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Bioactivity of vitamin E

  • Regina Brigelius-Flohé (a1)
  • DOI: http://dx.doi.org/10.1017/S0954422407202938
  • Published online: 01 December 2006
Abstract

More than 80 years after the discovery of the essentiality of vitamin E for mammals, the molecular basis of its action is still an enigma. From the eight different forms of vitamin E, only α-tocopherol is retained in the body. This is in part due to the specific selection of RRR-α-tocopherol by the α-tocopherol transfer protein and in part by its low rate of degradation and elimination compared with the other vitamers. Since the tocopherols have comparable antioxidant properties and some tocotrienols are even more effective in scavenging radicals, the antioxidant capacity cannot be the explanation for its essentiality, at least not the only one. In the last decade, a high number of so-called novel functions of almost all forms of vitamin E have been described, including regulation of cellular signalling and gene expression. α-Tocopherol appears to be most involved in gene regulation, whereas γ-tocopherol appears to be highly effective in preventing cancer-related processes. Tocotrienols appear to be effective in amelioration of neurodegeneration. Most of the novel functions of individual forms of vitamin E have been demonstrated in vitro only and require in vivo confirmation. The distinct bioactivities of the various vitamers are discussed, considering their metabolism and the potential functions of metabolites.

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Corresponding author
*Corresponding author: Professor Dr Regina Brigelius-Flohé, fax +49 33200 88407, email flohe@dife.de
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C Abe , S Ikeda & K Yamashita (2005) Dietary sesame seeds elevate α-tocopherol concentration in rat brain. Journal of Nutritional Science and Vitaminology (Tokyo) 51, 223230

E Aratri , SE Spycher , I Breyer & A Azzi (1999) Modulation of α-tropomyosin expression by α-tocopherol in rat vascular smooth muscle cells. FEBS Letters 447, 9194

A Azzi & A Stocker (2000) Vitamin E: non-antioxidant roles. Progress in Lipid Research 39, 231255

A Azzi , R Gysin , P Kempna , A Munteanu , L Villacorta , T Visarius & JM Zingg (2004) Regulation of gene expression by α-tocopherol. Biological Chemistry 385, 585591

L Barella , PY Muller , M Schlachter , W Hunziker , E Stöcklin , V Spitzer , N Meier , S de Pascual-Teresa , AM Minihane & G Rimbach (2004) Identification of hepatic molecular mechanisms of action of α-tocopherol using global gene expression profile analysis in rats. Biochimica et Biophysica Acta 1689, 6674

M Ben Hamida , S Belal , G Sirugo , . (1993) Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred. Neurology 43, 21792183

K Berman & H Brodaty (2004) Tocopherol (vitamin E) in Alzheimer's disease and other neurodegenerative disorders. CNS Drugs 18, 807825

A Betancor-Fernandez , H Sies , W Stahl & MC Polidori (2002) 2,5,7,8-Tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman (α-CEHC), a vitamin E metabolite in human serum and urine, possesses antioxidant activity. Free Radical Research 36, 915921

M Birringer , D Drogan & R Brigelius-Flohé (2001) Tocopherols are metabolized in HepG2 cells by side chain ω-oxidation and consecutive β-oxidation. Free Radical Biology and Medicine 31, 226232

D Boscoboinik , A Szewczyk & A Azzi (1991) α-Tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Archives of Biochemistry and Biophysics 286, 264269

R Brigelius-Flohé (2003) Vitamin E and drug metabolism. Biochemical and Biophysical Research Communications 305, 737740

R Brigelius-Flohé (2005) Induction of drug metabolizing enzymes by vitamin E. Journal of Plant Physiology 162, 797802

GW Burton & KU Ingold (1981) Autoxidation of biological molecules. 1. The antioxidant activity of vitamin E and related chainbreaking phenolic antioxidants in vitro. Journal of the American Chemical Society 103, 64726477

GW Burton & MG Traber (1990) Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annual Review of Nutrition 10, 357382

O Cachia , JE Benna , E Pedruzzi , B Descomps , MA Gougerot-Pocidalo & CL Leger (1998) α-Tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylation. Journal of Biological Chemistry 273, 3280132805

S Campbell , W Stone , S Whaley & K Krishnan (2003a) Development of gamma (γ)-tocopherol as a colorectal cancer chemopreventive agent. Critical Reviews in Oncology/Hematology 47, 249259

SE Campbell , WL Stone , SG Whaley , M Qui & K Krishnan (2003b) Gamma (γ) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (γ) expression in SW 480 human colon cancer cell lines. BMC Cancer 3, 25

E Chatelain , DO Boscoboinik , GM Bartoli , VE Kagan , FK Gey , L Packer & A Azzi (1993) Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochimica et Biophysica Acta 1176, 8389

S Christen , AA Woodall , MK Shigenaga , PT Southwell-Keely , MW Duncan & BN Ames (1997) γ-Tocopherol traps mutagenic electrophiles such as NO(X) and complements α-tocopherol: physiological implications. Proceedings of the National Academy of Sciences USA 94, 32173222

RV Cooney , LJ Custer , L Okinaka & AA Franke (2001) Effects of dietary sesame seeds on plasma tocopherol levels. Nutrition and Cancer 39, 6671

RV Cooney , AA Franke , PJ Harwood , V Hatch-Pigott , LJ Custer & LJ Mordan (1993) γ-Tocopherol detoxification of nitrogen dioxide: superiority to α-tocopherol. Proceedings of the National Academy of Sciences USA 90, 17711775

MC De Pascale , AM Bassi , V Patrone , L Villacorta , A Azzi & JM Zingg (2006) Increased expression of transglutaminase-1 and PPARγ after vitamin E treatment in human keratinocytes. Archives of Biochemistry and Biophysics 447, 97106

A Fischer , J Pallauf , K Gohil , SU Weber , L Packer & G Rimbach (2001) Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochemical and Biophysical Research Communications 285, 470475

J Frank , A Kamal-Eldin , T Lundh , K Maatta , R Torronen & B Vessby (2002) Effects of dietary anthocyanins on tocopherols and lipids in rats. Journal of Agricultural and Food Chemistry 50, 72267230

J Frank , A Kamal-Eldin , A Razdan , T Lundh & B Vessby (2003a) The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenic acid increase vitamin E and cholesterol concentrations in Sprague-Dawley rats. Journal of Agricultural and Food Chemistry 51, 25262531

F Galli , R Lee , J Atkinson , A Floridi & FJ Kelly (2003) γ-Tocopherol biokinetics and transformation in humans. Free Radical Research 37, 12251233

F Galli , R Lee , C Dunster & FJ Kelly (2002) Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of α- and γ-tocopherol in human plasma. Free Radical Biology and Medicine 32, 333340

F Galli , AM Stabile , M Betti , C Conte , A Pistilli , M Rende , A Floridi & A Azzi (2004) The effect of α- and γ-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. Archives of Biochemistry and Biophysics 423, 97102

JM Genkinger , EA Platz , SC Hoffman , GW Comstock & KJ Helzlsouer (2004) Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland. American Journal of Epidemiology 160, 12231233

A Gimeno , R Zaragoza , JR Vina & VJ Miralles (2004) Vitamin E activates CRABP-II gene expression in cultured human fibroblasts, role of protein kinase C. FEBS Letters 569, 240244

K Gohil , BC Schock , AA Chakraborty , Y Terasawa , J Raber , RV Farese Jr, L Packer , CE Cross & MG Traber (2003) Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in α-tocopherol transfer protein. Free Radical Biology and Medicine 35, 13431354

A Hattori , T Fukushima , H Yoshimura , K Abe & K Ima (2000) Production of LLU-α following an oral administration of γ-tocotrienol or γ-tocopherol to rats. Biological and Pharmaceutical Bulletin 23, 13951397

SM Hayton , T Kriss , A Wade & DP Muller (2006) Effects on neural function of repleting vitamin E-deficient rats with α-tocopherol. Journal of Neurophysiology 95, 25532559

Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360, 2333

OP Heinonen , D Albanes , J Virtamo , . (1998) Prostate cancer and supplementation with α-tocopherol and β-carotene: incidence and mortality in a controlled trial. Journal of the National Cancer Institute 90, 440446

KJ Helzlsouer , HY Huang , AJ Alberg , S Hoffman , A Burke , EP Norkus , JS Morris & GW Comstock (2000) Association between α-tocopherol, γ-tocopherol, selenium, and subsequent prostate cancer. Journal of the National Cancer Institute 92, 20182023

K Hensley , EJ Benaksas , R Bolli , . (2004) New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radical Biology and Medicine 36, 115

A Hentati , HX Deng , WY Hung , M Nayer , MS Ahmed , X He , R Tim , DA Stumpf & T Siddique (1996) Human α-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency. Annals of Neurology 39, 295300

NC Hoglen , SC Waller , IG Sipes & DC Liebler (1997) Reactions of peroxynitrite with γ-tocopherol. Chemical Research in Toxicology 10, 401407

A Hosomi , M Arita , Y Sato , C Kiyose , T Ueda , O Igarashi , H Arai & K Inoue (1997) Affinity of α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Letters 409, 105108

CC Hsieh , CJ Huang & BF Lin (2006) Low and high levels of α-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPAR-γ, IκBα, and apoptotic pathway in activated splenocytes. Nutrition 22, 433440

HY Huang , AJ Alberg , EP Norkus , SC Hoffman , GW Comstock & KJ Helzlsouer (2003) Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. American Journal of Epidemiology 157, 335344

KM Jervis & B Robaire (2004) The effects of long-term vitamin E treatment on gene expression and oxidative stress damage in the aging Brown Norway rat epididymis. Biology of Reproduction 71, 10881095

Q Jiang & BN Ames (2003) γ-Tocopherol, but not α-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB Journal 17, 816822

Q Jiang , I Elson-Schwab , C Courtemanche & BN Ames (2000) γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences USA 97, 1149411499

Q Jiang , J Wong & BN Ames (2004) γ-Tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms. Annals of the New York Academy of Sciences 1031, 399400

K Jishage , M Arita , K Igarashi , T Iwata , M Watanabe , M Ogawa , O Ueda , N Kamada , K Inoue , H Arai & H Suzuki (2001) α-Tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice. Journal of Biological Chemistry 276, 16691672

A Kamal-Eldin & LA Appelqvist (1996) The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671701

A Kamal-Eldin , J Frank , A Razdan , S Tengblad , S Basu & B Vessby (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35, 427435

C Kiyose , H Saito , K Kaneko , K Hamamura , M Tomioka , T Ueda & O Igarashi (2001) α-Tocopherol affects the urinary and biliary excretion of 2,7,8- trimethyl-2 (2′-carboxyethyl)-6-hydroxychroman, γ-tocopherol metabolite, in rats. Lipids 36, 467472

D Kluth , N Landes , P Pfluger , K Müller-Schmehl , K Weiss , C Bumke-Vogt , M Ristow & R Brigelius-Flohé (2005) Modulation of Cyp3a11 mRNA expression by α-tocopherol but not γ-tocotrienol in mice. Free Radical Biology and Medicine 38, 507514

N Landes , P Pfluger , D Kluth , M Birringer , R Rühl , GF Böl , H Glatt & R Brigelius-Flohé (2003) Vitamin E activates gene expression via the pregnane X receptor. Biochemical Pharmacology 65, 269273

JM Lehmann , DD McKee , MA Watson , TM Willson , JT Moore & SA Kliewer (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Journal of Clinical Investigation 102, 10161023

M Leist , B Raab , S Maurer , U Rosick & R Brigelius-Flohé (1996) Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity. Free Radical Biology and Medicine 21, 297306

SW Leonard , E Gumpricht , MW Devereaux , RJ Sokol & MG Traber (2005a) Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration. Journal of Lipid Research 46, 10681075

SW Leonard , E Paterson , JK Atkinson , R Ramakrishnan , CE Cross & MG Traber (2005b) Studies in humans using deuterium-labeled α- and γ-tocopherols demonstrate faster plasma γ-tocopherol disappearance and greater γ-metabolite production. Free Radical Biology and Medicine 38, 857866

JK Lodge , J Ridlington , S Leonard , H Vaule & MG Traber (2001) α- and γ-Tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. Lipids 36, 4348

BS McIntyre , KP Briski , A Gapor & PW Sylvester (2000a) Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proceedings of the Society for Experimental Biology and Medicine 224, 292301

BS McIntyre , KP Briski , MA Tirmenstein , MW Fariss , A Gapor & PW Sylvester (2000b) Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 35, 171180

ER Miller III, R Pastor-Barriuso , D Dalal , RA Riemersma , LJ Appel & E Guallar (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of Internal Medicine 142, 3746

A Munteanu , M Taddei , I Tamburini , E Bergamini , A Azzi & JM Zingg (2006) Antagonistic effects of oxidized low density lipoprotein and α-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 281, 64896497

A Munteanu , JM Zingg & A Azzi (2004) Anti-atherosclerotic effects of vitamin E – myth or reality? Journal of Cellular and Molecular Medicine 8, 5976

K Nesaretnam , HT Khor , J Ganeson , YH Chong , K Sundram & A Gapor (1992) The effect of vitamin-E tocotrienols from palm oil on chemically-induced mammary carcinogenesis in female rats. Nutrition Research 12, 879892

K Nesaretnam , R Stephen , R Dils & P Darbre (1998) Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33, 461469

D O'Byrne , S Grundy , L Packer , S Devaraj , K Baldenius , PP Hoppe , K Kraemer , I Jialal & MG Traber (2000) Studies of LDL oxidation following α-, γ-, or δ-tocotrienyl acetate supplementation of hypercholesterolemic humans. Free Radical Biology and Medicine 29, 834845

K Ouahchi , M Arita , H Kayden , F Hentati , MB Hamida , R Sokol , H Arai , K Inoue , J-L Mandel & M Koenig (1995) Ataxia with isolated vitamin E deficiency is caused by mutations in the α-tocopherol transfer protein. Nature Genetics 9, 141145

RS Parker , TJ Sontag & JE Swanson (2000) Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin. Biochemical and Biophysical Research Communications 277, 531534

RS Parker & JE Swanson (2000) A novel 5′-carboxychroman metabolite of γ-tocopherol secreted by HepG2 cells and excreted in human urine. Biochemical and Biophysical Research Communications 269, 580583

RC Petersen , RG Thomas , M Grundman , . (2005) Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine 352, 23792388

P Pfluger , D Kluth , N Landes , C Bumke-Vogt & R Brigelius-Flohé (2004) Vitamin E: underestimated as an antioxidant. Redox Report 9, 249254

DQ Pham & R Plakogiannis (2005) Vitamin E supplementation in cardiovascular disease and cancer prevention: part 1. Annals of pharmacotherapy 39, 18701878

L Poston , AL Briley , PT Seed , FJ Kelly & AH Shennan (2006) Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 367, 11451154

AA Qureshi , SA Sami , WA Salser & FA Khan (2002) Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 161, 199207

D Radosavac , P Graf , MC Polidori , H Sies & W Stahl (2002) Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2′-carboxyethyl)-6- hydroxychroman (α-CEHC) and 2, 7, 8-trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman (γ-CEHC) in human serum after a single dose of natural vitamin E. European Journal of Nutrition 41, 119124

R Ricciarelli , A Tasinato , S Clement , NK Özer , D Boscoboinik & A Azzi (1998) α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state. Biochemical Journal 334, 243249

R Ricciarelli , JM Zingg & A Azzi (2000) Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation 102, 8287

C Rota , L Barella , AM Minihane , E Stocklin & G Rimbach (2004) Dietary α-tocopherol affects differential gene expression in rat testes. IUBMB Life 56, 277280

S Roy , BH Lado , S Khanna & CK Sen (2002) Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis. FEBS Letters 530, 1723

H Saito , C Kiyose , H Yoshimura , T Ueda , K Kondo & O Igarashi (2003) γ-Tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor. Journal of Lipid Research 44, 15301535

M Sano , C Ernesto , RG Thomas , . (1997) A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. New England Journal of Medicine 336, 12161222

CK Sen , S Khanna & S Roy (2006) Tocotrienols: vitamin E beyond tocopherols. Life Science 78, 20882098

CK Sen , S Khanna , S Roy & L Packer (2000) Molecular basis of vitamin E action – tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. Journal of Biological Chemistry 275, 1304913055

E Serbinova , V Kagan , D Han & L Packer (1991) Free radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol. Free Radical Biology and Medicine 10, 263275

W Stahl , P Graf , R Brigelius-Flohé , W Wechter & H Sies (1999) Quantification of the α- and γ-tocopherol metabolites 2,5,7,8-tetramethyl-2-(2′-carboxyethyl)-6-hydroxychroman and 2,7,8-trimethyl-2-(2′-carboxyethyl)-6-hydroxychroman in human serum. Analytical Biochemistry 275, 254259

R Stocker & JF Keaney (2004) Role of oxidative modifications in atherosclerosis. Physiological Reviews 84, 13811478

WL Stone , AM Papas , IO LeClair , M Qui & T Ponder (2002) The influence of dietary iron and tocopherols on oxidative stress and ras-p21 levels in the colon. Cancer Detection and Prevention 26, 7884

PW Sylvester , A Nachnani , S Shah & KP Briski (2002) Role of GTP-binding proteins in reversing the antiproliferative effects of tocotrienols in preneoplastic mammary epithelial cells. Asia Pacific Journal of Clinical Nutrition 11, S452S459

K Takahashi & G Loo (2004) Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells. Biochemical Pharmacology 67, 315324

M Tanabe , T Fukushima , N Usui , N Aoyama , M Tsunoda & K Imai (2004) Intravenous administration of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman (γ-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion. Biomedical Chromatography 18, 727734

A Tappel & H Zalkin (1960) Inhibition of lipid peroxidation in microsomes by vitamin E. Nature 185, 35

A Tasinato , D Boscoboinik , GM Bartoli , P Maroni & A Azzi (1995) d-α-Tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proceedings of the National Academy of Sciences USA 92, 1219012194

MG Traber (2004) Vitamin E, nuclear receptors and xenobiotic metabolism. Archives of Biochemistry and Biophysics 423, 611

MG Traber , LK Siddens , SW Leonard , B Schock , K Gohil , SK Krueger , CE Cross & DE Williams (2005) α-Tocopherol modulates Cyp3a expression, increases γ-CEHC production, and limits tissue γ-tocopherol accumulation in mice fed high γ-tocopherol diets. Free Radical Biology and Medicine 38, 773785

JM Upston , L Kritharides & R Stocker (2003) The role of vitamin E in atherosclerosis. Progress in Lipid Research 42, 405422

DP Vivekananthan , MS Penn , SK Sapp , A Hsu & EJ Topol (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361, 20172023

KH Wagner , A Kamal-Eldin & I Elmadfa (2004) γ-Tocopherol – an underestimated vitamin? Annals of Nutrition and Metabolism 48, 169188

RE Watkins , GB Wisely , LB Moore , JL Collins , MH Lambert , SP Williams , TM Willson , SA Kliewer & MR Redinbo (2001) The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292, 23292333

JW Wechter , D Kantoci , ED Murray , DC D'Amico , ME Jung & W-H Wang (1996) A new endogenous natriuretic factor: LLU-α. Proceedings of the National Academy of Sciences USA 93, 60026007

SJ Weinstein , ME Wright , P Pietinen , I King , C Tan , PR Taylor , J Virtamo & D Albanes (2005) Serum α-tocopherol and γ-tocopherol in relation to prostate cancer risk in a prospective study. Journal of the National Cancer Institute 97, 396399

K Yamashita , Y Iizuka , T Imai & M Namiki (1995) Sesame seed and its lignans produce marked enhancement of vitamin-E activity in rats fed a low α-tocopherol diet. Lipids 30, 10191028

SP Yap , KH Yuen & JW Wong (2001) Pharmacokinetics and bioavailability of α-, γ- and δ-tocotrienols under different food status. Journal of Pharmacy and Pharmacology 53, 6771

C Zhou , MM Tabb , A Sadatrafiei , F Grün & B Blumberg (2004) Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metabolism and Disposition 32, 10751082

JM Zingg & A Azzi (2004) Non-antioxidant activities of vitamin E. Current Medicinal Chemistry 11, 11131133

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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
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