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Development of magnetically active scaffolds as intrinsically-deformable bioreactors

Published online by Cambridge University Press:  27 June 2017

Darina A. Gilroy ,
Chris Hobbs ,
Valeria Nicolosi ,
Conor T. Buckley ,
Fergal J. O'Brien  and
Cathal J. Kearney Open the ORCID record for Cathal J. Kearney [Opens in a new window]
Darina A. Gilroy
Affiliation:
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland Trinity Centre for Bioengineering, Trinity College Dublin (TCD), Dublin 2, Ireland
Chris Hobbs
Affiliation:
Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, Ireland CRANN, TCD, Dublin, Ireland School of Physics, TCD, Dublin, Ireland
Valeria Nicolosi
Affiliation:
Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, Ireland CRANN, TCD, Dublin, Ireland School of Chemistry, TCD, Dublin, Ireland
Conor T. Buckley
Affiliation:
Trinity Centre for Bioengineering, Trinity College Dublin (TCD), Dublin 2, Ireland Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, Ireland
Fergal J. O'Brien
Affiliation:
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland Trinity Centre for Bioengineering, Trinity College Dublin (TCD), Dublin 2, Ireland Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, Ireland
Cathal J. Kearney*
Affiliation:
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland Trinity Centre for Bioengineering, Trinity College Dublin (TCD), Dublin 2, Ireland Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI & TCD, Dublin 2, Ireland
*
Address all correspondence to Cathal J. Kearney at cathalkearney@rcsi.ie
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Abstract

Mesenchymal stem cell behavior can be regulated through mechanical signaling, either by dynamic loading or through biomaterial properties. We developed intrinsically responsive tissue engineering scaffolds that can dynamically load cells. Porous collagen- and alginate-based scaffolds were functionalized with iron oxide to produce magnetically active scaffolds. Reversible deformations in response to magnetic stimulation of up to 50% were recorded by tuning the material properties. Cells could attach to these scaffolds and magnetically induced compressive deformation did not adversely affect viability or cause cell release. This platform should have broad application in the mechanical stimulation of cells for tissue engineering applications.

Information

Type
Biomaterials for 3D Cell Biology Research Letters
Information
MRS Communications , Volume 7 , Issue 3 , September 2017 , pp. 367 - 374
Copyright
Copyright © Materials Research Society 2017 

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