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Next generation tissue engineering of orthopedic soft tissue-to-bone interfaces

  • Alexander J. Boys (a1), Mary Clare McCorry (a2), Scott Rodeo (a3) (a4) (a5) (a6) (a7) (a8), Lawrence J. Bonassar (a2) (a9) and Lara A. Estroff (a1) (a10)...
Abstract

Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.

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Corresponding author
Address all correspondence to Lawrence J. Bonassar at lb244@cornell.edu and Lara A. Estroff at lae37@cornell.edu
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Authors contributed equally to the manuscript.

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References
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