. (eds) Toxic dinoflagellates. Proceedings of the Third International Conference on Toxic Dinoflagellates, New Brunswick, Canada 8–12 June 1985. New York, NY: Elsevier, pp. 159164.
Lawrence, J., Loreal, H., Toyufuku, H., Hess, P., Karunasagar, I. and Ababouch, L. (2011) Assessment and management of biotoxin risks in bivalve molluscs. FAO Fisheries Technical Paper 551. Rome: FAO Fisheries Department.
Laycock, M.V., Anderson, D.M., Naar, J., Goodman, A., Easy, D.J., Donovan, M.A., Li, A., Quilliam, M.A., Al Jamali, E. and Alshihi, R. (2012) Removal of four algal toxins from seawater during desalination using reverse osmosis and distillation. Desalination 293, 1.
Lefebvre, K.A., Frame, E.R., Gulland, F., Hansen, J.D., Kendrick, P.S., Beyer, R.P., Bammler, T.K., Farin, F.M., Hiolski, E.M., Smith, D.R. and Marcinek, D.J. (2012) A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity. PloS ONE 7, e36213. doi: 10.1371/journal.pone.0036213.
Lehane, L. and Lewis, R.J. (2000) Ciguatera: recent advances but the risk remains. International Journal of Food Microbiology 61, 91125.
Lemée, R., Mangiajo, L., Cohu, S., Amzil, Z., Blanfune, A., Chomerat, N., Ganzin, N., Gasparin, S., Grossel, H., Guidi-Guivar, L., Hoareau, L., Le Duf, F., Marr, S., Simo, N., Néza, E., Pedrott, M.L., Séche, V., Soliveres, O. and Thibaut, T. (2012) Interactions between scientists, managers and policy makers in the framework of the French MediOs project on Ostreopsis (2008–2010). Cryptogamie, Algologie 33, 137142.
Levin, E.D., Pizarro, P., Pang, W.G., Harrison, J. and Ramsdell, J.S. (2005) Persisting behavioral consequences of prenatal domoic acid exposure in rats. Neurotoxicology and Teratology 27, 719725.
Lewis, R. and Ruff, T.A. (1993) Ciguatera: ecological, clinical and socioeconomic perspectives. Critical Reviews in Environmental Science and Technology 23, 137156.
Lewitus, A.J., Horner, R.A., Caron, D.A., Garcia-Mendoza, E., Hickey, B.M., Hunte, M., Huppert, D.D., Kudela, R.M., Langlois, G.W., Largier, J.L., Lessard, E.J., RaLonde, R., Rensel, J.E.J., Strutton, P.G., Trainer, V.L. and Tweddle, J.F. (2012) Harmful algal blooms along the North American west coast region: history, trends, causes, and impacts. Harmful Algae 19, 133159.
Lilly, E.L., Halanych, K.M. and Anderson, D.M. (2007) Species boundaries and global biogeography of the Alexandrium tamarense complex (Dinophyceae). Journal of Phycology 43, 13291338.
Liss, P.S., Malin, G., Turner, S.M. and Holligan, P.M. (1994) Dimethyl sulphide and Phaeocystis: a review. Journal of Marine Systems 5, 4153.
Litaker, R.W., Vandersea, M.W., Faust, M.A., Kibler, S.R., Nau, A.W., Holland, W.C., Chinain, M., Holmes, M.J. and Tester, P.A. (2010) Global distribution of ciguatera causing dinoflagellates in the genus Gambierdiscus. Toxicon 56, 711730.
Longhurst, A. (2007) Ecological geography of the sea. London: Academic Press.
Louzao, M.C., Vilariño, N. and Yotsu-Yamashita, M. (2014) Polycavernosides and other scarce new toxins. In Botana, L.M. (ed.) Seafood and freshwater toxins. Boca Raton, FL: CRC Press, pp. 857872.
MacKenzie, L. (1991) Toxic and noxious phytoplankton in Big Glory Bay, Stewart Island, New Zealand. Journal of Applied Phycology 3, 1934.
MacKenzie, L., Beuzenberg, V., Holland, P., McNabb, P. and Selwood, A. (2004) Solid phase adsorption toxin tracking (SPATT): a new monitoring tool that simulates the biotoxin contamination of filter feeding bivalves. Toxicon 44, 901918.
MacKenzie, L., Smith, K., Rhodes, L., Brown, A., Langi, V., Edgar, M., Lovell, G. and Preece, M. (2011) Mortalities of sea-cage salmon (Oncorhynchus tshawytscha) due to a bloom of Pseudochattonella verruculosa (Dictyochophyceae) in Queen Charlotte Sound, New Zealand. Harmful Algae 11, 4553.
Magaña, H.A., Contreras, C. and Villareal, T.A. (2003) A historical assessment of Karenia brevis in the western Gulf of Mexico. Harmful Algae 2, 163171.
Mangialajo, L., Ganzin, N., Accoroni, S., Asnaghi, V., Blanfune, A., Cabrini, M., Cattaneo-Vietti, R., Chavanon, F., Chiantore, M., Cohu, S., Costa, E., Fornasaro, D., Grossel, H., Marco-Miralles, F., Masó, M., Reñé, A., Rossi, A.M., Sala, M.M., Thibaut, T., Totti, C., Vila, M. and Lemée, R. (2011) Trends in Ostreopsis proliferation along the Northern Mediterranean coasts. Toxicon 57, 408420.
Magnien, R.E. (2001) The dynamics of science, perception, and policy during the outbreak of Pfiesteria in the Chesapeake Bay. BioScience 51, 843852.
Margalef, R. (1998) Red tides and ciguatera as successful ways in the evolution and survival of an admirable old phylum. In Reguera, B., Blanco, J., Fernández, M.L. and Wyatt, T. (eds) Harmful algae. Proceedings of the VIII International Conference on Harmful Algae, Vigo, Spain, 25–27 June 1997. Santiago de Compostela, Spain Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO, pp. 37.
Marshall, J.A. and Hallegraeff, G.M. (1999) Comparative ecophysiology of the harmful alga Chattonella marina (Raphidophyceae) from South Australian and Japanese waters. Journal of Plankton Research 21, 18091822.
Martin, J.L., Haya, K. and Wildish, D.J. (1993) Distribution and domoic acid content of Nitzschia pseudodelicatissima in the Bay of Fundy. In Smayda, T.J. and Shimizu, Y. (eds) Toxic phytoplankton blooms in the sea. Amsterdam: Elsevier, pp. 613618.
Mattei, C., Vetter, I., Eisenblätter, A., Krock, B., Ebbecke, M., Desel, H. and Zimmermann, K. (2014) Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries. Toxicon 91, 7683.
McCall, J.R., Jacocks, H.M., Baden, D.G. and Bourdelais, A.J. (2012) Development of a competitive fluorescence-based synaptosome binding assay for brevetoxins. Harmful Algae 19, 8591.
McCarron, P., Rourke, W.A., Hardstaff, W., Pooley, B. and Quilliam, M.A. (2012) Identification of pinnatoxins and discovery of their fatty acid ester metabolites in mussels (Mytilus edulis) from Eastern Canada. Journal of Agricultural and Food Chemistry 60, 14371446.
McGillicuddy, D.J. Jr, Anderson, D.M., Lynch, D.R. and Townsend, D.W. (2005) Mechanisms regulating large-scale seasonal fluctuations in Alexandrium fundyense populations in the Gulf of Maine: results from a physical-biological model. Deep-Sea Research Part II 52, 26982714.
McKee, D., Fleming, L.E., Tamer, R. and Weisman, R. (2001) Ciguatera fish poisoning reporting by physicians in an endemic area. In Hallegraeff, G.M., Blackburn, S.I., Bolch, C.J. and Lewis, R.J. (eds) Harmful algal blooms 2000. Paris: IOC of UNESCO, pp. 451453.
Medcof, J.F.R. (1985) Life and death with Gonyaulax: an historical perspective. In Anderson, D.M., White, A.W. and Baden, D.G. (eds) Toxic dinoflagellates. Proceedings of the Third International Conference on Toxic Dinoflagellates, New Brunswick, Canada, 8–12 June 1985. New York, NY: Elsevier Science, pp. 110.
Medlin, L.K., Lange, M., Wellbrock, U., Donner, G., Elbrachter, M., Hummert, C. and Luckas, B. (1998) Sequence comparisons link toxic European isolates of Alexandrium tamarense from the Orkney Islands to toxic North American stocks. European Journal of Protistology 34, 329335.
Milian, A., Nierenberg, K., Fleming, L., Bean, J.A., Wanner, A., Reich, A., Backer, L.C., Jayroe, D. and Kirkpatrick, B. (2007) Reported asthma symptom intensity during exposure to aerosolized Florida red tide toxins. Journal of Asthma 44, 583587.
Moestrup, Ø., Akselman, R., Cronberg, G., Elbraechter, M., Fraga, S., Halim, Y., Hansen, G., Hoppenrath, M., Larsen, J., Lundholm, N., Nguyen, L.N. and Zingone, A. (2009) IOC-UNESCO taxonomic reference list of harmful micro algae. Accessed at http://www.marinespecies.org/hab (last accessed 20 April 2015).
Molgó, J., Aráoz, R., Benoit, E. and Iorga, B.I. (2014) Cyclic imine toxins. In Botana, L.M. (ed.) Seafood and freshwater toxins, 3rd edn.Boca Raton, FL: CRC Press, pp. 951990.
Moore, S.K., Johnstone, J.A., Banas, N.S. and Salathé, E.P. Jr (2015) Present-day and future climate pathways affecting Alexandrium blooms in Puget Sound, WA, USA. Harmful Algae 48, 111.
Moore, S.K., Trainer, V.L., Mantua, N.J., Parker, M.S., Laws, E.A., Backer, L.C. and Fleming, L.E. (2008) Impacts of climate variability and future climate change on harmful algal blooms and human health. Environmental Health 7, Supplement 2, 112.
Morgan, K., Larkin, S.L. and Adams, C.M. (2010) Red tides and participation in marine-based activities: estimating the response of Southwest Florida residents. Harmful Algae 9, 333341.
Morris, P., Campbell, D.S., Taylor, T.J. and Freeman, J.I. (1991) Clinical and epidemiological features of neurotoxic shellfish poisoning in North Carolina. American Journal of Public Health 81, 471473.
Mudie, P.J., Rochon, A. and Levac, E. (2002) Palynological records of red tide-producing species in Canada: past trends and implications for the future. Palaeogeography, Palaeoclimatology, Palaeoecology 180, 159186.
Murray, S. and Suthers, I. (1999) Population ecology of Noctiluca scintillans Macartney, a red-tide forming dinoflagellate. Marine and Freshwater Research 50, 243252.
Naar, J.P., Flewelling, L.J., Lenzi, A., Abbott, J.P., Granholm, A., Jacocks, H.M., Gannon, D., Henry, M., Pierce, R., Baden, D.G., Wolny, J. and Landsberg, J.H. (2007) Brevetoxins, like ciguatoxins, are potent ichthyotoxins that accumulate in fish. Toxicon 50, 707723.
Nakamura, Y., Suzuki, S.Y. and Hiromi, J. (1995) Population dynamics of heterotrophic dinoflagellates during a Gymnodinium mikimotoi red tide in the Seto Inland Sea. Marine Ecology Progress Series 125, 269277.
Nishiwaki-Matsushima, R., Ohta, T., Nishiwaki, S., Suganuma, M., Kohyama, K., Ishikawa, T., Carmichael, W.W. and Fujiki, H. (1992) Liver cancer promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. Journal of Cancer Research and Clinical Oncology 118, 420424.
Noguchi, T., Hwang, D.F., Arakawa, O., Daigo, K., Sato, S., Ozaki, H. and Kawai, N. (1987) Palytoxin as the causative agent in parrotfish poisoning. In Gopalakrishnakone, P. and Tan, C.K. (eds) Progress in venom and toxin research. Singapore: National University of Singapore, pp. 325335.
O'Connor, A. (2008) The claim: never eat shellfish in a month without an r. The New York Times. Available online: http://www.nytimes.com/2008/07/22/health/nutrition/22real.html?_r=0 (accessed 4 November 2015).
Olson, R.J. and Sosik, H.M. (2007) A submersible imaging-in-flow instrument to analyze nano- and microplankton: imaging FlowCytobot. Limnology and Oceanography: Methods 5, 195203.
Parsons, G., Morgan, A., Whitehead, J.C. and Haab, T.C. (2006) The welfare effects of Pfiesteria-related fish kills in seafood markets: a contingent behavior analysis. Agricultural and Resource Economic Review 35, 348356.
Paz, B., Riobó, P., Fernández, M.L., Fraga, S. and Franco, J.M. (2004) Production and release of yessotoxins by the dinoflagellates Protoceratium reticulatum and Lingulodinium polyedrum in culture. Toxicon 44, 251258.
Pennotti, R., Scallan, E., Backer, L., Thomas, J. and Angulo, F.J. (2013) Ciguatera and scombroid fish poisoning in the United States. Foodborne Pathogens and Disease 10, 10591066.
Place, A.R., Munday, R. and Munday, J.S. (2014) Acute toxicity of karlotoxins to mice. Toxicon 90, 184190.
Pottier, I., Vernoux, J.P. and Lewis, R.J. (2001) Ciguatera fish poisoning in the Caribbean Islands and Western Atlantic. Reviews of Environmental Contamination and Toxicology 168, 99141.
Powers, L., Creed, I.F. and Trick, C.G. (2015) Sinking of Heterosigma akashiwo results in increased toxicity of this harmful algal bloom species. Harmful Algae 13, 95104.
Proença, L.A.O., Boemer, G.L., Dias, J.P., Hatherly, M.M., Mendes, I.L., Mendes, L.A.M., Mendes, M.C.Q., Rossi, W.C., Tamanaha, M.S., Tenenbaum, D.R. and Schramm, M.A. (2010) Can the cases of airborne intoxication of beach users in south coast of Bahia (16°24′S–39°02′W) be related to microalgae? GEOHAB Open Science Meeting: HABs in Benthic Systems, Honolulu, Hawai′i, 21–23 June.
Radke, E.G., Reich, A. and Morris, J.G. Jr (2015) Epidemiology of ciguatera in Florida. American Journal of Tropical Medicine and Hygiene 93, 425432.
Raine, R., McDermott, G., Silke, J., Lyons, K., Nolan, G. and Cusack, C. (2010) A simple model for the prediction of harmful algal events in the bays of southwestern Ireland. Journal of Marine Systems 83, 150157.
Raine, R., O'Boyle, S., O'Higgins, T., White, M., Patching, J., Cahill, B. and McMahon, T. (2001) A satellite and field portrait of a Karenia mikimotoi bloom off the south coast of Ireland, August 1998. Hydrobiologia 465, 187193.
Ramos, P.B., Dieh, F., dos Santos, J.M., Monserrat, J.M. and Yunes, J.S. (2014) Oxidative stress in rats induced by consumption of saxitoxin contaminated drink water. Harmful Algae 37, 6874.
Ramstad, H., Hovgaard, P., Yasumoto, T., Larsen, S. and Aune, T. (2001) Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway. Toxicon 39, 10351043.
Reguera, B. and Pizarro, G. (2008) Planktonic dinoflagellates which contain polyether toxins of the old “DSP Complex”. In Botana, L.M. (ed.) Seafood and freshwater toxins: pharmacology, physiology and detection, 2nd edn.London: Taylor and Francis, pp. 257284.
Reguera, B., Riobó, P., Rodríguez, F., Díaz, P.A., Pizarro, G., Paz, B., Franco, J.M. and Blanco, J. (2014) Causative organisms, distributions and fate in shellfish. Marine Drugs 12, 394461.
Reguera, B., Velo-Suárez, L., Raine, R. and Park, M.G. (2012) Harmful Dinophysis species: a review. Harmful Algae 14, 87106.
Reich, A., Lazensky, R., Faris, J., Fleming, L.E., Kirkpatrick, B., Watkins, S., Ullman, S., Kohler, K. and Hoagland, P. (2015) Assessing the impact of shellfish harvesting area closures on neurotoxic shellfish poisoning (NSP) incidence during red tide (Karenia brevis) blooms. Harmful Algae 43, 1319.
Reiss, C.R., Robert, C., Owen, C. and Taylor, J.S. (2006) Control of MIB, geosmin and TON by membrane systems. Journal of Water Supply: Research and Technology – AQUA 55, 95108.
Réveillon, D., Abadie, E., Sechet, V., Brien, L., Savar, V., Bardouil, M., Hess, P. and Amzil, Z. (2014) Beta-N-methylamino-L-alanine: LC-MS/MS optimization, screening of cyanobacterial strains and occurrence in shellfish from Thau, a French Mediterranean Lagoon. Marine Drugs 12, 54415467.
Réveillon, D., Abadie, E., Séchet, V., Masseret, E., Hess, P. and Amzil, Z. (2015) β-methylamino-L-alanine (BMAA) and isomers: distribution in different food web compartments of Thau Lagoon, French Mediterranean Sea. Marine Environmental Research 110, 818.
Rhodes, L. (2011) World-wide occurrence of the toxic dinoflagellate genus Ostreopsis Schmidt. Toxicon 57, 400407.
Rhodes, L., Smith, K., Selwood, A., McNabb, P., Munday, R., Suda, S., Molenaar, S. and Hallegraeff, G. (2011) Dinoflagellate Vulcanodinium rugosum identified as the causative organism of pinnatoxins in Australia, New Zealand and Japan. Phycologia 50, 624628.
Rhodes, L., Smith, K., Selwood, A.I., McNabb, P., van Ginkel, R., Holland, P.T. and Munday, R. (2010) Production of pinnatoxins by a peridinoid dinoflagellate isolated from Northland, New Zealand. Harmful Algae 9, 384389.
Richlen, M.L., Morton, S.L., Jamali, E.A., Rajan, A. and Anderson, D.M. (2010) The catastrophic 2008–2009 red tide in the Arabian Gulf region, with observations on the identification and phylogeny of the fish-killing dinoflagellate Cochlodinium polykrikoides. Harmful Algae 9, 163172.
Rongo, T. and van Woesik, R. (2012) Socioeconomic consequences of ciguatera poisoning in Rarotonga, southern Cook Islands. Harmful Algae 20, 92100.
Roué, M., Cruchet, P., Ung, A., Darius, T., Chinain, M. and Laurent, D. (2013) Giant clams: new vectors of ciguatera? Toxicon 75, 206.
Roué, M., Gugger, M., Golubic, S., Amzil, Z., Aráoz, R., Turquet, J., Chinain, M. and Laurent, D. (2014) Marine cyanotoxins potentially harmful to human health. In La Barre, S. and Kornprobst, J.-M. (eds) Outstanding marine molecules. Weinheim: Wiley-VCH Verlag GmbH and Co. KGaA, pp. 122.
Ruiz, N., Petit, K., Vansteelandt, M., Kerzaon, I., Baudet, J., Amzil, Z., Biard, J.F., Grovel, O. and Pouchus, Y.F. (2010) Enhancement of domoic acid neurotoxicity on Diptera larvae bioassay by marine fungal metabolites. Toxicon 55, 805810.
Rundberget, T., Aasen, J.A.B., Selwood, A.I. and Miles, C.O. (2011) Pinnatoxins and spirolides in Norwegian blue mussels and seawater. Toxicon 58, 700711.
Ryan, J.P., Chavez, F.P. and Bellingham, J.G. (2005) Coastal ocean physics and red tides. An example from Monterey Bay, California. Oceanography 18, 246255.
Ryan, J.P., Greenfield, D., Marin, R. III, Preston, C., Roman, B., Jensen, S., Pargett, D., Birch, J., Mikulski, C., Doucette, G. and Scholin, C. (2011) Harmful phytoplankton ecology studies using an autonomous molecular analytical and ocean observing network. Limnology and Oceanography 56, 12551272.
Sansoni, G., Borghini, B., Camici, G., Casotti, M., Righini, P. and Rustighi, C. (2003) Fioriture algali di Ostreopsis ovata (Gonyaulacales: Dinophyceae): un problema emergente. Biologia Ambientale 17, 1723.
Satake, M., Ofuji, K., Naoki, H., James, K.J., Furey, A., McMahon, T., Silke, J. and Yasumoto, T. (1998) Azaspiracid, a new marine toxin having unique spiro ring assemblies, isolated from Irish mussels, Mytilus edulis. Journal of the American Chemical Society 120, 99679968.
Satake, M., Shoji, M., Oshima, Y., Naoki, H., Fujita, T. and Yasumoto, T. (2002) Gymnocin-A, a cytotoxic polyether from the notorious red tide dinoflagellate, Gymnodinium mikimotoi. Tetrahedron Letters 43, 58295832.
Scatasta, S., Stolte, W., Granéli, E. and van Ierland, E. (2003) the socio economic impact of harmful algal blooms in european marine waters and description of future risks. Fifth Deliverable for the EU-funded project ECOHARM.
Schoemann, V., Becquevort, S., Stefels, J., Rousseau, V. and Lancelot, C. (2005) Phaeocystis blooms in the global ocean and their controlling mechanisms: a review. Journal of Sea Research 53, 4366.
Scholin, C., Doucette, G., Jensen, S., Roman, B., Pargett, D., Marin, R. III, Preston, C., Jones, W., Feldman, J., Everlove, C., Harris, A., Alvarado, N., Massion, E., Birch, J., Greenfield, D., Vrijenhoek, R., Mikulski, C. and Jones, K. (2009) Remote detection of marine microbes, small invertebrates, harmful algae, and biotoxins using the Environmental Sample Processor (ESP). Oceanography 22, 158167.
Scholin, C.A., Gulland, F., Doucette, G.J., Benson, S., Busman, M., Chavez, F.P., Cordaro, J., DeLong, R., De Vogelaere, A., Harvey, J., Haulena, M., Lefebvre, K., Lipscomb, T. and Van Dolah, F.M. (2000) Mortality of sea lions along the central California coast linked to a toxic diatom bloom. Nature 403, 8084.
Seki, T., Satake, M., MacKenzie, A.L., Kaspar, H.F. and Yasumoto, T. (1995) Gymnodimine, a new marine toxin of unprecedented structure isolated from New Zealand oysters and the dinoflagellate, Gymnodinium sp. Tetrahedron Letters 36, 70937096.
Sellner, K.G., Doucette, G.J. and Kirkpatrick, G.J. (2003) Harmful algal blooms: causes, impacts and detection. Journal of Industrial Microbiology and Biotechnology 30, 383406.
Sengco, M.R. and Anderson, D.M. (2004) Controlling harmful algal blooms through clay flocculation. Journal of Eukaryotic Microbiology 51, 10671072.
Seubert, E.L., Trussell, S., Eagleton, J., Schnetzer, A., Cetinic, I., Lauri, P., Jones, B.H. and Caron, D.A. (2012) Algal toxins and reverse osmosis desalination operations: laboratory bench testing and field monitoring of domoic acid, saxitoxin, brevetoxin and okadaic acid. Water Research 46, 65636573.
Shears, N.T. and Ross, P.M. (2009) Blooms of benthic dinoflagellates of the genus Ostreopsis; an increasing and ecologically important phenomenon on temperate reefs in New Zealand and worldwide. Harmful Algae 8, 916925.
Shumway, S.E., Allen, S.M. and Boersma, P.D. (2003) Marine birds and harmful algal blooms: sporadic victims or under-reported events? Harmful Algae 2, 117.
Sierra-Beltrán, A., Palafox-Uribe, M., Grajales-Montiel, J., Cruz-Villacorta, A. and Ochoa, J.L. (1997) Sea bird mortality at Cabo San Lucas, Mexico: evidence that toxic diatom blooms are spreading. Toxicon 35, 447453.
Silke, J., O'Beirn, F. and Cronin, M. (2005) Karenia: an exceptional dinoflagellate bloom in western Irish waters, summer 2005. Marine Environment and Health Series 21. Galway: Marine Institute.
Silva, C.A., Morais, E.C.P., Costa, M.D.M., Ribas, J.L.C., Guiloski, I.C., Ramsdorf, W.A., Zanata, S.M., Cestari, M.M., Oliveira Ribeiro, C.A., Magalhaes, V.F., Trudeau, V.L. and Silva de Assis, H.C. (2014) Saxitoxins induce cytotoxicity, genotoxicity and oxidative stress in teleost neurons in vitro. Toxicon 86, 815.
Simoni, F., Gaddi, A., Paolo, C.D. and Lepri, L. (2003) Harmful epiphytic dinoflagellate on Tyrrhenian Sea reefs. Harmful Algae News 24, 1314.
Skinner, M.P., Brewer, T.D., Johnstone, R., Fleming, L.E. and Lewis, R.J. (2011) Ciguatera fish poisoning in the Pacific Islands (1998 to 2008). PLoS Neglected Tropical Diseases 5, e1416. doi: 10.1371/journal.pntd.0001416.
Smayda, T.J. (1990) Novel and nuisance phytoplankton blooms in the sea: evidence for a global epidemic. In Granéli, E., Sundstrøm, B., Edler, L. and Anderson, D.M. (eds) Toxic marine phytoplankton. New York, NY: Elsevier, pp. 2940.
Smayda, T.J. (1997) Harmful algal blooms: their ecophysiology and general relevance to phytoplankton blooms in the sea. Limnology and Oceanography 42, 11371153.
Sosa, S., Ardizzone, M., Beltramo, D., Vita, F., Dell'Ovo, V., Barreras, A., Yasumoto, T. and Tubaro, A. (2013) Repeated oral co-exposure to yessotoxin and okadaic acid: a short term toxicity study in mice. Toxicon 76, 94102.
Sournia, A. (1995) Red tide and toxic marine phytoplankton of the world ocean: an inquiry into biodiversity. In Lassus, P., Arzul, G., Erard, E., Gentien, P. and Marcaillou, C. (eds) Harmful marine algal blooms. Proceedings of the 6th International Conference on Toxic Marine Phytoplankton October 1993, Nantes, France. Paris: Lavoisier, pp. 103112.
Steidinger, K.A., Vargo, G.A., Tester, P.A. and Tomas, C.R. (1998) Bloom dynamics and physiology of Gymnodinium breve with emphasis on the Gulf of Mexico. In Anderson, D.M., Cembella, A.D. and Hallegraeff, G.M. (eds) Physiological ecology of harmful algal blooms. Heidelberg: Springer-Verlag, pp. 133153.
Stewart, I., Seawright, A.A. and Shaw, G.R. (2008) Cyanobacterial poisoning in livestock, wild mammals and birds – an overview. Advances in Experimental Medicine and Biology 6, 613637.
Stumpf, R.P., Litaker, R.W., Lanerolle, L. and Tester, P.A. (2008) Hydrodynamic accumulation of Karenia off the west coast of Florida. Continental Shelf Research 28, 189213.
Suikkanen, S., Kremp, A., Hautala, H. and Krock, B. (2013) Paralytic shellfish toxins or spirolides? The role of environmental and genetic factors in toxin production of the Alexandrium ostenfeldii complex. Harmful Algae 26, 5259.
Sun, J., Hutchins, D.A., Feng, Y., Seubert, E.L., Caron, D.A. and Fu, F.-X. (2011) Effects of changing pCO2 and phosphate availability on domoic acid production and physiology of the marine harmful bloom diatom Pseudo-nitzschia multiseries. Limnology and Oceanography 56, 829840.
Suzuki, T. and Watanabe, R. (2012) Shellfish toxin monitoring system in Japan and some Asian countries. In Cabado, A.G. and Vieites, J.M. (eds) New trends in marine and freshwater toxins: food safety concerns. New York, NY: Nova Science Publishers, pp. 347377.
Tang, Y.Z. and Gobler, C.J. (2008) Characterization of the toxicity of Cochlodinium polykrikoides isolates from Northeast US estuaries to finfish and shellfish. Harmful Algae 8, 454462.
Tangen, K. (1977) Blooms of Gyrodinium aureolum (Dinophyceae) in north European waters, accompanied by mortality in marine organisms. Sarsia 63, 123133.
Taniyama, S., Arakawa, O., Terada, M., Nishio, S., Takatani, T., Mahmud, Y. and Noguci, T. (2003) Ostreopsis sp., a possible origin of palytoxin (PTX) in parrotfish Scaris ovifrons. Toxicon 42, 37–33.
Tatters, A.O., Flewelling, L.J., Fu, F.-X., Granholm, A.A. and Hutchins, D.A. (2013) High CO2 promotes the production of paralytic shellfish poisoning toxins by Alexandrium catenella from Southern California waters. Harmful Algae 30, 3743.
Tatters, A.O., Fu, F.-X. and Hutchins, D.A. (2012a) High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. PLoS ONE 7, e32116.
Tatters, A.O., Schnetzer, A., Fu, F., Lie, A.Y.A., Caron, D.A. and Hutchins, D.A. (2012b) Short- versus long-term responses to changing CO2 in a coastal dinoflagellate bloom: implications for interspecific competitive interactions and community structure. Evolution 67, 18791891.
Taylor, F.J.R. and Harrison, P.J. (2002) Harmful marine algal blooms in western Canada. In Taylor, F.J.R. and Trainer, V.L. (eds) Harmful algal blooms in the PICES region of the North Pacific, PICES Scientific Report No. 23. Sidney, BC: North Pacific Marine Science Organization (PICES), pp. 7788.
Taylor, M., Mcintyre, L., Ritson, M., Stone, J., Bronson, R., Bitzikos, O., Rourke, W., Galanis, E. and Team, O. (2013) Outbreak of diarrhetic shellfish poisoning associated with mussels, British Columbia, Canada. Marine Drugs 11, 16691676.
Tester, P.A., Feldman, R.L., Nau, A.W., Kibler, S. and Litaker, R.W. (2010) Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies. Harmful Algae 56, 698710.
Tester, P.A., Kibler, S.R., Holland, W.C., Usup, G., Vandersea, M.W., Leaw, C.P., Lim, P.T., Jacob Larsen, J., Mohammad-Noor, N., Faust, M.A. and Litaker, R.W. (2014) Sampling harmful benthic dinoflagellates: comparison of artificial and natural substrate methods. Harmful Algae 39, 825.
Tichadou, L., Glaizal, M., Armengaud, A., Grossel, H., Lemée, R. and Kantin, R. (2010) Health impact of unicellular algae of the Ostreopsis genus blooms in the Mediterranean Sea: experience of the French Mediterranean coast surveillance network from 2006 to 2009. Clinical Toxicology 48, 839844.
Tillmann, U. (2003) Kill and eat your predator: a winning strategy of the planktonic flagellate Prymnesium parvum. Aquatic Microbial Ecology 32, 7384.
Tillmann, U., Elbrächter, M., Krock, B., John, U. and Cembella, A.D. (2009) Azadinium spinosum gen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins. European Journal of Phycology 44, 6379.
Tillmann, U., Salas, R., Jauffrais, T., Hess, P. and Silke, J. (2014) AZA: the producing organisms – biology and trophic transfer. In Botana, L.M. (ed.) Seafood and freshwater toxins. Pharmacology, physiology and detection, 3rd edn.Boca Raton, FL: CRC Press, pp. 773798.
Todd, E.C.D. (1993) Domoic acid and amnesic shellfish poisoning – a review. Journal of Food Protection 56, 6983.
Todd, E.C.D. (1995) Estimated costs of paralytic shellfish, diarrhetic shellfish, and ciguatera poisoning in Canada. In Lassus, P., Arzul, G., Erard, E., Gentien, P. and Marcaillou-Le Bout, C. (eds) Harmful algal blooms. Paris: Lavoisier Science Publishers, pp. 831834.
Touzet, N., Davidson, K., Pete, R., Flanagan, K., McCoy, G.R., Amzil, Z., Maher, M., Chapelle, A. and Raine, R. (2010) Co-occurrence of the West European (Gr. III) and North American (Gr. I) ribotypes of Alexandrium tamarense (Dinophyceae) in Shetland, Scotland. Protist 161, 370384.
Touzet, N., Franco, J.M. and Raine, R. (2007) Characterization of nontoxic and toxin-producing strains of Alexandrium minutum (Dinophyceae) in Irish coastal waters. Applied Environmental Microbiology 73, 33333342.
Trainer, V.L., Eberhart, B.-T.L., Wekell, J.C., Adams, N.G., Hanson, L., Cox, F. and Dowell, J. (2003) Paralytic shellfish toxins in Puget Sound, Washington State. Journal of Shellfish Research 22, 213223.
Trainer, V.L., Moore, L., Bill, B.D., Adams, N.G., Harrington, N., Borchert, J., Silva, D.A.M. and Eberhart, B.-T.L. (2013) Diarrhetic shellfish toxins and other lipophilic toxins of human health concern in Washington State. Marine Drugs 11, 18151835.
Trainer, V.L. and Suddleson, M. (2005) Monitoring approaches for early warning of domoic acid events in Washington state. Oceanography 18, 228237.
Trainer, V.L. and Yoshida, T. (eds) (2014) Proceedings of the Workshop on Economic Impacts of Harmful Algal Blooms on Fisheries and Aquaculture. PICES Scientific Reports 47, 85 pp.
Treasurer, J.W., Hannah, F. and Cox, D. (2003) Impact of a phytoplankton bloom on mortalities and feeding response of farmed Atlantic salmon, Salmo salar, in west Scotland. Aquaculture 218, 103113.
Tubaro, A., Durando, P., Del Favero, G., Ansaldi, F., Icardi, G. and Deeds, J.R. (2011) Case definitions for human poisonings postulated to palytoxins exposure. Toxicon 57, 478495.
Turner, A., Higgins, C., Veszelovski, A., Payne, D., Davidson, K., Hungerford, J. and Higman, W. (2015) Monitoring of new or emerging marine biotoxins in UK waters: brevetoxins. Marine Drugs 13, 12241254.
Twiner, M.J., Doucette, G.J., Rasky, A., Huang, X.-P., Roth, B.L. and Sanguinetti, M.C. (2012a) The marine algal toxin azaspiracid is an open state blocker of hERG potassium channels. Chemical Research in Toxicology 25, 19751984.
Twiner, M.J., Hanagriff, J.C., Butler, S., Madhkoor, A.K. and Doucette, G.J. (2012b) Induction of apoptosis pathways in several cell lines following exposure to the marine algal toxin azaspiracid. Chemical Research in Toxicology 25, 14931501.
Twiner, M., Hess, P. and Doucette, G.J. (2014) Azaspiracids: toxicology, pharmacology, and risk assessment. In Botana, L.M. (ed.) Seafood and freshwater toxins. Pharmacology, physiology and detection, 3rd edn.Boca Raton, FL: CRC Press, pp. 823855.
Twiner, M.J., Rehmann, N., Hess, P. and Doucette, G.J. (2008) Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts. Marine Drugs 6, 3972.
Uemura, D., Chou, T., Haino, T., Nagatsu, A., Fukuzawa, S., Zheng, S. and Chen, H. (1995) Pinnatoxin A: a toxic amphoteric macrocycle from the Okinawan bivalve Pinna muricata. Journal of the American Chemical Society 117, 11551156.
Vale, P., Botelho, M.J., Rodrigues, S.M., Gomes, S.S. and Sampayo, M. (2008) Two decades of marine biotoxin monitoring in bivalves from Portugal (1986–2006): a review of exposure assessment. Harmful Algae 7, 1125.
Vanhoutte-Brunier, A., Fernand, L., Ménesguen, A., Lyons, S., Gohin, F. and Cugier, P. (2008) Modelling the Karenia mikimotoi bloom that occurred in the western English Channel during summer 2003. Ecological Modelling 210, 351376.
Van Dolah, F.M. (2000) Marine algal toxins: origins, health effects, and their increased occurrence. Environmental Health Perspectives 108, Supplement 1, 133141.
Van Dolah, F.M., Fire, S.E., Leighfield, T.A., Mikulski, T.A. and Doucette, G.L. (2012) Determination of paralytic shellfish toxins in shellfish by receptor binding assay: a collaborative study. Journal of AOAC International 95, 795812.
Van Wagoner, R.M., Deeds, J.R., Tatters, A.O., Place, A.R., Tomas, C.R. and Wright, J.L.C. (2010) Structure and relative potency of several karlotoxins from Karlodinium veneficum. Journal of Natural Products 73, 13601365.
Velo-Suárez, L., González-Gil, S., Pazos, Y. and Reguera, B. (2014) The growth season of Dinophysis acuminata in an upwelling system embayment: a conceptual model based on in situ measurements. Deep Sea Research Part II 101, 141151.
Vila, M., Arin, L., Battocchi, C., Bravo, I., Fraga, S., Penna, A., Reñé, A., Riobó, P., Rodríguez, F., Sala, M.M., Camp, J., de Torres, M. and Franco, J.M. (2012) Management of Ostreopsis blooms in recreational waters along the Catalan coast (NW Mediterranean Sea): cooperation between a research project and a monitoring program. Cryptogamie, Algologie 33, 143152.
Vila, M., Masó, M., Sampedro, N., Illoul, H., Arin, L., Garcés, E., Giacobbe, M.G., Àlvarez, J. and Camp, J. (2008) The genus Ostreopsis in recreational waters of the Catalan Coast and Balearic Islands (NW Mediterranean Sea): is this the origin of human respiratory difficulties? In Moestrup, Ø., Doucette, G., Enevoldsen, H., Godhe, A., Hallegraeff, G., Luckas, B., Lundholm, N., Lewis, J., Rengefors, K., Selner, K., Steidinger, K., Tester, P. and Zingone, A. (eds) Proceedings of the 12th International Conference on Harmful Algae, Copenhagen, Denmark, 4–8 September 2006. Copenhagen: ISSHA and IOC of UNESCO, pp. 334336.
Vila, M., Riobó, P., Bravo, I., Masó, M., Penna, A. and Reñé, A. (2014) A Three-year time series of toxic Ostreopsis blooming in a NW Mediterranean coastal site: preliminary results. In Pagou, P. and Hallegraeff, G. (eds) Proceedings of the 14th International Conference on Harmful Algae. Copenhagen: ISSHA and IOC of UNESCO, pp. 111113.
Villareal, T.A., Hanson, S., Qualia, S., Jester, E.L.E., Granade, H.R. and Dickey, R.W. (2007) Petroleum production platforms as sites for the expansion of ciguatera in the northwestern Gulf of Mexico. Harmful Algae 6, 253259.
Watkins, S.M., Reich, A., Fleming, L.E. and Hammond, R. (2008) Neurotoxic shellfish poisoning. Marine Drugs 6, 431455.
Wessells, C.R., Miller, C.J. and Brooks, P.M. (1995) Toxic algae contamination and demand for shellfish: a case study of demand for mussels in Montreal. Marine Resource Economics 10, 143159.
White, A.W. (1984) Paralytic shellfish toxins and finfish. American Chemical Society Symposium Series 262, 171180.
Whitehead, J.C., Haab, T.C. and Parsons, G.R. (2003) Economic effects of Pfiesteria. Ocean and Coastal Management 46, 845858.
Whitelegge, T. (1891) On the recent discoloration of the waters of Port Jackson. Records of the Australian Museum Sydney 1, 179192.
Whyte, C. (2013) Why its safer to eat shellfish in months with a letter ‘R.’ Available online: http://theconversation.com/why-its-safer-to-eat-shellfish-in-months-with-a-letter-r-20174 (accessed 4 November 2015).
Whyte, C., Swan, S. and Davidson, K. (2014) Changing wind patterns linked to unusually high Dinophysis blooms around the coast of the Shetland Islands, Scotland. Harmful Algae 39, 365373.
Whyte, J.N.C., Haigh, N., Ginther, N.G. and Keddy, L.J. (2001) First record of blooms of Cochlodinium sp (Gymnodiniales, Dinophyceae) causing mortality to aquacultured salmon on the west coast of Canada. Phycologia 40, 298304.
Yamochi, S. (1989) Mechanisms for outbreak of Heterosigma akashiwo red tide in Osaka Bay. In Okaichi, T., Anderson, D.M. and Nemoto, T. (eds) Red tides biology, environmental science, and toxicology. Amsterdam: Elsevier, pp. 253256.
Yasumoto, T., Sugawara, W., Fukuyo, Y., Oguri, H., Igarashi, T. and Fujita, N. (1980) Identification of Dinophysis fortii as the causative organism of diarrhetic shellfish poisoning in the Tohoku district. Bulletin of the Japanese Society of Scientific Fisheries 46, 14051411.
Yndestad, M. and Underdal, B. (1985) Survey of PSP in mussels (Mytilus edulis L.) in Norway. In Anderson, D.M., White, A.W. and Baden, D.G. (eds) Toxic dinoflagellates. Proceedings of the Third International Conference on Toxic Dinoflagellates, New Brunswick, Canada 8–12 June 1985. New York, NY: Elsevier Science, pp. 457460.
Yuki, K. and Yoshimatsu, S. (1989) Two fish-killing species of Cochlodinium from Harima-Nada, Seto Inland Sea, Japan. In Okaichi, T., Anderson, D.M. and Nemoto, T. (eds) Red tides: biology, environmental science, and toxicology. New York, NY: Elsevier, pp. 451454.
Zaias, J., Backer, L.C. and Fleming, L.E. (2010) Harmful algal blooms (HABs). In Rabinowitz, P. and Conti, L. (eds) Human-animal medicine: a clinical guide to toxins, zoonoses, and other shared health risks. New York, NY: Elsevier Science Publishers, pp. 91104.
Zendong, Z., Herrenknecht, C., Abadie, E., Brissard, C., Tixier, C., Mondeguer, F., Séchet, V., Amzil, Z. and Hess, P. (2014) Extended evaluation of polymeric and lipophilic sorbents for passive sampling of marine toxins. Toxicon 91, 5768.
Zhao, J., Hu, C., Lener, J.M., Weisberg, R.H., Lembke, C., English, D., Wolny, J., Zheng, L., Walsh, J.J. and Kirkpatrick, G. (2013) Three-dimensional structure of a Karenia brevis bloom: observations from gliders, satellites, and field measurements. Harmful Algae 29, 2230.
Zhou, M.-Z., Liu, D.-Y., Anderson, D.M. and Valiela, I. (2015) Introduction to the Special Issue on green tides in the Yellow Sea. Estuarine, Coastal and Shelf Science, Part A, 163: 17.
Zingone, A. and Wyatt, T. (2005) Harmful algal blooms: keys to the understanding of phytoplankton ecology. In Robinson, A.R. and Brinks, K.H. (eds) The sea, the global coastal ocean; multiscale interdisciplinary processes, Volume 13. Boston, MA: Harvard University Press, pp. 867926.