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A highly efficient and antifouling microfluidic platform for portable hemodialysis devices

Published online by Cambridge University Press:  19 March 2018

Irfani R. Ausri ,
Eliana M. Feygin ,
Connie Q. Cheng ,
Yuxing Wang ,
Zhi Yuan (William) Lin  and
Xiaowu (Shirley) Tang
Irfani R. Ausri
Affiliation:
Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
Eliana M. Feygin
Affiliation:
Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
Connie Q. Cheng
Affiliation:
Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
Yuxing Wang
Affiliation:
Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
Zhi Yuan (William) Lin
Affiliation:
Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
Xiaowu (Shirley) Tang*
Affiliation:
Department of Chemistry & Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada
*
Address all correspondence to X. S. Tang at tangxw@uwaterloo.ca
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Abstract

End-stage renal disease (ESRD) is a life-threatening illness that presents significant healthcare challenges. About 90% of ESRD patients receive hemodialysis treatment, but the currently available hemodialysis systems are bulky and prone to complications. We report the design of a microfluidic hemodialysis device composed of two polydimethylsiloxane (PDMS) chambers separated by a cellulose ester (CE) membrane. The polyethylene glycol-passivated PDMS and CE surfaces reduced platelet adhesion by 74% and 86%, respectively. Moreover, the device exhibited a higher urea clearance rate per unit area than a healthy kidney. The reported design sets the foundation for a next-generation biomimetic portable hemodialysis device.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 2 , June 2018 , pp. 474 - 479
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Copyright
Copyright © Materials Research Society 2018 

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