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Iodine deficiency, thyroid function and hearing deficit: a review

  • Alida Melse-Boonstra (a1) and Ian Mackenzie (a2)
Abstract

Iodine deficiency affects an estimated 241 million school-aged children in the world. Little is known about iodine deficiency in relation to auditory function, except for the fact that deaf–mutism is one of the features of cretinism. In the present review, we documented the scientific knowledge on the role of iodine and hypothyroidism in the auditory system. We found that ear development and hearing function depend on thyroid hormones. Multiple pathways are involved in this, including both inner ear morphology as well as neurological processes. Conductive as well as sensorineural hearing loss is found in studies with animals that were rendered hypothyroidic. In humans, auditory impairment is reported frequently in relation to hypothyroidism, ranging from mild disturbances to severe handicap. Auditory impairment has been related more explicitly to congenital hypothyroidism than to acquired hypothyroidism. The critical period for thyroid function-related hearing maturation is the first and second trimesters of pregnancy. Although only a limited number of studies have directly investigated the relationship between iodine deficiency and auditory function, most studies point toward an association. However, evidence from good randomised controlled trials is lacking. Inclusion of auditory outcomes in iodine supplementation studies is therefore to be recommended, especially for trials in pregnancy. Hearing deficit is an invisible abnormality, but has major consequences for educational and social skills if not detected. In view of this, auditory impairment should be mapped in iodine-deficient areas in order to realistically estimate the magnitude of the problem.

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Corresponding author
*Corresponding author: Alida Melse-Boonstra, fax +31 317 483342, email alida.melse@wur.nl
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1 M Andersson , V Karumbunathan & MB Zimmermann (2012) Global iodine status in 2011 and trends over the past decade. J Nutr 142, 744750.

2 EN Pearce , M Andersson & MB Zimmermann (2013) Global iodine nutrition – where do we stand in 2013? Thyroid 23, 523528.

3 F DeLange (1994) The disorders induced by iodine deficiency. Thyroid 4, 107128.

4 MB Zimmermann (2007) The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. Thyroid 17, 829835.

5 SP Walker , TD Wachs , JM Gardner , et al. (2007) Child development: risk factors for adverse outcomes in developing countries. Lancet 369, 145157.

6 N Bleichrodt , P Drenth & A Querido (1980) Effects of iodine deficiency on mental and psychomotor abilities. Am J Phys Anthropol 53, 5567.

9 RC Gordon , MC Rose , SA Skeaff , et al. (2009) Iodine supplementation improves cognition in mildly iodine-deficient children. Am J Clin Nutr 90, 12641271.

10 A Melse-Boonstra & N Jaiswal (2010) Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development. Best Pract Res Clin Endocrinol Metab 24, 2938.

11 C Yoshinago-Itano & ML Apuzzo (1998) Identification of hearing loss after 18 months is not early enough. Am Ann Deaf 143, 380387.

13 ZP Chen & BS Hetzel (2010) Cretinism revisted. Best Pract Res Clin Endocrinol Metab 24, 3950.

17 M François , P Bonfils , J Leger , et al. (1994) The role of congenital hypothyroidism in hearing loss in children. J Pediatr 124, 444446.

19 GF Maberly , DP Haxton & F Van der Haar (2003) Iodine deficiency: consequences and progress toward elimination. Food Nutr Bull 24, S91S98.

21 SC Boyages , JP Halpern , JF Marbley , et al. (1988) A comparative study of neurological and myxedematous endemic cretinism in Western China. J Clin Endocrinol Metab 67, 12621271.

22 MB Zimmermann , PL Jooste & SP Chandrakant (2008) Iodine deficiency disorders. Lancet 372, 12511262.

23 D Forrest (1996) Deafness and goiter: molecular genetic considerations. J Clin Endocrinol Metab 81, 27642767.

24 DJ Bradley , HC Towle & WS Young III (1994) Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogeneis: evidence for TR isoform-specific transcriptional regulation in vivo. Proc Natl Acad Sci U S A 91, 439443.

25 D Forrest , LC Erway , L Ng , et al. (1996) Thyroid hormone receptor B is essential for development of auditory function. Nature Genet 13, 354357.

26 SN Graven & JV Browne (2008) Auditory development in the fetus and infant. Newborn Infant Nurs Rev 8, 187193.

27 JC Coakley , EH Keir & JF Connelly (1992) The association between thyroid dyshormonogenesis and deafness (Pendred syndrome): experience of the Victorian neonatal thyroid screening program. J Paediatr Child Health 28, 398401.

28 B Coyle , R Coffey , JAL Armour , et al. (1996) Pendred syndrome (goitre and sensorineural hearing loss) maps to chromosome 7 in the region containing the nonsyndromic deafness gene DFNB4. Nature Genet 12, 421423.

29 VC Sheffield , Z Kraiem , JC Beck , et al. (1996) Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification. Nature Genet 12, 424426.

30 AA Dror , Z Brownstein & KB Avraham (2011) Integration of human and mouse genetics reveals pendrin function in hearing and deafness. Cell Physiol Biochem 28, 535544.

31 F Bogazzi , D Russo , F Raggi , et al. (2004) Mutations in the SLC26A4 (pendrin) gene in patients with sensorineural hearing loss and enlarged vestibular aqueduct. J Endocrinol Invest 27, 430435.

32 AC Madeo , A Manichaikul , JC Reynolds , et al. (2009) Evaluation of the thyroid in patients with hearing loss and enlarged vestibular aqueducts. Arch Otolaryngol Head Neck Surg 135, 670676.

33 S Dossena , C Nofziger , F Lang , et al. (2011) The ESF meeting on the proteomics, epigenetics and pharmacogenetics of pendrin. Cell Physiol Biochem 28, 377384.

34 DA Scott , R Wang , TM Kreman , et al. (2000) Functional differences of the PDS gene product are associated with phenotypic variation in patients with Pendred syndrome and non-syndromic hearing loss (DFNB4). Hum Mol Genet 9, 17091715.

35 A Bizhanova & P Kopp (2011) Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells. Cell Physiol Biochem 28, 485490.

36 S Refetoff , LT De Wind & LJ De Groot (1967) Familial syndrome combining deaf–mutism, stuppled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone. Clin Endocrinol Metab 27, 279294.

37 F Brucker-Davis , MC Skarulis , MB Grace , et al. (1995) Genetic and clinical features of 42 kindreds with resistance to thyroid hormone. The National Institutes of Health Prospective Study. Ann Intern Med 123, 572583.

38 F Brucker-Davis , MC Skarulis , A Pikus , et al. (1996) Prevalence and mechanisms of hearing loss in patients with resistance to thyroid hormone (RTH). J Clin Endocrinol Metab 81, 27682772.

39 S Refetoff , RE Weiss & SJ Usala (1993) The syndromes of resistance to thyroid hormone. Endocr Rev 14, 348399.

40 DP Corey (1994) Transcription factors in inner ear development. Proc Natl Acad Sci U S A 91, 433436.

42 T Weber , U Zimmermann , H Winter , et al. (2002) Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin. Proc Natl Acad Sci U S A 99, 29012906.

43 H Winter , C Braig , U Zimmermann , et al. (2006) Thyroid hormone receptors TRα1 and TRβ differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells. J Cell Sci 119, 29752984.

44 M Knipper , G Richardson , A Mack , et al. (2001) Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of β-tectorin protein in the tectorial membrane. Implications for hearing loss. J Biol Chem 276, 3904639052.

45 KR Johnson , CC Marden , P Ward-Bailey , et al. (2007) Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. Mol Endocrinol 21, 15931602.

46 VT Anand , SBS Mann , RJ Dash , et al. (1989) Auditory investigations in hypothyroidism. Acta Otolaringol 108, 8387.

47 PL Bhatia , OP Gupta , MK Agrawal , et al. (1977) Audiological and vestibular function test in hypothyroidism. Laryngoscope 87, 20822089.

49 MS Deol (1973) An experimental approach to the understanding and treatment of hereditary syndromes with congenital deafness and hypothyroidism. J Med Genet 10, 235242.

50 WL Meyerhoff (1979) Hypothyroidism and the ear: electrophysiological, morphological, and chemical considerations. Laryngoscope 89, Suppl. 19, 125.

51 FN Ritter (1967) The effect of hypothyroidism upon the ear, nose and throat. Laryngoscope 77, 14271479.

52 A Uziel , J Gabrion , M Ohresser , et al. (1981) Effects of hypothyroidism on the structural development of the organ of Corti in the rat. Acta Otolaryngol 92, 469480.

53 A Kohonen , T Jauhiain , K Liewenda , et al. (1971) Deafness in experimental hypothyroidism and hyperthyroidism. Laryngoscope 81, 947956.

55 MS Deol (1976) The role of thyroxine in the differentiation of the organ of Corti. Acta Otolaryngol 81, 429435.

56 L Van Middlesworth & CH Norris (1980) Audiogeneic seizures and cochlear damage in rats after prenatal antithyroid treatment. Endocrinology 106, 16861690.

57 M Wasniewska , F De Luca , S Siclari , et al. (2002) Hearing loss in congenital hypothalamic hypothyroidism: a wide therapeutic window. Hear Res 172, 8791.

58 N Brandt , S Kuhn , S Münkner , et al. (2007) Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells. J Neurosci 27, 31743186.

59 A Ruiz-Marcos , J Salas , J Sanchez-Toscano , et al. (1983) Effect of neonatal and adult onset hypothyroidism on pyramidal cells in the rat auditory cortex. Brain Res 9, 205213.

60 ES Goldey , LS Kehn , C Lau , et al. (1995) Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol Appl Pharmacol 135, 7788.

61 U Rickenbacher , JD McKinney , SJ Oatley , et al. (1986) Structurally specific binding of halogenated biphenyls to thyroxine transport protein. J Med Chem 29, 641648.

62 JD McKinney (1989) Multifunctional receptor model for dioxin and related compound toxic action: possible thyroid hormone-responsive effector-linked site. Environ Health Perspect 82, 323336.

63 JD McKinney & CL Waller (1994) Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect 102, 290297.

64 JH Dussault & J Ruel (1987) Thyroid hormones and brain development. Ann Rev Physiol 49, 321334.

65 ES Goldey , LS Kehn , GL Rehnberg , et al. (1995) Effects of developmental hypothyroidism on auditory and motor function in the rat. Toxicol Appl Pharmacol 135, 6776.

67 M Knipper , L Gestwa , WJ Ten Cate , et al. (1999) Distinct thyroid hormone-dependent expression of TrkB and p75NGFR in nonneuronal cells during the critical TH-dependent period of the cochlea. J Neurobiol 38, 338356.

68 JA Hilger (1956) Otolaryngologic aspects of hypometabolism. Ann Otol Rhinol Laryngol 65, 395413.

70 AR Thornton & SJ Jarvis (2008) Auditory brainstem response findings in hypothyroid and hyperthyroid disease. Clin Neurophysiol 119, 786790.

71 HI Ozisik & F Arman (2008) Evaluation of auditory event-provoked potentials in hyperthyroid and hypothyroid patients. Endocrinologist 18, 286289.

72 S Crifò , R Lazzari , GB Salabè , et al. (1980) A retrospective study of audiological functions in a group of congenital hypothyroid patients. Int J Pediatr Otorhinolaryngol 2, 347355.

73 Vanderschueren-Lodeweyckx , F De Bruyne , L Dooms , et al. (1983) Sensorineural hearing loss in sporadic congenital hypothyroidism. Arch Dis Child 58, 419422.

74 F Debruyne , M Vandeschuren-Lodeweyckx & P Bastijns (1983) Hearing in congenital hypothyroidism. Audiology 22, 404409.

75 J Rovet , W Walker , B Bliss , et al. (1996) Long-term sequelae of hearing impairment in congenital hypothyroidism. J Pediatr 128, 776783.

76 R Hébert , E Laureau , M Vanasse , et al. (1986) Auditory brainstem response audiometry in congenitally hypothyroid children under early replacement therapy. Pediatr Res 20, 570573.

78 PY Su , K Huang , JH Hao , et al. (2011) Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: a prospective population-based cohort study in China. J Clin Endocrinol Metab 96, 32343241.

85 F Soriguer , MC Millon , R Munoz , et al. (2000) The auditory threshold in a school-age population is related to iodine intake and thyroid function. Thyroid 10, 991999.

88 F Azizi , P Mirmiram , M Hedayati , et al. (2005) Effect of 10 yr of the iodine supplementation on the hearing threshold of iodine deficient schoolchildren. J Endocrinol Invest 28, 595598.

89 T Van den Briel , CE West , JGAJ Hautvast , et al. (2001) Mild iodine deficiency is associated with elevated hearing thresholds in children in Benin. Eur J Clin Nutr 55, 763768.

90 I Mackenzie & A Smith (2009) Deafness – the neglected and hidden disability. Ann Trop Med Parasitol 103, 565571.

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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
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