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Nutrition Research Reviews Nutrition Research Reviews

Article contents

High-fat diet-induced obesity in animal models

Published online by Cambridge University Press:  27 October 2010

Niloofar Hariri  and
Louise Thibault
Niloofar Hariri
Affiliation:
School of Dietetics and Human Nutrition, McGill University, Quebec, Canada
Louise Thibault*
Affiliation:
School of Dietetics and Human Nutrition, McGill University, Quebec, Canada
*
*Corresponding author: Dr Louise Thibault, fax +1 514 398 7739, email louise.thibault@mcgill.ca
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Abstract

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Epidemiological studies have shown a positive relationship between dietary fat intake and obesity. Since rats and mice show a similar relationship, they are considered an appropriate model for studying dietary obesity. The present paper describes the history of using high-fat diets to induce obesity in animals, aims to clarify the consequences of changing the amount and type of dietary fats on weight gain, body composition and adipose tissue cellularity, and explores the contribution of genetics and sex, as well as the biochemical basis and the roles of hormones such as leptin, insulin and ghrelin in animal models of dietary obesity. The major factors that contribute to dietary obesity – hyperphagia, energy density and post-ingestive effects of the dietary fat – are discussed. Other factors that affect dietary obesity including feeding rhythmicity, social factors and stress are highlighted. Finally, we comment on the reversibility of high-fat diet-induced obesity.

Keywords

Dietary obesityRatsMiceHigh-fat diet
Type
Review Article
Information
Nutrition Research Reviews , Volume 23 , Issue 2 , December 2010 , pp. 270 - 299
Copyright
Copyright © The Authors 2010

References

1World Health Organization (2005) Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/index.html.Google Scholar
2Ichihara, S & Yamada, Y (2008) Genetic factors for human obesity. Cell Mol Life Sci 65, 1086–1098.CrossRefGoogle ScholarPubMed
3Bouchard, C & Tremblay, A (1997) Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins. J Nutr 127, 943S–947S.CrossRefGoogle ScholarPubMed
4Farooqi, IS & O'Rahilly, S (2005) New advances in the genetics of early onset obesity. Int J Obes 29, 1149–1152.CrossRefGoogle ScholarPubMed
5De Castro, JM (2004) Genes, the environment and the control of food intake. Br J Nutr 92, S59–S62.CrossRefGoogle ScholarPubMed
6Martínez-Hernandez, A, Enríquez, LM, Moreno-Moreno, MJ, et al. . (2007) Genetics of obesity. Public Health Nutr 10, 1138–1144.CrossRefGoogle Scholar
7Reuter, TY (2007) Diet-induced models for obesity and type 2 diabetes. Drug Discov Today Dis Models 4, 3–8.CrossRefGoogle Scholar
8Speakman, J, Hambly, C, Mitchell, S, et al. . (2007) Animal models of obesity. Obes Rev 8, 55–61.CrossRefGoogle ScholarPubMed
9James, WPT (2008) The epidemiology of obesity: the size of the problem. J Intern Med 263, 336–352.CrossRefGoogle Scholar
10Jequier, E (2002) Pathways to obesity. Int J Obes 26, S12–S17.CrossRefGoogle ScholarPubMed
11Rosengren, A & Lissner, L (2008) The sociology of obesity. In Obesity and Metabolism, pp. 260–270 [Rosengren, A and Lissner, L, editors]. Basel: Karger.CrossRefGoogle Scholar
12Hill, JO, Melanson, EL & Wyatt, HT (2000) Dietary fat intake and regulation of energy balance: implications for obesity. J Nutr 130, 284S–288S.CrossRefGoogle ScholarPubMed
13French, S & Robinson, T (2003) Fats and food intake. Curr Opin Clin Nutr Metab Care 6, 629–634.CrossRefGoogle ScholarPubMed
14Bray, GA & Popkin, BM (1998) Dietary fat intake does affect obesity. Am J Clin Nutr 68, 1157–1173.CrossRefGoogle ScholarPubMed
15Schrauwen, P & Westerterp, KR (2000) The role of high-fat diets and physical activity in the regulation of body weight. Br J Nutr 84, 417–427.CrossRefGoogle ScholarPubMed
16George, V, Tremblay, A, Despres, JP, et al. . (1990) Effect of dietary fat content on total and regional adiposity in men and women. Int J Obes 14, 1085–1094.Google ScholarPubMed
17Popkin, BM, Keyou, G, Fengying, Z, et al. . (1993) The nutrition transition in China: a cross-sectional analysis. Eur J Clin Nutr 47, 333–346.Google ScholarPubMed
18Saris, WHM, Astrup, A, Prentice, AM, et al. . (2000) Randomized controlled trial of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates on body weight and blood lipids: The CARMEN study. The Carbohydrate Ratio Management in European National diets. Int J Obes 24, 1310–1318.CrossRefGoogle Scholar
19Tucker, LA & Kano, MJ (1992) Dietary fat and body fat: a multivariate study of 205 adult females. Am J Clin Nutr 56, 616–622.CrossRefGoogle ScholarPubMed
20Rothwell, NJ & Stock, MJ (1984) The development of obesity in animals – the role of dietary factors. Clin Endocrinol Metab 13, 437–449.CrossRefGoogle ScholarPubMed
21Buettner, R, Scholmerich, J & Bollheimer, LC (2007) High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity 15, 798–808.CrossRefGoogle ScholarPubMed
22Warwick, ZS & Schiffman, SS (1992) Role of dietary fat in calorie intake and weight gain. Neurosci Biobehav Rev 16, 585–596.CrossRefGoogle ScholarPubMed
23Boozer, CN, Schoenbach, G & Atkinson, RL (1995) Dietary fat and adiposity – a dose–response relationship in adult male rats fed isocalorically. Am J Physiol Endocrinol Metab 268, E546–E550.CrossRefGoogle ScholarPubMed
24Ghibaudi, L, Cook, J, Farley, C, et al. . (2002) Fat intake affects adiposity, comorbidity factors, and energy metabolism of Sprague–Dawley rats. Obes Res 10, 956–963.CrossRefGoogle ScholarPubMed
25Bourgeois, F, Alexiu, A & Lemonnier, D (1983) Dietary-induced obesity: effect of dietary fats on adipose tissue cellularity in mice. Br J Nutr 49, 17–26.CrossRefGoogle ScholarPubMed
26Takahashi, M, Ikemoto, S & Ezaki, O (1999) Effect of the fat/carbohydrate ratio in the diet on obesity and oral glucose tolerance in C57BL/6J mice. J Nutr Sci Vitaminol (Tokyo) 45, 583–593.CrossRefGoogle ScholarPubMed
27Deuel, HJ Jr, Movitt, E, Hallman, LF, et al. . (1944) Studies of the comparative nutritive value of fats: I. Growth rate and efficiency of conversion of various diets to tissue. J Nutr 27, 107–121.CrossRefGoogle Scholar
28Deuel, HJ Jr, Meserve, ER, Straub, E, et al. . (1947) The effect of fat level of the diet on general nutrition: I. Growth, reproduction and physical capacity of rats receiving diets containing various levels of cottonseed oil or margarine fat ad libitum. J Nutr 33, 569–582.CrossRefGoogle ScholarPubMed
29Ingle, D (1949) A simple means of producing obesity in the rat. Proc Soc Exp Biol Med 72, 604–605.CrossRefGoogle ScholarPubMed
30Fenton, PF & Dowling, MT (1953) Studies on obesity. 1. Nutritional obesity in mice. J Nutr 49, 319–331.CrossRefGoogle Scholar
31Sclafani, A & Springer, D (1976) Dietary obesity in adult rats – similarities to hypothalamic and human obesity syndromes. Physiol Behav 17, 461–471.CrossRefGoogle ScholarPubMed
32Hebert, JR, Patterson, RE, Gorfine, M, et al. . (2003) Differences between estimated caloric requirements and self-reported caloric intake in the Women's Health Initiative. Ann Epidemiol 13, 629–637.CrossRefGoogle ScholarPubMed
33Poppitt, SD, Swann, D, Black, AE, et al. . (1998) Assessment of selective under-reporting of food intake by both obese and non-obese women in a metabolic facility. Int J Obes 22, 303–311.CrossRefGoogle Scholar
34Voss, S, Kroke, A, Klipstein-Grobusch, K, et al. . (1998) Is macronutrient composition of dietary intake data affected by underreporting? Results from the EPIC-Potsdam Study. Eur J Clin Nutr 52, 119–126.CrossRefGoogle ScholarPubMed
35Thibault, L, Woods, SC & Westerterp-Plantenga, MS (2004) The utility of animal models of human energy homeostasis. Br J Nutr 92, S41–S45.CrossRefGoogle ScholarPubMed
36Young, GS & Kirkland, JB (2007) Rat models of caloric intake and activity: relationships to animal physiology and human health. Appl Physiol Nutr Metab 32, 161–176.CrossRefGoogle ScholarPubMed
37Mickelsen, O, Takahashi, S & Craig, C (1955) Experimental obesity. 1. Production of obesity in rats by feeding high-fat diets. J Nutr 57, 541–554.CrossRefGoogle Scholar
38Oscai, LB (1982) Dietary-induced severe obesity – a rat model. Am J Physiol 242, R212–R215.Google ScholarPubMed
39Ainslie, DA, Proietto, J, Fam, BC, et al. . (2000) Short-term, high-fat diets lower circulating leptin concentrations in rats. Am J Clin Nutr 71, 438–442.CrossRefGoogle ScholarPubMed
40Chang, S, Graham, B, Yakubu, F, et al. . (1990) Metabolic differences between obesity-prone and obesity-resistant rats. Am J Physiol 259, R1103–R1110.Google ScholarPubMed
41Harrold, JA, Williams, G & Widdowson, PS (2000) Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus. J Neurochem 74, 1224–1228.CrossRefGoogle ScholarPubMed
42Woods, SC, Seeley, RJ, Rushing, PA, et al. . (2003) A controlled high-fat diet induces an obese syndrome in rats. J Nutr 133, 1081–1087.CrossRefGoogle ScholarPubMed
43Yaqoob, P, Sherrington, EJ, Jeffery, NM, et al. . (1995) Comparison of the effects of a range of dietary lipds upon serum and tissue lipid composition in the rat. Int J Biochem Cell Biol 27, 297–310.CrossRefGoogle Scholar
44Sclafani, A & Gorman, AN (1977) Effects of age, sex, and prior body weight on the development of dietary obesity in adult rats. Physiol Behav 18, 1021–1026.CrossRefGoogle ScholarPubMed
45Schemmel, R, Mickelsen, O & Tolgay, Z (1969) Dietary obesity in rats: influence of diet, weight, age, and sex on body composition. Am J Physiol 216, 373–379.Google ScholarPubMed
46Levin, BE & Dunn-Meynell, AA (2002) Reduced central leptin sensitivity in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 283, R941–R948.CrossRefGoogle ScholarPubMed
47Bell, RR, Spencer, MJ & Sherriff, JL (1997) Voluntary exercise and monounsaturated canola oil reduce fat gain in mice fed diets high in fat. J Nutr 127, 2006–2010.CrossRefGoogle Scholar
48Cunnane, SC, McAdoo, KR & Horrobin, DF (1986) n-3 Essential fatty acids decrease weight gain in genetically obese mice. Br J Nutr 56, 87–95.CrossRefGoogle ScholarPubMed
49Herberg, L, Doppen, W, Major, E, et al. . (1974) Dietary-induced hypertrophic–hyperplastic obesity in mice. J Lipid Res 15, 580–585.Google ScholarPubMed
50Lemonnier, D, Suquet, JP, Aubert, R, et al. . (1975) Metabolism of mouse made obese by a high-fat diet. Diabetes Metab 1, 77–85.Google ScholarPubMed
51Huang, XF, Xin, X, McLennan, P, et al. . (2004) Role of fat amount and type in ameliorating diet-induced obesity: insights at the level of hypothalamic arcuate nucleus leptin receptor, neuropeptide Y and pro-opiomelanocortin mRNA expression. Diabetes Obes Metab 6, 35–44.CrossRefGoogle ScholarPubMed
52Ikemoto, S, Takahashi, M, Tsunoda, N, et al. . (1996) High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils. Metab Clin Exp 45, 1539–1546.CrossRefGoogle ScholarPubMed
53Ellis, J, Lake, A & Hoover-Plow, J (2002) Monounsaturated canola oil reduces fat deposition in growing female rats fed a high or low fat diet. Nutr Res 22, 609–621.CrossRefGoogle Scholar
54Lissner, L, Heitmann, BL & Bengtsson, C (2000) Population studies of diet and obesity. Br J Nutr 83, S21–S24.CrossRefGoogle ScholarPubMed
55Gray-Donald, K, Jacobs-Starkey, L & Johnson-Down, L (2000) Food habits of Canadians: reduction in fat intake over a generation. Can J Public Health 91, 381–385.Google ScholarPubMed
56Moussavi, N, Gavino, V & Receveur, O (2008) Could the quality of dietary fat, and not just its quantity, be related to risk of obesity? Obesity 16, 7–15.CrossRefGoogle Scholar
57DeLany, JP, Windhauser, MM, Champagne, CM, et al. . (2000) Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 72, 905–911.CrossRefGoogle ScholarPubMed
58Kien, CL, Bunn, JY & Ugrasbul, F (2005) Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr 82, 320–326.CrossRefGoogle ScholarPubMed
59Storlien, LH, Huang, XF, Lin, S, et al. . (2001) Dietary fat subtypes and obesity. World Rev Nutr Diet 88, 148–154.CrossRefGoogle ScholarPubMed
60Wang, H, Storlien, LH & Huang, XF (2002) Effects of dietary fat types on body fatness, leptin, and Arc leptin receptor, NPY, and AgRP mRNA expression. Am J Physiol Endocrinol Metab 282, E1352–E1359.CrossRefGoogle ScholarPubMed
61Okere, IC, Chandler, MP, McElfresh, TA, et al. . (2006) Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. Am J Physiol Heart Circ Physiol 291, H38–H44.CrossRefGoogle ScholarPubMed
62Cha, MC & Jones, PJH (1998) Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats. J Lipid Res 39, 1655–1660.Google ScholarPubMed
63Hill, JO, Peters, JC, Lin, D, et al. . (1993) Lipid accumulation and body fat distribution is influenced by type of dietary fat fed to rats. Int J Obes 17, 223–236.Google ScholarPubMed
64Jones, PJH, Toy, BR & Cha, MC (1995) Differential fatty acid accretion in heart, liver and adipose tissues of rats fed beef tallow, fish-oil, olive oil and safflower oils at 3 levels of energy-intake. J Nutr 125, 1175–1182.Google Scholar
65Okuno, M, Kajiwara, K, Imai, S, et al. . (1997) Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. J Nutr 127, 1752–1757.CrossRefGoogle ScholarPubMed
66Su, W & Jones, PJH (1993) Dietary fatty acid composition influences energy accretion in rats. J Nutr 123, 2109–2114.Google ScholarPubMed
67Preiss-Landl, K, Zimmermann, R, Hämmerle, G, et al. . (2002) Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Curr Opin Lipidol 13, 471–481.CrossRefGoogle ScholarPubMed
68Westerterp-Plantenga, MS (2004) Fat intake and energy balance effects. Physiol Behav 83, 579–585.CrossRefGoogle ScholarPubMed
69Blundell, JE & Macdiarmid, JI (1997) Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating. J Am Diet Assoc 97, S63–S69.CrossRefGoogle ScholarPubMed
70Golay, A & Bobbioni, E (1997) The role of dietary fat in obesity. Int J Obes 21, S2–S11.Google ScholarPubMed
71Rolls, BJ (2000) The role of energy density in the overconsumption of fat. J Nutr 130, 268S–271S.CrossRefGoogle ScholarPubMed
72Poppitt, SD & Prentice, AM (1996) Energy density and its role in the control of food intake: evidence from metabolic and community studies. Appetite 26, 153–174.CrossRefGoogle ScholarPubMed
73Skelton, JA, DeMattia, L, Miller, L, et al. . (2006) Obesity and its therapy: from genes to community action. Pediatr Clin North Am 53, 777–794.CrossRefGoogle ScholarPubMed
74Kiess, W, Petzold, S, Topfer, M, et al. . (2008) Adipocytes and adipose tissue. Best Pract Res Clin Endocrinol Metab 22, 135–153.CrossRefGoogle ScholarPubMed
75Kershaw, EE & Flier, JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89, 2548–2556.CrossRefGoogle ScholarPubMed
76Sorisky, A (1999) From preadipocyte to adipocyte: differentiation-directed signals of insulin from the cell surface to the nucleus. Crit Rev Clin Lab Sci 36, 1–34.CrossRefGoogle ScholarPubMed
77de Ferranti, S & Mozaffarian, D (2008) The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 54, 945–955.CrossRefGoogle ScholarPubMed
78Avram, MM, Avram, AS & James, WD (2005) Subcutaneous fat in normal and diseased states – 1. Introduction. J Am Acad Dermatol 53, 663–670.CrossRefGoogle ScholarPubMed
79Hirsch, J & Han, PW (1969) Cellularity of rat adipose tissue – effects of growth starvation and obesity. J Lipid Res 10, 77–82.Google ScholarPubMed
80Greenwood, M & Hirsch, J (1974) Postnatal development of adipocyte cellularity in normal rat. J Lipid Res 15, 474–483.Google ScholarPubMed
81Prins, JB & Orahilly, S (1997) Regulation of adipose cell number in man. Clin Sci 92, 3–11.CrossRefGoogle ScholarPubMed
82Levin, BE & Dunn-Meynell, AA (2002) Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 282, R46–R54.CrossRefGoogle ScholarPubMed
83Lee, MO (1929) Determination of the surface area of the white rat with its application to the expression of metabolic results. Am J Physiol 89, 24–33.Google Scholar
84Li, XL, Wu, GH, Xie, L, et al. . (2004) Experimental study on the obesity rat model induced by vitamin D. Chin J Clin Rehab 8, 1786–1787.Google Scholar
85Sun, Z, Zhang, ZC & Liu, ZC (2002) Experimental study of diet-induced obesity animal model. Chin Pharmacol Bull 18, 466–467.Google Scholar
86Kanarek, RB & Markskaufman, R (1979) Developmental aspects of sucrose-induced obesity in rats. Physiol Behav 23, 881–885.CrossRefGoogle ScholarPubMed
87Li, H, Matheny, M, Nicolson, M, et al. . (1997) Leptin gene expression increases with age independent of increasing adiposity in rats. Diabetes 46, 2035–2039.CrossRefGoogle ScholarPubMed
88Stephens, DN (1980) Does the Lee obesity index measure general obesity? Physiol Behav 25, 313–315.CrossRefGoogle ScholarPubMed
89Bernardis, LL (1970) Sex and age differences in hyperthermia response to ether anesthesia in weanling rats with ventromedial hypothalamic lesions. Experientia 26, 1322–1324.CrossRefGoogle Scholar
90Bernardis, LL & Patterson, BD (1968) Correlation between ‘Lee index’ and carcass fat content in weanling and adult female rats with hypothalamic lesions. J Endocrinol 40, 527–528.CrossRefGoogle ScholarPubMed
91Rogers, P & Webb, GP (1980) Estimation of body fat in normal and obese mice. Br J Nutr 43, 83–86.CrossRefGoogle ScholarPubMed
92Lindsay, RS, Hanson, RL, Roumain, J, et al. . (2001) Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy X-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 86, 4061–4067.CrossRefGoogle ScholarPubMed
93Tzotzas, T, Krassas, GE & Doumas, A (2008) Body composition analysis in obesity: radionuclide and non radionuclide methods. Hell J Nucl Med 11, 63–71.Google ScholarPubMed
94Holemans, K, Caluwaerts, S, Poston, L, et al. . (2004) Diet-induced obesity in the rat: a model for gestational diabetes mellitus. Am J Obstet Gynecol 190, 858–865.CrossRefGoogle ScholarPubMed
95Tulipano, G, Vergoni, AV, Soldi, D, et al. . (2004) Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet. J Endocrinol 183, 289–298.CrossRefGoogle ScholarPubMed
96Dourmashkin, JT, Chang, GQ, Hill, JO, et al. . (2006) Model for predicting and phenotyping at normal weight the long-term propensity for obesity in Sprague–Dawley rats. Physiol Behav 87, 666–678.CrossRefGoogle ScholarPubMed
97Dourmashkin, JT, Chang, GQ, Gayles, EC, et al. . (2005) Different forms of obesity as a function of diet composition. Int J Obes 29, 1368–1378.CrossRefGoogle ScholarPubMed
98Hassanain, M & Levin, BE (2002) Dysregulation of hypothalamic serotonin turnover in diet-induced obese rats. Brain Res 929, 175–180.CrossRefGoogle ScholarPubMed
99Michel, C, Levin, BE & Dunn-Meynell, AA (2003) Stress facilitates body weight gain in genetically predisposed rats on medium-fat diet. Am J Physiol Regul Integr Comp Physiol 285, R791–R799.CrossRefGoogle ScholarPubMed
100Lissner, L, Levitsky, DA, Strupp, BJ, et al. . (1987) Dietary fat and the regulation of energy intake in human subjects. Am J Clin Nutr 46, 886–892.CrossRefGoogle ScholarPubMed
101Bartness, TJ, Polk, DR, McGriff, WR, et al. . (1992) Reversal of high-fat diet-induced obesity in female rats. Am J Physiol 263, R790–R797.Google ScholarPubMed
102Jen, KLC, Buison, A, Pellizzon, M, et al. . (2003) Differential effects of fatty acids and exercise on body weight regulation and metabolism in female wistar rats. Exp Biol Med 228, 843–849.CrossRefGoogle ScholarPubMed
103Faust, IM, Johnson, PR, Stern, JS, et al. . (1978) Diet-induced adipocyte number increase in adult rats – new model of obesity. Am J Physiol 235, E279–E286.Google ScholarPubMed
104Loh, MY, Flatt, WP, Martin, RJ, et al. . (1998) Dietary fat type and level influence adiposity development in obese but not lean Zucker rats. Proc Soc Exp Biol Med 218, 38–44.CrossRefGoogle Scholar
105Rolland, V, Roseau, S, Fromentin, G, et al. . (2002) Body weight, body composition, and energy metabolism in lean and obese Zucker rats fed soybean oil or butter. Am J Clin Nutr 75, 21–30.CrossRefGoogle ScholarPubMed
106Wade, GN (1982) Obesity without overeating in golden hamsters. Physiol Behav 29, 701–707.CrossRefGoogle ScholarPubMed
107Pichon, L, Huneau, JF, Fromentin, G, et al. . (2006) A high-protein, high-fat, carbohydrate-free diet reduces energy intake, hepatic lipogenesis, and adiposity in rats. J Nutr 136, 1256–1260.CrossRefGoogle ScholarPubMed
108Sinitskaya, N, Gourmelen, S, Schuster-Klein, C, et al. . (2007) Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. Clin Sci 113, 417–425.CrossRefGoogle Scholar
109Weigle, DS, Breen, PA, Matthys, CC, et al. . (2005) A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr 82, 41–48.CrossRefGoogle ScholarPubMed
110Potier, M, Darcel, N & Tome, D (2009) Protein, amino acids and the control of food intake. Curr Opin Clin Nutr Metab Care 12, 54–58.CrossRefGoogle ScholarPubMed
111Blom, WAM, Lluch, A, Stafleu, A, et al. . (2006) Effect of a high-protein breakfast on the postprandial ghrelin response. Am J Clin Nutr 83, 211–220.CrossRefGoogle ScholarPubMed
112Saris, WHM (2006) Macronutrient intake balance and the problem of obesity – old recipes and some new spices. Aktuel Ernahr Med 31, S49–S54.CrossRefGoogle Scholar
113Morrison, CD, Xi, X, White, CL, et al. . (2007) Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. Am J Physiol Endocrinol Metab 293, E165–E171.CrossRefGoogle ScholarPubMed
114Huang, XF, Liu, YX, Rahardjo, GL, et al. . (2008) Effects of diets high in whey, soy, red meat and milk protein on body weight maintenance in diet-induced obesity in mice. Nutr Diet 65, S53–S59.CrossRefGoogle Scholar
115Ailhaud, G, Massiera, F, Weill, P, et al. . (2006) Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog Lipid Res 45, 203–236.CrossRefGoogle ScholarPubMed
116Clarke, SD (2000) Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. Br J Nutr 83, S59–S66.CrossRefGoogle ScholarPubMed
117Lawton, GL, Delargy, HJ, Brockman, J, et al. . (2000) The degree of saturation of fatty acids influences post-ingestive satiety. Br J Nutr 83, 473–482.Google ScholarPubMed
118Lichtenbelt, WDV, Mensink, RP & Westerterp, KR (1997) The effect of fat composition of the diet on energy metabolism. Z Ernahrungswiss 36, 303–305.CrossRefGoogle Scholar
119Piers, LS, Walker, KZ, Stoney, RM, et al. . (2003) Substitution of saturated with monounsaturated fat in a 4-week diet affects body weight and composition of overweight and obese men. Br J Nutr 90, 717–727.CrossRefGoogle Scholar
120Shillabeer, G & Lau, DCW (1994) Regulation of new fat-cell formation in rats – the role of dietary fats. J Lipid Res 35, 592–600.Google ScholarPubMed
121Silva, APS, Guimaraes, DED, Mizurini, DM, et al. . (2006) Dietary fatty acids early in life affect lipid metabolism and adiposity in young rats. Lipids 41, 535–541.CrossRefGoogle ScholarPubMed
122Takeuchi, H, Matsuo, T, Tokuyama, K, et al. . (1995) Diet-induced thermogenesis is lower in rats fed a lard diet than in those fed a high-oleic acid safflower oil diet, a safflower oil diet or a linseed oil diet. J Nutr 125, 920–925.Google ScholarPubMed
123Casas-Agustench, P, Lopez-Uriarte, P, Bullo, M, et al. . (2009) Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Clin Nutr 28, 39–45.CrossRefGoogle ScholarPubMed
124Piers, LS, Walker, KZ, Stoney, RM, et al. . (2002) The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream). Int J Obes 26, 814–821.CrossRefGoogle Scholar
125Soares, MJ, Cummings, SJ, Mamo, JCL, et al. . (2004) The acute effects of olive oil v. cream on postprandial thermogenesis and substrate oxidation in postmenopausal women. Br J Nutr 91, 245–252.CrossRefGoogle ScholarPubMed
126Beardshall, K, Morarji, Y, Bloom, SR, et al. . (1989) Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. Lancet ii, 1008–1010.CrossRefGoogle Scholar
127Alfenas, RCG & Mattes, RD (2003) Effect of fat sources on satiety. Obes Res 11, 183–187.CrossRefGoogle ScholarPubMed
128George, J, Mulkins, M, Casey, S, et al. . (2000) The effects of n-6 polyunsaturated fatty acid supplementation on the lipid composition and atherogenesis in mouse models of atherosclerosis. Atherosclerosis 150, 285–293.CrossRefGoogle ScholarPubMed
129Nagao, K & Yanagita, T (2008) Bioactive lipids in metabolic syndrome. Prog Lipid Res 47, 127–146.CrossRefGoogle ScholarPubMed
130Takeuchi, H, Sekine, S, Kojima, K, et al. . (2008) The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation. Asia Pac J Clin Nutr 17, 320–323.Google ScholarPubMed
131Simón, E, Fernández-Quintela, A, Del Puy Portillo, M, et al. . (2000) Effects of medium-chain fatty acids on body composition and protein metabolism in overweight rats. J Physiol Biochem 56, 337–346.CrossRefGoogle ScholarPubMed
132Takeuchi, H, Noguchi, O, Sekine, S, et al. . (2006) Lower weight gain and higher expression and blood levels of adiponectin in rats fed medium-chain TAG compared with long-chain TAG. Lipids 41, 207–212.CrossRefGoogle ScholarPubMed
133Bray, GA, Lee, M & Bray, TL (1980) Weight gain of rats fed medium-chain triglycerides is less than rats fed long-chain triglycerides. Int J Obes 4, 27–32.Google ScholarPubMed
134Hwang, SG, Yano, H & Kawashima, R (1992) The influence of dietary medium and long chain triglycerides on growth performances and fat deposition in growing rats. J Nutr Sci Vitaminol 38, 127–139.CrossRefGoogle ScholarPubMed
135Noguchi, O, Takeuchi, H, Kubota, F, et al. . (2002) Larger diet-induced thermogenesis and less body fat accumulation in rats fed medium-chain triacylglycerols than in those fed long-chain triacylglycerols. J Nutr Sci Vitaminol 48, 524–529.CrossRefGoogle ScholarPubMed
136Stubbs, RJ & Harbron, CG (1996) Covert manipulation of the ratio of medium- to long-chain triglycerides in isoenergetically dense diets: effect on food intake in ad libitum feeding men. Int J Obes 20, 435–444.Google ScholarPubMed
137Tsuji, H, Kasai, M, Takeuchi, H, et al. . (2001) Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. J Nutr 131, 2853–2859.CrossRefGoogle Scholar
138Garaulet, M, Perez-Llamas, F, Perez-Ayala, M, et al. . (2001) Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am J Clin Nutr 74, 585–591.CrossRefGoogle Scholar
139Nogi, A, Yang, JJ, Li, LM, et al. . (2007) Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workers. J Occup Health 49, 205–216.CrossRefGoogle ScholarPubMed
140Simopoulos, AP (2004) Omega-6/omega-3 essential fatty acid ratio and chronic diseases. Food Rev Int 20, 77–90.CrossRefGoogle Scholar
141Kennedy, A, Martinez, K, Schmidt, S, et al. . (2010) Antiobesity mechanisms of action of conjugated linoleic acid. J Nutr Biochem 21, 171–179.CrossRefGoogle ScholarPubMed
142Park, Y (2009) Conjugated linoleic acid (CLA): good or bad trans fat? J Food Comp Anal 22, Suppl. 1, S4–S12.CrossRefGoogle Scholar
143Moon, HS, Lee, HG, Seo, JH, et al. . (2009) Antiobesity effect of ??pegylated conjugated linoleic acid on high-fat diet-induced obese C57BL/6J (ob/ob) mice: attenuation of insulin resistance and enhancement of antioxidant defenses. J Nutr Biochem 20, 187–194.CrossRefGoogle ScholarPubMed
144Parra, P, Palou, A & Serra, F (2010) Moderate doses of conjugated linoleic acid reduce fat gain, maintain insulin sensitivity without impairing inflammatory adipose tissue status in mice fed a high fat diet. Nutr Metab 7, 5.CrossRefGoogle ScholarPubMed
145Norris, LE, Collene, AL, Asp, ML, et al. . (2009) Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. Am J Clin Nutr 90, 468–476.CrossRefGoogle ScholarPubMed
146Sahin, H, Uyanik, F & Inanc, N (2008) Effects of conjugated linoleic acid on body composition and selected biochemical parameters in obese women. Pak J Nutr 7, 546–549.CrossRefGoogle Scholar
147Halade, GV, Rahman, MM & Fernandes, G (2010) Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57BL/6J mice. J Nutr Biochem 21, 332–337.CrossRefGoogle ScholarPubMed
148Ingelsson, E & Risérus, U (2008) Effects of trans10cis 12CLA-induced insulin resistance on retinol-binding protein 4 concentrations in abdominally obese men. Diabetes Res Clin Pract 82, e23–e24.CrossRefGoogle ScholarPubMed
149Van Nieuwenhuyzen, W & Adelmann, R (2007) Multipurpose functions of MCT oils – medium chain triglycerides have unique functions. Agro Food Ind Hi-Tech 18, 34–36.Google Scholar
150Prpic, V, Watson, PM, Frampton, IC, et al. . (2002) Adaptive changes in adipocyte gene expression differ in AKR/J and SWR/J mice during diet-induced obesity. J Nutr 132, 3325–3332.CrossRefGoogle ScholarPubMed
151Roberts, CK, Berger, JJ & Barnard, RJ (2002) Long-term effects of diet on leptin, energy intake, and activity in a model of diet-induced obesity. J Appl Physiol 93, 887–893.CrossRefGoogle Scholar
152Drewnowski, A (2003) The role of energy density. Lipids 38, 109–115.CrossRefGoogle ScholarPubMed
153Rolls, BJ, Bell, EA, Castellanos, VH, et al. . (1999) Energy density but not fat content of foods affected energy in lean and obese women. Am J Clin Nutr 69, 863–871.CrossRefGoogle Scholar
154Westerterp-Plantenga, MS (2004) Effects of energy density of daily food intake on long-term energy intake. Physiol Behav 81, 765–771.CrossRefGoogle ScholarPubMed
155Rolls, BJ & Bell, EA (1999) Intake of fat and carbohydrate: role of energy density. Eur J Clin Nutr 53, S166–S173.CrossRefGoogle ScholarPubMed
156Stubbs, RJ & Whybrow, S (2004) Energy density, diet composition and palatability: influences on overall food energy intake in humans. Physiol Behav 81, 755–764.CrossRefGoogle ScholarPubMed
157Institute for Laboratory Animal Research (1995) The Nutritional Requirements of Rats, 4th revised ed.Washington, DC: National Academies Press.Google Scholar
158Blundell, JE, Lawton, CL, Cotton, JR, et al. . (1996) Control of human appetite: implications for the intake of dietary fat. Annu Rev Nutr 16, 285–319.CrossRefGoogle ScholarPubMed
159Lucas, F, Ackroff, K & Sclafani, A (1998) High-fat diet preference and overeating mediated by postingestive factors in rats. Am J Physiol Regul Integr Comp Physiol 275, R1511–R1522.CrossRefGoogle ScholarPubMed
160Warwick, ZS & Weingarten, HP (1995) Determinants of high-fat diet hyperphagia – experimental dissection of orosensory and postingestive effects. Am J Physiol Regul Integr Comp Physiol 269, R30–R37.CrossRefGoogle ScholarPubMed
161Covasa, M & Ritter, RC (2000) Adaptation to high-fat diet reduces inhibition of gastric emptying by CCK and intestinal oleate. Am J Physiol Regul Integr Comp Physiol 278, R166–R170.CrossRefGoogle ScholarPubMed
162Little, TJ, Horowitz, M & Feinle-Bisset, C (2007) Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity. Am J Clin Nutr 86, 531–541.CrossRefGoogle ScholarPubMed
163Scharrer, E (1999) Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 15, 704–714.CrossRefGoogle ScholarPubMed
164Kahler, A, Zimmermann, M & Langhans, W (1999) Suppression of hepatic fatty acid oxidation and food intake in men. Nutrition 15, 819–828.CrossRefGoogle ScholarPubMed
165Tso, P & Liu, M (2004) Apolipoprotein A-IV, food intake, and obesity. Physiol Behav 83, 631–643.CrossRefGoogle ScholarPubMed
166Woods, SC, D'Alessio, DA, Tso, P, et al. . (2004) Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiol Behav 83, 573–578.CrossRefGoogle ScholarPubMed
167Coll, AP, Farooqi, IS & O'Rahilly, S (2007) The hormonal control of food intake. Cell 129, 251–262.CrossRefGoogle ScholarPubMed
168Crowell, MD, Decker, GA, Levy, R, et al. . (2006) Gut–brain neuropeptides in the regulation of ingestive behaviors and obesity. Am J Gastroenterol 101, 2848–2856.CrossRefGoogle ScholarPubMed
169Gale, SM, Castracane, VD & Mantzoros, CS (2004) Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. J Nutr 134, 295–298.CrossRefGoogle ScholarPubMed
170Zhang, YY, Proenca, R, Maffei, M, et al. . (1994) Positional cloning of the mouse obese gene and its human homolog. Nature 372, 425–432.CrossRefGoogle Scholar
171Lin, S, Storlien, LH & Huang, XF (2000) Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res 875, 89–95.CrossRefGoogle ScholarPubMed
172MacDougald, OA, Hwang, CS, Fan, H, et al. . (1995) Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 92, 9034–9037.CrossRefGoogle ScholarPubMed
173Pelleymounter, MA, Cullen, MJ, Baker, MB, et al. . (1995) Effects of the obese gene-product on body-weight regulation in ob/ob mice. Science 269, 540–543.CrossRefGoogle ScholarPubMed
174Halaas, JL, Gajiwala, KS, Maffei, M, et al. . (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543–546.CrossRefGoogle ScholarPubMed
175Randeva, HS, Karteris, E, Lewandowski, KC, et al. . (2003) Circadian rhythmicity of salivary leptin in healthy subjects. Mol Genet Metab 78, 229–235.CrossRefGoogle ScholarPubMed
176Saad, MF, Riad-Gabriel, MG, Khan, A, et al. . (1998) Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. J Clin Endocrinol Metab 83, 453–459.Google ScholarPubMed
177Poppitt, SD, Leahy, E, Keogh, GF, et al. . (2006) Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men. Eur J Clin Nutr 60, 77–84.CrossRefGoogle ScholarPubMed
178Bodosi, B, Gardi, J, Hajdu, I, et al. . (2004) Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol Regulat Integr Comp Physiol 287, R1071–R1079.CrossRefGoogle ScholarPubMed
179Chacon, F, Esquifino, AI, Perello, M, et al. . (2005) 24-Hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction. Chronobiol Int 22, 253–265.CrossRefGoogle ScholarPubMed
180Frederich, RC, Hamann, A, Anderson, S, et al. . (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1, 1311–1314.CrossRefGoogle ScholarPubMed
181Leibowitz, SF, Chang, GQ, Dourmashkin, JT, et al. . (2006) Leptin secretion after a high-fat meal in normal-weight rats: strong predictor of long-term body fat accrual on a high-fat diet. Am J Physiol Endocrinol Metab 290, E258–E267.CrossRefGoogle ScholarPubMed
182Lin, L, Martin, R, Schaffhauser, AO, et al. . (2001) Acute changes in the response to peripheral leptin with alteration in the diet composition. Am J Physiol Regul Integr Comp Physiol 280, R504–R509.CrossRefGoogle ScholarPubMed
183Surwit, RS & Collins, S (2001) Revisiting lessons from the C57BL/6J mouse. Am J Physiol Endocrinol Metab 280, E825–E826.CrossRefGoogle ScholarPubMed
184Levin, BE, Dunn-Meynell, AA, Ricci, MR, et al. . (2003) Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. Am J Physiol Endocrinol Metab 285, E949–E957.CrossRefGoogle ScholarPubMed
185Fam, BC, Morris, MJ, Hansen, MJ, et al. . (2007) Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity. Diabetes Obes Metab 9, 840–852.CrossRefGoogle Scholar
186Lin, S, Thomas, TC, Storlien, LH, et al. . (2000) Development of high fat diet-induced obesity and leptin resistance in C57B1/6J mice. Int J Obes 24, 639–646.CrossRefGoogle Scholar
187Hynes, GR, Heshka, J, Chadee, K, et al. . (2003) Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats. J Lipid Res 44, 893–901.CrossRefGoogle ScholarPubMed
188Jang, IS, Hwang, DY, Chae, KR, et al. . (2003) Role of dietary fat type in the development of adiposity from dietary obesity-susceptible Sprague–Dawley rats. Br J Nutr 89, 429–437.CrossRefGoogle ScholarPubMed
189Kojima, M, Hosoda, H, Date, Y, et al. . (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660.CrossRefGoogle ScholarPubMed
190Cummings, DE, Purnell, JQ, Frayo, RS, et al. . (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714–1719.CrossRefGoogle ScholarPubMed
191Tschop, M, Smiley, DL & Heiman, ML (2000) Ghrelin induces adiposity in rodents. Nature 407, 908–913.CrossRefGoogle ScholarPubMed
192Natalucci, G, Riedl, S, Gleiss, A, et al. . (2005) Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol 152, 845–850.CrossRefGoogle ScholarPubMed
193English, PJ, Ghatei, MA, Malik, IA, et al. . (2002) Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 87, 2984–2987.CrossRefGoogle ScholarPubMed
194Marzullo, P, Verti, B, Savia, G, et al. . (2004) The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure. J Clin Endocrinol Metab 89, 936–939.CrossRefGoogle ScholarPubMed
195Reinehr, T, Roth, CL, Alexy, U, et al. . (2005) Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents. Int J Obes 29, 362–368.CrossRefGoogle ScholarPubMed
196le Roux, CW, Patterson, M, Vincent, RP, et al. . (2005) Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab 90, 1068–1071.CrossRefGoogle Scholar
197Tentolouris, N, Kokkinos, A, Tsigos, C, et al. . (2004) Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active ghrelin concentrations in lean and obese women. Horm Metab Res 36, 559–563.CrossRefGoogle ScholarPubMed
198Lithander, FE, Keogh, GF, Wang, Y, et al. . (2008) No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks. Obesity 16, 592–599.CrossRefGoogle ScholarPubMed
199Sanchez, J, Oliver, P, Pico, C, et al. . (2004) Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats. Pflugers Arch 448, 500–506.CrossRefGoogle ScholarPubMed
200Moesgaard, SG, Ahren, B, Carr, RD, et al. . (2004) Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach. Regul Pept 120, 261–267.CrossRefGoogle ScholarPubMed
201Perreault, M, Istrate, N, Wang, L, et al. . (2004) Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss. Int J Obes 28, 879–885.CrossRefGoogle ScholarPubMed
202Liu, X, York, DA & Bray, GA (2004) Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of rats. Peptides 25, 2171–2177.CrossRefGoogle ScholarPubMed
203Beck, B, Musse, N & Stricker-Krongrad, A (2002) Ghrelin, macronutrient intake and dietary preferences in Long–Evans rats. Biochem Biophys Res Commun 292, 1031–1035.CrossRefGoogle ScholarPubMed
204Greeley, GH, Reed, JT, Qi, X, et al. . (2007) Increased adiposity during high fat diet does not participate in suppression of stomach ghrelin production and secretion. Gastroenterology 132, A586.Google Scholar
205Overduin, J, Frayo, RS, Grill, HJ, et al. . (2005) Role of the duodenum and macronutrient type in ghrelin regulation. Endocrinology 146, 845–850.CrossRefGoogle ScholarPubMed
206Sánchez, J, Cladera, MM, Llopis, M, et al. . (2010) The different satiating capacity of CHO and fats can be mediated by different effects on leptin and ghrelin systems. Behav Brain Res 124, 183–188.CrossRefGoogle Scholar
207Lichtenstein, AH & Schwab, US (2000) Relationship of dietary fat to glucose metabolism. Atherosclerosis 150, 227–243.CrossRefGoogle ScholarPubMed
208Riccardi, G, Giacco, R & Rivellese, AA (2004) Dietary fat, insulin sensitivity and the metabolic syndrome. Clin Nutr 23, 447–456.CrossRefGoogle ScholarPubMed
209Bray, GA, Lovejoy, JC, Smith, SR, et al. . (2002) The influence of different fats and fatty acids on obesity, insulin resistance and inflammation. J Nutr 132, 2488–2491.CrossRefGoogle ScholarPubMed
210Lovejoy, JC, Champagne, CM, Smith, SR, et al. . (2001) Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance. Metab Clin Exp 50, 86–92.CrossRefGoogle ScholarPubMed
211Vessby, B, Uusitupa, M, Hermansen, K, et al. . (2001) Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study. Diabetologia 44, 312–319.CrossRefGoogle ScholarPubMed
212Barnard, RJ, Roberts, CK, Varon, SM, et al. . (1998) Diet-induced insulin resistance precedes other aspects of the metabolic syndrome. J Appl Physiol 84, 1311–1315.CrossRefGoogle ScholarPubMed
213Storlien, LH, Higgins, JA, Thomas, TC, et al. . (2000) Diet composition and insulin action in animal models. Br J Nutr 83, S85–S90.CrossRefGoogle ScholarPubMed
214Tsitouras, PD, Gucciardo, F, Salbe, AD, et al. . (2008) High omega-3 fat intake improves insulin sensitivity and reduces CRP and IL6, but does not affect other endocrine axes in healthy older adults. Horm Metab Res 40, 199–205.CrossRefGoogle Scholar
215Lombardo, YB, Hein, G & Chicco, A (2007) Metabolic syndrome: effects of n-3 PUFAs on a model of dyslipidemia, insulin resistance and adiposity. Lipids 42, 427–437.CrossRefGoogle ScholarPubMed
216Toschke, AM, Kuchenhoff, H, Koletzko, B, et al. . (2005) Meal frequency and childhood obesity. Obes Res 13, 1932–1938.CrossRefGoogle ScholarPubMed
217Ma, YS, Bertone, ER, Stanek, EJ, et al. . (2003) Association between eating patterns and obesity in a free-living US adult population. Am J Epidemiol 158, 85–92.CrossRefGoogle Scholar
218De Castro, JM (1995) Social facilitation of food intake in humans. Appetite 24, 260.CrossRefGoogle ScholarPubMed
219Herman, CP, Roth, DA & Polivy, J (2003) Effects of the presence of others on food intake: a normative interpretation. Psychol Bull 129, 873–886.CrossRefGoogle ScholarPubMed
220Redd, M & De Castro, JM (1992) Social facilitation of eating: effects of social instruction on food intake. Physiol Behav 52, 749–754.CrossRefGoogle ScholarPubMed
221Brown, KJ & Grunberg, NE (1996) Effects of environmental conditions on food consumption in female and male rats. Physiol Behav 60, 293–297.CrossRefGoogle ScholarPubMed
222Feunekes, GIJ, De Graaf, C & Van Staveren, WA (1995) Social facilitation of food intake is mediated by meal duration. Physiol Behav 58, 551–558.CrossRefGoogle ScholarPubMed
223Lopak, V & Eikelboom, R (2000) Pair housing induced feeding suppression: individual housing not novelty. Physiol Behav 71, 329–333.CrossRefGoogle Scholar
224Lopak, V & Eikelboom, R (2004) Modulation of the pair housing induced feeding suppression. Physiol Behav 83, 157–164.CrossRefGoogle ScholarPubMed
225O'Connor, R & Eikelboom, R (2000) The effects of changes in housing on feeding and wheel running. Physiol Behav 68, 361–371.CrossRefGoogle ScholarPubMed
226Perez, C, Canal, JR, Dominguez, E, et al. . (1997) Individual housing influences certain biochemical parameters in the rat. Lab Anim 31, 357–361.CrossRefGoogle ScholarPubMed
227Scalera, G (1992) Taste preferences, body weight gain, food and fluid intake in singly or group-housed rats. Physiol Behav 52, 935–943.CrossRefGoogle ScholarPubMed
228Sclafani, A & Springer, D (1976) Dietary obesity in adult rats – similarities to hypothalamic and human obesity syndromes. Physiol Behav 17, 461–471.CrossRefGoogle ScholarPubMed
229Dallman, MF, La Fleur, SE, Pecoraro, NC, et al. . (2004) Minireview: glucocorticoids – food intake, abdominal obesity, and wealthy nations in 2004. Endocrinology 145, 2633–2638.CrossRefGoogle ScholarPubMed
230Dallman, MF, Pecoraro, N, Akana, SF, et al. . (2003) Chronic stress and obesity: a new view of ‘comfort food’. Proc Natl Acad Sci U S A 100, 11696–11701.CrossRefGoogle Scholar
231Torres, SJ & Nowson, CA (2007) Relationship between stress, eating behavior, and obesity. Nutrition 23, 887–894.CrossRefGoogle ScholarPubMed
232Yeomans, MR, Blundell, JE & Leshem, M (2004) Palatability: response to nutritional need or need-free stimulation of appetite? Br J Nutr 92, S3–S14.CrossRefGoogle ScholarPubMed
233Yamaguchi, S & Ninomiya, K (2000) Umami and food palatability. J Nutr 130, 921S–926S.CrossRefGoogle ScholarPubMed
234Swinburn, BA & Ravussin, E (1994) Energy and macronutrient metabolism. Baillieres Clin Endocrinol Metab 8, 527–548.CrossRefGoogle ScholarPubMed
235LeBlanc, J & Labrie, A (1997) A possible role for palatability of the food in diet-induced thermogenesis. Int J Obes 21, 1100–1103.CrossRefGoogle ScholarPubMed
236Holt, SHA, Delargy, HJ, Lawton, CL, et al. . (1999) The effects of high-carbohydrate vs high-fat breakfasts on feelings of fullness and alertness, and subsequent food intake. Int J Food Sci Nutr 50, 13–28.CrossRefGoogle ScholarPubMed
237Sclafani, A (2001) Post-ingestive positive controls of ingestive behavior. Appetite 36, 79–83.CrossRefGoogle ScholarPubMed
238Warwick, ZS, Schiffman, SS & Anderson, JJB (1990) Relationship of dietary fat content to food preferences in young rats. Physiol Behav 48, 581–586.CrossRefGoogle ScholarPubMed
239Fushiki, T & Kawai, T (2005) Chemical reception of fats in the oral cavity and the mechanism of addiction to dietary fat. Chem Senses 30, i184–i185.CrossRefGoogle ScholarPubMed
240Mizushige, T, Inoue, K & Fushiki, T (2007) Why is fat so tasty? Chemical reception of fatty acid on the tongue. J Nutr Sci Vitaminol 53, 1–4.CrossRefGoogle Scholar
241Gilbertson, TA, Fontenot, DT, Liu, LD, et al. . (1997) Fatty acid modulation of K+ channels in taste receptor cells: gustatory cues for dietary fat. Am J Physiol Cell Physiol 272, C1203–C1210.CrossRefGoogle ScholarPubMed
242Mattes, RD (2005) Fat taste and lipid metabolism in humans. Physiol Behav 86, 691–697.CrossRefGoogle ScholarPubMed
243Fabry, P, Hejda, S, Cerny, K, et al. . (1966) Effect of meal frequency in schoolchildren. Changes in weight-height proportion and skinfold thickness. Am J Clin Nutr 18, 358–361.CrossRefGoogle ScholarPubMed
244Bertéus Forslund, H, Lindroos, AK, Sjöström, L, et al. . (2002) Meal patterns and obesity in Swedish women – a simple instrument describing usual meal types, frequency and temporal distribution. Eur J Clin Nutr 56, 740–747.CrossRefGoogle ScholarPubMed
245Andersson, I & Rössner, S (1996) Meal patterns in obese and normal weight men: the ‘Gustaf’ study. Eur J Clin Nutr 50, 639–646.Google ScholarPubMed
246Qin, LQ, Li, J, Wang, Y, et al. . (2003) The effects of nocturnal life on endocrine circadian patterns in healthy adults. Life Sci 73, 2467–2475.CrossRefGoogle ScholarPubMed
247Kant, AK, Schatzkin, A & Ballard-Barbash, R (1997) Evening eating and subsequent long-term weight change in a national cohort. Int J Obes 21, 407–412.CrossRefGoogle Scholar
248Taylor, E, Missik, E, Hurley, R, et al. . (2004) Obesity treatment: broadening our perspective. Am J Health Behav 28, 242–249.CrossRefGoogle ScholarPubMed
249Bellisle, F (2004) Impact of the daily meal pattern on energy balance. Scand J Nutr Naringsforsk 48, 114–118.CrossRefGoogle Scholar
250LeMagnen, J & Devos, M (1970) Metabolic correlates of meal onset in free food intake of rats. Physiol Behav 5, 805–814.CrossRefGoogle Scholar
251Clifton, PG (2000) Meal patterning in rodents: psychopharmacological and neuroanatomical studies. Neurosci Biobehav Rev 24, 213–222.CrossRefGoogle ScholarPubMed
252Prins, AA, Dejongnagelsmit, A, Keijser, J, et al. . (1986) Daily rhythms of feeding in the genetically-obese and lean Zucker rats. Physiol Behav 38, 423–426.CrossRefGoogle Scholar
253LeMagnen, J (1988) Lipogenesis, lipolysis and feeding rhythms. Ann Endocrinol (Paris) 49, 98–104.Google Scholar
254Becker, EE & Grinker, JA (1977) Meal patterns in genetically obese Zucker rat. Physiol Behav 18, 685–692.CrossRefGoogle ScholarPubMed
255Fukagawa, K, Sakata, T, Yoshimatsu, H, et al. . (1992) Advance shift of feeding circadian-rhythm induced by obesity progression in Zucker rats. Am J Physiol 263, R1169–R1175.Google ScholarPubMed
256Ho, A & Chin, A (1988) Circadian feeding and drinking patterns of genetically-obese mice fed solid chow diet. Physiol Behav 43, 651–656.CrossRefGoogle ScholarPubMed
257Strohmayer, AJ & Smith, GP (1987) The meal pattern of genetically-obese (ob ob) mice. Appetite 8, 111–123.CrossRefGoogle ScholarPubMed
258Drewnowski, A, Cohen, AE, Faust, IM, et al. . (1984) Meal-taking behavior is related to predisposition to dietary obesity in the rat. Physiol Behav 32, 61–67.CrossRefGoogle ScholarPubMed
259Farley, C, Cook, JA, Spar, BD, et al. . (2003) Meal pattern analysis of diet-induced obesity in susceptible and resistant rats. Obes Res 11, 845–851.CrossRefGoogle ScholarPubMed
260Cottone, P, Sabino, V, Nagy, TR, et al. . (2007) Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2. J Physiol (London) 583, 487–504.CrossRefGoogle ScholarPubMed
261Paulino, G, Darcel, N, Tome, D, et al. . (2008) Adaptation of lipid-induced satiation is not dependent on caloric density in rats. Physiol Behav 93, 930–936.CrossRefGoogle Scholar
262Synowski, SJ, Smart, AB & Warwick, ZS (2005) Meal size of high-fat food is reliably greater than high-carbohydrate food across externally-evoked single-meal tests and long-term spontaneous feeding in rat. Appetite 45, 191–194.CrossRefGoogle ScholarPubMed
263Mistlberger, RE, Lukman, H & Nadeau, BG (1998) Circadian rhythms in the Zucker obese rat: assessment and intervention. Appetite 30, 255–267.CrossRefGoogle ScholarPubMed
264Thibault, L & Booth, DA (1999) Macronutrient-specific dietary selection in rodents and its neural bases. Neurosci Biobehav Rev 23, 457–528.CrossRefGoogle ScholarPubMed
265Branth, S, Ronquist, G, Stridsberg, M, et al. . (2007) Development of abdominal fat and incipient metabolic syndrome in young healthy men exposed to long-term stress. Nutr Metab Cardiovasc Dis 17, 427–435.CrossRefGoogle ScholarPubMed
266Laitinen, J, Ek, E & Sovio, U (2002) Stress-related eating and drinking behavior and body mass index and predictors of this behavior. Prev Med 34, 29–39.CrossRefGoogle ScholarPubMed
267Rivenes, AC, Harvey, SB & Mykletun, A (2009) The relationship between abdominal fat, obesity, and common mental disorders: results from the HUNT Study. J Psychosom Res 66, 269–275.CrossRefGoogle ScholarPubMed
268Zhao, G, Ford, ES, Dhingra, S, et al. . (2009) Depression and anxiety among US adults: associations with body mass index. Int J Obes 33, 257–266.CrossRefGoogle ScholarPubMed
269Allison, DB, Newcomer, JW, Dunn, AL, et al. . (2009) Obesity among those with mental disorders. A National Institute of Mental Health meeting report. Am J Prev Med 36, 341–350.CrossRefGoogle ScholarPubMed
270Pecoraro, N, Reyes, F, Gomez, F, et al. . (2004) Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. Endocrinology 145, 3754–3762.CrossRefGoogle ScholarPubMed
271Oliver, G & Wardle, J (1999) Perceived effects of stress on food choice. Physiol Behav 66, 511–515.CrossRefGoogle ScholarPubMed
272Levin, BE, Richard, D, Michel, C, et al. . (2000) Differential stress responsivity in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 279, R1357–R1364.CrossRefGoogle ScholarPubMed
273Marti, O, Marti, J & Armario, A (1994) Effects of chronic stress on food intake in rats: influence of stressor intensity and duration of daily exposure. Physiol Behav 55, 747–753.CrossRefGoogle ScholarPubMed
274Rowland, NE & Antelman, SM (1976) Stress-induced hyperphagia and obesity in rats: a possible model for understanding human obesity. Science 191, 310–312.CrossRefGoogle ScholarPubMed
275Legendre, A & Harris, RBS (2006) Exaggerated response to mild stress in rats fed high-fat diet. Am J Physiol Regul Integr Comp Physiol 291, R1288–R1294.CrossRefGoogle ScholarPubMed
276Tamashiro, KLK, Hegeman, MA & Sakai, RR (2006) Chronic social stress in a changing dietary environment. Physiol Behav 89, 536–542.CrossRefGoogle Scholar
277Teegarden, SL & Bale, TL (2008) Effects of stress on dietary preference and intake are dependent on access and stress sensitivity. Physiol Behav 93, 713–723.CrossRefGoogle ScholarPubMed
278Adam, TC & Epel, ES (2007) Stress, eating and the reward system. Physiol Behav 91, 449–458.CrossRefGoogle ScholarPubMed
279Ochi, M, Tominaga, K, Tanaka, F, et al. . (2008) Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats. Life Sci 82, 862–868.CrossRefGoogle ScholarPubMed
280Kristenssson, E, Sundqvist, M, Astin, M, et al. . (2006) Acute psychological stress raises plasma ghrelin in the rat. Regul Pept 134, 114–117.CrossRefGoogle ScholarPubMed
281Karnehed, N, Tynelius, P, Heitmann, BL, et al. . (2006) Physical activity, diet and gene–environment interactions in relation to body mass index and waist circumference: the Swedish Young Male Twins Study. Public Health Nutr 9, 851–858.CrossRefGoogle ScholarPubMed
282Marrades, MP, Martinez, JA & Moreno-Aliaga, MJ (2007) Differences in short-term metabolic responses to a lipid load in lean (resistant) vs obese (susceptible) young male subjects with habitual high-fat consumption. Eur J Clin Nutr 61, 166–174.CrossRefGoogle ScholarPubMed
283Speechly, DP & Buffenstein, R (2000) Appetite dysfunction in obese males: evidence for role of hyperinsulinaemia in passive overconsumption with a high fat diet. Eur J Clin Nutr 54, 225–233.CrossRefGoogle ScholarPubMed
284Levin, BE, Dunn-Meynell, AA, McMinn, JE, et al. . (2003) A new obesity-prone, glucose-intolerant rat strain (f.Dio). Am J Physiol Regul Integr Comp Physiol 285, R1184–R1191.CrossRefGoogle Scholar
285Commerford, SR, Pagliassotti, MJ, Melby, CL, et al. . (2000) Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats. Am J Physiol Endocrinol Metab 279, E875–E885.CrossRefGoogle ScholarPubMed
286Commerford, SR, Pagliassotti, MJ, Melby, CL, et al. . (2001) Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 280, R1680–R1687.CrossRefGoogle Scholar
287Abdoulaye, D, Wetzler, S, Goubern, M, et al. . (2006) Comparison of energy balance in two inbred strains of rats: Fischer F344 prone to obesity and Lou rats resistant to obesity. Physiol Behav 87, 245–250.CrossRefGoogle ScholarPubMed
288Levin, BE & Dunn-Meynell, AA (2000) Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats. Am J Physiol Regul Integr Comp Physiol 278, R231–R237.CrossRefGoogle ScholarPubMed
289Jackman, MR, Kramer, RE, MacLean, PS, et al. . (2006) Trafficking of dietary fat in obesity-prone and obesity-resistant rats. Am J Physiol-Endocrinol Metab 291, E1083–E1091.CrossRefGoogle ScholarPubMed
290Pagliassotti, MJ, Knobel, SM, Shahrokhi, KA, et al. . (1994) Time-course of adaptation to a high-fat diet in obesity-resistant and obesity-prone rats. Am J Physiol 267, R659–R664.Google ScholarPubMed
291Levin, BE & Dunn-Meynell, AA (1997) Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet- induced obese rats. Am J Physiol Regul Integr Comp Physiol 272, R1365–R1370.CrossRefGoogle ScholarPubMed
292Levin, BE (1995) Reduced norepinephrine turnover in organs and brains of obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 268, R389–R394.CrossRefGoogle ScholarPubMed
293Blaak, E (2001) Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 4, 499–502.CrossRefGoogle ScholarPubMed
294Power, ML & Schulkin, J (2008) Sex differences in fat storage, fat metabolism, and the health risks from obesity: possible evolutionary origins. Br J Nutr 99, 931–940.CrossRefGoogle ScholarPubMed
295Sweeting, HN (2008) Gendered dimensions of obesity in childhood and adolescence. Nutr J (epublication 14 January 2008).CrossRefGoogle ScholarPubMed
296Geary, N (2004) Is the control of fat ingestion sexually differentiated? Physiol Behav 83, 659–671.CrossRefGoogle ScholarPubMed
297Charles River Laboratories (2006) Research models and services. http://www.criver.com/flex_content_area/documents/rm_rm_c_sprague_dawley_rats.pdf (accessed February 2009).Google Scholar
298Mayes, JS & Watson, GH (2004) Direct effect of sex steroid hormones on adipose tissues and obesity. Obes Rev 5, 197–216.CrossRefGoogle Scholar
299Rodríguez, AM, Quevedo-Coli, S, Roca, P, et al. . (2001) Sex-dependent dietary obesity, induction of UCPs, and leptin expression in rat adipose tissues. Obes Res 9, 579–588.CrossRefGoogle ScholarPubMed
300Gayle, DA, Desai, M, Casillas, E, et al. . (2006) Gender-specific orexigenic and anorexigenic mechanisms in rats. Life Sci 79, 1531–1536.CrossRefGoogle ScholarPubMed
301Andersen, ME, Clewell, HJ, Gearhart, J, et al. . (1997) Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors. J Toxicol Environ Health 52, 189–209.CrossRefGoogle ScholarPubMed
302Hill, JO, Dorton, J, Sykes, MN, et al. . (1989) Reversal of dietary obesity is influenced by its duration and severity. Int J Obes 13, 711–722.Google ScholarPubMed
303Parekh, PI, Petro, AE, Tiller, JM, et al. . (1998) Reversal of diet-induced obesity and diabetes in C57BL/6J mice. Metab Clin Exp 47, 1089–1096.CrossRefGoogle ScholarPubMed
304Wade, GN (1983) Dietary obesity in golden hamsters: reversibility and effects of sex and photoperiod. Physiol Behav 30, 131–137.CrossRefGoogle ScholarPubMed
305Levin, BE & Keesey, RE (1998) Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 274, R412–R419.CrossRefGoogle ScholarPubMed
306Miller, WH Jr, Faust, IM, Goldberger, AC, et al. . (1983) Effects of severe long-term food deprivation and refeeding on adipose tissue cells in the rat. Am J Physiol Endocrinol Metab 8, E74–E80.CrossRefGoogle Scholar
307Yang, MU, Presta, E & Bjorntorp, P (1990) Refeeding after fasting in rats: effects of duration of starvation and refeeding on food efficiency in diet-induced obesity. Am J Clin Nutr 51, 970–978.CrossRefGoogle ScholarPubMed
308Shi, H, Akunuru, S, Bierman, JC, et al. . (2009) Diet-induced obese mice are leptin insufficient after weight reduction. Obesity 17, 1702–1709.CrossRefGoogle ScholarPubMed
309Gullicksen, PS, Hausman, DB, Dean, RG, et al. . (2003) Adipose tissue cellularity and apoptosis after intracerebroventricular injections of leptin and 21 days of recovery in rats. Int J Obes 27, 302–312.CrossRefGoogle ScholarPubMed
310Qian, H, Azain, MJ, Hartzell, DL, et al. . (1998) Increased leptin resistance as rats grow to maturity. Proc Soc Exp Biol Med 219, 160–165.CrossRefGoogle Scholar
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