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Dietary α-linolenic acid and health-related outcomes: a metabolic perspective

  • Graham C Burdge (a1) and Philip C Calder (a1)

α-Linolenic acid (αLNA; 18: 3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids, principally EPA (20: 5n-3) and DHA (22: 6n-3), which confer important biophysical properties on cell membranes and so are required for tissue function. The extent to which this molecular transformation occurs in man is controversial. The present paper reviews the recent literature on the metabolism of αLNA in man, including the use of dietary αLNA in β-oxidation, recycling of carbon by fatty acid synthesis de novo and conversion to longer-chain PUFA. Sex differences in αLNA metabolism and the possible biological consequences are discussed. Increased consumption of EPA and DHA in fish oil has a number of well-characterised beneficial effects on health. The present paper also reviews the efficacy of increased αLNA consumption in increasing the concentrations of EPA and DHA in blood and cell lipid pools, and the extent to which such dietary interventions might be protective against CVD and inflammation. Although the effects on CVD risk factors and inflammatory markers are variable, where beneficial effects have been reported these are weaker than have been achieved from increasing consumption of EPA+DHA or linoleic acid. Overall, the limited capacity for conversion to longer-chain n-3 fatty acids, and the lack of efficacy in ameliorating CVD risk factors and inflammatory markers in man suggests that increased consumption of αLNA may be of little benefit in altering EPA+DHA status or in improving health outcomes compared with other dietary interventions.

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*Corresponding author: Dr Philip C. Calder, fax +44 2380 594379, email
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Adolph EF & Heggeness FW (1971) Age changes in body water and fat in fetal and infant mammals. Growth 35, 5563.
Allman MA, Pena MM & Pang D (1995) Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. European Journal of Clinical Nutrition 49, 169178.
Allman-Farinelli MA, Hall D, Kingham K, Pang D, Petocz P & Favaloro EJ (1999) Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. Atherosclerosis 142, 159168.
Anderson RE (1970) Lipids of ocular tissues. IV. A comparison of the phospholipids from the retina of six mammalian species. Experimental Eye Research 10, 339344.
Arjmandi BH, Khan DA, Juma S, Drum ML, Venkatesh S, Sohn E, Wei L & Derman R (1998) Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women. Nutrition Research 18, 12031214.
Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M & Willett WC (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 313, 8490.
Astorg P, Arnault N, Czernichow S, Noisette N, Galan P & Hercberg S (2004) Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women. Lipids 39, 527535.
Bang HO, Dyerberg J & Hjoorne N (1976) The composition of food consumed by Greenland Eskimos. Acta Medica Scandinavia 200, 6973.
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D & Campos H (2003) Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. Circulation 107, 15861591.
Bemelmans WJ, Broer J, Feskens EJ, Smit AJ, Muskiet FA, Lefrandt JD, Bom VJ, May JF & Meyboom-de Jong B (2002) Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. American Journal of Clinical Nutrition 75, 221227.
Bemelmans WJ, Lefrandt JD, Feskens EJ, van Haelst PL, Broer J, Meyboom-de Jong B, May JF, Tervaert JW & Smit AJ (2004) Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. European Journal of Clinical Nutrition 58, 10831089.
Berry EM & Hirsch J (1986) Does dietary linolenic acid influence blood pressure? American Journal of Clinical Nutrition 44, 336340.
Bieri JG & Prival EL (1965) Lipid composition of testes from various species. Comparative Biochemistry and Physiology 15, 275282.
Bjerregaard P & Dyerberg J (1988) Fish oil and ischaemic heart disease in Greenland. Lancet ii, 514.
Bretillon L, Chardigny JM, Sebedio JL, Noel JP, Scrimgeour CM, Fernie CE, Loreau O, Gachon P & Beaufrere B (2001) Isomerization increases the postprandial oxidation of linoleic acid but not α-linolenic acid in men. Journal of Lipid Research 42, 995997.
British Nutrition Foundation (1992) Unsaturated Fatty Acids: Nutritional and Physiological Significance. London: Chapman & Hall.
Broadhurst CL, Wang Y, Crawford MA, Cunnane SC, Parkington JE & Schmidt WF (2002) Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early African Homo sapiens. Comparative Biochemistry and Physiology 131B, 653673.
Brouwer IA, Katan MB & Zock PL (2004) Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. Journal of Nutrition 134, 919922.
Bucher HC, Hengstler P, Schindler C & Meier G (2002) n-3 Polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. American Journal of Medicine 112, 298304.
Burdge GC, Derrick PR, Russell JJ, Tricon S, Kew S, Banerjee T, Grimble RF, Williams CM, Yaqoob P & Calder PC (2005) Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into human erythrocytes in vivo. Nutrition Research 25, 1319.
Burdge GC, Finnegan YE, Minihane AM, Williams CM & Wootton SA (2003) Effect of altered dietary n-3 fatty aid intake upon plasma lipid fatty acid composition, conversion of [ 13C]α-linolenic acid to longer-chain fatty acids and partitioning towards β-oxidation in older men. British Journal of Nutrition 90, 311321.
Burdge GC, Hunt AN & Postle AD (1994) Mechanisms of hepatic phosphatidylcholine synthesis in adult rat: effects of pregnancy. Biochemical Journal 303, 941947.
Burdge GC, Jones AE & Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. British Journal of Nutrition 88, 355363.
Burdge GC & Wootton SA (2002) Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. British Journal of Nutrition 88, 411420.
Burdge GC & Wootton SA (2003) Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins, Leukotrienes and Essential Fatty Acids 69, 283290.
Calder PC (2001) Polyunsaturated fatty acids, inflammation and immunity. Lipids 36, 10071024.
Calder PC (2002) Dietary modification of inflammation with lipids. Proceedings of the Nutrition Society 61, 345358.
Calder PC (2003) n-3 Polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 342352.
Calder PC (2004 a) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clinical Science 107, 111.
Calder PC (2004 b) n-3 Fatty acids, inflammation and immunity – relevance to postsurgical and critically ill patients. Lipids 39, 11471161.
Calder PC (2005) Polyunsaturated fatty acids and inflammation. Biochemical Society Transactions 33, 423427.
Calder PC, Yaqoob P, Thies F, Wallace FA & Miles EA (2002) Fatty acids and lymphocyte functions. British Journal of Nutrition 87, S31–S48.
Carnielli VP, Wattimena DJ, Luijendijk IH, Boerlage A, Degenhart HJ & Sauer PJ (1996) The very-low-birth-weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acid from linolenic and linolenic acid. Pediatric Research 40, 169174.
Caughey GE, Mantzioris E, Gibson RA, Cleland LG & James MJ (1996) The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition 63, 116122.
Chan JK, Bruce VM & McDonald BE (1991) Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. American Journal of Clinical Nutrition 53, 12301234.
Chan JK, McDonald BE, Gerrard JM, Bruce VM, Weaver BJ & Holub BJ (1993) Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis. Lipids 28, 811817.
Chang MC, Bell JM, Purdon AD, Chikhale EG & Grange E (1999) Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. Neurochemistry Research 24, 399406.
Chapkin RS, Ziboh VA, Marcelo CL & Voorhees JJ (1986) Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation. Journal of Lipid Research 27, 945954.
Chin JPF, Gust A, Nestel PJ & Dart AM (1993) Fish oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans. Hypertension 21, 2228.
Cho HP, Nakamura M & Clarke SD (1999) Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. Journal of Biological Chemistry 274, 3733537339.
Christensen JH, Gustenhoff P, Korup E, Aaroe J, Toft E, Moller J, Rasmussen K, Dyerberg J & Schmidt EB (1996) Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. BMJ 312, 677678.
Christensen JH, Skou HA, Fog L, Hansen V, Vesterlund T, Dyerberg J, Toft E & Schmidt EB (2001) Marine n-3 fatty acids, wine intake, and heart rate variability in patients referred for coronary angiography. Circulation 103, 651657.
Clandinin MT, Chappell JE, Heim T, Swyer PR & Chance GW (1981) Fatty acid utilization in perinatal de novo synthesis of tissues. Early Human Development 5, 355366.
Clouet P, Niot I & Bezard J (1989) Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. Biochemical Journal 263, 867873.
Connor WE & Neuringer M (1988) The effects of n-3 fatty acid deficiency and repletion upon the fatty acid composition and function of the brain and retina. Progress in Clinical and Biological Research 282, 275294.
Correia HR, Balseiro SC, Correia ER, Mota PG & de Areia ML (2004) Why are human newborns so fat? Relationship between fatness and brain size at birth. American Journal of Human Biology 16, 2430.
Crawford MA, Casperd NM & Sinclair AJ (1976) The long chain metabolites of linoleic and linolenic acids in liver and brain in herbivores and carnivores. Comparative Biochemistry and Physiology 54B, 395401.
Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TM & Jenkins DJ (1995) Nutritional attributes of traditional flaxseed in healthy young adults. American Journal of Clinical Nutrition 61, 6268.
Cunnane SC, Ryan MA, Nadeau CR, Bazinet RP, Musa-Veloso K & McCloy U (2003) Why is carbon from some polyunsaturates extensively recycled in lipid synthesis? Lipids 38, 477484.
Cunnane SC, Williams SC, Bell JD, Brookes S, Craig K, Iles RA & Crawford MA (1994) Utilization of uniformly labeled 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain. Journal of Neurochemistry 62, 24292436.
D'andrea S, Guillou H, Jan S, Catheline D, Thibault JN, Bouriel M, Rioux V & Legrand P (2002) The same rat Δ6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. Biochemical Journal 364, 4955.
de Antueno RJ, Knickle LC, Smith H, Elliot ML, Allen SJ, Nwaka S & Winther MD (2001) Activity of human Δ5 and Δ6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids. FEBS Letters 509, 7780.
de Gomez Dumm IN & Brenner RR (1975) Oxidative desaturation of alpha-linoleic, linoleic, and stearic acids by human liver microsomes. Lipids 10, 315317.
de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P & Delaye J (1994) Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343, 14541459.
Del Prado M, Villalpando S, Elizondo A, Rodriguez M, Demmelmair H & Koletzko B (2001) Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. American Journal of Clinical Nutrition 74, 242247.
DeLany JP, Windhauser MM, Champagne CM & Bray GA (2000) Differential oxidation of individual dietary fatty acids in humans. American Journal of Clinical Nutrition 72, 905911.
Djousse L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA & Ellison RC (2005) Investigators of the NHLBI FHS Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart. Lung, and Blood Institute Family Heart Study. Circulation 111, 29212926.
Djousse L, Folsom AR, Province MA, Hunt SC & Ellison RC (2003) Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. American Journal of Clinical Nutrition 77, 819825.
Djousse L, Pankow JS, Eckfeldt JH, Folsom AR, Hopkins PN, Province MA, Hong Y & Ellison RC (2001) Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. American Journal of Clinical Nutrition 74, 612619.
Dolecek TA (1992) Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proceedings of the Society for Experimental Biology and Medicine 200, 177182.
Dyerberg J, Bang HO, Stoffersen E, Moncada S & Vane JR (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet ii, 117119.
Emken EA (2001) Stable isotope approaches, applications and issues related to polyunsaturated fatty acid metabolism studies. Lipids 36, 965973.
Emken EA, Adlof RO, Duval SM & Nelson GJ (1999) Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic and linolenic acids by male subjects. Lipids 34, 785798.
Emken EA, Adlof RO & Gulley RM (1994) Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochimica et Biophysica Acta 1213, 277288.
Evans K, Burdge GC, Wootton SA, Clark ML & Frayn KN (2002) Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 51, 26842690.
Ezaki O, Takahashi M, Shigematsu T, Shimamura K, Kimura J, Ezaki H & Gotoh T. (1999) Long-term effects of dietary alpha-linolenic acid from perilla oil on serum fatty acids composition and on the risk factors of coronary heart disease in Japanese elderly subjects. Journal of Nutrition Science Vitaminology (Tokyo) 45, 759772.
Fernstrom JD (1999) Effects of dietary polyunsaturated fatty acids on neuronal function. Lipids 34, 161169.
Finnegan YE, Howarth D, Minihane AM, Kew S, Miller GJ, Calder PC & Williams CM. (2003 a) Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. Journal of Nutrition 133, 22102213.
Finnegan YE, Minihane AM, Leigh-Firbank EC, Kew S, Meijer GW, Muggli R, Calder PC & Williams CM (2003 b) Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. American Journal of Clinical Nutrition 77, 783795.
Francois CA, Connor SL, Bolewicz LC & Connor WE (2003) Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. American Journal of Clinical Nutrition 77, 226233.
Freese R & Mutanen M (1997) Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. American Journal of Clinical Nutrition 66, 591598.
Freese R, Mutanen M, Valsta LM & Salminen I (1994) Comparison of the effects of two diets rich in monounsaturated fatty acids differing in their linoleic/alpha-linolenic acid ratio on platelet aggregation. Thrombosis and Haemostasis 71, 7377.
Ge L, Gordon JS, Hsuan C, Stenn K & Prouty SM (2003) Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. Journal of Investigative Dermatology 120, 707714.
Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR & Kok FJ (2002) Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. Journal of Hypertension 20, 14931499.
Gibbons A (2002 a) American Association of Physical Anthropologists meeting. Humans' head start: new views of brain evolution. Science 296, 835837.
Gibbons A (2002 b) Becoming human. In search of the first hominids. Science 295, 12141219.
Giltay EJ, Duschek EJ, Katan MB, Zock PL, Neele SJ & Netelenbos JC (2004 a) Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. Journal of Endocrinology 182, 399408.
Giltay EJ, Gooren LJ, Toorians AW, Katan MB & Zock PL (2004 b) Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. American Journal of Clinical Nutrition 80, 11671174.
Goode GK, Garcia S & Heagerty AM (1997) Dietary supplementation with marine fish oil improves in vitro small artery endothelial function in hypercholesterolemic patients: a double-blind placebo-controlled study. Circulation 96, 28022807.
Goodnight SH, Harris WS & Connor WE (1981) The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study. Blood 58, 880885.
Goyens PL, Spilker ME, Zock PL, Katan MB & Mensink RP (2005) Development of a compartmental model to quantify alpha-linolenic acid conversion after longer-term intake of multiple tracer boluses. Journal of Lipid Research 46, 14741483.
Gregersen MI & Rawson RA (1959) Blood volume. Physiological Reviews 39, 307342.
Hacia JG (2001) Genome of the apes. Trends in Genetics 17, 637645.
Harmon SD, Kaduce TL, Manuel TD & Spector AA (2003) Effect of Δ6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells. Lipids 38, 469476.
Harris WS (1996) n-3 Fatty acids and lipoproteins: comparison of results from human and animal studies. Lipids 31, 243252.
He K, Rimm EB, Merchant A, Rosner BA, Stampfer MJ, Willett WC & Ascherio A (2004) Fish consumption and risk of stroke in men. JAMA 288, 31303136.
Healy DA, Wallace FA, Miles EA, Calder PC & Newsholm P (2000) Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. Lipids 35, 763768.
Heath RB, Karpe F, Milne RW, Burdge GC, Wootton SA & Frayn KN (2003) Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period. Journal of Lipid Research 44, 20652072.
Hu FB, Stampfer MJ, Manson JE, Rimm EB, Wolk A, Colditz GA, Hennekens CH & Willett WC (1999) Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. American Journal of Clinical Nutrition 69, 890897.
Hulshof KFAM, van Erp-Baart MA, Anttolainen M, Becker W, Church SM, Couet C, Hermann-Kunz E, Kesteloot H, Leth T, Martins I, Moreiras O, Moschandreas J, et al. (1999) Intake of fatty acids in Western Europe with emphasis on trans fatty acids: the TRANSFAIR Study. European Journal of Clinical Nutrition 53, 143157.
Hussein N, Ah-Sing E, Wilkinson P, Leach C, Griffin BA & Millward DJ (2005) Relative rates of long chain conversion of 13C linoleic and α-linolenic acid in response to marked changes in their dietary intake in male adults. Journal of Lipid Research 46, 269280.
Infante JP & Huszagh VA. (1998) Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n–3 1998) acids. FEBS Letters 43, 16.
Innis SM, Elias SJ (2003) Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. American Journal of Clinical Nutrition 77, 473478.
Irving CS, Wong WW, Shulman RJ, Smith EO, Klein PD (1983) [13C]Bicarbonate kinetics in humans: intra- vs interindividual variations. American Journal of Physiology 245, R190–R202.
James MJ, Ursin VM & Cleland LG (2003) Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. American Journal of Clinical Nutrition 77, 11401145.
Jeffrey BG, Weisinger HS, Neuringer M & Mitchell DC (2001) The role of docosahexaenoic acid in retinal function. Lipids 36, 859871.
Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H, Nowak-Gottl U, Assmann G & Wahrburg U (2001) Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system. Thrombosis and Haemostasis 85, 280286.
Kaminskas A, Zieden B, Elving B, Kristenson M, Abaravicius A, Bergdahl B, Olsson AG & Kucinskiene Z (1999) Adipose tissue fatty acids in men from two populations with different cardiovascular risk: the LiVicordia study. Scandinavian Journal of Clinical Laboratory Investigation 59, 227232.
Karvonen HM, Aro A, Tapola NS, Salminen I, Uusitupa MIJ & Sarkkinen ES (2002) Effect of alpha-linolenic acid-rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. Metabolism – Clinical and Experimental 51, 12531260.
Kelley DS, Branch LB, Love JE, Taylor PC, Rivera YM & Iacono JM (1991) Dietary alpha-linolenic acid and immunocompetence in humans. American Journal of Clinical Nutrition 53, 4046.
Kelley DS, Nelson GJ, Love JE, Branch LB, Taylor PC, Schmidt PC, Mackey BE & Iacono JM (1993) Dietary alpha-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28, 533537.
Kestin M, Clifton P, Belling GB & Nestel PJ (1990) n-3 Fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. American Journal of Clinical Nutrition 51, 10281034.
Kew S, Banerjee T, Minihane AM, Finnegan YE, Muggli R, Albers R, Williams CM & Calder PC (2003) Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. American Journal of Clinical Nutrition 77, 12871295.
Knapp HR, Reilly IA, Alessandrini P & FitzGerald GA (1986) In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. New England Journal of Medicine 314, 937942.
Kris-Etherton PM, Harris WS & Appel LJ (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 27472757.
Kris-Etherton PM, Taylor DS, Yu-Poth S, Huth P, Moriarty K, Fishell V, Hargrove RL, Zhao G & Etherton TD (2000) Polyunsaturated fatty acids in the food chain in the United States. American Journal of Clinical Nutrition 71, Suppl.179S188S.
Kromann N & Green A (1980) Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950–1974. Acta Medica Scandanavia 208, 401406.
Kuzawa CW (1998) Adipose tissue in human infancy and childhood: an evolutionary perspective. American Journal of Physical Anthropology 27, Suppl.177209.
Kwon JS, Snook JT, Wardlaw GM & Hwang DH (1991) Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. American Journal of Clinical Nutrition 154, 351358.
Lands WE (2003) Diets could prevent many diseases. Lipids 38, 317321.
Larque E, Garcia-Ruiz PA, Perez-Llamas F, Zamora S & Gil A (2003) Dietary trans fatty acids alter the compositions of microsomes and mitochondria and the activities of microsome Δ6-fatty acid desaturase and glucose-6-phosphatase in livers of pregnant rats. Journal of Nutrition 133, 25262531.
Lauritzen L, Hansen HS, Jorgensen MH & Michaelsen KF (2001) The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Progress in Lipid Research 40, 194.
Layne KS, Goh YK, Jumpsen JA, Ryan EA, Chow P & Clandinin MT. (1996) Normal subjects consuming physiological levels of 18:3(n-3) and 20:5(n-3) from flaxseed or fish oils have characteristic differences in plasma lipid and lipoprotein fatty acid levels. Journal of Nutrition 126, 21302140.
Lewis DS, Bertrand HA, Masoro EJ, McGill HC, Carey KD & McMahan CA (1983) Preweaning nutrition and fat development in baboons. Journal of Nutrition 113, 22532259.
Lewis RA, Austen KF & Soberman RJ (1990) Leukotrienes and other products of the 5-lipoxygenase pathway: biochemistry and relation to pathobiology in human diseases. New England Journal of Medicine 323, 645655.
Li D, Sinclair A, Wilson A, Nakkote S, Kelly F, Abedin L, Mann N & Turner A (1999) Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. American Journal of Clinical Nutrition 69, 872882.
Li Z, Kaplan ML & Hachey DL (2000) Hepatic microsomal and peroxisomal docosahexaenoate biosynthesis during piglet development. Lipids 35, 13251333.
Lichtenstein AH, Ausman LM, Carrasco W, Jenner JL, Gualtieri LJ, Goldin BR, Ordovas JM & Schaefer EJ (1993) Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. Arteriosclerosis and Thrombosis 13, 15331542.
Lopez-Garcia E, Schulze MB, Fung TT, Meigs JB, Rifai N, Manson JE & Hu FB (2004) Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. American Journal of Clinical Nutrition 80, 10291035.
Macaulay V, Hill C, Achilli A, Rengo C, Clarke D, Meehan W, Blackburn J, Semino O, Scozzari R, Cruciani F, Taha A, Shaari NK, et al. (2005) Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes. Science 308, 10341036.
McCloy U, Ryan MA, Pencharz PB, Ross RJ & Cunnane SCA (2004) Comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women. Journal of Lipid Research 45, 474485.
McVeigh GE, Brennan GM, Cohn JN, Finkelstein SM, Hayes RJ & Johnston GD (1994) Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arteriosclerosis and Thrombosis 14, 14251429.
Mantzioris E, James MJ, Gibson RA & Cleland LG (1994) Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. American Journal of Clinical Nutrition 59, 13041309.
Martinez M (2000) The fundamentals and practice of docosahexaenoic acid therapy in peroxisomal disorders. Current Opinion in Clinical Nutrition and Metabolic Care 3, 101108.
Marzo I, Alava MA, Pineiro A & Naval J (1996) Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. Biochimica et Biophysica Acta 1301, 263272.
Marzo I, Martinez-Lorenzo MJ, Anel A, Desportes P, Alava MA, Naval J & Pineiro A (1995) Biosynthesis of unsaturated fatty acids in the main cell lineages of human leukemia and lymphoma. Biochimica et Biophysica Acta 1257, 140148.
Ministry of Agriculture, Fisheries and Food (1997) Dietary Intake of Iodine and Fatty Acids. Food Information Surveillance Sheet no. 127. London: Ministry of Agriculture, Fisheries and Food.
Mitchell DC, Niu SL & Litman BJ. (2003) Enhancement of G protein-coupled signalling by DHA phospholipids. Lipids 38, 437443.
Muskiet FA, Fokkema MR, Schaafsma A, Boersma ER & Crawford MA. (2004) Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials. Journal of Nutrition 134, 183186.
Mutanen M, Freese R, Valsta LM, Ahola I & Ahlstrom A (1992) Rapeseed oil and sunflower oil diets enhance platelet in vitro aggregation and thromboxane production in healthy men when compared with milk fat or habitual diets. Thrombosis and Haemostasis 67, 352356.
Needleman P, Wyche A & Raz A (1979) Platelet and blood vessel arachidonate metabolism and interactions. Journal of Clinical Investigation 63, 345349.
Nestel PJ, Pomeroy SE, Sasahara T, Yamashita T, Liang YL, Dart AM, Jennings GL, Abbey M & Cameron JD (1997) Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arteriosclerosis, Thrombosis and Vascular Biology 17, 11631170.
Neuringer M, Connor WE, Lin DS, Barstad L & Luck S (1986) Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proceedings of the National Academy of Sciences USA 83, 40214025.
Newman WP, Middaugh JP, Propst MT & Rogers DR (1993) Atherosclerosis in Alaska natives and non-natives. Lancet 341, 10561057.
O'Brien JS & Sampson EL (1965) Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin. Journal of Lipid Research 6, 545551.
Ollis TE, Meyer BJ & Howe PR (1999) Australian food sources and intakes of omega-6 and omega-3 polyunsaturated fatty acids. Annals of Nutrition and Metabolism 43, 346355.
Oomen CM, Ocke MC, Feskens EJ, Kok FJ & Kromhout D (2001) Alpha-linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. American Journal of Clinical Nutrition 74, 457463.
Ottosson UB, Lagrelius A, Rosing U & von Schoultz B (1984) Relative fatty acids composition of lecithin during postmenopausal replacement therapy – a comparison between ethinyl estradiol and estradiol valerate. Gynaecologic and Obstetric Investigation 18, 296302.
Pang D, Allman-Farinelli MA, Wong T, Barnes R & Kingham KM (1998) Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. British Journal of Nutrition 80, 163167.
Pawlosky R, Hibbeln J, Lin Y & Salem N (2003 a) n-3 Fatty acid metabolism in women. British Journal of Nutrition 90, 993994.
Pawlosky RJ, Hibbeln JR, Lin Y, Goodson S, Riggs P, Sebring N, Brown GL & Salem N (2003 b) Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. American Journal of Clinical Nutrition 77, 565572.
Pawlosky RJ, Hibbeln JR, Novotny JA & Salem N (2001) Physiological compartmental analysis of α-linolenic acid metabolism in adult humans. Journal of Lipid Research 42, 12571265.
Pietinen P, Ascherio A, Korhonen P, Hartman AM, Willett WC, Albanes D & Virtamo J (1997) Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. American Journal of Epidemiology 145, 876887.
Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC & Rimm EB (2003) Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 108, 155160.
Poisson J-P, Dupuy R-P, Sarda P, Descomps B, Narce M, Rieu D & Crastes de Paulet A (1993) Evidence that liver microsomes of human neonates desaturate essential fatty acids. Biochimica et Biophysica Acta 1167, 109113.
Poissonnet CM, Burdi AR & Garn SM (1984) The chronology of adipose tissue appearance and distribution in the human fetus. Early Human Development 10, 111.
Postle AD, Al MDM, Burdge GC & Hornstra G (1995) The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy. Early Human Development 43, 4758.
Poulos A, Darin-Bennett A & White IG (1973) The phospholipid-bound fatty acids and aldehydes of mammalian spermatozoa. Comparative Biochemistry and Physiology 46B, 541549.
Rallidis LS, Paschos G, Liakos GK, Velissaridou AH, Anastasiadis G & Zampelas A (2003) Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 167, 237242.
Rallidis LS, Paschos G, Papaioannou ML, Liakos GK, Panagiotakos DB, Anastasiadis G & Zampelas A (2004) The effect of diet enriched with alpha-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients. Atherosclerosis 174, 127132.
Roche HM & Gibney MJ (1999) Long-chain n-3 polyunsaturated fatty acids and triacylglycerol metabolism in the postprandial state. Lipids 34, Suppl., S259–S265.
Salem N, Powlosky R, Wegher B & Hibbeln J (1999) In vivo conversion of linoleic acid to arachidonic acid in human adults. Prostaglandins, Leukotrienes and Essential Fatty Acids 60, 407410.
Salem N, Wegher B, Mena P & Uauy R (1996) Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proceedings of the National Academy of Science USA 93, 4954.
Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppanen R, Kantola M, Seppanen K & Rauramaa R (1988) Blood pressure, dietary fats, and antioxidants. American Journal of Clinical Nutrition 48, 12261232.
Sanders TA & Roshanai F. (1983) The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. Clinical Science (London) 64, 9199.
Sanders TA, Vickers M & Haines AP. (1981) Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clinical Science (London) 61, 317324.
Sanders TA & Younger KM (1981) The effect of dietary supplements of omega 3 polyunsaturated fatty acids on the fatty acid composition of platelets and plasma choline phosphoglycerides. British Journal of Nutrition 45, 613616.
Sauerwald TU, Hachey DL, Jensen CL, Chen H, Anderson RE & Heird WC (1997) Intermediates in endogenous synthesis of C22:6ω3 and C20:4ω6 by term and preterm infants. Pediatric Research 141, 183187.
Saunders DR & Sillery JK (1988) Absorption of triglyceride by human small intestine: dose-response relationships. American Journal of Clinical Nutrition 48, 988991.
Schrepf R, Limmert T, Claus Weber P, Theisen K & Sellmayer A (2004) Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia. Lancet 363, 14411442.
Sheaff-Greiner RC, Zhang Q, Goodman KJ, Giussani DA, Nathanielsz PW & Brenna JT (1996) Linoleate, α-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. Journal of Lipid Research 37, 26752686.
Shoda R, Matsueda K, Yamato S & Umeda N (1996) Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. American Journal of Clinical Nutrition 63, 741745.
Simon JA, Fong J, Bernert JT & Browner WS (1995) Serum fatty acids and the risk of stroke. Stroke 26, 778782.
Simopoulos AP (2001) n-3 Fatty acids and human health: defining strategies for public policy. Lipids 36, S83–S89.
Sinclair AJ, Attar-Bashi NM & Li D (2000) What is the role of α-linolenic acid for mammals? Lipids 37, 11131123.
Singer P, Berger I, Wirth M, Godicke W & Jaeger W, Voigt S (1986) Slow desaturation and elongation of linoleic and α-linolenic acids as rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipidemic subjects. Prostaglandins Leukotrienes and Medicine 24, 173193.
Sodergren E, Gustafsson IB, Basu S, Nourooz-Zadeh J, Nalsen C, Turpeinen A, Berglund L & Vessby B (2001) A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids. European Journal of Clinical Nutrition 55, 922931.
Sorensen NS, Marckmann P, Hoy CE, van Duyvenvoorde W, Princen HM (1998) Effect of fish-oil-enriched margarine on plasma lipids, low-density-lipoprotein particle composition, size, and susceptibility to oxidation. American Journal of Clinical Nutrition 68, 235241.
Sprecher H (2002) The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids 67, 7983.
Suzukawa M, Abbey M, Howe PR & Nestel PJ (1995) Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages. Journal of Lipid Research 36, 473484.
Tagawa H, Shimokawa H, Tagawa T, Kuroiwa-Matsumoto M, Hirooka Y & Takeshita A (1999) Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease. Journal of Cardiovascular Pharmacology 33, 633640.
Tang AB, Nishimura KY & Phinney SD (1993) Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. Lipids 28, 987993.
Tang C, Cho HP, Nakamura MT & Clarke SD (2003) Regulation of human (Δ-6 desaturase gene transcription: identification of a functional direct repeat-1 element. Journal of Lipid Research 44, 686695.
Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA & Calder PC (2001 a) Influence of dietary supplementation with long chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids 36, 11831193.
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA & Calder PC (2001 b) Dietary supplementation with eicosapentaenoic acid, but not with other long chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 years. American Journal of Clinical Nutrition 73, 539548.
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob PNewsholme EA, Calder PC (2001 c) Dietary supplementation with γ-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. Journal of Nutrition 131, 19181927.
Tilley SL, Coffman TM & Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. Journal of Clinical Investigation 108, 1523.
Vermunt SHF, Mensink RP, Simonis AMG & Hornstra G (2000) Effects of dietary α-linolenic acid on the conversion and oxidation of [13C]-α-linolenic acid. Lipids 35, 137142.
Vinton NE, Heckenlively JR, Laidlaw SA, Martin DA, Foxman SR, Ament ME & Kopple JD (1990) Visual function in patients undergoing parenteral nutrition. American Journal of Clinical Nutrition 52, 895902.
von Schacky C, Fischer S & Weber PC (1985) Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. Journal of Clinical Investigation 76, 16261631.
Wallace FA, Miles EA & Calder PC (2003) Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. British Journal of Nutrition 89, 679689.
Weaver BJ, Corner EJ, Bruce VM, McDonald BE & Holub BJ (1990) Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. American Journal of Clinical Nutrition 51, 594598.
Wensing AG, Mensink RP & Hornstra G (1999) Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. British Journal of Nutrition 82, 183191.
Wiegand RD, Koutz CA, Stinson AM & Anderson RE (1991) Conservation of docosahexaenoic acid in rod outer segments of rat retina during n-3 and n-6 fatty acid deficiency. Journal of Neurochemistry 57, 16901699.
Williams CM (1997) Postprandial lipid metabolism: effects of dietary fatty acids. Proceedings of the Nutrition Society 56, 679692.
Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ & Kris-Etherton PM (2004) Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. Journal of Nutrition 134, 29912997.
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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
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