1Atta-Ur-Rahman, ZK (1989) Medicinal plants with hypoglycaemic activity. J Ethnopharmacol 26, 1–55.
2Al-Rowais, NA (2002) Herbal medicine in the treatment of diabetes mellitus. Saudi Med J 23, 1327–1331.
3Lin, CC (1992) Crude drugs used for the treatment of diabetes mellitus in Taiwan. Am J Clin Med 20, 269–279.
4Mahabir, D & Gulliford, MC (1997) Use of medicinal plants for diabetes in Trinidad and Tobago. Rev Panam Salud Publica 1, 174–179.
5Geetha, BS, Biju, CM & Augusti, KT (1994) Hypoglycemic effects of leucodelphinidin derivative isolated from Fiscus bengalensis (Linn.). Indian J Pharmacol 38, 220–222.
6Rao, BK, Sudarshan, PR, Rajsekher, MD, et al. . (2003) Antidiabetic activity of Terminalia pallida fruit in alloxan-induced diabetic rats. J Ethnopharmacol 85, 169–172.
7Edwards, OT, Colquist, S & Maradiegue, A (2005) What's cooking with garlic: is this complementary and alternative medicine for hypertension? J Am Acad Nurse Pract 17, 381–385.
8Fan, K (2005) National Center for Complementary and Alternative Medicine website. J Med Libr Assoc 93, 410–412.
9World Health Organization (1978) The Promotion and Development of Traditional Medicine. . Geneva: WHO.
10Okerele, O (1992) WHO guidelines for the assessment of herbal medicines. Fitoterapia 63, 99–110.
11Stovel, DD (2005) Pumpkin: A Super Food for All 12 Months of the Year. North Adams, MA: Storey Publishing, LLC.
12Matsui, T, Guth, H & Grosch, W (1998) A comparative study of potent odorants in peanut, hazelnut, and pumpkin seed oils on the basis of aroma extract dilution analysis (AEDA) and gas chromatography–olfactometry of headspace samples (GCOH). Lipid Fett 100, 51–56.
13Robinson, RW & Decker-Walters, DS (1997) Cucurbits. New York: CAB International.
14Whitaker, TW & Davis, GN (1962) Cucurbits: Botany, Cultivation and Utilization. New York: Interscience Publication Inc.
15Caili, F, Huan, S & Quanhong, L (2006) A review on pharmacological activities and utilization technologies of pumpkin. Plant Foods Hum Nutr 61, 73–80.
16Buchbauer, G, Boucek, B & Nikiforov, A (1998) On the aroma of Austrian pumpkin seed oil: correlation of analytical data with olfactoric characteristics. Nutrition 22, 246–249.
17Murkovic, M, Mulleder, U & Neunteufl, H (2002) Carotenoid content in different varieties of pumpkins. J Food Comp Anal 15, 633–638.
18Matus, Z, Molnár, P & Szabó, LG (1993) Main carotenoids in pressed seeds (Cucurbitae semen) of oil pumpkin (Cucurbita pepo convar. pepo var. styriaca) (article in Hungarian). Acta Pharm Hung 63, 247–256.
19Mansour, EH, Dworschak, E, Pollhamer, Z, et al. . (1999) Pumpkin and canola seed proteins and bread quality. Acta Alimentaria 28, 59–70.
20Glew, RH, Glew, RS, Chuang, LT, et al. . (2006) Amino acid, mineral and fatty acid content of pumpkin seeds (Cucurbita spp) and Cyperus esculentus nuts in the Republic of Niger. Plant Foods Hum Nutr 61, 51–56.
21Nwokolo, E & Sim, JS (1987) Nutritional assessment of defatted oil meals of melon (Colocynthis citrullus) and fluted pumpkin (Telfairia occidentalis) by chick assay. J Sci Food Agric 38, 237–246.
22Koike, K, Li, W, Liu, L, et al. . (2005) New phenolic glycosides from the seeds of Cucurbita moschata. Chem Pharm Bull 53, 225–228.
23Jun, HI, Lee, CH, Song, GS, et al. . (2006) Characterization of the pectic polysaccharides from pumpkin peel. Food Sci Tech 39, 554–561.
24Xiong, XM (2000) Study on extraction and separation of effective composition of pumpkin polysaccharide and its glucatonic effect. Chin Tradit Patent Med 22, 563–565.
25Vassiliou, AG, Neumann, GM, Condron, R, et al. . (1998) Purification and mass spectrometry-assisted sequencing of basic antifungal proteins from seeds of pumpkin (Cucurbita maxima). Plant Sci 134, 141–162.
26Xia, T & Wang, Q (2007) Hypoglycaemic role of Cucurbita ficifolia (Cucurbitaceae) fruit extract in streptozotocin-induced diabetic rats. J Sci Food Agric 87, 1753–1757.
27Kwon, YI, Apostolidis, E, Kim, YC, et al. . (2007) Health benefits of traditional corn, beans, and pumpkin: in vitro studies for hyperglycemia and hypertension management. J Med Food 10, 266–275.
28Acosta-Patiño, JL, Jiménez-Balderas, E, Juárez-Oropeza, MA, et al. . (2001) Hypoglycemic action of Cucurbita ficifolia on type 2 diabetic patients with moderately high blood glucose levels. J Ethnopharmacol 77, 99–101.
29Andrade-Cetto, A & Heinrich, M (2005) Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol 99, 325–348.
30Alarcon-Aguilar, FJ, Hernandez-Galicia, E, Campos-Sepulveda, AE, et al. . (2002) Evaluation of the hypoglycemic effect of Cucurbita ficifolia Bouché (Cucurbitaceae) in different experimental models. J Ethnopharmacol 82, 185–189.
31Xia, T & Wang, Q (2006) Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats. Fitoterapia 77, 530–533.
32Xia, T & Wang, Q (2006) d-chiro-Inositol found in Cucurbita ficifolia (Cucurbitaceae) fruit extracts plays the hypoglycaemic role in streptozocin-diabetic rats. J Pharm Pharmacol 58, 1527–1532.
33Quanhong, LI, Caili, F, Yukui, R, et al. . (2005) Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats. Plant Food Hum Nutr 60, 13–16.
34Halliwell, B (1993) The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis 23, 118–126.
35Imaeda, N, Tokudome, Y, Ikeda, M, et al. . (1999) Foods contributing to absolute intake and variance in intake of selected vitamins, minerals and dietary fiber in middle-aged Japanese. J Nutr Sci Vitaminol 45, 519–532.
36Dang, C (2004) Effect of pumpkin distillable subject on lipid peroxidation and the activity of antioxidative enzyme induced by Plumbum in mouse (article in Chinese). Chin J Clin Rehabil 8, 4378–4379.
37Xu, GH (2000) A study of the possible antitumour effect and immunompetence of pumpkin polysaccharide. J Wuhan Prof Med Coll 28, 1–4.
38Craig, WJ (1997) Phytochemicals: guardians of our health. J Am Diet Assoc 977, S199–S204.
39Huang, XE, Hirose, K, Wakai, K, et al. . (2004) Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer. Asian Pac J Cancer Prev 5, 419–427.
40Jian, L, Du, CJ, Lee, AH, et al. . (2005) Do dietary lycopene and other carotenoids protect against prostate cancer? Int J Cancer 113, 1010–1014.
41Binns, CW, Jian, L & Lee, AH (2004) The relationship between dietary carotenoids and prostate cancer risk in southeast Chinese men. Asia Pac J Clin Nutr 13, S117.
42Hong, LH (2005) Effect of pumpkin extracts on tumor growth inhibition in S180-bearing mice. Pract Prev Med 12, 745–747.
43Cheong, NE, Choi, YO, Kim, WY, et al. . (1997) Purification and characterization of an antifungal PR-5 protein from pumpkin leaves. Mol Cell 7, 214–219.
44Xie, JM (2004) Induced polarization effect of pumpkin protein on B16 cell. Fujian Med Univ Acta 38, 394–395.
45Xia, HC, Li, F, Li, Z, et al. . (2003) Purification and characterization of moschatin, a novel type I ribosome-inactivating protein from the mature seeds of pumpkin (Cucurbita moschata), and preparation of its immunotoxin against human melanoma cells. Cell Res 13, 369–374.
46Hou, X, Meehan, EJ, Xie, J, et al. . (2008) Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. J Struct Biol 164, 81–87.
47Hammer, KA, Carson, CF & Riley, TV (1999) Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 86, 985–990.
48Ng, TB, Parkash, A & Tso, WW (2002) Purification and characterization of moschins, arginine–glutamate-rich proteins with translation inhibiting activity from brown pumpkin (Cucurbita moschata) seeds. Protein Expr Purif 26, 9–13.
49MacGibbon, DB & Mann, JD (1986) Inhibition of animal and pathogenic fungal proteases by phloem exudate from pumpkin fruits (Cucurbitaceae). J Sci Food Agric 37, 515–522.
50Park, SC, Lee, JR, Kim, JY, et al. . (2010) Pr-1, a novel antifungal protein from pumpkin rinds. Biotechnol Lett 32, 125–130.
51Fahim, AT, Abd-el Fattah, AA, Agha, AM, et al. . (1995) Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats. Pharmacol Res 31, 73–79.
52Zuhair, HA, Abd El-Fattah, AA & El-Sayed, MI (2000) Pumpkin-seed oil modulates the effect of felodipine and captopril in spontaneously hypertensive rats. Pharmacol Res 41, 555–563.
53Suphiphat, V, Morjaroen, N, Pukboonme, I, et al. . (1993) The effect of pumpkin seeds snack on inhibitors and promoters of urolithiasis in Thai adolescents. J Med Assoc Thai 76, 487–493.
54Suphakarn, VS, Yarnnon, C & Ngunboonsri, P (1987) The effect of pumpkin seeds on oxalcrystalluria and urinary compositions of children in hyperendemic area. Am J Clin Nutr 45, 115–121.
55Nakamura, Y, Suganuma, E, Kuyama, N, et al. . (1998) Comparative bio-antimutagenicity of common vegetables and traditional vegetables in Kyoto. Biosci Biotechnol Biochem 62, 1161–1165.
56Eagles, JM (1990) Treatment of depression with pumpkin seeds. Br J Psychiatry 157, 937–938.
57Mahmoud, LH, Basiouny, SO & Dawoud, HA (2002) Treatment of experimental heterophyiasis with two plant extracts, areca nut and pumpkin seed. J Egypt Soc Parasitol 32, 501–506.
58Díaz-Obregón, D, Lloja-Lozano, L & Carbajal-Zúñiga, V (2004) Preclinical studies of Cucurbita maxima (pumpkin seeds) a traditional intestinal antiparasitic in rural urban areas (article in Spanish). Rev Gastroenterol Peru 24, 323–327.
59Nkosi, CZ, Opoku, AR & Terblanche, SE (2005) Effect of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of certain plasma enzymes in CCl4-induced liver injury in low-protein fed rats. Phytother Res 19, 341–345.
60Wang, P (1999) Experimental study on pharmacological actions about analgesia, anti-inflammation of Cucurbita moschata Duch. Shizhen Med Mteria Med Res 19, 567–569.
61Krishnamoorthi, R, Gong, YX & Richardson, M (1999) A new protein inhibitor of trypsin and activated Hageman factor from pumpkin (Cucurbita maxima) seeds. FEBS Lett 273, 163–167.
62Dannenhoffer, JM, Suhr, RC & Thompson, GA (2001) Phloem-specific expression of the pumpkin fruit trypsin inhibitor. Planta 212, 155–162.
63Hernández-Ramírez, BD & Guerra-Modernell, MJ (1997) Development and evaluation of a dietetic formula made of pumpkin, rice, chicken and vegetable oils for children with diarrhea (article in Spanish). Arch Latinoam Nutr 47, 57–61.
64Ito, Y, Maeda, S & Sugiyama, T (1986) Suppression of 7, 12-dimethylbenz [α]anthracene-induced chromosome aberrations in rat bone marrow cells by vegetable juices. Mutat Res 172, 55–60.
65de Escalada Pla, MF, Ponce, NM, Wider, ME et al. . (2005) Chemical and biochemical changes of pumpkin (Cucurbita moschata Duch) tissue in relation to osmotic stress. J Sci Food Agric 85, 1852–1860.