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Calcium economy in human pregnancy and lactation

  • Hanna Olausson (a1), Gail R. Goldberg (a1) (a2), M. Ann Laskey (a1), Inez Schoenmakers (a1), Landing M. A. Jarjou (a2) and Ann Prentice (a1) (a2)...
Abstract

Pregnancy and lactation are times of additional demand for Ca. Ca is transferred across the placenta for fetal skeletal mineralisation, and supplied to the mammary gland for secretion into breast milk. In theory, these additional maternal requirements could be met through mobilisation of Ca from the skeleton, increased intestinal Ca absorption efficiency, enhanced renal Ca retention or greater dietary Ca intake. The extent to which any or all of these apply, the underpinning biological mechanisms and the possible consequences for maternal and infant bone health in the short and long term are the focus of the present review. The complexities in the methodological aspects of interpreting the literature in this area are highlighted and the inter-individual variation in the response to pregnancy and lactation is reviewed. In summary, human pregnancy and lactation are associated with changes in Ca and bone metabolism that support the transfer of Ca between mother and child. The changes generally appear to be independent of maternal Ca supply in populations where Ca intakes are close to current recommendations. Evidence suggests that the processes are physiological in humans and that they provide sufficient Ca for fetal growth and breast-milk production, without relying on an increase in dietary Ca intake or compromising long-term maternal bone health. Further research is needed to determine the limitations of the maternal response to the Ca demands of pregnancy and lactation, especially among mothers with marginal and low dietary Ca intake, and to define vitamin D adequacy for reproductive women.

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*Corresponding author: Dr Ann Prentice, fax +44 1223 437515, email ann.prentice@mrc-hnr.cam.ac.uk
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3 A Prentice (2003) Pregnancy and lactation. In Pediatric Bone: Biology and Diseases, pp. 249269 [ J Pettifor , H Juppner and F Glorieux , editors]. London: Academic Press.

4 CS Kovacs & HM Kronenberg (1997) Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 18, 832872.

8 MA Laskey & A Prentice (1999) Bone mineral changes during and after lactation. Obstet Gynecol 94, 608615.

10 TJ Parsons , A Prentice , EA Smith , . (1996) Bone mineral mass consolidation in young British adults. J Bone Miner Res 11, 264274.

12 U Ulrich , PB Miller , DR Eyre , . (2003) Bone remodeling and bone mineral density during pregnancy. Arch Gynecol Obstet 268, 309316.

13 KE Naylor , P Iqbal , C Fledelius , . (2000) The effect of pregnancy on bone density and bone turnover. J Bone Miner Res 15, 129137.

14 M Sowers (1996) Pregnancy and lactation as risk factors for subsequent bone loss and osteoporosis. J Bone Miner Res 11, 10521060.

15 JZ Ilich & JE Kerstetter (2000) Nutrition in bone health revisited: a story beyond calcium. J Am Coll Nutr 19, 715737.

17 SC Marks Jr & PR Odgren (2002) Structure and development of the skeleton. In Principles of Bone Biology, pp. 315 [ JP Bilezikian , LG Raisz and GA Rodan , editors]. San Diego: Academic Press.

19 MA Laskey (1996) Dual-energy X-ray absorptiometry and body composition. Nutrition 12, 4551.

20 ES Orwoll (2003) Towards an expanded understanding of the role of the periosteum in skeletal health. J Bone Miner Res 18, 949954.

28 C Molgaard , BL Thomsen , A Prentice , . (1997) Whole body bone mineral content in healthy children and adolescents. Arch Dis Child 76, 915.

29 MS Fewtrell British Paediatric and Adolescent Bone Group (2003) Bone densitometry in children assessed by dual X ray absorptiometry: uses and pitfalls. Arch Dis Child 88, 795798.

30 MA Laskey , PR Murgatroyd & A Prentice (2004) Comparison of narrow-angle fan-beam and pencil-beam densitometers: in vivo and phantom study of the effect of bone density, scan mode, and tissue depth on spine measurements. J Clin Densitom 7, 341348.

32 A Johansen & MD Stone (1997) The effect of ankle oedema at the heel. Osteoporos Int 7, 4447.

33 MA Laskey & A Prentice (2004) Do appendicular bone measurements reflect changes in the axial skeleton?: the use of dual-energy X-ray absorptiometry and ultrasound measurements during lactation. J Clin Densitom 7, 296301.

34 A Stewart & DM Reid (2000) Precision of quantitative ultrasound: comparison of three commercial scanners. Bone 27, 139143.

35 CF Njeh , D Hans , J Li , . (2000) Comparison of six calcaneal quantitative ultrasound devices: precision and hip fracture discrimination. Osteoporos Int 11, 10511062.

36 GM Blake , M Naeem & M Boutros (2006) Comparison of effective dose to children and adults from dual X-ray absorptiometry examinations. Bone 38, 935942.

37 CF Njeh , T Fuerst , D Hans , . (1999) Radiation exposure in bone mineral density assessment. Appl Radiat Isot 50, 215236.

38 WA Kalender (1992) Effective dose values in bone mineral measurements by photon absorptiometry and computed tomography. Osteoporos Int 2, 8287.

39 AJ Black , J Topping , B Durham , . (2000) A detailed assessment of alterations in bone turnover, calcium homeostasis, and bone density in normal pregnancy. J Bone Miner Res 15, 557563.

40 GN Kent , RI Price , DH Gutteridge , . (1993) Effect of pregnancy and lactation on maternal bone mass and calcium metabolism. Osteoporos Int 3, Suppl. 1, S44S47.

41 N Kolthoff , P Eiken , B Kristensen , . (1998) Bone mineral changes during pregnancy and lactation: a longitudinal cohort study. Clin Sci (Lond) 94, 405412.

42 C More , P Bettembuk , HP Bhattoa , . (2001) The effects of pregnancy and lactation on bone mineral density. Osteoporos Int 12, 732737.

43 J Wisser , I Florio , M Neff , . (2005) Changes in bone density and metabolism in pregnancy. Acta Obstet Gynecol Scand 84, 349354.

47 R Hannon & R Eastell (2000) Preanalytical variability of biochemical markers of bone turnover. Osteoporos Int 11, Suppl. 6, S30S44.

48 J Riordan & KG Auerbach (1993) Breastfeeding and Human Lactation. Boston, MA: Jones and Bartlett Publishers Inc.

49 A Gasser , A Celada , B Courvoisier , . (1979) The clinical measurement of urinary total hydroxyproline excretion. Clin Chim Acta 95, 487491.

50 M Kaur , IM Godber , N Lawson , . (2003) Changes in serum markers of bone turnover during normal pregnancy. Ann Clin Biochem 40, 508513.

52 CM Weaver (2006) Clinical approaches for studying calcium metabolism and its relationship to disease. In Calcium in Human Health, pp. 6582 [ CM Weaver and RP Heaney , editors]. Totowa, NJ: Humana Press.

53 CJ Boushey (2006) Nutritional epidemiology: dietary assessment methods. In Calcium in Human Health, pp. 3964 [ CM Weaver and RP Heaney , editors]. Totowa, NJ: Humana Press.

55 GR Goldberg (2003) Assessment of dietary intake and nutritional status. In Nutritional Aspects of Bone Health, pp. 91109 [ S New and J-P Bonjour , editors]. Cambridge: Royal Society of Chemistry.

59 CM Weaver , AP Rothwell & KV Wood (2006) Measuring calcium absorption and utilization in humans. Curr Opin Clin Nutr Metab Care 9, 568574.

61 NF Butte , KJ Ellis , WW Wong , . (2003) Composition of gestational weight gain impacts maternal fat retention and infant birth weight. Am J Obstet Gynecol 189, 14231432.

63 D Pearson , M Kaur , P San , . (2004) Recovery of pregnancy mediated bone loss during lactation. Bone 34, 570578.

64 M Kaur , D Pearson , I Godber , . (2003) Longitudinal changes in bone mineral density during normal pregnancy. Bone 32, 449454.

65 BL Drinkwater & CH III Chesnut (1991) Bone density changes during pregnancy and lactation in active women: a longitudinal study. Bone Miner 14, 153160.

66 D Holmberg-Marttila , H Sievanen , . (1999) Changes in bone mineral density during pregnancy and postpartum: prospective data on five women. Osteoporos Int 10, 4146.

68 M Gambacciani , A Spinetti , R Gallo , . (1995) Ultrasonographic bone characteristics during normal pregnancy: longitudinal and cross-sectional evaluation. Am J Obstet Gynecol 173, 890893.

69 MK Javaid , SR Crozier , NC Harvey , . (2005) Maternal and seasonal predictors of change in calcaneal quantitative ultrasound during pregnancy. J Clin Endocrinol Metab 90, 51825187.

70 WW To , MW Wong & TW Leung (2003) Relationship between bone mineral density changes in pregnancy and maternal and pregnancy characteristics: a longitudinal study. Acta Obstet Gynecol Scand 82, 820827.

71 A Akesson , M Vahter , M Berglund , . (2004) Bone turnover from early pregnancy to postweaning. Acta Obstet Gynecol Scand 83, 10491055.

72 A Yamaga , M Taga , H Minaguchi , . (1996) Changes in bone mass as determined by ultrasound and biochemical markers of bone turnover during pregnancy and puerperium: a longitudinal study. J Clin Endocrinol Metab 81, 752756.

74 AL Tranquilli , SR Giannubilo & A Corradetti (2004) Ultrasound measurement of pregnancy-induced changes in maternal bone mass: a longitudinal, cross-sectional and biochemical study. Gynecol Endocrinol 18, 258262.

75 W Pluskiewicz (2004) Drozdzowska B & Stolecki M Quantitative ultrasound at the hand phalanges in pregnancy: a longitudinal study. Ultrasound Med Biol 30, 13731378.

76 F Aguado , M Revilla , ER Hernandez , . (1998) Ultrasonographic bone velocity in pregnancy: a longitudinal study. Am J Obstet Gynecol 178, 10161021.

77 B Specker & T Binkley (2005) High parity is associated with increased bone size and strength. Osteoporos Int 16, 19691974.

78 MA Laskey & A Prentice (1997) Effect of pregnancy on recovery of lactational bone loss. Lancet 349, 15181519.

79 M Sowers , J Randolph , B Shapiro , . (1995) A prospective study of bone density and pregnancy after an extended period of lactation with bone loss. Obstet Gynecol 85, 285289.

80 C Karlsson , KJ Obrant & M Karlsson (2001) Pregnancy and lactation confer reversible bone loss in humans. Osteoporos Int 12, 828834.

82 F Polatti , E Capuzzo , F Viazzo , . (1999) Bone mineral changes during and after lactation. Obstet Gynecol 94, 5256.

83 HJ Kalkwarf , BL Specker , DC Bianchi , . (1997) The effect of calcium supplementation on bone density during lactation and after weaning. N Engl J Med 337, 523528.

85 P Affinito , GA Tommaselli , C di Carlo , . (1996) Changes in bone mineral density and calcium metabolism in breast feeding women: a one year follow-up study. J Clin Endocrinol Metab 81, 23142318.

86 HJ Kalkwarf & BL Specker (1995) Bone mineral loss during lactation and recovery after weaning. Obstet Gynecol 86, 2632.

87 NA Cross , LS Hillman , SH Allen , . (1995) Changes in bone mineral density and markers of bone remodeling during lactation and postweaning in women consuming high amounts of calcium. J Bone Miner Res 10, 13121320.

89 M Sowers , G Corton , B Shapiro , . (1993) Changes in bone density with lactation. JAMA 269, 31303135.

90 H Dobnig , F Kainer , V Stepan , . (1995) Elevated parathyroid hormone-related peptide levels after human gestation: relationship to changes in bone and mineral metabolism. J Clin Endocrinol Metab 80, 36993707.

91 SM Chan , EA Nelson , SS Leung , . (2005) Bone mineral density and calcium metabolism of Hong Kong Chinese postpartum women - a 1-y longitudinal study. Eur J Clin Nutr 59, 868876.

92 A Honda , T Kurabayashi , T Yahata , . (1998) Lumbar bone mineral density changes during pregnancy and lactation. Int J Gynaecol Obstet 63, 253258.

93 T Yasumizu , Y Nakamura , K Hoshi , . (1998) Bone metabolism after human parturition and the effect of lactation: longitudinal analysis of serum bone-related proteins and bone mineral content of the lumbar spine. Endocr J 45, 679686.

94 JM Lopez , G Gonzalez , V Reyes , . (1996) Bone turnover and density in healthy women during breastfeeding and after weaning. Osteoporos Int 6, 153159.

95 HJ Kalkwarf , BL Specker & M Ho (1999) Effects of calcium supplementation on calcium homeostasis and bone turnover in lactating women. J Clin Endocrinol Metab 84, 464470.

96 HJ Kalkwarf (1999) Hormonal and dietary regulation of changes in bone density during lactation and after weaning in women. J Mammary Gland Biol Neoplasia 4, 319329.

98 D Holmberg-Marttila , H Sievanen , TL Jarvinen , . (2000) Vitamin D and estrogen receptor polymorphisms and bone mineral changes in postpartum women. Calcif Tissue Int 66, 184189.

99 MF Sowers , T Scholl , L Harris , . (2000) Bone loss in adolescent and adult pregnant women. Obstet Gynecol 96, 189193.

102 D Holmberg-Marttila , H Sievanen , P Laippala , . (2000) Factors underlying changes in bone mineral during postpartum amenorrhea and lactation. Osteoporos Int 11, 570576.

103 RP Heaney & TG Skillman (1971) Calcium metabolism in normal human pregnancy. J Clin Endocrinol 33, 661669.

105 KE Naylor , A Rogers , RB Fraser , . (2003) Serum osteoprotegerin as a determinant of bone metabolism in a longitudinal study of human pregnancy and lactation. J Clin Endocrinol Metab 88, 53615365.

106 BK Yoon , JW Lee , DS Choi , . (2000) Changes in biochemical bone markers during pregnancy and puerperium. J Korean Med Sci 15, 189193.

107 H Uemura , T Yasui , M Kiyokawa , . (2002) Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers. J Endocrinol 174, 353359.

108 SN Zeni , CR Ortela Soler , A Lazzari , . (2003) Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: a longitudinal study. Bone 33, 606613.

109 C More , HP Bhattoa , P Bettembuk , . (2003) The effects of pregnancy and lactation on hormonal status and biochemical markers of bone turnover. Eur J Obstet Gynecol Reprod Biol 106, 209213.

110 SJ Gallacher , WD Fraser , OJ Owens , . (1994) Changes in calciotrophic hormones and biochemical markers of bone turnover in normal human pregnancy. Eur J Endocrinol 131, 369374.

111 A Rodin , A Duncan , HW Quartero , . (1989) Serum concentrations of alkaline phosphatase isoenzymes and osteocalcin in normal pregnancy. J Clin Endocrinol Metab 68, 11231127.

113 A Prentice , LM Jarjou , DM Stirling , . (1998) Biochemical markers of calcium and bone metabolism during 18 months of lactation in Gambian women accustomed to a low calcium intake and in those consuming a calcium supplement. J Clin Endocrinol Metab 83, 10591066.

115 GN Kent , RI Price , DH Gutteridge , . (1990) Human lactation: forearm trabecular bone loss, increased bone turnover, and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning. J Bone Miner Res 5, 361369.

116 E Casanueva , ME Flores-Quijano , E Frike , . (2004) Bone mineral density and bone turnover in adolescent mothers after lactation. Adv Exp Med Biol 554, 341343.

117 M Sowers , D Eyre , BW Hollis , . (1995) Biochemical markers of bone turnover in lactating and nonlactating postpartum women. J Clin Endocrinol Metab 80, 22102216.

118 RM Carneiro , L Prebehalla , MB Tedesco , . (2010) Lactation and bone turnover: a conundrum of marked bone loss in the setting of coupled bone turnover. J Clin Endocrinol Metab 95, 17671776.

119 SM O'Sullivan , AB Grey , R Singh , . (2006) Bisphosphonates in pregnancy and lactation-associated osteoporosis. Osteoporos Int 17, 10081012.

120 M Rousiere , A Kahan & C Job-Deslandre (2001) Postnatal sacral fracture without osteoporosis. Joint Bone Spine 68, 7173.

121 HE Gruber , DH Gutteridge & DJ Baylink (1984) Osteoporosis associated with pregnancy and lactation: bone biopsy and skeletal features in three patients. Metab Bone Dis Relat Res 5, 159165.

123 JF Aloia , AN Vaswani , JK Yeh , . (1983) Determinants of bone mass in postmenopausal women. Arch Intern Med 143, 17001704.

124 PJ Feldblum , J Zhang , LE Rich , . (1992) Lactation history and bone mineral density among perimenopausal women. Epidemiology 3, 527531.

125 MM Hreshchyshyn , A Hopkins , S Zylstra , . (1988) Associations of parity, breast-feeding, and birth control pills with lumbar spine and femoral neck bone densities. Am J Obstet Gynecol 159, 318322.

126 LJ III Melton , SC Bryant , HW Wahner , . (1993) Influence of breastfeeding and other reproductive factors on bone mass later in life. Osteoporos Int 3, 7683.

127 PF Schnatz , KG Barker , KA Marakovits , . (2010) Effects of age at first pregnancy and breast-feeding on the development of postmenopausal osteoporosis. Menopause 17, 11611166.

128 L Lissner , C Bengtsson & T Hansson (1991) Bone mineral content in relation to lactation history in pre- and postmenopausal women. Calcif Tissue Int 48, 319325.

130 PH III Henderson , M Sowers , KE Kutzko , . (2000) Bone mineral density in grand multiparous women with extended lactation. Am J Obstet Gynecol 182, 13711377.

132 CJ Chantry , P Auinger & RS Byrd (2004) Lactation among adolescent mothers and subsequent bone mineral density. Arch Ped Adol Med 158, 650656.

134 S Hoffman , JA Grisso , JL Kelsey , . (1993) Parity, lactation and hip fracture. Osteoporos Int 3, 171176.

135 TA Hillier , JH Rizzo , KL Pedula , . (2003) Nulliparity and fracture risk in older women: the study of osteoporotic fractures. J Bone Miner Res 18, 893899.

136 K Michaelsson , JA Baron , BY Farahmand , . (2001) Influence of parity and lactation on hip fracture risk. Am J Epidemiol 153, 11661172.

138 N Kreiger , A Gross & G Hunter (1992) Dietary factors and fracture in postmenopausal women: a case–control study. Int J Epidemiol 21, 953958.

139 RG Cumming & RJ Klineberg (1993) Breastfeeding and other reproductive factors and the risk of hip fractures in elderly women. Int J Epidemiol 22, 684691.

141 J Lenora , S Lekamwasam & MK Karlsson (2009) Effects of multiparity and prolonged breast-feeding on maternal bone mineral density: a community-based cross-sectional study. BMC Women's Health 9, 19.

142 ARP Walker , B Richardson & F Walker (1972) The influence of numerous pregnancies and lactations on bone dimensions in South African Bantu and Caucasian mothers. Clin Sci 42, 189196.

143 C Cure-Cure , P Cure-Ramirez , E Teran , . (2002) Bone-mass peak in multiparity and reduced risk of bone-fractures in menopause. Int J Gynaecol Obstet 76, 285291.

145 JM Gertner , DR Coustan , AS Kliger , . (1986) Pregnancy as state of physiologic absorptive hypercalciuria. Am J Med 81, 451456.

146 RM Pitkin (1985) Calcium metabolism in pregnancy and the perinatal period: a review. Am J Obstet Gynecol 151, 99109.

149 A Prentice (2000) Calcium in pregnancy and lactation. Annu Rev Nutr 20, 249272.

150 CS Kovacs (2005) Calcium and bone metabolism during pregnancy and lactation. J Mammary Gland Biol Neoplasia 10, 105118.

151 K Lippuner , HJ Zehnder , JP Casez , . (1996) PTH-related protein is released into the mother's bloodstream during lacation: evidence for beneficial effects on maternal calcium-phosphate metabolism. J Bone Miner Res 11, 13941399.

156 SJ Fomon & SE Nelson (2002) Body composition of the male and female reference infants. Annu Rev Nutr 22, 117.

158 WW Koo , AJ Bush , J Walters , . (1998) Postnatal development of bone mineral status during infancy. J Am Coll Nutr 17, 6570.

159 WW Koo , J Walters , AJ Bush , . (1996) Dual-energy X-ray absorptiometry studies of bone mineral status in newborn infants. J Bone Miner Res 11, 9971002.

160 A Horsman , SW Ryan , PJ Congdon , . (1989) Bone mineral content and body size 65 to 100 weeks' postconception in preterm and full term infants. Arch Dis Child 64, 15791586.

161 K Godfrey , K Walker-Bone , S Robinson , . (2001) Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Miner Res 16, 16941703.

162 NC Harvey , MK Javaid , JR Poole , . (2008) Paternal skeletal size predicts intrauterine bone mineral accrual. J Clin Endocrinol Metab 93, 16761681.

163 AJ Sawyer , LK Bachrach & EB Fung (editors) (2007) Bone Densitometry in Growing Patients. Guidelines for Clinical Practice. Totawa, NJ: Humana Press.

165 WW Koo , LR Massom & J Walters (1995) Validation of accuracy and precision of dual energy X-ray absorptiometry for infants. J Bone Miner Res 10, 11111115.

167 MA Laskey , A Prentice , J Shaw , . (1990) Breast-milk calcium concentrations during prolonged lactation in British and rural Gambian mothers. Acta Paediatr Scand 79, 507512.

168 LMA Jarjou , GR Goldberg , WA Coward , . (2012) Calcium intake of rural Gambian infants: a quantitative study of the relative contributions of breast-milk and complementary foods at 3 and 12 months of age. Eur J Clin Nutr 66, 673677.

170 H Uemura , T Yasui , N Yoneda , . (1997) Measurement of N- and C-terminal-region fragments of parathyroid hormone-related peptide in milk from lactating women and investigation of the relationship of their concentrations to calcium in milk. J Endocrinol 153, 445451.

171 K Seki , T Kato , S Sekiya , . (1997) Parathyroid-hormone-related protein in human milk and its relation to milk calcium. Gynecol Obstet Invest 44, 102106.

174 R Kumar , WR Cohen , P Silva , . (1979) Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Invest 63, 342344.

176 MS Ardawi , HA Nasrat & HS BA'Aqueel (1997) Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study. Eur J Endocrinol 137, 402409.

178 EO Reiter , GD Braunstein , A Vargas , . (1979) Changes in 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D during pregnancy. Am J Obstet Gynecol 135, 227229.

179 KN Evans , JN Bulmer , MD Kilby , . (2004) Vitamin D and placental-decidual function. J Soc Gynecol Investig 11, 263271.

181 JM Gomez (2006) The role of insulin-like growth factor I components in the regulation of vitamin D. Curr Pharm Biotechnol 7, 125132.

182 DJ Hosking (1996) Calcium homeostasis in pregnancy. Clin Endocrinol (Oxf) 45, 16.

183 JJ Wysolmerski & AF Stewart (1998) The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annu Rev Physiol 60, 431460.

184 MJ Horwitz , MB Tedesco , SM Sereika , . (2005) Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D. J Bone Miner Res 20, 17921803.

185 CS Kovacs (2001) Calcium and bone metabolism in pregnancy and lactation. J Clin Endocrinol Metab 86, 23442348.

187 RM Pitkin , WA Reynolds , GA Williams , . (1979) Calcium metabolism in normal pregnancy: a longitudinal study. Am J Obstet Gynecol 133, 781790.

188 S Khosla (2001) Minireview: the OPG/RANKL/RANK system. Endocrinology 142, 50505055.

189 K Yano , O Shibata , A Mizuno , . (2001) Immunological study on circulating murine osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF): possible role of OPG/OCIF in the prevention of osteoporosis in pregnancy. Biochem Biophys Res Commun 288, 217224.

192 L Hillman , S Sateesha , M Haussler , . (1981) Control of mineral homeostasis during lactation: interrelationships of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, calcitonin, prolactin, and estradiol. Am J Obstet Gynecol 139, 471476.

194 T Dahlman , HE Sjoberg & E Bucht (1994) Calcium homeostasis in normal pregnancy and puerperium. A longitudinal study. Acta Obstet Gynecol Scand 73, 393398.

196 MF Sowers , BW Hollis , B Shapiro , . (1996) Elevated parathyroid hormone-related peptide associated with lactation and bone density loss. JAMA 276, 549554.

197 V Grill , J Hillary , PM Ho , . (1992) Parathyroid hormone-related protein: a possible endocrine function in lactation. Clin Endocrinol (Oxf) 37, 405410.

198 KJ Mather , CL Chik & B Corenblum (1999) Maintenance of serum calcium by parathyroid hormone-related peptide during lactation in a hypoparathyroid patient. J Clin Endocrinol Metab 84, 424427.

199 PW Howie , AS McNeilly , MJ Houston , . (1982) Fertility after childbirth: post-partum ovulation and menstruation in bottle and breast feeding mothers. Clin Endocrinol (Oxf) 17, 323332.

201 E Bergel & JM Belizan (2004) Commentary: Maternal calcium intake and offspring cardiovascular risk factors. Int J Epidemiol 33, 13091310.

202 E Bergel & AJD Barros (2007) Effect of maternal calcium intake during pregnancy on children's blood pressure: a systematic review of the literature. BMC Pediatrics 7, 15.

203 GJ Hofmeyr , L Duley & A Atallah (2007) Dietary calcium supplementation for prevention of pre-eclampsia and related problems: a systematic review and commentary. Br J Obstet Gynaecol 114, 933943.

206 LMA Jarjou , MA Laskey , Y Sawo , . (2010) Effect of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake. Am J Clin Nutr 92, 450457.

207 Z Liu , L Qiu , YM Chen , . (2011) Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trial. Arch Gynecol Obstet 283, 205211.

210 V Janakiraman , A Ettinger , A Mercado-Garcia , . (2003) Calcium supplements and bone resorption in pregnancy: a randomized crossover trial. Am J Prev Med 24, 260264.

217 RM Ortega , RM Martinez , ME Quintas , . (1998) Calcium levels in maternal milk: relationships with calcium intake during the third trimester of pregnancy. Br J Nutr 79, 501507.

218 A Prentice , B Dibba , LM Jarjou , . (1994) Is breast milk calcium concentration influenced by calcium intake during pregnancy? Lancet 344, 411412.

220 TJ Aspray , A Prentice , TJ Cole , . (1996) Low bone mineral content is common but osteoporotic fractures are rare in elderly rural Gambian women. J Bone Miner Res 11, 10191025.

221 A Prentice , J Shaw , MA Laskey , . (1991) Bone mineral content of British and rural Gambian women aged 18–80+ years. Bone Miner 12, 201214.

223 WW Koo , JC Walters , J Esterlitz , . (1999) Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 94, 577582.

224 GM Chan , K McElligott , T McNaught , . (2006) Effects of dietary calcium intervention on adolescent mothers and newborns: a randomized controlled trial. Obstet Gynecol 108, 565571.

226 A Ganpule , CS Yajnik , CH Fall , . (2006) Bone mass in Indian children - relationships to maternal nutritional status and diet during pregnancy: the Pune Maternal Nutrition Study. J Clin Endocrinol Metab 91, 29943001.

228 S Hawkesworth , Y Sawo , AJC Fulford , . (2010) Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children. Am J Clin Nutr 92, 741747.

229 A Prentice (2008) Vitamin D deficiency: a global perspective. Nutr Rev 66, 153164.

233 PM Brannon & MF Picciano (2011) Vitamin D in pregnancy and lactation in humans. Annu Rev Nutr 31, 89115.

236 FR Greer , BW Hollis , DJ Cripps , . (1984) Effects of maternal ultraviolet B irradiation on vitamin D content of human milk. J Pediatr 105, 431433.

237 BW Hollis (1983) Individual quantitation of vitamin D2, vitamin D3, 25-hydroxyvitamin D2, and 25-hydroxyvitamin D3 in human milk. Anal Biochem 131, 211219.

238 LA Basile , SN Taylor , CL Wagner , . (2006) The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants. Breastfeed Med 1, 2735.

240 CL Wagner , TC Hulsey , D Fanning , . (2006) High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. Breastfeed Med 1, 5970.

241 FR Greer , BW Hollis & JL Napoli (1984) High concentrations of vitamin D2 in human milk associated with pharmacologic doses of vitamin D2. J Pediatr 105, 6164.

242 A Prentice , L Yan , LM Jarjou , . (1997) Vitamin D status does not influence the breast-milk calcium concentration of lactating mothers accustomed to a low calcium intake. Acta Paediatr 86, 10061008.

244 F Cockburn , NR Belton , RJ Purvis , . (1980) Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants. Br Med J 281, 1114.

246 JJ McGrath , D Keeping , S Saha , . (2005) Seasonal fluctuations in birth weight and neonatal limb length; does prenatal vitamin D influence neonatal size and shape? Early Hum Dev 81, 609618.

247 R Namgung , RC Tsang , BL Specker , . (1994) Low bone mineral content and high serum osteocalcin and 1,25-dihydroxyvitamin D in summer- versus winter-born newborn infants: an early fetal effect? J Pediatr Gastroenterol Nutr 19, 220227.

249 CA Mannion , K Gray-Donald & KG Koski (2006) Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. Can Med Assoc J 174, 12731277.

250 H Weiler , S Fitzpatrick-Wong , R Veitch , . (2005) Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. Can Med Assoc J 172, 757761.

251 R Morley , JB Carlin , JA Pasco , . (2006) Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab 91, 906912.

253 MK Javaid , SR Crozier , NC Harvey , . (2006) Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 367, 3643.

254 OG Brooke , IR Brown , CD Bone , . (1980) Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J 280, 751754.

255 OG Brooke , F Butters & C Wood (1981) Intrauterine vitamin D nutrition and postnatal growth in Asian infants. Br Med J (Clin Res Ed) 283, 1024.

256 EE Delvin , BL Salle , FH Glorieux , . (1986) Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr 109, 328334.

257 BL Specker , ML Ho , A Oestreich , . (1992) Prospective study of vitamin D supplementation and rickets in China. J Pediatr 120, 733739.

258 RK Marya , S Rathee , V Lata , . (1981) Effects of vitamin D supplementation in pregnancy. Gynecol Obstet Invest 12, 155161.

260 E Mallet , B Gugi , P Brunelle , . (1986) Vitamin D supplementation in pregnancy: a controlled trial of two methods. Obstet Gynecol 68, 300304.

261 P Congdon , A Horsman , PA Kirby , . (1983) Mineral content of the forearms of babies born to Asian and white mothers. Br Med J 286, 12331235.

262 SA Abrams (2011) Vitamin D supplementation during pregnancy. J Bone Miner Res 26, 23382340.

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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
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