1Neaton JD & Wentworth D (1992) Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med 152, 56–64.
2Mensink RP, Zock PL, Kester AD, et al. . (2003) Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 77, 1146–1155.
3Kannel WB (1996) Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 275, 1571–1576.
4Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. . (2006) Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113, 657–663.
5Yeboah J, Crouse JR, Hsu FC, et al. . (2007) Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 115, 2390–2397.
6Ross R (1999) Atherosclerosis – an inflammatory disease. N Engl J Med 340, 115–126.
7Triggle CR, Hollenberg M, Anderson TJ, et al. . (2003) The endothelium in health and disease – a target for therapeutic intervention. J Smooth Muscle Res 39, 249–267.
8Moens AL, Goovaerts I, Claeys MJ, et al. . (2005) Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 127, 2254–2263.
9Celermajer DS, Sorensen KE, Gooch VM, et al. . (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340, 1111–1115.
10Fichtlscherer S, Rosenberger G, Walter DH, et al. . (2000) Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102, 1000–1006.
11Morris SJ & Shore AC (1996) Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. J Physiol 496, 531–542.
12Gokce N, Keaney JF Jr, Hunter LM, et al. . (2003) Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 41, 1769–1775.
13Caballero AE, Arora S, Saouaf R, et al. . (1999) Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 48, 1856–1862.
14Farkas K, Kolossvary E, Jarai Z, et al. . (2004) Non-invasive assessment of microvascular endothelial function by laser Doppler flowmetry in patients with essential hypertension. Atherosclerosis 173, 97–102.
15Hansell J, Henareh L, Agewall S, et al. . (2004) Non-invasive assessment of endothelial function - relation between vasodilatory responses in skin microcirculation and brachial artery. Clin Physiol Funct Imaging 24, 317–322.
16Heitzer T, Schlinzig T, Krohn K, et al. . (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104, 2673–2678.
17Nichols WW (2005) Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertens 18, 3S–10S.
18Kelly RP, Millasseau SC, Ritter JM, et al. . (2001) Vasoactive drugs influence aortic augmentation index independently of pulse-wave velocity in healthy men. Hypertension 37, 1429–1433.
19McEniery CM, Wallace S, Mackenzie IS, et al. . (2006) Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension 48, 602–608.
20Levick JR (2003) An Introduction to Cardiovascular Physiology, 4th ed.New York: Hodder Arnold.
21Ter Avest E, Stalenhoef AF & de Graaf J (2007) What is the role of non-invasive measurements of atherosclerosis in individual cardiovascular risk prediction? Clin Sci (Lond) 112, 507–516.
22Laurent S, Cockcroft J, Van Bortel L, et al. . (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27, 2588–2605.
23Millasseau SC, Kelly RP, Ritter JM, et al. . (2002) Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clin Sci (Lond) 103, 371–377.
24Hamilton PK, Lockhart CJ, Quinn CE, et al. . (2007) Arterial stiffness: clinical relevance, measurement and treatment. Clin Sci (Lond) 113, 157–170.
25Millasseau SC, Patel SJ, Redwood SR, et al. . (2003) Pressure wave reflection assessed from the peripheral pulse: is a transfer function necessary? Hypertension 41, 1016–1020.
26Millasseau SC, Kelly RP, Ritter JM, et al. . (2003) The vascular impact of aging and vasoactive drugs: comparison of two digital volume pulse measurements. Am J Hypertens 16, 467–472.
27Williams B, Poulter NR, Brown MJ, et al. . (2004) Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004 – BHS IV. J Hum Hypertens 18, 139–185.
28Pickering TG, Shimbo D & Haas D (2006) Ambulatory blood-pressure monitoring. N Engl J Med 354, 2368–2374.
29Hu FB, Stampfer MJ, Manson JE, et al. . (1997) Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 337, 1491–1499.
30Oh K, Hu FB, Manson JE, et al. . (2005) Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses' Health Study. Am J Epidemiol 161, 672–679.
31Appel LJ, Sacks FM, Carey VJ, et al. . (2005) Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA 294, 2455–2464.
32Rasmussen OW, Thomsen C, Hansen KW, et al. . (1993) Effects on blood pressure, glucose, and lipid levels of a high-monounsaturated fat diet compared with a high-carbohydrate diet in NIDDM subjects. Diabetes Care 16, 1565–1571.
33Shah M, Adams-Huet B, Bantle JP, et al. . (2005) Effect of a high-carbohydrate versus a high-cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes. Diabetes Care 28, 2607–2612.
34Moore TJ, Vollmer WM, Appel LJ, et al. . (1999) Effect of dietary patterns on ambulatory blood pressure: results from the Dietary Approaches to Stop Hypertension (DASH) Trial. Hypertension 34, 472–477.
35Brussaard JH, van Raaij JM, Stasse-Wolthuis M, et al. . (1981) Blood pressure and diet in normotensive volunteers: absence of an effect of dietary fiber, protein, or fat. Am J Clin Nutr 34, 2023–2029.
36Clifton PM, Noakes M & Keogh JB (2004) Very low-fat (12 %) and high monounsaturated fat (35 %) diets do not differentially affect abdominal fat loss in overweight, nondiabetic women. J Nutr 134, 1741–1745.
37Mensink RP, Janssen MC & Katan MB (1988) Effect on blood pressure of two diets differing in total fat but not in saturated and polyunsaturated fatty acids in healthy volunteers. Am J Clin Nutr 47, 976–980.
38Schack-Nielsen L, Molgaard C, Larsen D, et al. . (2005) Arterial stiffness in 10-year-old children: current and early determinants. Br J Nutr 94, 1004–1011.
39Ashton EL, Pomeroy S, Foster JE, et al. . (2000) Diet high in monounsaturated fat does not have a different effect on arterial elasticity than a low-fat, high-carbohydrate diet. J Am Diet Assoc 100, 537–542.
40de Roos NM, Bots ML, Siebelink E, et al. . (2001) Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat. Br J Nutr 86, 181–188.
41Keogh JB, Brinkworth GD, Noakes M, et al. . (2008) Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity. Am J Clin Nutr 87, 567–576.
42Bae JH, Schwemmer M, Lee IK, et al. . (2003) Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. Int J Cardiol 87, 259–267.
43Djousse L, Ellison RC, McLennan CE, et al. . (1999) Acute effects of a high-fat meal with and without red wine on endothelial function in healthy subjects. Am J Cardiol 84, 660–664.
44Ong PJ, Dean TS, Hayward CS, et al. . (1999) Effect of fat and carbohydrate consumption on endothelial function. Lancet 354, 2134.
45Padilla J, Harris RA, Fly AD, et al. . (2006) The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol 98, 256–262.
46Shimabukuro M, Chinen I, Higa N, et al. . (2007) Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr 86, 923–928.
47Skilton MR, Lai NT, Griffiths KA, et al. . (2005) Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow. Am J Physiol Heart Circ Physiol 288, H1404–H1410.
48Steer P, Sarabi DM, Karlstrom B, et al. . (2003) The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans. Clin Sci (Lond) 105, 81–87.
49Tsai WC, Li YH, Lin CC, et al. . (2004) Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci (Lond) 106, 315–319.
50Tushuizen ME, Nieuwland R, Scheffer PG, et al. . (2006) Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men. J Thromb Haemost 4, 1003–1010.
51Westphal S, Taneva E, Kastner S, et al. . (2006) Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal. Atherosclerosis 185, 313–319.
52Williams MJ, Sutherland WH, McCormick MP, et al. . (1999) Impaired endothelial function following a meal rich in used cooking fat. J Am Coll Cardiol 33, 1050–1055.
53Williams MJ, Sutherland WH, McCormick MP, et al. . (2001) Normal endothelial function after meals rich in olive or safflower oil previously used for deep frying. Nutr Metab Cardiovasc Dis 11, 147–152.
54Vogel RA, Corretti MC & Plotnick GD (1997) Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol 79, 350–354.
55Marchesi S, Lupattelli G, Schillaci G, et al. . (2000) Impaired flow-mediated vasoactivity during post-prandial phase in young healthy men. Atherosclerosis 153, 397–402.
56Fard A, Tuck CH, Donis JA, et al. . (2000) Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol 20, 2039–2044.
57Berry SEE, Tucker S, Banerji R, et al. . (2008) Impaired postprandial endothelial function depends on the type of fat consumed by healthy men. J Nutr 138, 1910–1914.
58Cortes B, Nunez I, Cofan M, et al. . (2006) Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. J Am Coll Cardiol 48, 1666–1671.
59de Roos NM, Siebelink E, Bots ML, et al. . (2002) Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation. Eur J Clin Nutr 56, 674–679.
60Nicholls SJ, Lundman P, Harmer JA, et al. . (2006) Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. J Am Coll Cardiol 48, 715–720.
61Raitakari OT, Lai N, Griffiths K, et al. . (2000) Enhanced peripheral vasodilation in humans after a fatty meal. J Am Coll Cardiol 36, 417–422.
62Rueda-Clausen CF, Silva FA, Lindarte MA, et al. . (2007) Olive, soybean and palm oils intake have a similar acute detrimental effect over the endothelial function in healthy young subjects. Nutr Metab Cardiovasc Dis 17, 50–57.
63Vogel RA, Corretti MC & Plotnick GD (2000) The postprandial effect of components of the Mediterranean diet on endothelial function. J Am Coll Cardiol 36, 1455–1460.
64Ling L, Zhao SP, Gao M, et al. . (2002) Vitamin C preserves endothelial function in patients with coronary heart disease after a high-fat meal. Clin Cardiol 25, 219–224.
65Nestel PJ, Shige H, Pomeroy S, et al. . (2001) Post-prandial remnant lipids impair arterial compliance. J Am Coll Cardiol 37, 1929–1935.
66Williams PT, Fortmann SP, Terry RB, et al. . (1987) Associations of dietary fat, regional adiposity, and blood pressure in men. JAMA 257, 3251–3256.
67Salonen JT, Salonen R, Ihanainen M, et al. . (1988) Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr 48, 1226–1232.
68Dauchet L, Kesse-Guyot E, Czernichow S, et al. . (2007) Dietary patterns and blood pressure change over 5-y follow-up in the SU.VI.MAX cohort. Am J Clin Nutr 85, 1650–1656.
69Bingham SA (1991) Limitations of the various methods for collecting dietary intake data. Ann Nutr Metab 35, 117–127.
70Hodson L, Skeaff CM & Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47, 348–380.
71Simon JA, Fong J & Bernert JT Jr (1996) Serum fatty acids and blood pressure. Hypertension 27, 303–307.
72Grimsgaard S, Bonaa KH, Hansen JB, et al. . (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. Am J Clin Nutr 68, 52–59.
73Oster P, Arab L, Schellenberg B, et al. . (1979) Blood pressure and adipose tissue linoleic acid. Res Exp Med (Berl) 175, 287–291.
74Rubba P, Mancini M, Fidanza F, et al. . (1987) Adipose tissue fatty acids and blood pressure in middle-aged men from Southern Italy. Int J Epidemiol 16, 528–531.
75Riemersma RA, Wood DA, Butler S, et al. . (1986) Linoleic acid content in adipose tissue and coronary heart disease. Br Med J (Clin Res Ed) 292, 1423–1427.
76Ciocca S, Arca M, Montali A, et al. . (1987) Lack of association between arterial blood pressure and erythrocyte fatty acid composition in an Italian population sample. Scand J Clin Lab Invest 47, 105–110.
77Zheng ZJ, Folsom AR, Ma J, et al. . (1999) Plasma fatty acid composition and 6-year incidence of hypertension in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 150, 492–500.
78Miettinen TA, Naukkarinen V, Huttunen JK, et al. . (1982) Fatty-acid composition of serum lipids predicts myocardial infarction. Br Med J (Clin Res Ed) 285, 993–996.
79Berry EM & Hirsch J (1986) Does dietary linolenic acid influence blood pressure? Am J Clin Nutr 44, 336–340.
80Cambien F, Warnet JM, Vernier V, et al. . (1988) An epidemiologic appraisal of the associations between the fatty acids esterifying serum cholesterol and some cardiovascular risk factors in middle-aged men. Am J Epidemiol 127, 75–86.
81Miura K, Stamler J, Nakagawa H, et al. . (2008) Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study. Hypertension 52, 408–414.
82Lind L, Sodergren E, Gustafsson IB, et al. . (2002) The types of circulating fatty acids influence vascular reactivity. Lipids 37, 1141–1145.
83Sarabi M, Vessby B, Millgard J, et al. . (2001) Endothelium-dependent vasodilation is related to the fatty acid composition of serum lipids in healthy subjects. Atherosclerosis 156, 349–355.
84Steer P, Vessby B & Lind L (2003) Endothelial vasodilatory function is related to the proportions of saturated fatty acids and α-linolenic acid in young men, but not in women. Eur J Clin Invest 33, 390–396.
85Ascherio A, Rimm EB, Giovannucci EL, et al. . (1992) A prospective study of nutritional factors and hypertension among US men. Circulation 86, 1475–1484.
86Stamler J, Caggiula A, Grandits GA, et al. . (1996) Relationship to blood pressure of combinations of dietary macronutrients. Findings of the Multiple Risk Factor Intervention Trial (MRFIT). Circulation 94, 2417–2423.
87Uusitupa MI, Sarkkinen ES, Torpstrom J, et al. . (1994) Long-term effects of four fat-modified diets on blood pressure. J Hum Hypertens 8, 209–218.
88Iacono JM, Puska P, Dougherty RM, et al. . (1983) Effect of dietary fat on blood pressure in a rural Finnish population. Am J Clin Nutr 38, 860–869.
89Lahoz C, Alonso R, Ordovas JM, et al. . (1997) Effects of dietary fat saturation on eicosanoid production, platelet aggregation and blood pressure. Eur J Clin Invest 27, 780–787.
90Piers LS, Walker KZ, Stoney RM, et al. . (2003) Substitution of saturated with monounsaturated fat in a 4-week diet affects body weight and composition of overweight and obese men. Br J Nutr 90, 717–727.
91Rasmussen BM, Vessby B, Uusitupa M, et al. . (2006) Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects. Am J Clin Nutr 83, 221–226.
92Zock PL, Blijlevens RA, de Vries JH, et al. . (1993) Effects of stearic acid and trans fatty acids versus linoleic acid on blood pressure in normotensive women and men. Eur J Clin Nutr 47, 437–444.
93Sacks FM, Rouse IL, Stampfer MJ, et al. . (1987) Effect of dietary fats and carbohydrate on blood pressure of mildly hypertensive patients. Hypertension 10, 452–460.
94Mutanen M, Kleemola P, Valsta LM, et al. . (1992) Lack of effect on blood pressure by polyunsaturated and monounsaturated fat diets. Eur J Clin Nutr 46, 1–6.
95Mensink RP, Stolwijk AM & Katan MB (1990) Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. Eur J Clin Invest 20, 463–469.
96Aro A, Pietinen P, Valsta LM, et al. . (1998) Lack of effect on blood pressure by low fat diets with different fatty acid compositions. J Hum Hypertens 12, 383–389.
97Sacks FM, Stampfer MJ, Munoz A, et al. . (1987) Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport. J Am Coll Nutr 6, 179–185.
98Thomsen C, Rasmussen OW, Hansen KW, et al. . (1995) Comparison of the effects on the diurnal blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with a diet rich in polyunsaturated fatty acids in type 2 diabetic subjects. Diabet Med 12, 600–606.
99Wendland E, Farmer A, Glasziou P, et al. . (2006) Effect of α linolenic acid on cardiovascular risk markers: a systematic review. Heart 92, 166–169.
100Fuentes F, Lopez-Miranda J, Sanchez E, et al. . (2001) Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med 134, 1115–1119.
101Sanders TA, Lewis F, Frost G, et al. . (2009) Impact of the amount and type of fat and carbohydrate on vascular function in the RISCK study. Proc Nutr Soc 68, .
102Keogh JB, Grieger JA, Noakes M, et al. . (2005) Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet. Arterioscler Thromb Vasc Biol 25, 1274–1279.
103Storm H, Thomsen C, Pedersen E, et al. . (1997) Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. Diabetes Care 20, 1807–1813.
104Berry SE, Miller GJ & Sanders TA (2007) The solid fat content of stearic acid-rich fats determines their postprandial effects. Am J Clin Nutr 85, 1486–1494.
105Katz DL, Nawaz H, Boukhalil J, et al. . (2001) Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am J Prev Med 20, 124–129.
106Plotnick GD, Corretti MC & Vogel RA (1997) Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA 278, 1682–1686.
107Plotnick GD, Corretti MC, Vogel RA, et al. . (2003) Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. J Am Coll Cardiol 41, 1744–1749.
108Esposito K, Nappo F, Giugliano F, et al. . (2003) Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. Am J Clin Nutr 77, 139–143.
109Dokholyan RS, Albert CM, Appel LJ, et al. . (2004) A trial of omega-3 fatty acids for prevention of hypertension. Am J Cardiol 93, 1041–1043.
110Bucher HC, Hengstler P, Schindler C, et al. . (2002) n-3 Polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 112, 298–304.
111Hu FB & Willett WC (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 2569–2578.
112Mori TA (2006) Omega-3 fatty acids and hypertension in humans. Clin Exp Pharmacol Physiol 33, 842–846.
113Ueshima H, Stamler J, Elliott P, et al. . (2007) Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension 50, 313–319.
114Geleijnse JM, Giltay EJ, Grobbee DE, et al. . (2002) Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 20, 1493–1499.
115Theobald HE, Goodall AH, Sattar N, et al. . (2007) Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr 137, 973–978.
116Cazzola R, Russo-Volpe S, Miles EA, et al. . (2007) Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects. Atherosclerosis 193, 159–167.
117Mori TA, Bao DQ, Burke V, et al. . (1999) Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 34, 253–260.
118Hamazaki T, Urakaze M, Sawazaki S, et al. . (1988) Comparison of pulse wave velocity of the aorta between inhabitants of fishing and farming villages in Japan. Atherosclerosis 73, 157–160.
119McVeigh GE, Brennan GM, Cohn JN, et al. . (1994) Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arterioscler Thromb 14, 1425–1429.
120Nestel P, Shige H, Pomeroy S, et al. . (2002) The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 76, 326–330.
121Tomiyama H, Takazawa K, Osa S, et al. . (2005) Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia? A preliminary study. Hypertens Res 28, 651–655.
122Mita T, Watada H, Ogihara T, et al. . (2007) Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis 191, 162–167.
123Mark G & Sanders TA (1994) The influence of different amounts of n-3 polyunsaturated fatty acids on bleeding time and in vivo vascular reactivity. Br J Nutr 71, 43–52.
124Shimokawa H, Aarhus LL & Vanhoutte PM (1988) Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig. Br J Pharmacol 95, 1191–1196.
125Shimokawa H & Vanhoutte PM (1988) Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 78, 1421–1430.
126Leeson CPM, Mann A, Kattenhorn M, et al. . (2002) Relationship between circulating n-3 fatty acid concentrations and endothelial function in early adulthood. Eur Heart J 23, 216–222.
127Lopez-Garcia E, Schulze MB, Manson JE, et al. . (2004) Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr 134, 1806–1811.
128Chin JP, Gust AP, Nestel PJ, et al. . (1993) Marine oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans. Hypertension 21, 22–28.
129Goodfellow J, Bellamy MF, Ramsey MW, et al. . (2000) Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 35, 265–270.
130Khan F, Elherik K, Bolton-Smith C, et al. . (2003) The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res 59, 955–962.
131McVeigh GE, Brennan GM, Johnston GD, et al. . (1993) Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 36, 33–38.
132Mori TA, Watts GF, Burke V, et al. . (2000) Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 102, 1264–1269.
133Shah AP, Ichiuji AM, Han JK, et al. . (2007) Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers. J Cardiovasc Pharmacol Ther 12, 213–219.
134Tagawa H, Shimokawa H, Tagawa T, et al. . (1999) Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease. J Cardiovasc Pharmacol 33, 633–640.
135Tagawa T, Hirooka Y, Shimokawa H, et al. . (2002) Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease. Hypertens Res 25, 823–829.
136Walser B, Giordano RM & Stebbins CL (2006) Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction. Eur J Appl Physiol 97, 347–354.
137Hall WL, Sanders KA, Sanders TA, et al. . (2008) A high-fat meal enriched with eicosapentaenoic acid reduces postprandial arterial stiffness measured by digital volume pulse analysis in healthy men. J Nutr 138, 287–291.
138West SG, Hecker KD, Mustad VA, et al. . (2005) Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia 48, 113–122.
139Hilpert KF, West SG, Kris-Etherton PM, et al. . (2007) Postprandial effect of n-3 polyunsaturated fatty acids on apolipoprotein B-containing lipoproteins and vascular reactivity in type 2 diabetes. Am J Clin Nutr 85, 369–376.
140Armah CK, Jackson KG, Doman I, et al. . (2008) Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci (Lond) 114, 679–686.
141Langley-Evans SC, Clamp AG, Grimble RF, et al. . (1996) Influence of dietary fats upon systolic blood pressure in the rat. Int J Food Sci Nutr 47, 417–425.
142Staiger H, Staiger K, Stefan N, et al. . (2004) Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes 53, 3209–3216.
143Sarafidis PA & Bakris GL (2006) Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance? J Hum Hypertens 21, 12–19.
144Steinberg HO, Paradisi G, Hook G, et al. . (2000) Free fatty acid elevation impairs insulin-mediated vasodilation and NO production. Diabetes 49, 1231–1238.
145Steinberg HO, Tarshoby M, Monestel R, et al. . (1997) Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100, 1230–1239.
146Kim F, Tysseling KA, Rice J, et al. . (2005) Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKβ. Arterioscler Thromb Vasc Biol 25, 989–994.
147Muniyappa R & Quon MJ (2007) Insulin action and insulin resistance in vascular endothelium. Curr Opin Clin Nutr Metab Care 10, 523–530.
148Sainsbury CA, Sattar N, Connell JM, et al. . (2004) Non-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels. Clin Sci (Lond) 107, 625–629.
149Edirisinghe I, McCormick Hallam K & Kappagoda CT (2006) Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta. Clin Sci (Lond) 111, 145–151.
150Anderson RA, Evans LM, Ellis GR, et al. . (2006) Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in type 2 diabetes. Diabet Med 23, 258–264.
151Norata GD, Grigore L, Raselli S, et al. . (2007) Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies. Atherosclerosis 193, 321–327.
152Williams CM, Maitin V & Jackson KG (2004) Triacylglycerol-rich lipoprotein–gene interactions in endothelial cells. Biochem Soc Trans 32, 994–998.
153Nappo F, Esposito K, Cioffi M, et al. . (2002) Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 39, 1145–1150.
154Doi H, Kugiyama K, Ohgushi M, et al. . (1998) Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation. Atherosclerosis 137, 341–349.
155Kugiyama K, Doi H, Motoyama T, et al. . (1998) Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 97, 2519–2526.
156Wheeler-Jones CP (2007) Chylomicron remnants: mediators of endothelial dysfunction? Biochem Soc Trans 35, 442–445.
157Shaw DI, Hall WL, Jeffs NR, et al. . (2007) Comparative effects of fatty acids on endothelial inflammatory gene expression. Eur J Nutr 46, 321–328.
158De Caterina R & Massaro M (2005) Omega-3 fatty acids and the regulation of expression of endothelial pro-atherogenic and pro-inflammatory genes. J Membr Biol 206, 103–116.
159De Caterina R, Cybulsky MI, Clinton SK, et al. . (1994) The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb 14, 1829–1836.
160De Caterina R, Cybulsky MA, Clinton SK, et al. . (1995) Omega-3 fatty acids and endothelial leukocyte adhesion molecules. Prostaglandins Leukot Essent Fatty Acids 52, 191–195.
161Weber C, Erl W, Pietsch A, et al. . (1995) Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-α. Arterioscler Thromb Vasc Biol 15, 622–628.
162Hashimoto M, Hossain S, Yamasaki H, et al. . (1999) Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. Lipids 34, 1297–1304.
163Li Q, Zhang Q, Wang M, et al. . (2007) Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. Arch Biochem Biophys 466, 250–259.
164Chen W, Jump DB, Esselman WJ, et al. . (2007) Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid. Invest Ophthalmol Vis Sci 48, 18–26.
165Li Q, Zhang Q, Wang M, et al. . (2007) Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase. Biochimie 89, 169–177.
166Okuda Y, Kawashima K, Sawada T, et al. . (1997) Eicosapentaenoic acid enhances nitric oxide production by cultured human endothelial cells. Biochem Biophys Res Commun 232, 487–491.
167Omura M, Kobayashi S, Mizukami Y, et al. . (2001) Eicosapentaenoic acid (EPA) induces Ca(2+)-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent vasorelaxation. FEBS Lett 487, 361–366.
168Achard F, Gilbert M, Benistant C, et al. . (1997) Eicosapentaenoic and docosahexaenoic acids reduce PGH synthase 1 expression in bovine aortic endothelial cells. Biochem Biophys Res Commun 241, 513–518.
169Gilbert M, Dalloz S, Maclouf J, et al. . (1999) Differential effects of long chain n-3 fatty acids on the expression of PGH synthase isoforms in bovine aortic endothelial cells. Prostaglandins Leukot Essent Fatty Acids 60, 363–365.
170Abeywardena MY, Fischer S, Schweer H, et al. . (1989) In vivo formation of metabolites of prostaglandins I2 and I3 in the marmoset monkey (Callithrix jacchus) following dietary supplementation with tuna fish oil. Biochim Biophys Acta 1003, 161–166.
171Hishinuma T, Yamazaki T & Mizugaki M (1999) Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. Prostaglandins Other Lipid Mediat 57, 333–340.
172Lauterbach B, Barbosa-Sicard E, Wang MH, et al. . (2002) Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39, 609–613.
173Gao L, Yin H, Milne GL, et al. . (2006) Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. J Biol Chem 281, 14092–14099.
174Henderson L, Gregory J, Irving K, et al. . (2003) The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years. Volume 2: Energy, Protein, Carbohydrate, Fat and Alcohol Intake. London: The Stationery Office.
175Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. London: HM Stationery Office.
176Scientific Advisory Committee on Nutrition & Committee on Toxicity (2004) Advice on Fish Consumption: Benefits and Risks. London: HM Stationery Office.
177O'Brien E, Asmar R, Beilin L, et al. . (2003) European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens 21, 821–848.
178Nielsen S, Hermansen K, Rasmussen OW, et al. . (1995) Urinary albumin excretion rate and 24-h ambulatory blood pressure in NIDDM with microalbuminuria: effects of a monounsaturated-enriched diet. Diabetologia 38, 1069–1075.
179Margetts BM, Beilin LJ, Armstrong BK, et al. . (1985) Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. Clin Sci (Lond) 69, 165–175.
180Puska P, Iacono JM, Nissinen A, et al. . (1985) Dietary fat and blood pressure: an intervention study on the effects of a low-fat diet with two levels of polyunsaturated fat. Prev Med 14, 573–584.
181de Roos NM, Bots ML & Katan MB (2001) Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women. Arterioscler Thromb Vasc Biol 21, 1233–1237.
182Ambring A, Friberg P, Axelsen M, et al. . (2004) Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects. Clin Sci (Lond) 106, 519–525.