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Light-triggered modulation of cell antioxidant defense by polymer semiconducting nanoparticles in a model organism

  • Maria Moros (a1), Anna Lewinska (a2), Giada Onorato (a1), Maria Rosa Antognazza (a3), Francesca Di Maria (a4), Martina Blasio (a1), Guglielmo Lanzani (a3) (a5), Angela Tino (a1), Maciej Wnuk (a6) and Claudia Tortiglione (a1)...

Abstract

Photovoltaic organic semiconductors are emerging in many therapeutic applications, including drug delivery and optical control of cell function. However, for their safe use the possible concomitant elicitation of undesired responses in target cells need to be carefully evaluated. Here we describe molecular responses activated by semiconducting polymer nanoparticles based on poly(3-hexyl)thiophene (P3HT) in the model Hydra vulgaris, previously shown to respond to P3HT-NP photostimulation and showed a decrease in the total antioxidant capacity and an increase in the DNA and protein oxidation levels, paving the way to a novel use of photovoltaic devices to control intracellular redox equilibrium.

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Corresponding author

Address all correspondence to Claudia Tortiglione at claudia.tortiglione@cnr.it

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These authors contributed equally to this work.

Present address: Instituto de Ciencia de Materiales de Aragón, C/Mariano Esquillor s/n, 50018 Zaragoza, Spain.

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