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Dietary saturated and unsaturated fats as determinants of blood pressure and vascular function

  • Wendy L. Hall (a1)
  • DOI: http://dx.doi.org/10.1017/S095442240925846X
  • Published online: 01 February 2009
Abstract

The amount and type of dietary fat have long been associated with the risk of CVD. Arterial stiffness and endothelial dysfunction are important risk factors in the aetiology of CHD. A range of methods exists to assess vascular function that may be used in nutritional science, including clinic and ambulatory blood pressure monitoring, pulse wave analysis, pulse wave velocity, flow-mediated dilatation and venous occlusion plethysmography. The present review focuses on the quantity and type of dietary fat and effects on blood pressure, arterial compliance and endothelial function. Concerning fat quantity, the amount of dietary fat consumed habitually appears to have little influence on vascular function independent of fatty acid composition, although single high-fat meals postprandially impair endothelial function compared with low-fat meals. The mechanism is related to increased circulating lipoproteins and NEFA which may induce pro-inflammatory pathways and increase oxidative stress. Regarding the type of fat, cross-sectional data suggest that saturated fat adversely affects vascular function whereas polyunsaturated fat (mainly linoleic acid (18 : 2n-6) and n-3 PUFA) are beneficial. EPA (20 : 5n-3) and DHA (22 : 6n-3) can reduce blood pressure, improve arterial compliance in type 2 diabetics and dyslipidaemics, and augment endothelium-dependent vasodilation. The mechanisms for this vascular protection, and the nature of the separate physiological effects induced by EPA and DHA, are priorities for future research. Since good-quality observational or interventional data on dietary fatty acid composition and vascular function are scarce, no further recommendations can be suggested in addition to current guidelines at the present time.

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Corresponding author: Dr Wendy L. Hall, fax +44 20 7848 4185, email wendy.hall@kcl.ac.uk
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3WB Kannel (1996) Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 275, 15711576.

5J Yeboah , JR Crouse , FC Hsu , . (2007) Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 115, 23902397.

7CR Triggle , M Hollenberg , TJ Anderson , . (2003) The endothelium in health and disease – a target for therapeutic intervention. J Smooth Muscle Res 39, 249267.

8AL Moens , I Goovaerts , MJ Claeys , . (2005) Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 127, 22542263.

9DS Celermajer , KE Sorensen , VM Gooch , . (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340, 11111115.

10S Fichtlscherer , G Rosenberger , DH Walter , . (2000) Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102, 10001006.

11SJ Morris & AC Shore (1996) Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. J Physiol 496, 531542.

12N Gokce , JF Keaney Jr, LM Hunter , . (2003) Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 41, 17691775.

13AE Caballero , S Arora , R Saouaf , . (1999) Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 48, 18561862.

15J Hansell , L Henareh , S Agewall , . (2004) Non-invasive assessment of endothelial function - relation between vasodilatory responses in skin microcirculation and brachial artery. Clin Physiol Funct Imaging 24, 317322.

16T Heitzer , T Schlinzig , K Krohn , . (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104, 26732678.

17WW Nichols (2005) Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertens 18, 3S10S.

18RP Kelly , SC Millasseau , JM Ritter , . (2001) Vasoactive drugs influence aortic augmentation index independently of pulse-wave velocity in healthy men. Hypertension 37, 14291433.

19CM McEniery , S Wallace , IS Mackenzie , . (2006) Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension 48, 602608.

21E Ter Avest , AF Stalenhoef & J de Graaf (2007) What is the role of non-invasive measurements of atherosclerosis in individual cardiovascular risk prediction? Clin Sci (Lond) 112, 507516.

22S Laurent , J Cockcroft , L Van Bortel , . (2006) Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27, 25882605.

26SC Millasseau , RP Kelly , JM Ritter , . (2003) The vascular impact of aging and vasoactive drugs: comparison of two digital volume pulse measurements. Am J Hypertens 16, 467472.

28TG Pickering , D Shimbo & D Haas (2006) Ambulatory blood-pressure monitoring. N Engl J Med 354, 23682374.

29FB Hu , MJ Stampfer , JE Manson , . (1997) Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 337, 14911499.

30K Oh , FB Hu , JE Manson , . (2005) Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses' Health Study. Am J Epidemiol 161, 672679.

31LJ Appel , FM Sacks , VJ Carey , . (2005) Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA 294, 24552464.

32OW Rasmussen , C Thomsen , KW Hansen , . (1993) Effects on blood pressure, glucose, and lipid levels of a high-monounsaturated fat diet compared with a high-carbohydrate diet in NIDDM subjects. Diabetes Care 16, 15651571.

34TJ Moore , WM Vollmer , LJ Appel , . (1999) Effect of dietary patterns on ambulatory blood pressure: results from the Dietary Approaches to Stop Hypertension (DASH) Trial. Hypertension 34, 472477.

39EL Ashton , S Pomeroy , JE Foster , . (2000) Diet high in monounsaturated fat does not have a different effect on arterial elasticity than a low-fat, high-carbohydrate diet. J Am Diet Assoc 100, 537542.

42JH Bae , M Schwemmer , IK Lee , . (2003) Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. Int J Cardiol 87, 259267.

43L Djousse , RC Ellison , CE McLennan , . (1999) Acute effects of a high-fat meal with and without red wine on endothelial function in healthy subjects. Am J Cardiol 84, 660664.

44PJ Ong , TS Dean , CS Hayward , . (1999) Effect of fat and carbohydrate consumption on endothelial function. Lancet 354, 2134.

45J Padilla , RA Harris , AD Fly , . (2006) The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol 98, 256262.

48P Steer , DM Sarabi , B Karlstrom , . (2003) The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans. Clin Sci (Lond) 105, 8187.

49WC Tsai , YH Li , CC Lin , . (2004) Effects of oxidative stress on endothelial function after a high-fat meal. Clin Sci (Lond) 106, 315319.

50ME Tushuizen , R Nieuwland , PG Scheffer , . (2006) Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men. J Thromb Haemost 4, 10031010.

51S Westphal , E Taneva , S Kastner , . (2006) Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal. Atherosclerosis 185, 313319.

52MJ Williams , WH Sutherland , MP McCormick , . (1999) Impaired endothelial function following a meal rich in used cooking fat. J Am Coll Cardiol 33, 10501055.

58B Cortes , I Nunez , M Cofan , . (2006) Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. J Am Coll Cardiol 48, 16661671.

59NM de Roos , E Siebelink , ML Bots , . (2002) Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation. Eur J Clin Nutr 56, 674679.

60SJ Nicholls , P Lundman , JA Harmer , . (2006) Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. J Am Coll Cardiol 48, 715720.

61OT Raitakari , N Lai , K Griffiths , . (2000) Enhanced peripheral vasodilation in humans after a fatty meal. J Am Coll Cardiol 36, 417422.

65PJ Nestel , H Shige , S Pomeroy , . (2001) Post-prandial remnant lipids impair arterial compliance. J Am Coll Cardiol 37, 19291935.

66PT Williams , SP Fortmann , RB Terry , . (1987) Associations of dietary fat, regional adiposity, and blood pressure in men. JAMA 257, 32513256.

69SA Bingham (1991) Limitations of the various methods for collecting dietary intake data. Ann Nutr Metab 35, 117127.

70L Hodson , CM Skeaff & BA Fielding (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47, 348380.

71JA Simon , J Fong & JT Bernert Jr (1996) Serum fatty acids and blood pressure. Hypertension 27, 303307.

73P Oster , L Arab , B Schellenberg , . (1979) Blood pressure and adipose tissue linoleic acid. Res Exp Med (Berl) 175, 287291.

74P Rubba , M Mancini , F Fidanza , . (1987) Adipose tissue fatty acids and blood pressure in middle-aged men from Southern Italy. Int J Epidemiol 16, 528531.

75RA Riemersma , DA Wood , S Butler , . (1986) Linoleic acid content in adipose tissue and coronary heart disease. Br Med J (Clin Res Ed) 292, 14231427.

76S Ciocca , M Arca , A Montali , . (1987) Lack of association between arterial blood pressure and erythrocyte fatty acid composition in an Italian population sample. Scand J Clin Lab Invest 47, 105110.

81K Miura , J Stamler , H Nakagawa , . (2008) Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study. Hypertension 52, 408414.

82L Lind , E Sodergren , IB Gustafsson , . (2002) The types of circulating fatty acids influence vascular reactivity. Lipids 37, 11411145.

85A Ascherio , EB Rimm , EL Giovannucci , . (1992) A prospective study of nutritional factors and hypertension among US men. Circulation 86, 14751484.

89C Lahoz , R Alonso , JM Ordovas , . (1997) Effects of dietary fat saturation on eicosanoid production, platelet aggregation and blood pressure. Eur J Clin Invest 27, 780787.

95RP Mensink , AM Stolwijk & MB Katan (1990) Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. Eur J Clin Invest 20, 463469.

96A Aro , P Pietinen , LM Valsta , . (1998) Lack of effect on blood pressure by low fat diets with different fatty acid compositions. J Hum Hypertens 12, 383389.

97FM Sacks , MJ Stampfer , A Munoz , . (1987) Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport. J Am Coll Nutr 6, 179185.

99E Wendland , A Farmer , P Glasziou , . (2006) Effect of α linolenic acid on cardiovascular risk markers: a systematic review. Heart 92, 166169.

100F Fuentes , J Lopez-Miranda , E Sanchez , . (2001) Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med 134, 11151119.

102JB Keogh , JA Grieger , M Noakes , . (2005) Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet. Arterioscler Thromb Vasc Biol 25, 12741279.

105DL Katz , H Nawaz , J Boukhalil , . (2001) Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am J Prev Med 20, 124129.

106GD Plotnick , MC Corretti & RA Vogel (1997) Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA 278, 16821686.

109RS Dokholyan , CM Albert , LJ Appel , . (2004) A trial of omega-3 fatty acids for prevention of hypertension. Am J Cardiol 93, 10411043.

111FB Hu & WC Willett (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 25692578.

112TA Mori (2006) Omega-3 fatty acids and hypertension in humans. Clin Exp Pharmacol Physiol 33, 842846.

113H Ueshima , J Stamler , P Elliott , . (2007) Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. Hypertension 50, 313319.

114JM Geleijnse , EJ Giltay , DE Grobbee , . (2002) Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 20, 14931499.

117TA Mori , DQ Bao , V Burke , . (1999) Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 34, 253260.

118T Hamazaki , M Urakaze , S Sawazaki , . (1988) Comparison of pulse wave velocity of the aorta between inhabitants of fishing and farming villages in Japan. Atherosclerosis 73, 157160.

119GE McVeigh , GM Brennan , JN Cohn , . (1994) Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. Arterioscler Thromb 14, 14251429.

121H Tomiyama , K Takazawa , S Osa , . (2005) Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia? A preliminary study. Hypertens Res 28, 651655.

122T Mita , H Watada , T Ogihara , . (2007) Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis 191, 162167.

124H Shimokawa , LL Aarhus & PM Vanhoutte (1988) Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig. Br J Pharmacol 95, 11911196.

125H Shimokawa & PM Vanhoutte (1988) Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries. Circulation 78, 14211430.

126CPM Leeson , A Mann , M Kattenhorn , . (2002) Relationship between circulating n-3 fatty acid concentrations and endothelial function in early adulthood. Eur Heart J 23, 216222.

128JP Chin , AP Gust , PJ Nestel , . (1993) Marine oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans. Hypertension 21, 2228.

129J Goodfellow , MF Bellamy , MW Ramsey , . (2000) Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 35, 265270.

132TA Mori , GF Watts , V Burke , . (2000) Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 102, 12641269.

134H Tagawa , H Shimokawa , T Tagawa , . (1999) Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease. J Cardiovasc Pharmacol 33, 633640.

135T Tagawa , Y Hirooka , H Shimokawa , . (2002) Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease. Hypertens Res 25, 823829.

136B Walser , RM Giordano & CL Stebbins (2006) Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction. Eur J Appl Physiol 97, 347354.

138SG West , KD Hecker , VA Mustad , . (2005) Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia 48, 113122.

142H Staiger , K Staiger , N Stefan , . (2004) Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes 53, 32093216.

144HO Steinberg , G Paradisi , G Hook , . (2000) Free fatty acid elevation impairs insulin-mediated vasodilation and NO production. Diabetes 49, 12311238.

145HO Steinberg , M Tarshoby , R Monestel , . (1997) Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100, 12301239.

146F Kim , KA Tysseling , J Rice , . (2005) Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKβ. Arterioscler Thromb Vasc Biol 25, 989994.

147R Muniyappa & MJ Quon (2007) Insulin action and insulin resistance in vascular endothelium. Curr Opin Clin Nutr Metab Care 10, 523530.

148CA Sainsbury , N Sattar , JM Connell , . (2004) Non-esterified fatty acids impair endothelium-dependent vasodilation in rat mesenteric resistance vessels. Clin Sci (Lond) 107, 625629.

149I Edirisinghe , Hallam K McCormick & CT Kappagoda (2006) Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta. Clin Sci (Lond) 111, 145151.

150RA Anderson , LM Evans , GR Ellis , . (2006) Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in type 2 diabetes. Diabet Med 23, 258264.

151GD Norata , L Grigore , S Raselli , . (2007) Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies. Atherosclerosis 193, 321327.

152CM Williams , V Maitin & KG Jackson (2004) Triacylglycerol-rich lipoprotein–gene interactions in endothelial cells. Biochem Soc Trans 32, 994998.

153F Nappo , K Esposito , M Cioffi , . (2002) Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 39, 11451150.

154H Doi , K Kugiyama , M Ohgushi , . (1998) Remnants of chylomicron and very low density lipoprotein impair endothelium-dependent vasorelaxation. Atherosclerosis 137, 341349.

155K Kugiyama , H Doi , T Motoyama , . (1998) Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 97, 25192526.

157DI Shaw , WL Hall , NR Jeffs , . (2007) Comparative effects of fatty acids on endothelial inflammatory gene expression. Eur J Nutr 46, 321328.

159R De Caterina , MI Cybulsky , SK Clinton , . (1994) The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler Thromb 14, 18291836.

160R De Caterina , MA Cybulsky , SK Clinton , . (1995) Omega-3 fatty acids and endothelial leukocyte adhesion molecules. Prostaglandins Leukot Essent Fatty Acids 52, 191195.

161C Weber , W Erl , A Pietsch , . (1995) Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-α. Arterioscler Thromb Vasc Biol 15, 622628.

163Q Li , Q Zhang , M Wang , . (2007) Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. Arch Biochem Biophys 466, 250259.

165Q Li , Q Zhang , M Wang , . (2007) Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase. Biochimie 89, 169177.

166Y Okuda , K Kawashima , T Sawada , . (1997) Eicosapentaenoic acid enhances nitric oxide production by cultured human endothelial cells. Biochem Biophys Res Commun 232, 487491.

167M Omura , S Kobayashi , Y Mizukami , . (2001) Eicosapentaenoic acid (EPA) induces Ca(2+)-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent vasorelaxation. FEBS Lett 487, 361366.

168F Achard , M Gilbert , C Benistant , . (1997) Eicosapentaenoic and docosahexaenoic acids reduce PGH synthase 1 expression in bovine aortic endothelial cells. Biochem Biophys Res Commun 241, 513518.

170MY Abeywardena , S Fischer , H Schweer , . (1989) In vivo formation of metabolites of prostaglandins I2 and I3 in the marmoset monkey (Callithrix jacchus) following dietary supplementation with tuna fish oil. Biochim Biophys Acta 1003, 161166.

171T Hishinuma , T Yamazaki & M Mizugaki (1999) Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. Prostaglandins Other Lipid Mediat 57, 333340.

172B Lauterbach , E Barbosa-Sicard , MH Wang , . (2002) Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39, 609613.

177E O'Brien , R Asmar , L Beilin , . (2003) European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens 21, 821848.

178S Nielsen , K Hermansen , OW Rasmussen , . (1995) Urinary albumin excretion rate and 24-h ambulatory blood pressure in NIDDM with microalbuminuria: effects of a monounsaturated-enriched diet. Diabetologia 38, 10691075.

179BM Margetts , LJ Beilin , BK Armstrong , . (1985) Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. Clin Sci (Lond) 69, 165175.

180P Puska , JM Iacono , A Nissinen , . (1985) Dietary fat and blood pressure: an intervention study on the effects of a low-fat diet with two levels of polyunsaturated fat. Prev Med 14, 573584.

181NM de Roos , ML Bots & MB Katan (2001) Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women. Arterioscler Thromb Vasc Biol 21, 12331237.

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