1Koh-Banerjee P & Rimm EB (2003) Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research. Proc Nutr Soc 62, 25–29.
2van de Vijver LPL, van den Bosch LMC, van den Brandt PA, et al. . (2009) Whole-grain consumption, dietary fibre intake and body mass index in the Netherlands cohort study. Eur J Clin Nutr 63, 31–38.
3Esmaillzadeh A, Mirmiran P & Azizi F (2005) Whole-grain consumption and the metabolic syndrome: a favorable association in Tehranian adults. Eur J Clin Nutr 59, 353–362.
4Sahyoun NR, Jacques PF, Zhang XL, et al. . (2006) Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr 83, 124–131.
5de Munter JS, Hu FB, Spiegelman D, et al. . (2007) Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med 4, e261.
6Murtaugh MA, Jacobs DR, Jacob B, et al. . (2007) Epidemiological support for the protection of whole grains against diabetes. Proc Nutr Soc 62, 143–149.
7Mellen PB, Walsh TF & Herrington DM (2008) Whole grain intake and cardiovascular disease: a meta-analysis. Nutr Metab Cardiovasc Dis 18, 283–290.
8Chan JM, Wang F & Holly EA (2007) Whole grains and risk of pancreatic cancer in a large population-based case–control study in the San Francisco Bay area, California. Am J Epidemiol 166, 1174–1185.
9Chatenoud L, Tavani A, La Vecchia C, et al. . (1998) Whole grain food intake and cancer risk. Int J Cancer 77, 24–28.
10Jacobs DR Jr, Marquart L, Slavin J, et al. . (1998) Whole-grain intake and cancer: an expanded review and meta-analysis. Nutr Cancer 30, 85–96.
11Larsson SC, Giovannucci E, Bergkvist L, et al. . (2005) Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60 000 women. Br J Cancer 92, 1803–1807.
12Schatzkin A, Park Y, Leitzmann MF, et al. . (2008) Prospective study of dietary fiber, whole grain foods, and small intestinal cancer. Gastroenterology 135, 1163–1167.
13Jacobs DR Jr, Andersen LF & Blomhoff R (2007) Whole-grain consumption is associated with a reduced risk of noncardiovascular, noncancer death attributed to inflammatory diseases in the Iowa Women's Health Study. Am J Clin Nutr 85, 1606–1614.
14Adom KK, Sorrells ME & Liu RH (2003) Phytochemical profiles and antioxidant activity of wheat varieties. J Agric Food Chem 51, 7825–7834.
15Jacobs DR, Meyer HE & Solvoll K (2001) Reduced mortality among whole grain bread eaters in men and women in the Norwegian County Study. Eur J Clin Nutr 55, 137–143.
16Chatenoud L, La Vecchia C, Franceschi S, et al. . (1999) Refined-cereal intake and risk of selected cancers in Italy. Am J Clin Nutr 70, 1107–1110.
17Jensen MK, Koh-Banerjee P, Franz M, et al. . (2006) Whole grains, bran, and germ in relation to homocysteine and markers of glycemic control, lipids, and inflammation. Am J Clin Nutr 83, 275–283.
18Liu RH (2007) Whole grain phytochemicals and health. J Cereal Sci 46, 207–219.
19Truswell AS (2002) Cereal grains and coronary heart disease. Eur J Clin Nutr 56, 1–14.
24Jones JM (2008) Whole grains – issues and deliberations from the Whole Grain Task Force. Cereal Foods World 53, 260–264.
25Srivastava AK, Sudha ML, Baskaran V, et al. . (2007) Studies on heat stabilized wheat germ and its influence on rheological characteristics of dough. Eur Food Res Technol 224, 365–372.
27Jacobs DR Jr, Meyer KA, Kushi LH, et al. . (1998) Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr 68, 248–257.
28Liu SM, Manson JE, Stampfer MJ, et al. . (2000) Whole grain consumption and risk of ischemic stroke in women – a prospective study. JAMA 284, 1534–1540.
29Thane CW, Jones AR, Stephen AM, et al. . (2005) Whole-grain intake of British young people aged 4–18 years. Br J Nutr 94, 825–831.
30Thane CW, Stephen AM & Jebb SA (2009) Whole grains and adiposity: little association among British adults. Eur J Clin Nutr 63, 229–237.
31Cleveland LE, Moshfegh AJ, Albertson AM, et al. . (2000) Dietary intake of whole grains. J Am Coll Nutr 19, 331S–338S.
32Lang R & Jebb SA (2003) Who consumes whole grains, and how much? Proc Nutr Soc 62, 123–127.
33Welsh S, Shaw A & Davis C (1994) Achieving dietary recommendations – whole-grain foods in the food guide pyramid. Crit Rev Food Sci Nutr 34, 441–451.
34Albertson AM & Tobelmann RC (1995) Consumption of grain and whole-grain foods by an American population during the years 1990 to 1992. J Am Diet Assoc 95, 703–704.
35National Council on Nutrition and Physical Activity and the Institute for Nutrition Research (1998) Development of the Norwegian Diet. Oslo: University of Oslo.
36Prättälä R, Helasoja V & Mykkänen H (2007) The consumption of rye bread and white bread as dimensions of health lifestyles in Finland. Public Health Nutr 4, 813–819.
37Adams JF & Engstrom A (2000) Helping consumers achieve recommended intakes of whole grain foods. J Am Coll Nutr 19, 339S–344S.
38Jenkins DJ, Wesson V, Wolever TM, et al. . (1988) Wholemeal versus wholegrain breads: proportion of whole or cracked grain and the glycaemic response. BMJ 297, 958–960.
39Jacobs DR Jr, Pereira MA, Stumpf K, et al. . (2002) Whole grain food intake elevates serum enterolactone. Br J Nutr 88, 111–116.
40Lutsey PL, Jacobs DR, Kori S, et al. . (2007) Whole grain intake and its cross-sectional association with obesity, insulin resistance, inflammation, diabetes and subclinical CVD: The MESA Study. Br J Nutr 98, 397–405.
41McKeown NM, Meigs JB, Liu S, et al. . (2002) Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr 76, 390–398.
42Newby P, Maras J, Bakun P, et al. . (2007) Intake of whole grains, refined grains, and cereal fiber measured with 7-d diet records and associations with risk factors for chronic disease. Am J Clin Nutr 86, 1745–1753.
43Vanharanta M, Voutilainen S, Lakka TA, et al. . (1999) Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case–control study. Lancet 354, 2112–2115.
44Levi F, Pasche C, Lucchini F, et al. . (2000) Refined and whole grain cereals and the risk of oral, oesophageal and laryngeal cancer. Eur J Clin Nutr 54, 487–489.
45Slavin JL (2000) Mechanisms for the impact of whole grain foods on cancer risk. J Am Coll Nutr 19, 300S–307S.
46Slavin JL, Martini MC, Jacobs DR Jr, et al. . (1999) Plausible mechanisms for the protectiveness of whole grains. Am J Clin Nutr 70, 459S–463S.
47Haber GB, Heaton KW, Murphy D, et al. . (1977) Depletion and disruption of dietary fibre. Effects on satiety, plasma-glucose, and serum-insulin. Lancet ii, 679–682.
48Read NW, Welch IM, Austen CJ, et al. . (1986) Swallowing food without chewing; a simple way to reduce postprandial glycaemia. Br J Nutr 55, 43–47.
49Fardet A, Leenhardt F, Lioger D, et al. . (2006) Parameters controlling the glycaemic response to breads. Nutr Res Rev 19, 18–25.
50Granfeldt Y, Hagander B & Bjorck I (1995) Metabolic responses to starch in oat and wheat products. On the importance of food structure, incomplete gelatinization or presence of viscous dietary fibre. Eur J Clin Nutr 49, 189–199.
51Liljeberg H, Granfeldt Y & Bjorck I (1992) Metabolic responses to starch in bread containing intact kernels versus milled flour. Eur J Clin Nutr 46, 561–575.
52Nilsson AC, Ostman EM, Granfeldt Y, et al. . (2008) Effect of cereal test breakfasts differing in glycemic index and content of indigestible carbohydrates on daylong glucose tolerance in healthy subjects. Am J Clin Nutr 87, 645–654.
53American Association of Cereal Chemists (2001) The definition of dietary fiber. Cereal Foods World 46, 112–129.
54Nilsson AC, Ostman EM, Holst JJ, et al. . (2008) Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast. J Nutr 138, 732–739.
55Topping D (2007) Cereal complex carbohydrates and their contribution to human health. J Cereal Sci 46, 220–229.
56Wood PJ (2007) Cereal β-glucans in diet and health. J Cereal Sci 46, 230–238.
57Koh-Banerjee P, Franz M, Sampson L, et al. . (2004) Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men. Am J Clin Nutr 80, 1237–1245.
58Slavin JL (2005) Dietary fiber and body weight. Nutrition 21, 411–418.
59Jenkins AL, Jenkins DJ, Zdravkovic U, et al. . (2002) Depression of the glycemic index by high levels of β-glucan fiber in two functional foods tested in type 2 diabetes. Eur J Clin Nutr 56, 622–628.
60Zhang JX, Hallmans G, Andersson H, et al. . (1992) Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies. Am J Clin Nutr 56, 99–105.
61Lia A, Hallmans G, Sandberg AS, et al. . (1995) Oat β-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects. Am J Clin Nutr 62, 1245–1251.
62Scheppach W, Bartram HP & Richter F (1995) Role of short-chain fatty acids in the prevention of colorectal cancer. Eur J Cancer 31, 1077–1080.
63Slavin J (2003) Why whole grains are protective: biological mechanisms. Proc Nutr Soc 62, 129–134.
64Costabile A, Klinder A, Fava F, et al. . (2008) Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study. Br J Nutr 99, 110–120.
65Brouns F, Kettlitz B & Arrigoni E (2002) Resistant starch and ‘the butyrate revolution’. Trends Food Sci Technol 13, 251–261.
66Boffa LC, Lupton JR, Mariani MR, et al. . (1992) Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats. Cancer Res 52, 5906–5912.
67Higgins J, Higbee D, Donahoo W, et al. . (2004) Resistant starch consumption promotes lipid oxidation. Nutr Metab 1, 8.
68McIntosh GH, Noakes M, Royle PJ, et al. . (2003) Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men. Am J Clin Nutr 77, 967–974.
69Ferguson LR & Harris PJ (1999) Protection against cancer by wheat bran: role of dietary fibre and phytochemicals. Eur J Cancer Prev 8, 17–25.
70Lopez HW, Coudray C, Bellanger J, et al. . (2000) Resistant starch improves mineral assimilation in rats adapted to a wheat bran diet. Nutr Res 20, 141–155.
71Lopez HW, Levrat-Verny MA, Coudray C, et al. . (2001) Class 2 resistant starches lower plasma and liver lipids and improve mineral retention in rats. J Nutr 131, 1283–1289.
72Coudray C, Bellanger J, Castiglia-Delavaud C, et al. . (1997) Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr 51, 375–380.
73Lopez HW, Coudray C, Levrat-Verny MA, et al. . (2000) Fructooligosaccharides enhance mineral apparent absorption and counteract the deleterious effects of phytic acid on mineral homeostasis in rats. J Nutr Biochem 11, 500–508.
74Reddy B, Hamid R & Rao C (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 18, 1371–1374.
75McIntyre A, Gibson PR & Young GP (1993) Butyrate production from dietary fiber and protection against large bowel cancer in a rat model. Gut 34, 386–391.
76Heerdt BG, Houston MA, Anthony GM, et al. . (1999) Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity. Cancer Res 59, 1584–1591.
77Ellerhorst J, Nguyen T, Cooper DNW, et al. . (1999) Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1. Int J Oncol 14, 225–232.
78Bird AR, Vuaran MS, King RA, et al. . (2008) Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects. Br J Nutr 99, 1032–1040.
79Liljeberg H & Bjorck I (1994) Bioavailability of starch in bread products. Postprandial glucose and insulin responses in healthy subjects and in vitro resistant starch content. Eur J Clin Nutr 48, 151–163.
80Hara H, Haga S, Aoyama Y, et al. . (1999) Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine. J Nutr 129, 942–948.
81Jenkins DJA, Wolever TMS, Nineham R, et al. . (1980) Improved glucose tolerance four hours after taking guar with glucose. Diabetologia 19, 21–24.
82Jenkins D, Wolever T, Taylor R, et al. . (1982) Slow release dietary carbohydrate improves second meal tolerance. Am J Clin Nutr 35, 1339–1346.
83Nilsson A, Granfeldt Y, Ostman E, et al. . (2006) Effects of GI and content of indigestible carbohydrates of cereal-based evening meals on glucose tolerance at a subsequent standardised breakfast. Eur J Clin Nutr 60, 1092–1099.
84Cherbut C (2003) Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract. Proc Nutr Soc 62, 95–99.
85Wolever T, Spadafora P & Eshuis H (1991) Interaction between colonic acetate and propionate in humans. Am J Clin Nutr 53, 681–687.
86Homko CJ, Cheung P & Boden G (2003) Effects of free fatty acids on glucose uptake and utilization in healthy women. Diabetes 52, 487–491.
87Anderson JW & Bridges SR (1984) Short-chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes. Proc Soc Exp Biol Med 177, 372–376.
88Liu RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134, 3479S–3485S.
89Reddy BS, Hirose Y, Cohen LA, et al. . (2000) Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention. Cancer Res 60, 4792–4797.
90Sang SM, Ju JY, Lambert JD, et al. . (2006) Wheat bran oil and its fractions inhibit human colon cancer cell growth and intestinal tumorigenesis in Apc(min/+) mice. J Agric Food Chem 54, 9792–9797.
91Bartsch H & Nair J (2006) Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg 391, 499–510.
92Graf E & Eaton JW (1985) Dietary suppression of colonic cancer; fiber or phytate? Cancer 56, 717–718.
93Kohlmeier L, Simonsen N & Mottus K (1995) Dietary modifiers of carcinogenesis. Environ Health Perspect 103, Suppl. 8, 177–184.
94Nesaretnam K, Yew WW & Wahid MB (2007) Tocotrienols and cancer: beyond antioxidant activity. Eur J Lipid Sci Technol 109, 445–452.
95Shamsuddin AM (2002) Anti-cancer function of phytic acid. Int J Food Sci Technol 37, 769–782.
96Adlercreutz H (2002) Phyto-oestrogens and cancer. Lancet Oncol 3, 364–373.
97Adlercreutz H, Mousavi Y, Clark J, et al. . (1992) Dietary phytoestrogens and cancer: in vitro and in vivo studies. J Steroid Biochem Molec Biol 41, 331–337.
98Markaverich BM, Webb B, Densmore CL, et al. . (1995) Effects of coumestrol on estrogen receptor function and uterine growth in ovariectomized rats. Environ Health Perspect 103, 574–581.
99Reddy BS (1999) Prevention of colon carcinogenesis by components of dietary fiber. Anticancer Res 19, 3681–3683.
100Ullah A & Shamsuddin AM (1990) Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis 11, 2219–2222.
101Vucenik I, Yang G & Shamsuddin AM (1997) Comparison of pure inositol hexaphosphate and high-bran diet in the prevention of DMBA-induced rat mammary carcinogenesis. Nutr Cancer 28, 7–13.
102Hollman P & Katan M (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 51, 305–310.
103Edenharder R, Rauscher R & Platt KL (1997) The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure–activity relationship study. Mutat Res 379, 21–32.
104Barone E, Calabrese V & Mancuso C (2009) Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 10, 97–108.
105Kawabata K, Yamamoto T, Hara A, et al. . (2000) Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Lett 157, 15–21.
106Alabaster O, Tang ZC & Shivapurkar N (1996) Dietary fiber and the chemopreventive modelation of colon carcinogenesis. Mutat Res 350, 185–197.
107Eastwood MA & Girdwood RH (1968) Lignin: a bile-salt sequestrating agent. Lancet ii, 1170–1172.
108Eastwood MA & Hamilton D (1968) Studies on the adsorption of bile salts to non-absorbed components of diet. Biochim Biophys Acta 152, 165–173.
109Labaj J, Slamenova D, Lazarova M, et al. . (2004) Lignin-stimulated reduction of oxidative DNA lesions in testicular cells and lymphocytes of Sprague–Dawley rats in vitro and ex vivo. Nutr Cancer 50, 198–205.
110Wattenberg LW (1985) Chemoprevention of cancer. Cancer Res 45, 1–8.
111Jablonska E, Gromadzinska J, Sobala W, et al. . (2008) Joint effect of GPx1 polymorphism and selenium status on lung cancer risk. Eur J Cancer Suppl 6, 203.
112Stavric B (1994) Antimutagens and anticarcinogens in foods. Food Chem Toxicol 32, 79–90.
113Harris PJ & Ferguson LR (1993) Dietary fiber – its composition and role in protection against colorectal cancer. Mutat Res 290, 97–110.
114Harris PJ, Roberton AM, Watson ME, et al. . (1993) The effects of soluble-fiber polysaccharides on the adsorption of a hydrophobic carcinogen to an insoluble dietary fiber. Nutr Cancer 19, 43–54.
115Morita T, Tanabe H, Sugiyama K, et al. . (2004) Dietary resistant starch alters the characteristics of colonic mucosa and exerts a protective effect on trinitrobenzene sulfonic acid-induced colitis in rats. Biosci Biotechnol Biochem 68, 2155–2164.
116Toden S, Bird AR, Topping DL, et al. . (2007) Dose-dependent reduction of dietary protein-induced colonocyte DNA damage by resistant starch in rats correlates more highly with caecal butyrate than with other short chain fatty acids. Cancer Biol Ther 6, 253–258.
117Story JA & Kritchevsky D (1994) Denis Parsons Burkitt (1911–1993). J Nutr 124, 1551–1554.
118Bauer-Marinovic M, Florian S, Muller-Schmehl K, et al. . (2006) Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon. Carcinogenesis 27, 1849–1859.
119Bingham SA (2007) Mechanisms and experimental and epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer. Proc Nutr Soc 49, 153–171.
120O'Keefe SJD, Kidd M, Espitalier-Noel G, et al. . (1999) Rarity of colon cancer in Africans is associated with low animal product consumption, not fiber. Am J Gastroenterol 94, 1373–1380.
121Cho E, Willett WC, Colditz GA, et al. . (2007) Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 99, 1224–1231.
122Klaunig JE, Xu Y, Isenberg JS, et al. . (1998) The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect 106, 289–295.
123Harris PJ & Ferguson LR (1999) Dietary fibres may protect or enhance carcinogenesis. Mutat Res 443, 95–110.
124Ford ES, Mokdad AH, Giles WH, et al. . (2003) The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 52, 2346–2352.
125Higdon JV & Frei B (2003) Obesity and oxidative stress – a direct link to CVD? Arterioscler Thromb Vasc Biol 23, 365–367.
126Keaney JF, Larson MG, Vasan RS, et al. . (2002) Obesity as a source of systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Circulation 106, 467.
127Evans JL, Goldfine ID, Maddux BA, et al. . (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23, 599–622.
128Maiese K, Morhan SD & Chong ZZ (2007) Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res 4, 63–71.
129Cai H & Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87, 840–844.
130Castelao JE & Gago-Dominguez M (2008) Risk factors for cardiovascular disease in women: relationship to lipid peroxidation and oxidative stress. Med Hypotheses 71, 39–44.
131Martinez-Tome M, Murcia MA, Frega N, et al. . (2004) Evaluation of antioxidant capacity of cereal brans. J Agric Food Chem 52, 4690–4699.
132Miller HE, Rigelhof F, Marquart L, et al. . (2000) Antioxidant content of whole grain breakfast cereals, fruits and vegetables. J Am Coll Nutr 19, 312S–319S.
133Perez-Jimenez J & Saura-Calixto F (2005) Literature data may underestimate the actual antioxidant capacity of cereals. J Agric Food Chem 53, 5036–5040.
134Serpen A, Gökmen V, Pellegrini N, et al. . (2008) Direct measurement of the total antioxidant capacity of cereal products. J Cereal Sci 48, 816–820.
135Zielinski H & Kozlowska H (2000) Antioxidant activity and total phenolics in selected cereal grains and their different morphological fractions. J Agric Food Chem 48, 2008–2016.
136Fardet A, Rock E & Rémésy C (2008) Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo? J Cereal Sci 48, 258–276.
137Andersson A, Tengblad S, Karlstrom B, et al. . (2007) Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects. J Nutr 137, 1401–1407.
138Beattie RK, Lee AM, Strain JJ, et al. . (2003) Evaluation of the in vivo antioxidant activity of wheat bran in human subjects. Proc Nutr Soc 62, 17A.
139Bruce B, Spiller GA, Klevay LM, et al. . (2000) A diet high in whole and unrefined foods favorably alters lipids, antioxidant defenses, and colon function. J Am Coll Nutr 19, 61–67.
140Chen CYO, Milbury PE, Collins FW, et al. . (2007) Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oats. J Nutr 137, 1375–1382.
141Hamill LL, Keaveney EM, Price RK, et al. . (2007) Assessment of antioxidant biomarkers in human plasma and urine after consumption of wheat bran and aleurone fractions. Proc Nutr Soc 66, 88A.
142Jang Y, Lee JH, Kim OY, et al. . (2001) Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial. Arterioscler Thromb Vasc Biol 21, 2065–2071.
143Kim JY, Kim JH, Lee DH, et al. . (2008) Meal replacement with mixed rice is more effective than white rice in weight control, while improving antioxidant enzyme activity in obese women. Nutr Res 28, 66–71.
144Lewis S, Bolton C & Heaton K (1996) Lack of influence of intestinal transit on oxidative status in premenopausal women. Eur J Clin Nutr 50, 565–568.
145Maki KC, Galant R, Samuel P, et al. . (2007) Effects of consuming foods containing oat β-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure. Eur J Clin Nutr 61, 786–795.
146Price RK, Welch RW, Lee-Manion AM, et al. . (2008) Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran. Cereal Chem 85, 152–157.
147Wang Q, Han PH, Zhang MW, et al. . (2007) Supplementation of black rice pigment fraction improves antioxidant and anti-inflammatory status in patients with coronary heart disease. Asia Pac J Clin Nutr 16, 295–301.
148Graf E, Empson KL & Eaton JW (1987) Phytic acid. A natural antioxidant. J Biol Chem 262, 11647–11650.
149Dizhbite T, Telysheva G, Jurkjane V, et al. . (2004) Characterization of the radical scavenging activity of lignins – natural antioxidants. Bioresour Technol 95, 309–317.
150Vitaglione P, Napolitano A & Fogliano V (2008) Cereal dietary fibre: a natural functional ingredient to deliver phenolic compounds into the gut. Trends Food Sci Technol 19, 451–463.
151Babbs CF (1990) Free radicals and the etiology of colon cancer. Free Radicic Biol Med 8, 191–200.
152Adam A, Crespy V, Levrat-Verny MA, et al. . (2002) The bioavailability of ferulic acid is governed primarily by the food matrix rather than its metabolism in intestine and liver in rats. J Nutr 132, 1962–1968.
153Mateo Anson N, van den Berg R, Havenaar R, et al. . (2009) Bioavailability of ferulic acid is determined by its bioaccessibility. J Cereal Sci 49, 296–300.
154Rondini L, Peyrat-Maillard MN, Marsset-Baglieri A, et al. . (2004) Bound ferulic acid from bran is more bioavailable than the free compound in rat. J Agric Food Chem 52, 4338–4343.
155Pellegrini N, Serafini M, Salvatore S, et al. . (2006) Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol Nutr Food Res 50, 1030–1038.
156McCarty MF (2005) Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Med Hypotheses 64, 619–627.
157Durlach J & Collery P (1984) Magnesium and potassium in diabetes and carbohydrate metabolism. Review of the present status and recent results. Magnesium 3, 315–323.
158Paolisso G, Sgambato S, Gambardella A, et al. . (1992) Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 55, 1161–1167.
159Paolisso G, Sgambato S, Pizza G, et al. . (1989) Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects. Diabetes Care 12, 265–269.
160Pereira MA, Jacobs DR Jr, Pins JJ, et al. . (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 75, 848–855.
161Balon T, Jasman A, Scott S, et al. . (1994) Dietary magnesium prevents fructose-induced insulin insensitivity in rats. Hypertension 23, 1036–1039.
162Balon TW, Gu JL, Tokuyama Y, et al. . (1995) Magnesium supplementation reduces development of diabetes in a rat model of spontaneous NIDDM. Am J Physiol Endocrinol Metab 269, E745–E752.
163Gould MK & Chaudry IH (1970) The action of insulin on glucose uptake by isolated rat soleus muscle. 1. Effects of cations. Biochim Biophys Acta 215, 249–257.
164Weglicki WB, Mak IT, Kramer JH, et al. . (1996) Role of free radicals and substance P in magnesium deficiency. Cardiovasc Res 31, 677–682.
165Ceriello A, Bortolotti N, Crescentini A, et al. . (1998) Antioxidant defences are reduced during the oral glucose tolerance test in normal and non-insulin-dependent diabetic subjects. Eur J Clin Invest 28, 329–333.
166Pereira EC, Ferderbar S, Bertolami MC, et al. . (2008) Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus. Clin Biochem 41, 1454–1460.
167Iseri LT & French JH (1984) Magnesium – Nature's physiologic calcium blocker. Am Heart J 108, 188–193.
168Resnick LM (1992) Cellular calcium and magnesium metabolism in the pathophysiology and treatment of hypertension and related metabolic disorders. Am J Med 93, S11–S20.
169Liao F, Folsom AR & Brancati FL (1998) Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 136, 480–490.
170Shechter M, Merz CNB, Paul-Labrador M, et al. . (1999) Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. Am J Cardiol 84, 152–156.
171Kawano Y, Matsuoka H, Takishita S, et al. . (1998) Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressures. Hypertension 32, 260–265.
172Al-Mamary M, Al-Habori M, Al-Aghbari A, et al. . (2001) In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption. Nutr Res 21, 1393–1401.
173Thompson LU (1993) Potential health benefits and problems associated with antinutrients in foods. Food Res Int 26, 131–149.
174Gillooly M, Bothwell TH, Charlton RW, et al. . (1984) Factors affecting the absorption of iron from cereals. Br J Nutr 51, 37–46.
175Tatala S, Svanberg U & Mduma B (1998) Low dietary iron availability is a major cause of anemia: a nutrition survey in the Lindi District of Tanzania. Am J Clin Nutr 68, 171–178.
176Lestienne I, Besancon P, Caporiccio B, et al. . (2005) Iron and zinc in vitro availability in pearl millet flours (Pennisetum glaucum) with varying phytate, tannin, and fiber contents. J Agric Food Chem 53, 3240–3247.
177Hassan IAG & El Tinay AH (1995) Effect of fermentation on tannin content and in-vitro protein and starch digestibilities of two sorghum cultivars. Food Chem 53, 149–151.
178Matuschek E, Towo E & Svanberg U (2001) Oxidation of polyphenols in phytate-reduced high-tannin cereals: effect on different phenolic groups and on in vitro accessible iron. J Agric Food Chem 49, 5630–5638.
179Mbithi-Mwikya S, Van Camp J, Yiru Y, et al. . (2000) Nutrient and antinutrient changes in finger millet (Eleusine coracan) during sprouting. Lebensm-Wiss Technol Food Sci Technol 33, 9–14.
180Towo E, Matuschek E & Svanberg U (2006) Fermentation and enzyme treatment of tannin sorghum gruels: effects on phenolic compounds, phytate and in vitro accessible iron. Food Chem 94, 369–376.
181Thompson LU (1988) Antinutrients and blood glucose. Food Technol 42, 123–132.
182Yoon J, Thompson L & Jenkins D (1983) The effect of phytic acid on in vitro rate of starch digestibility and blood glucose response. Am J Clin Nutr 38, 835–842.
183Manach C, Williamson G, Morand C, et al. . (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S–242S.
184Choi J-S, Choi Y-J, Shin S-Y, et al. . (2008) Dietary flavonoids differentially reduce oxidized LDL-induced apoptosis in human endothelial cells: role of MAPK- and JAK/STAT-signaling. J Nutr 138, 983–990.
185Crespo I, García-Mediavilla MV, Gutiérrez B, et al. . (2008) A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells. Br J Nutr 100, 968–976.
186Maggi-Capeyron MF, Ceballos P, Cristol JP, et al. . (2001) Wine phenolic antioxidants inhibit AP-1 transcriptional activity. J Agric Food Chem 49, 5646–5652.
187Yun K-J, Koh D-J, Kim S-H, et al. . (2008) Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-κB inactivation. J Agric Food Chem 56, 10265–10272.
188Moskaug JO, Carlsen H, Myhrstad MC, et al. . (2005) Polyphenols and glutathione synthesis regulation. Am J Clin Nutr 81, 277S–283S.
189Rahman I, Biswas SK & Kirkham PA (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72, 1439–1452.
190Ramos S (2008) Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 52, 507–526.
191Williams RJ, Spencer JPE & Rice-Evans C (2004) Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36, 838–849.
192McCallum JA & Walker JRL (1990) Proanthocyanidins in wheat bran. Cereal Chem 67, 282–285.
193Feng Y & McDonald CE (1989) Comparison of flavonoids in bran of four classes of wheat. Cereal Chem 66, 516–518.
194Gallardo C, Jiménez L & García-Conesa M-T (2006) Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions. Food Chem 99, 455–463.
195Myhrstad MCW, Carlsen H, Nordstrom O, et al. . (2002) Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med 32, 386–393.
196Kern SM, Bennett RN, Mellon FA, et al. . (2003) Absorption of hydroxycinnamates in humans after high-bran cereal consumption. J Agric Food Chem 51, 6050–6055.
197Li L, Shewry PR & Ward JL (2008) Phenolic acids in wheat varieties in the HEALTHGRAIN diversity screen. J Agric Food Chem 56, 9732–9739.
198Métayer S, Seiliez I, Collin A, et al. . (2008) Mechanisms through which sulfur amino acids control protein metabolism and oxidative status. J Nutr Biochem 19, 207–215.
199Tesseraud S, Métayer Coustard S, Collin A, et al. . (2009) Role of sulfur amino acids in controlling nutrient metabolism and cell functions: implications for nutrition. Br J Nutr 101, 1132–1139.
200Morand C, Rios L, Moundras C, et al. . (1997) Influence of methionine availability on glutathione synthesis and delivery by the liver. J Nutr Biochem 8, 246–255.
201Nkabyo YS, Gu LH, Jones DP, et al. . (2006) Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake. J Nutr 136, 1242–1248.
202Tateishi N, Hirasawa M, Higashi T, et al. . (1982) The l-methionine-sparing effect of dietary glutathione in rats. J Nutr 112, 2217–2226.
203Flagg EW, Coates RJ, Eley JW, et al. . (1994) Dietary glutathione intake in humans and the relationship between intake and plasma total glutathione level. Nutr Cancer 21, 33–46.
204Martin A (2001) Apports nutritionnels conseillés pour la population française (Recommended Dietary Allowances for the French Population), 3rd ed.Paris: Editions TEC & DOC.
206Smith AT, Kuznesof S, Richardson DP, et al. . (2003) Behavioural, attitudinal and dietary responses to the consumption of wholegrain foods. Proc Nutr Soc 62, 455–467.
207Hagen TM, Wierzbicka GT, Bowman BB, et al. . (1990) Fate of dietary glutathione: disposition in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 259, G530–G535.
208Gmünder H, Roth S, Eck H-P, et al. . (1990) Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells. Cell Immunol 130, 520–528.
209Witschi A, Reddy S, Stofer B, et al. . (1992) The systemic availability of oral glutathione. Eur J Clin Pharmacol 43, 667–669.
210Sarwin R, Walther C, Laskawy G, et al. . (1992) Determination of free reduced and total glutathione in wheat flours by an isotope-dilution assay. Z Lebens Unters Forsch 195, 27–32.
211Li W, Bollecker SS & Schofield JD (1995) Glutathione and related thiol compounds. I. Glutathione and related thiol compounds in flour. J Cereal Sci 39, 205–212.
212Weber F & Grosch W (1978) Determination of reduced and oxidized glutathione in wheat flours and doughs. Z Lebens Unters Forsch 167, 87–92.
213Lotito SB & Frei B (2004) The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic Biol Med 37, 251–258.
214Lotito SB & Frei B (2006) Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 41, 1727–1746.
215Souci SW, Fachmann W & Kraut H (2000) Food Composition and Nutritional Tables. Stuttgart: Medpharm Scientific Publishers.
216Natella F, Nardini M, Giannetti I, et al. . (2002) Coffee drinking influences plasma antioxidant capacity in humans. J Agric Food Chem 50, 6211–6216.
217Lopez HW, Leenhardt F, Coudray C, et al. . (2002) Minerals and phytic acid interactions: is it a real problem for human nutrition? Int J Food Sci Technol 37, 727–739.
218Graf E & Eaton GW (1990) Antioxidant functions of phytic acid. Free Radic Biol Med 8, 61–69.
219Levrat-Verny MA, Coudray C, Bellanger J, et al. . (1999) Wholewheat flour ensures higher mineral absorption and bioavailability than white wheat flour in rats. Br J Nutr 82, 17–21.
220Leenhardt F, Levrat-Verny MA, Chanliaud E, et al. . (2005) Moderate decrease of pH by sourdough fermentation is sufficient to reduce phytate content of whole wheat flour through endogenous phytase activity. J Agric Food Chem 53, 98–102.
221Begum AN, Nicolle C, Mila I, et al. . (2004) Dietary lignins are precursors of mammalian lignans in rats. J Nutr 134, 120–127.
222Kitts DD, Yuan YV, Wijewickreme AN, et al. . (1999) Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem 202, 91–100.
223Bach Knudsen KE, Serena A, Kjaer AKB, et al. . (2003) Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces. J Nutr 133, 1368–1375.
224Labaj J, Wsolova L, Lazarova M, et al. . (2004) Repair of oxidative DNA lesions in blood lymphocytes isolated from Sprague–Dawley rats; the influence of dietary intake of lignin. Neoplasma 51, 450–455.
225Craig SAS (2004) Betaine in human nutrition. Am J Clin Nutr 80, 539–549.
226Zeisel SH & Blusztajn JK (1994) Choline and human nutrition. Annu Rev Nutr 14, 269–296.
227Likes R, Madl RL, Zeisel SH, et al. . (2007) The betaine and choline content of a whole wheat flour compared to other mill streams. J Cereal Sci 46, 93–95.
228Cho S, Johnson G & Song WO (2002) Folate content of foods: comparison between databases compiled before and after new FDA fortification requirements. J Food Comp Anal 15, 293–307.
229Bertram HC, Bach Knudsen KE, Serena A, et al. . (2006) NMR-based metabonomic studies reveal changes in the biochemical profile of plasma and urine from pigs fed high-fibre rye bread. Br J Nutr 95, 955–962.
230Fardet A, Canlet C, Gottardi G, et al. . (2007) Whole grain and refined wheat flours show distinct metabolic profiles in rats as assessed by a 1H NMR-based metabonomic approach. J Nutr 4, 923–929.
231Borgschulte G, Kathirvel E, Herrera M, et al. . (2008) Betaine treatment reverses insulin resistance and fatty liver disease without reducing oxidative stress or endoplasmic reticulum stress in an animal model of NAFLD. Gastroenterology 134, A414–A415.
232Brouwer IA, van Dusseldorp M, Thomas CM, et al. . (1999) Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr 69, 99–104.
233Graham IM, Daly LE, Refsum HM, et al. . (1997) Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 277, 1775–1781.
234Mills JL, McPartlin JM, Kirke PN, et al. . (1995) Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 345, 149–151.
235Wu LL & Wu JT (2002) Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 322, 21–28.
236Loscalzo J (1996) The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 98, 5–7.
237Tyagi N, Sedoris KC, Steed M, et al. . (2005) Mechanisms of homocysteine-induced oxidative stress. Am J Physiol Heart Circ Physiol 289, H2649–H2656.
238Christman JK, Chen M-L, Sheikhnejad G, et al. . (1993) Methyl deficiency, DNA methylation, and cancer: studies on the reversibility of the effects of a lipotrope-deficient diet. J Nutr Biochem 4, 672–680.
239Newberne PM & Rogers AE (1986) Labile methyl groups and the promotion of cancer. Annu Rev Nutr 6, 407–432.
240Zeisel S, Da Costa K, Franklin P, et al. . (1991) Choline, an essential nutrient for humans. FASEB J 5, 2093–2098.
241Iqbal TH, Lewis KO & Cooper BT (1994) Phytase activity in the human and rat small intestine. Gut 35, 1233–1236.
242Okazaki Y, Setoguchi T & Katayama T (2006) Effects of dietary myo-inositol, d-chiro-inositol and l-chiro-inositol on hepatic lipids with reference to the hepatic myo-inositol status in rats fed on 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane. Biosci Biotechnol Biochem 70, 2766–2770.
243Horbowicz M & Obendorf RL (2005) Fagopyritol accumulation and germination of buckwheat seeds matured at 15, 22, and 30°C. Crop Sci 45, 1264–1270.
244Steadman KJ, Burgoon MS, Schuster RL, et al. . (2000) Fagopyritols, d-chiro-inositol, and other soluble carbohydrates in buckwheat seed milling fractions. J Agric Food Chem 48, 2843–2847.
245Kim JI, Kim JC, Joo HJ, et al. . (2005) Determination of total chiro-inositol content in selected natural materials and evaluation of the antihyperglycemic effect of pinitol isolated from soybean and carob. Food Sci Biotechnol 14, 441–445.
246Becker R, Wheeler EL, Lorenz K, et al. . (1981) A compositional study of amaranth grain. J Food Sci 46, 1175–1180.
247Darbre A & Norris FW (1956) Vitamins in germination – determination of free and combined inositol in germinating oats. Biochem J 64, 441–446.
248Koziol MJ (1992) Chemical composition and nutritional evaluation of quinoa (Chenopodium quinoa Willd.). J Food Comp Anal 5, 35–68.
249Horbowicz M & Obendorf RL (1994) Seed desiccation tolerance and storability: dependence on flatulence-producing oligosaccharides and cyclitols? – review and survey. Seed Sci Res 4, 385–405.
250Matheson NK & Strother S (1969) The utilization of phytate by germinating wheat. Phytochemistry 8, 1349–1356.
251Clements R Jr & Darnell B (1980) Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr 33, 1954–1967.
252Reddy NR, Sathe SK & Salunkhe DK (1982) Phytates in legumes and cereals. Adv Food Res 28, 1–92.
253Ferrel RE (1978) Distribution of bean and wheat inositol phosphate esters during autolysis and germination. J Food Sci 43, 563–565.
254Nakano T, Joh T, Narita K, et al. . (2000) The pathway of dephosphorylation of myo-inositol hexakisphosphate by phytases from wheat bran of Triticum aestivum L. cv. Nourin #61. Biosci Biotechnol Biochem 64, 995–1003.
255Bergman E-L, Fredlund K, Reinikainen P, et al. . (1999) Hydrothermal processing of barley (cv. Blenheim): optimisation of phytate degradation and increase of free myo-inositol. J Cereal Sci 29, 261–272.
256Pak Y, Huang L, Lilley K, et al. . (1992) In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues. J Biol Chem 267, 16904–16910.
257Reeves PG, Nielsen FH & Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123, 1939–1951.
258Locker J, Reddy TV & Lombardi B (1986) DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet. Carcinogenesis 7, 1309–1312.
259Gama-Sosa MA, Slagel VA, Trewyn RW, et al. . (1983) The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res 11, 6883–6894.
260Goelz S, Vogelstein B, Hamilton SR, et al. . (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187–190.
261Ou SY & Kwok KC (2004) Ferulic acid: pharmaceutical functions, preparation and applications in foods. J Sci Food Agric 84, 1261–1269.
262Srinivasan M, Sudheer AR & Menon VP (2007) Ferulic acid: therapeutic potential through its antioxidant property. J Clin Biochem Nutr 40, 92–100.
263Rybka K, Sitarski J & Raczynskabojanowska K (1993) Ferulic acid in rye and wheat-grain and grain dietary fiber. Cereal Chem 70, 55–59.
264Kroon PA, Faulds CB, Ryden P, et al. . (1997) Release of covalently bound ferulic acid from fiber in the human colon. J Agric Food Chem 45, 661–667.
265Akao Y, Seki N, Nakagawa Y, et al. . (2004) A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Bioorg Med Chem 12, 4791–4801.
266Ferguson LR & Harris PJ (1996) Studies on the role of specific dietary fibres in protection against colorectal cancer. Mutat Res 350, 173–184.
267Calvert GD & Yeates RA (1982) Adsorption of bile salts by soya-bean flour, wheat bran, lucerne (Medicago sativa), sawdust and lignin: the effect of saponins and other plant constituents. Br J Nutr 47, 45–52.
268Chang MLW & Johnson MA (1980) Effect of lignin versus cellulose on the absorption of taurocholate and lipid metabolism in rats fed cholesterol diet. Nutr Rep Int 21, 513–518.
269Drasar B & Jenkins D (1976) Bacteria, diet, and large bowel cancer. Am J Clin Nutr 29, 1410–1416.
270Anjaneyulu M & Chopra K (2004) Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats. Pharmacology 72, 42–50.
271Fardet A, Llorach R, Orsoni A, et al. . (2008) Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats. J Nutr 138, 1282–1287.
272Hindmarch I (2002) Beyond the monoamine hypothesis: mechanisms, molecules and methods. Eur Psychiatry 17, 294–299.
273Berry RJ, Li Z, Erickson JD, et al. . (1999) Prevention of neural-tube defects with folic acid in China. N Engl J Med 341, 1485–1490.
274Coppen A & Bolander-Gouaille C (2005) Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol 19, 59–65.
275Miller AL (2008) The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev 13, 216–226.
276Gilbody S, Lightfoot T & Sheldon T (2007) Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Community Health 61, 631–637.
277Lioger D, Leenhardt F, Demigne C, et al. . (2007) Sourdough fermentation of wheat fractions rich in fibres before their use in processed food. J Sci Food Agric 87, 1368–1373.
278Ohta A, Ohtsuki M, Hosono A, et al. . (1998) Dietary fructooligosaccharides prevent osteopenia after gastrectomy in rats. J Nutr 128, 106–110.
279Scholz-Ahrens KE, Ade P, Marten B, et al. . (2007) Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr 137, 838S–846S.
280Scholz-Ahrens KE & Schrezenmeir J (2007) Inulin and oligofructose and mineral metabolism: the evidence from animal trials. J Nutr 137, 2513S–2523S.
281Nordbö H & Rolla G (1972) Desorption of salivary proteins from hydroxyapatite by phytic acid and glycerophosphate and the plaque-inhibiting effect of the two compounds in vivo. J Dent Res 51, 800–802.
282McClure FJ (1964) Cariostatic effect of phosphates. Science 144, 1337–1338.
283Osborn TWB & Noriskin JN (1937) The relation between diet and caries in the South African Bantu. J Dent Res 16, 431–441.
284Osborn TWB, Noriskin JN & Staz J (1937) A comparison of crude and refined sugar and cereals in their ability to produce in vitro decalcification of teeth. J Dent Res 16, 165–171.
285Osborn TWB (1941) Further studies on the in vitro decalcification of teeth. J Dent Res 20, 59–69.
286McClure FJ (1960) The cariostatic effect in white rats of phosphorus and calcium supplements added to the flour of bread formulas and to bread diets. J Nutr 72, 131–136.
287McClure FJ (1963) Further studies on the cariostatic effect of organic and inorganic phosphates. J Dent Res 42, 693–699.
288McClure FJ & Muller A Jr (1959) Further observations on the cariostatic effect of phosphates. J Dent Res 38, 776–781.
289Wynn W, Haldi J, Bentley KD, et al. . (1956) Dental caries in the albino rat in relation to the chemical composition of the teeth and of the diet: II. Variations in the Ca/P ratio of the diet induced by changing the phosphorus content. J Nutr 58, 325–333.
290Magrill DS (1973) The reduction of the solubility of hydroxyapatite in acid by adsorption of phytate from solution. Arch Oral Biol 18, 591–600.
291Pruitt KM, Jamieson AD & Caldwell RC (1970) Possible basis for the cariostatic effect of inorganic phosphates. Nature 225, 1249.
292Cole MF & Bowen WH (1975) Effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (Macaca fascicularis). J Dent Res 54, 449–457.
293Adlercreutz H & Mazur W (1997) Phyto-oestrogens and Western diseases. Ann Med 29, 95–120.
294Chanvrier H, Appelqvist IA, Bird AR, et al. . (2007) Processing of novel elevated amylose wheats: functional properties and starch digestibility of extruded products. J Agric Food Chem 55, 10248–10257.
295Swennen K, Courtin CM & Delcour JA (2006) Non-digestible oligosaccharides with prebiotic properties. Crit Rev Food Sci Nutr 46, 459–471.
296Krause DO, Easter RA & Mackie RI (1994) Fermentation of stachyose and raffinose by hind-gut bacteria of the weanling pig. Lett Appl Microbiol 18, 349–352.
297Tortuero F, Fernández E, Rupérez P, et al. . (1997) Raffinose and lactic bacteria influence caecal fermentation and serum cholesterol in rats. Nutr Res 17, 41–49.
298Alessandri C, Pignatelli P, Loffredo L, et al. . (2006) α-Linolenic acid-rich wheat germ oil decreases oxidative stress and CD40 ligand in patients with mild hypercholesterolemia. Arterioscler Thromb Vasc Biol 26, 2577–2578.
299Farquhar JW, Smith RE & Dempsey ME (1956) The effect of beta sitosterol on the serum lipids of young men with arteriosclerotic heart disease. Circulation 14, 77–82.
300Jones PJ, Ntanios FY, Raeini-Sarjaz M, et al. . (1999) Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 69, 1144–1150.
301Kato S, Karino K-I, Hasegawa S, et al. . (1995) Octacosanol affects lipid metabolism in rats fed on a high-fat diet. Br J Nutr 73, 433–441.
302Taylor JC, Rapport L & Lockwood GB (2003) Octacosanol in human health. Nutrition 19, 192–195.
303Gouni-Berthold I & Berthold HK (2002) Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 143, 356–365.
304Varady KA, Wang Y & Jones PJH (2003) Role of policosanols in the prevention and treatment of cardiovascular disease. Nutr Rev 61, 376–383.
305Lin YG, Rudrum M, van der Wielen RPJ, et al. . (2004) Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism 53, 1309–1314.
306Menendez R, Arruzazabala L, Mas R, et al. . (1997) Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch–casein diet. Br J Nutr 77, 923–932.
307Menendez R, Fraga V, Amor AM, et al. . (1999) Oral administration of policosanol inhibits in vitro copper ion-induced rat lipoprotein peroxidation. Physiol Behav 67, 1–7.
308Hosseinian FS, Li W & Beta T (2008) Measurement of anthocyanins and other phytochemicals in purple wheat. Food Chem 109, 916–924.
309Asayama K, Yamadera H, Ito T, et al. . (2003) Double blind study of melatonin effects on the sleep–wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 70, 334–341.
310Maurizi CP (2001) Alzheimer's disease: roles for mitochondrial damage, the hydroxyl radical, and cerebrospinal fluid deficiency of melatonin. Med Hypotheses 57, 156–160.
311Garcia-Navarro A, Gonzalez-Puga C, Escames G, et al. . (2007) Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture. J Pineal Res 43, 195–205.
312Shiu SYW (2007) Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment. J Pineal Res 43, 1–9.
313Calhoun WK, Bechtel WG & Bradley WB (1958) The vitamin content of wheat, flour, and bread. Cereal Chem 35, 350–359.
314Calhoun WK, Hepburn FN & Bradley WB (1960) The distribution of the vitamins of wheat in commercial mill products. Cereal Chem 37, 755–761.
315Wang LH, Huang WS & Tai HM (2007) Simultaneous determination of p-aminobenzoic acid and its metabolites in the urine of volunteers, treated with p-aminobenzoic acid sunscreen formulation. J Pharm Biomed Anal 43, 1430–1436.
316Barbieri B, Papadogiannakis N, Eneroth P, et al. . (1995) Arachidonic acid is a preferred acetyl donor among fatty acids in the acetylation of p-aminobenzoic acid by human lymphoid cells. Biochim Biophys Acta 1257, 157–166.
317Failey RB & Childress RH (1962) The effect of para-aminobenzoic acid on the serum cholesterol level in man. Am J Clin Nutr 10, 158–162.
318Butcher NJ, Ilett KF & Minchin RF (2000) Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid. Biochem Pharmacol 60, 1829–1836.
319Hein DW, Doll MA, Gray K, et al. . (1993) Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of syrian hamsters congenic at the NAT2 locus. Cancer Res 53, 509–514.
320Minchin RF, Reeves PT, Teitel CH, et al. . (1992) N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. Biochem Biophys Res Commun 185, 839–844.
321Barbieri B, Papadogiannakis N, Eneroth P, et al. . (1997) p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. Thromb Res 86, 127–140.
322Elliott R, Pico C, Dommels Y, et al. . (2007) Nutrigenomic approaches for benefit–risk analysis of foods and food components: defining markers of health. Br J Nutr 98, 1095–1100.
323Steiner C, Arnould S, Scalbert A, et al. . (2008) Isoflavones and the prevention of breast and prostate cancer: new perspectives opened by nutrigenomics. Br J Nutr 99, E Suppl. 1, ES78–ES108.
324Trujillo E, Davis C & Milner J (2006) Nutrigenomics, proteomics, metabolomics, and the practice of dietetics. J Am Diet Assoc 106, 403–413.
325van Ommen B (2004) Nutrigenomics: exploiting systems biology in the nutrition and health arenas. Nutrition 20, 4–8.
326Zeisel SH (2007) Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline. Am J Clin Nutr 86, 542–548.
327Keun HC (2006) Metabonomic modeling of drug toxicity. Pharmacol Ther 109, 92–106.
328Rezzi S, Ramadan Z, Fay LB, et al. . (2007) Nutritional metabonomics: applications and perspectives. J Proteome Res 6, 513–525.
329Selman C, Kerrison ND, Cooray A, et al. . (2006) Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol Genomics 27, 187–200.
330Griffin JL, Muller D, Woograsingh R, et al. . (2002) Vitamin E deficiency and metabolic deficits in neuronal ceroid lipofuscinosis described by bioinformatics. Physiol Genomics 11, 195–203.
331Mutch DM, Grigorov M, Berger A, et al. . (2005) An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet. FASEB J 19, 599–619.
332Solanky KS, Bailey NJC, Beckwith-Hall BM, et al. . (2003) Application of biofluid H-1 nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile. Anal Biochem 323, 197–204.
333Wang Y, Tang H, Nicholson JK, et al. . (2005) A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion. J Agric Food Chem 53, 191–196.
334Van Dorsten FA, Daykin CA, Mulder TPJ, et al. . (2006) Metabonomics approach to determine metabolic differences between green tea and black tea consumption. J Agric Food Chem 54, 6929–6938.
335Solanky KS, Bailey NJC, Holmes E, et al. . (2003) NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat. J Agric Food Chem 51, 4139–4145.
336Fardet A, Llorach R, Martin JF, et al. . (2008) A liquid chromatography–quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets. J Proteome Res 7, 2388–2398.
337Dumas ME, Barton RH, Toye A, et al. . (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A 103, 12511–12516.
338Zhang S, Nagana Gowda GA, Asiago V, et al. . (2008) Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats. Anal Biochem 383, 76–84.
339Britz SJ, Prasad PVV, Moreau RA, et al. . (2007) Influence of growth temperature on the amounts of tocopherols, tocotrienols, and γ-oryzanol in brown rice. J Agric Food Chem 55, 7559–7565.
340Packer L, Witt EH & Tritschler HJ (1995) α-Lipoic acid as a biological antioxidant. Free Radic Biol Med 19, 227–250.
341Roy S, Sen CK, Tritschler HJ, et al. . (1997) Modulation of cellular reducing equivalent homeostasis by α-lipoic acid: mechanisms and implications for diabetes and ischemic injury. Biochem Pharmacol 53, 393–399.
342Maczurek A, Hager K, Kenklies M, et al. . (2008) Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev 60, 1463–1470.
343Wollin SD & Jones PJH (2003) α-Lipoic acid and cardiovascular disease. J Nutr 133, 3327–3330.
344Yu SG, Nehus ZT, Badger TM, et al. . (2007) Quantification of vitamin E and γ-oryzanol components in rice germ and bran. J Agric Food Chem 55, 7308–7313.
345Emmons CL, Peterson DM & Paul GL (1999) Antioxidant capacity of oat (Avena sativa L.) extracts. 2. In vitro antioxidant activity and contents of phenolic and tocol antioxidants. J Agric Food Chem 47, 4894–4898.
346Heinemann T, Kullak-Ublick G-A, Pietruck B, et al. . (1991) Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Eur J Clin Pharmacol 40, S59–S63.
347Sen CK, Khanna S & Roy S (2006) Tocotrienols: vitamin E beyond tocopherols. Life Sci 78, 2088–2098.
348Wilson TA, Nicolosi RJ, Woolfrey B, et al. . (2007) Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J Nutr Biochem 18, 105–112.
349Kahlon TS & Chow FI (2000) In vitro binding of bile acids by rice bran, oat bran, wheat bran, and corn bran. Cereal Chem 77, 518–521.
350Saulnier L, Vigouroux J & Thibault J-F (1995) Isolation and partial characterization of feruloylated oligosaccharides from maize bran. Carbohydr Res 272, 241–253.
351Saulnier L, Marot C, Elgorriaga M, et al. . (2001) Thermal and enzymatic treatments for the release of free ferulic acid from maize bran. Carbohydr Polym 45, 269–275.
352O'Dell BL, De Boland AR & Koityonann SR (1972) Distribution of phytate and nutritionally important elements among the morphological components of cereals grains. J Agric Food Chem 20, 718–721.
353Miller A & Engel KH (2006) Content of γ-oryzanol and composition of steryl ferulates in brown rice (Oryza sativa L.) of European origin. J Agric Food Chem 54, 8127–8133.
354Chen MH & Bergman CJ (2005) A rapid procedure for analysing rice bran tocopherol, tocotrienol and γ-oryzanol contents. J Food Comp Anal 18, 139–151.
355Schramm R, Abadie A, Hua N, et al. . (2007) Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide. J Biol Eng 1, 9.
356Shin T-S, Godber JS, Martin DE, et al. . (1997) Hydrolytic stability and changes in E vitamers and oryzanol of extruded rice bran during storage. J Food Sci 62, 704–728.
357Juliano C, Cossu M, Alamanni MC, et al. . (2005) Antioxidant activity of γ-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm 299, 146–154.
358Rong N, Ausman L & Nicolosi R (1997) Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids 32, 303–309.
359Seetharamaiah GS & Chandrasekhara N (1993) Comparative hypocholesterolemic activities of oryzanol, curcumin and ferulic acid in rats. J Food Sci Technol Mysore 30, 249–252.
360Suh MH, Yoo SH, Chang PS, et al. . (2005) Antioxidative activity of microencapsulated γ-oryzanol on high cholesterol-fed rats. J Agric Food Chem 53, 9747–9750.
361Cicero AFG & Gaddi A (2001) Rice bran oil and γ-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother Res 15, 277–289.
362Collins FW (1989) Oat phenolics: avenanthramides, novel substituted N-cinnamoylanthranilate alkaloids from oat groats and hulls. J Agric Food Chem 37, 60–66.
363Shewry PR, Piironen V, Lampi A-M, et al. . (2008) Phytochemical and fiber components in oat varieties in the HEALTHGRAIN diversity screen. J Agric Food Chem 56, 9777–9784.
364Dimberg LH, Theander O & Lingnert H (1993) Avenanthramides – a group of phenolic antioxidants in oats. Cereal Chem 70, 637–641.
365Mattila P, Pihlava J-M & Hellstrom J (2005) Contents of phenolic acids, alkyl- and alkenylresorcinols, and avenanthramides in commercial grain products. J Agric Food Chem 53, 8290–8295.
366Fagerlund A, Sunnerheim K & Dimberg LH (2009) Radical-scavenging and antioxidant activity of avenanthramides. Food Chem 113, 550–556.
367Peterson DM, Hahn MJ & Emmons CL (2002) Oat avenanthramides exhibit antioxidant activities in vitro. Food Chem 79, 473–478.
368Liu L, Zubik L, Collins FW, et al. . (2004) The antiatherogenic potential of oat phenolic compounds. Atherosclerosis 175, 39–49.
369Chen CY, Milbury PE, Kwak HK, et al. . (2004) Avenanthramides and phenolic acids from oats are bioavailable and act synergistically with vitamin C to enhance hamster and human LDL resistance to oxidation. J Nutr 134, 1459–1466.
370Güçlü-Üstündag Ö & Mazza G (2007) Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 47, 231–258.
371Osbourn AE (2003) Saponins in cereals. Phytochemistry 62, 1–4.
372Önning G, Asp N-G & Sivik B (1993) Saponin content in different oat varieties and in different fractions of oat grain. Food Chem 48, 251–254.
373Price KR, Johnson IT & Fenwick GR (1987) The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr 26, 27–135.
374Matsuura H (2001) Saponins in garlic as modifiers of the risk of cardiovascular disease. J Nutr 131, 1000S–1005S.
375Barr IG, Sjölander A & Cox JC (1998) ISCOMs and other saponin based adjuvants. Adv Drug Deliv Rev 32, 247–271.
376Sjölander A, Cox J & Barr I (1998) ISCOMs: an adjuvant with multiple functions. J Leukoc Biol 64, 713–723.
377Oakenfull DG, Fenwick DE, Hood RL, et al. . (1979) Effects of saponins on bile acids and plasma lipids in the rat. Br J Nutr 42, 209–216.
378Baik B-K & Ullrich SE (2008) Barley for food: characteristics, improvement, and renewed interest. J Cereal Sci 48, 233–242.
379Åman P & Graham H (1987) Analysis of total and insoluble mixed-linked (1 → 3),(1 → 4)-β-d-glucans in barley and oats. J Agric Food Chem 35, 704–709.
380Anker-Nilssen K, Sahlstrøm S, Knutsen SH, et al. . (2008) Influence of growth temperature on content, viscosity and relative molecular weight of water-soluble β-glucans in barley (Hordeum vulgare L.). J Cereal Sci 48, 670–677.
381Gajdosová A, Petruláková Z, Havrlentová M, et al. . (2007) The content of water-soluble and water-insoluble β-d-glucans in selected oats and barley varieties. Carbohydr Polym 70, 46–52.
382Holtekjølen AK, Uhlen AK, Bråthen E, et al. . (2006) Contents of starch and non-starch polysaccharides in barley varieties of different origin. Food Chem 94, 348–358.
383Izydorczyk MS & Dexter JE (2008) Barley β-glucans and arabinoxylans: molecular structure, physicochemical properties, and uses in food products – a review. Food Res Int 41, 850–868.
384Izydorczyk MS, Macri LJ & MacGregor AW (1998) Structure and physicochemical properties of barley non-starch polysaccharides – II. Alkaliextractable β-glucans and arabinoxylans. Carbohydr Polym 35, 259–269.
385Izydorczyk MS, Storsley J, Labossiere D, et al. . (2000) Variation in total and soluble β-glucan content in hulless barley: effects of thermal, physical, and enzymic treatments. J Agric Food Chem 48, 982–989.
386Prentice N, Babler S & Faber S (1980) Enzymic analysis of β-d-glucans in cereal grains. Cereal Chem 57, 198–202.
387Kim H, Stote KS, Behall KM, et al. . (2009) Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, β-glucan: a doase response study in obese women with increased risk for insulin resistance. Eur J Nutr 48, 170–175.
388Butt MS, Tahir-Nadeem M, Khan MKI, et al. . (2008) Oat: unique among the cereals. Eur J Nutr 47, 68–79.
389Kalra S & Joad S (2000) Effect of dietary barley β-glucan on cholesterol and lipoprotein fractions in rats. J Cereal Sci 31, 141–145.
390Hlebowicz J, Darwiche G, Bjorgell O, et al. . (2008) Effect of muesli with 4 g oat β-glucan on postprandial blood glucose, gastric emptying and satiety in healthy subjects: a randomized crossover trial. J Am Coll Nutr 27, 470–475.
391Mantovani MS, Bellini MF, Angeli JPF, et al. . (2008) β-Glucans in promoting health: prevention against mutation and cancer. Mutat Res 658, 154–161.
392Ross AB, Shepherd MJ, Schupphaus M, et al. . (2003) Alkylresorcinols in cereals and cereal products. J Agric Food Chem 51, 4111–4118.
393Ross AB, Kamal-Eldin A, Lundin EA, et al. . (2003) Cereal alkylresorcinols are absorbed by humans. J Nutr 133, 2222–2224.
394Landberg R, Aman P, Friberg LE, et al. . (2009) Dose response of whole-grain biomarkers: alkylresorcinols in human plasma and their metabolites in urine in relation to intake. Am J Clin Nutr 89, 290–296.
395Linko-Parvinen A-M, Landberg R, Tikkanen MJ, et al. . (2007) Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins. J Nutr 137, 1137–1142.
396Ross AB, Kamal-Eldin A & Aman P (2004) Dietary alkylresorcinols: absorption, bioactivities, and possible use as biomarkers of whole-grain wheat- and rye-rich foods. Nutr Rev 62, 81–95.
397Guyman LA, Adlercreutz H, Koskela A, et al. . (2008) Urinary 3-(3,5-dihydroxyphenyl)-1-propanoic acid, an alkylresorcinol metabolite, is a potential biomarker of whole-grain intake in a U.S. population. J Nutr 138, 1957–1962.
398Tsuge N, Mizokami M, Imai S, et al. . (1992) Adipostatin-A and adipostatin-B, new inhibitors of glycerol-3-phosphate dehydrogenase. J Antibiot 45, 886–891.
399Ross AB, Chen Y, Frank J, et al. . (2004) Cereal alkylresorcinols elevate γ-tocopherol levels in rats and inhibit γ-tocopherol metabolism in vitro. J Nutr 134, 506–510.
400Kozubek A & Tyman JHP (1999) Resorcinolic lipids, the natural non-isoprenoid phenolic amphiphiles and their biological activity. Chem Rev 99, 1–25.
401Ross JA & Kasum CM (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22, 19–34.
402Norton I, Moore S & Fryer P (2007) Understanding food structuring and breakdown: engineering approaches to obesity. Obes Rev 8, Suppl. 1, 83–88.
403Parada J & Aguilera JM (2007) Food microstructure affects the bioavailability of several nutrients. J Food Sci 72, R21–R32.
404Tedeschi C, Clement V, Rouvet M, et al. . (2009) Dissolution tests as a tool for predicting bioaccessibility of nutrients during digestion. Food Hydrocolloids 23, 1228–1235.
405Englyst H, Kingman S & Cummings J (1992) Classification and measurement of nutritionally important starch fractions. Eur J Clin Nutr 46, S33–S50.
406Lehmann U & Robin F (2007) Slowly digestible starch – its structure and health implications: a review. Trends Food Sci Technol 18, 346–355.
407Marangoni A, Idziak S & Rush J (2008) Controlled release of food lipids using monoglyceride gel phases regulates lipid and insulin metabolism in humans. Food Biophys 3, 241–245.
408Remond D, Machebeuf M, Yven C, et al. . (2007) Postprandial whole-body protein metabolism after a meat meal is influenced by chewing efficiency in elderly subjects. Am J Clin Nutr 85, 1286–1292.
409Armand M, Pasquier B, Andre M, et al. . (1999) Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am J Clin Nutr 70, 1096–1106.
410Giovannucci E, Rimm EB, Ascherio A, et al. . (1995) Alcohol, low-methionine–low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87, 265–273.
411Lu ZX, Walker KZ, Muir JG, et al. . (2000) Arabinoxylan fiber, a byproduct of wheat flour processing, reduces the postprandial glucose response in normoglycemic subjects. Am J Clin Nutr 71, 1123–1128.
412Moore MA, Park CB & Tsuda H (1998) Soluble and insoluble fiber influences on cancer development. Crit Rev Oncol Hematol 27, 229–242.
413Björck I & Asp N-G (1994) Controlling the nutritional properties of starch in foods – a challenge to the food industry. Trends Food Sci Technol 5, 213–218.
414Dongowski G, Jacobasch G & Schmiedl D (2005) Structural stability and prebiotic properties of resistant starch type 3 increase bile acid turnover and lower secondary bile acid formation. J Agric Food Chem 53, 9257–9267.
415Topping DL, Fukushima M & Bird AR (2003) Resistant starch as a prebiotic and synbiotic: state of the art. Proc Nutr Soc 62, 171–176.
416Rahman S, Bird A, Regina A, et al. . (2007) Resistant starch in cereals: exploiting genetic engineering and genetic variation. J Cereal Sci 46, 251–260.
417Goddard MS, Young G & Marcus R (1984) The effect of amylose content on insulin and glucose responses to ingested rice. Am J Clin Nutr 39, 388–392.
418Hallfrisch J & Behall KM (2000) Mechanisms of the effects of grains on insulin and glucose responses. J Am Coll Nutr 19, 320S–325S.
419Hawkesford MJ & Zhao F-J (2007) Strategies for increasing the selenium content of wheat. J Cereal Sci 46, 282–292.
420Singh BR (1991) Selenium content of wheat as affected by selenate and selenite contained in a Cl- or SO4-based NPK fertilizer. Fertilizer Res 30, 1–7.
421Soliman MF (1980) Zinc uptake by wheat plants as influenced by nitrogen fertilizers and calcium carbonate. Agric Res Rev 58, 113–121.
422Fallahi E, Mohtadinia J & Ali Mahboob S (2005) Effect of consumption of whole bread baked from cultivated wheat with micronutrient fertilizers on blood indices of iron. J Food Agric Environ 3, 39–42.
423Hanson AD & Wyse R (1982) Biosynthesis, translocation, and accumulation of betaine in sugar beet and its progenitors in relation to salinity. Plant Physiol 70, 1191–1198.
424Keles Y & Öncel I (2002) Response of antioxidative defence system to temperature and water stress combinations in wheat seedlings. Plant Sci 163, 783–790.
425King JC (2002) Biotechnology: a solution for improving nutrient bioavailability. Int J Vitam Nutr Res 72, 7–12.
426Cakmak I, Ozkan H, Braun HJ, et al. . (2000) Zinc and iron concentrations in seeds of wild, primitive, and modern wheats. Food Nutr Bull 21, 401–403.
427Ortiz-Monasterio JI, Palacios-Rojas N, Meng E, et al. . (2007) Enhancing the mineral and vitamin content of wheat and maize through plant breeding. J Cereal Sci 46, 293–307.
428Mendoza C, Viteri F, Lonnerdal B, et al. . (1998) Effect of genetically modified, low-phytic acid maize on absorption of iron from tortillas. Am J Clin Nutr 68, 1123–1127.
429Raboy V (2002) Progress in breeding low phytate crops. J Nutr 132, 503S–505S.
430King RA, Noakes M, Bird AR, et al. . (2008) An extruded breakfast cereal made from a high amylose barley cultivar has a low glycemic index and lower plasma insulin response than one made from a standard barley. J Cereal Sci 48, 526–530.
431Regina A, Bird A, Topping D, et al. . (2006) High-amylose wheat generated by RNA interference improves indices of large-bowel health in rats. Proc Natl Acad Sci U S A 103, 3546–3551.
432Saulnier L, Sado P-E, Branlard G, et al. . (2007) Wheat arabinoxylans: exploiting variation in amount and composition to develop enhanced varieties. J Cereal Sci 46, 261–281.
433Brinch-Pedersen H, Borg S, Tauris B, et al. . (2007) Molecular genetic approaches to increasing mineral availability and vitamin content of cereals. J Cereal Sci 46, 308–326.
434Hammes WP, Brandt MJ, Francis KL, et al. . (2005) Microbial ecology of cereal fermentations. Trends Food Sci Technol 16, 4–11.
435Nout MJR (2009) Rich nutrition from the poorest – cereal fermentations in Africa and Asia. Food Microbiology 26, 685–692.
436Napolitano A, Lanzuise S, Ruocco M, et al. . (2006) Treatment of cereal products with a tailored preparation of Trichoderma enzymes increases the amount of soluble dietary fiber. J Agric Food Chem 54, 7863–7869.
437Faulds CB & Williamson G (1995) Release of ferulic acid from wheat bran by a ferulic acid esterase (FAE-III) from Aspergillus niger. Appl Microbiol Biotechnol 43, 1082–1087.
438Wang XK, Geng X, Egashira Y, et al. . (2005) Release of ferulic acid from wheat bran by an inducible feruloyl esterase from an intestinal bacterium Lactobacillus acidophilus. Food Sci Technol Res 11, 241–247.
439Chavan JK & Kadam SS (1989) Nutritional improvement of cereals by fermentation. Crit Rev Food Sci Nutr 28, 349–400.
440Gadaga TH, Mutukumira AN, Narvhus JA, et al. . (1999) A review of traditional fermented foods and beverages of Zimbabwe. Int J Food Microbiol 53, 1–11.
441Lioger D, Leenhardt F & Rémésy C (2006) Intérêt de la fermentation, en milieu très hydraté, des produits céréaliers riches en fibres pour améliorer leur valeur nutritionnelle (Interest of fibre-rich cereal products fermentation in very hydrated environment to improve their nutritional value). Ind Cér 149, 14–22.
442Poutanen K, Flander L & Katina K (2009) Sourdough and cereal fermentation in a nutritional perspective. Food Microbiol 26, 693–699.
443Abd Elmoneim OE, Schiffler B & Bernhard R (2004) Effect of fermentation on the starch digestibility, resistant starch and some physicochemical properties of sorghum flour. Nahrung/Food 48, 91–94.
444Eklund-Jonsson C, Sandberg A-S & Larsson Alminger M (2006) Reduction of phytate content while preserving minerals during whole grain cereal tempe fermentation. J Cereal Sci 44, 154–160.
445El Hag ME, El Tinay AH & Yousif NE (2002) Effect of fermentation and dehulling on starch, total polyphenols, phytic acid content and in vitro protein digestibility of pearl millet. Food Chem 77, 193–196.
446Loponen J, Kanerva P, Zhang C, et al. . (2009) Prolamin hydrolysis and pentosan solubilization in germinated-rye sourdoughs determined by chromatographic and immunological methods. J Agric Food Chem 57, 746–753.
447Mugula JK, Sorhaug T & Stepaniak L (2003) Proteolytic activities in togwa, a Tanzanian fermented food. Int J Food Microbiol 84, 1–12.
448Thiele C, Grassl S & Ganzle M (2004) Gluten hydrolysis and depolymerization during sourdough fermentation. J Agric Food Chem 52, 1307–1314.
449Wedad HA, El-Tinay AH, Mustafa AI, et al. . (2008) Effect of fermentation, malt-pretreatment and cooking on antinutritional factors and protein digestibility of sorghum cultivars. Pak J Nutr 7, 335–341.
450Lopez HW, Krespine V, Guy C, et al. . (2001) Prolonged fermentation of whole wheat sourdough reduces phytate level and increases soluble magnesium. J Agric Food Chem 49, 2657–2662.
451Lopez HW, Duclos V, Coudray C, et al. . (2003) Making bread with sourdough improves mineral bioavailability from reconstituted whole wheat flour in rats. Nutrition 19, 524–530.
452Katina K, Liukkonen K-H, Kaukovirta-Norja A, et al. . (2007) Fermentation-induced changes in the nutritional value of native or germinated rye. J Cereal Sci 46, 348–355.
453Winata A & Lorenz K (1997) Effects of fermentation and baking of whole wheat and whole rye sourdough breads on cereal alkylresorcinols. Cereal Chem 74, 284–287.
454Katina K, Laitila A, Juvonen R, et al. . (2007) Bran fermentation as a means to enhance technological properties and bioactivity of rye. Food Microbiol 24, 175–186.
455Moore J, Luther M, Cheng Z, et al. . (2009) Effects of baking conditions, dough fermentation, and bran particle size on antioxidant properties of whole-wheat pizza crusts. J Agric Food Chem 57, 832–839.
456Garcia AL, Otto B, Reich SC, et al. . (2007) Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr 61, 334–341.
457Lioger D, Fardet A, Foassert P, et al. . (2009) Influence of sourdough prefermentation, of steam cooking suppression and of decreased sucrose content during wheat flakes processing on the plasma glucose and insulin responses and satiety of healthy subjects. J Am Coll Nutr 28, 30–36.
458Liljeberg H & Bjorck I (1996) Delayed gastric emptying rate as a potential mechanism for lowered glycemia after eating sourdough bread: studies in humans and rats using test products with added organic acids or an organic salt. Am J Clin Nutr 64, 886–893.
459Liljeberg HG, Lonner CH & Bjorck IM (1995) Sourdough fermentation or addition of organic acids or corresponding salts to bread improves nutritional properties of starch in healthy humans. J Nutr 125, 1503–1511.
460Brennan CS, Blake DE, Ellis PR, et al. . (1996) Effects of guar galactomannan on wheat bread microstructure and on the in vitro and in vivo digestibility of starch in bread. J Cereal Sci 24, 151–160.
461Burton P & Lightowler HJ (2006) Influence of bread volume on glycaemic response and satiety. Br J Nutr 96, 877–882.
462Granfeldt Y, Eliasson AC & Bjorck I (2000) An examination of the possibility of lowering the glycemic index of oat and barley flakes by minimal processing. J Nutr 130, 2207–2214.
463Antoine C, Lullien-Pellerin V, Abecassis J, et al. . (2002) Nutritional interest of the wheat seed aleurone layer. Sci Alim 22, 545–556.
464Buri RC, von Reding W & Gavin MH (2004) Description and characterization of wheat aleurone. Cereal Foods World 49, 274–282.
465Harris PJ, Chavan RR & Ferguson LR (2005) Production and characterisation of two wheat-bran fractions: an aleurone-rich and a pericarp-rich fraction. Mol Nutr Food Res 49, 536–545.
466Hemery Y, Rouau X, Lullien-Pellerin V, et al. . (2007) Dry processes to develop wheat fractions and products with enhanced nutritional quality. J Cereal Sci 46, 327–347.
467Fenech M, Noakes M, Clifton P, et al. . (1999) Aleurone flour is a rich source of bioavailable folate in humans. J Nutr 129, 1114–1119.
468Fenech M, Noakes M, Clifton P, et al. . (2005) Aleurone flour increases red-cell folate and lowers plasma homocyst(e)ine substantially in man. Br J Nutr 93, 353–360.
469Cheng BO, Trimble RP, Illman RJ, et al. . (1987) Comparative effects of dietary wheat bran and its morphological components (aleurone and pericarp-seed coat) on volatile fatty acid concentrations in the rat. Br J Nutr 57, 69–76.
470McIntosh GH, Royle PJ & Pointing G (2001) Wheat aleurone flour increases cecal β-glucuronidase activity and butyrate concentration and reduces colon adenoma burden in azoxymethane-treated rats. J Nutr 131, 127–131.
471Amrein TM, Granicher P, Arrigoni E, et al. . (2003) In vitro digestibility and colonic fermentability of aleurone isolated from wheat bran. Lebensm-Wiss Technol Food Sci Technol 36, 451–460.
472Fardet A, Hoebler C, Baldwin PM, et al. . (1998) Involvement of the protein network in the in vitro degradation of starch from spaghetti and lasagne: a microscopic and enzymic study. J Cereal Sci 27, 133–145.
473Chu FS & Li GY (1994) Simultaneous occurrence of fumonisin B1 and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of esophageal cancer. Appl Environ Microbiol 60, 847–852.
474Rheeder JP, Marasas WFO, Thiel PG, et al. . (1992) Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 82, 353–357.
475Lebailly P, Niez E & Baldi I (2007) Données épidémiologiques sur le lien entre cancers et pesticides (Epidemiological data on the link between cancer and pesticides). Oncologie 9, 361–369.
476Surget A & Barron C (2005) Histologie du grain de blé (Histology of the wheat grain). Ind Cér 145, 3–7.
477Zeisel SH, Mar MH, Howe JC, et al. . (2003) Concentrations of choline-containing compounds and betaine in common foods. J Nutr 133, 1302–1307.
478Poutanen K, Shepherd R, Shewry PR, et al. . (2008) Beyond whole grain: The European HEALTHGRAIN project aims at healthier cereal foods. Cereal Foods World 53, 32–35.
480Archer MJ (1972) Relationship between free glutathione content and quality assessment parameters of wheat cultivars (Triticum aestivum L.). J Sci Food Agric 23, 485–491.
481Shewry PR (2007) Improving the protein content and composition of cereal grain. J Cereal Sci 46, 239–250.
482Souci SW, Fachmann W & Kraut H (2008) Food Composition and Nutritional Tables, 7th ed.. Stuttgart, Germany: MedPharm Scientific Publishers.
483Waggle DH, Lambert MA, Miller GD, et al. . (1967) Extensive analyses of flours and millfeeds made from nine different wheat mixes. II. amino acids, minerals, vitamins, and gross energy. Cereal Chem 44, 48–60.
484Colonna P, Buléon A, Leloup V, et al. (1995) Constituants des céréales, des graines, des fruits et de leurs sous-produits (Constituents of grains, seeds, fruits and their by-products). In Nutrition des ruminants domestiques. Ingestion et digestion (Nutrition of domestic ruminants. Ingestion and digestion), [Jarrige R, Ruckebusch Y and Demarquilly C, et al. ., editors]. Paris: INRA.
485Knudsen KEB (1997) Carbohydrate and lignin contents of plant materials used in animal feeding. Anim Feed Sci Tech 67, 319–338.
486Gebruers K, Dornez E, Boros D, et al. . (2008) Variation in the content of dietary fiber and components thereof in wheats in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 9740–9749.
487Haskå L, Nyman M & Andersson R (2008) Distribution and characterisation of fructan in wheat milling fractions. J Cereal Sci 48, 768–774.
488Hernot DC, Boileau TW, Bauer LL, et al. . (2008) In vitro digestion characteristics of unprocessed and processed whole grains and their components. J Agric Food Chem 56, 10721–10726.
489Nyström L, Paasonen A, Lampi A-M, et al. . (2007) Total plant sterols, steryl ferulates and steryl glycosides in milling fractions of wheat and rye. J Cereal Sci 45, 106–115.
490Picolli da Silva L & de Lourdes Santorio Ciocca M (2005) Total, insoluble and soluble dietary fiber values measured by enzymatic-gravimetric method in cereal grains. J Food Comp Anal 18, 113–120.
491Ragaee SM, Campbell GL, Scoles GJ, et al. . (2001) Studies on rye (Secale cereale L.) lines exhibiting a range of extract viscosities. 1. Composition, molecular weight distribution of water extracts, and biochemical characteristics of purified water-extractable arabinoxylan. J Agric Food Chem 49, 2437–2445.
492Ward JL, Poutanen K, Gebruers K, et al. . (2008) The HEALTHGRAIN Cereal Diversity Screen: concept, results, and prospects. J Agric Food Chem 56, 9699–9709.
493Abdel-Aal E-SM & Hucl P (1999) A rapid method for quantifying total anthocyanins in blue aleurone and purple pericarp wheats. Cereal Chem 76, 350–354.
494Anderson J & Bridges S (1988) Dietary fiber content of selected foods. Am J Clin Nutr 47, 440–447.
495Fretzdorff B & Welge N (2003) Fructan and raffinose contents in cereals and pseudo-cereal grains. Getreide, Mehl und Brot 57, 3–8.
496Huynh BL, Palmer L, Mather DE, et al. . (2008) Genotypic variation in wheat grain fructan content revealed by a simplified HPLC method. J Cereal Sci 48, 369–378.
497Huynh BL, Wallwork H, Stangoulis JCR, et al. . (2008) Quantitative trait loci for grain fructan concentration in wheat (Triticum aestivum L.). Theor Appl Genet 117, 701–709.
498Henry RJ (1987) Pentosan and (1 → 3),(1 → 4)-β-glucan concentrations in endosperm and wholegrain of wheat, barley, oats and rye. J Cereal Sci 6, 253–258.
499Lempereur I, Rouau X & Abecassis J (1997) Genetic and agronomic variation in arabinoxylan and ferulic acid contents of durum wheat (Triticum durum L.) grain and its milling fractions. J Cereal Sci 25, 103–110.
500Genç H, Özdemir M & Demirbas A (2001) Analysis of mixed-linked (1 → 3), (1 → 4)-β-d-glucans in cereal grains from Turkey. Food Chem 73, 221–224.
501Hemery Y, Lullien-Pellerin V, Rouau X, et al. . (2009) Biochemical markers: efficient tools for the assessment of wheat grain tissue proportions in milling fractions. J Cereal Sci 49, 55–64.
502House WA & Welch RM (1987) Bioavailability to rats of iron in 6 varieties of wheat-grain intrinsically labeled with radioiron. J Nutr 117, 476–480.
503Lopez HW, Krespine V, Lemaire A, et al. . (2003) Wheat variety has a major influence on mineral bioavailability; studies in rats. J Cereal Sci 37, 257–266.
504O'Dell BL, Burpo CE & Savage JE (1972) Evaluation of zinc availability in foodstuffs of plant and animal origin. J Nutr 102, 653–660.
505Tabekhia MM & Donnelly BJ (1982) Phytic acid in durum-wheat and its milled products. Cereal Chem 59, 105–107.
506Tariq M, Talat M, Asia L, et al. . (2007) Influence of processing and cooking methodologies for reduction of phytic acid content in wheat (Triticum aestivum) varieties. J Food Process Preserv 31, 583–594.
507Davis KR, Peters LJ, Cain RF, et al. . (1984) Evaluation of the nutrient composition of wheat. III. Minerals. Cereal Foods World 29, 246–248.
508Frossard E, Bucher M, Mächler F, et al. . (2000) Potential for increasing the content and bioavailability of Fe, Zn and Ca in plants for human nutrition. J Sci Food Agric 80, 861–879.
509Lorenz K & Loewe R (1977) Mineral composition of U.S. and Canadian wheats and wheat blends. J Agric Food Chem 25, 806–809.
510Monasterio I & Graham RD (2000) Breeding for trace minerals in wheat. Food Nutr Bull 21, 392–396.
511Tang J, Zou C, He Z, et al. . (2008) Mineral element distributions in milling fractions of Chinese wheats. J Cereal Sci 48, 821–828.
512Zook EG, Greene FE & Morris ER (1970) Nutrient composition of selected wheats and wheat products. VI. Distribution of manganese, copper, nickel, zinc, magnesium, lead, tin, cadmium, chromium, and selenium as determined by atomic absorption spectroscopy and colorimetry. Cereal Chem 47, 720–731.
513Welch RM & Graham RD (2000) A new paradigm for world agriculture: productive, sustainable, nutritious, healthful food systems. Food Nutr Bull 21, 361–366.
514Fan MS, Zhao FJ, Poulton PR, et al. . (2008) Historical changes in the concentrations of selenium in soil and wheat grain from the Broadbalk experiment over the last 160 years. Sci Total Environ 389, 532–538.
515Zhao F, McGrath S, Gray C, et al. . (2007) Selenium concentrations in UK wheat and biofortification strategies. Comp Biochem Physiol A Mol Integr Physiol 146, Suppl. 1, S246.
516Batifoulier F, Verny M-A, Chanliaud E, et al. . (2005) Effect of different breadmaking methods on thiamine, riboflavin and pyridoxine contents of wheat bread. J Cereal Sci 42, 101–108.
517Davis KR, Cain RF, Peters LJ, et al. . (1981) Evaluation of the nutrient composition of wheat. 2. Proximate analysis, thiamin, riboflavin, niacin, and pyridoxine. Cereal Chem 58, 116–120.
518Davis KR, Peters LJ & Letourneau D (1984) Variability of the vitamin content in wheat. Cereal Foods World 29, 364–370.
519Ranhotra G, Gelroth J, Novak F, et al. . (1985) Bioavailability for rats of thiamin in whole wheat and thiamin-restored white bread. J Nutr 115, 601–606.
520Gujska E & Kuncewicz A (2005) Determination of folate in some cereals and commercial cereal-grain products consumed in Poland using trienzyme extraction and high-performance liquid chromatography methods. Eur Food Res Technol 221, 208–213.
521Perloff BP & Butrum RR (1977) Folacin in selected foods. J Am Diet Assoc 70, 161–172.
522Piironen V, Edelmann M, Kariluoto S, et al. . (2008) Folate in wheat genotypes in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 9726–9731.
523Lampi A-M, Nurmi T, Ollilainen V, et al. . (2008) Tocopherols and tocotrienols in wheat genotypes in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 9716–9721.
524Nielsen MM & Hansen A (2008) Stability of vitamin E in wheat flour and whole wheat flour during storage. Cereal Chem 85, 716–720.
525Nielsen MM & Hansen A (2008) Rapid high-performance liquid chromatography determination of tocopherols and tocotrienols in cereals. Cereal Chem 85, 248–251.
526Panfili G, Fratianni A & Irano M (2003) Normal phase high-performance liquid chromatography method for the determination of tocopherols and tocotrienols in cereals. J Agric Food Chem 51, 3940–3944.
527Moore J, Hao Z, Zhou K, et al. . (2005) Carotenoid, tocopherol, phenolic acid, and antioxidant properties of Maryland-grown soft wheat. J Agric Food Chem 53, 6649–6657.
528Konopka I, Kozirok W & Rotkiewicz D (2004) Lipids and carotenoids of wheat grain and flour and attempt of correlating them with digital image analysis of kernel surface and cross-sections. Food Res Int 37, 429–438.
529Leenhardt F, Lyan B, Rock E, et al. . (2006) Genetic variability of carotenoid concentration, and lipoxygenase and peroxidase activities among cultivated wheat species and bread wheat varieties. Eur J Agron 25, 170–176.
530Panfili G, Fratianni A & Irano M (2004) Improved normal-phase high-performance liquid chromatography procedure for the determination of carotenoids in cereals. J Agric Food Chem 52, 6373–6377.
531Roose M, Kahl J & Ploeger A (2009) Influence of the farming system on the xanthophyll content of soft and hard wheat. J Agric Food Chem 57, 182–188.
532Adom KK & Liu RH (2002) Antioxidant activity of grains. J Agric Food Chem 50, 6182–6187.
533Barron C, Surget A & Rouau X (2007) Relative amounts of tissues in mature wheat (Triticum aestivum L.) grain and their carbohydrate and phenolic acid composition. J Cereal Sci 45, 88–96.
534Lempereur I, Surget A & Rouau X (1998) Variability in dehydrodiferulic acid composition of durum wheat (Triticum durum Desf.) and distribution in milling fractions. J Cereal Sci 28, 251–258.
535Mpofu A, Sapirstein HD & Beta T (2006) Genotype and environmental variation in phenolic content, phenolic acid composition, and antioxidant activity of hard spring wheat. J Agric Food Chem 54, 1265–1270.
536Abdel-Aal ESM & Hucl P (2003) Composition and stability of anthocyanins in blue-grained wheat. J Agric Food Chem 51, 2174–2180.
537Abdel-Aal E-SM, Abou-Arab AA, Gamel TH, et al. . (2008) Fractionation of blue wheat anthocyanin compounds and their contribution to antioxidant properties. J Agric Food Chem 56, 11171–11177.
538Liggins J, Mulligan A, Runswick S, et al. . (2002) Daidzein and genistein content of cereals. Eur J Clin Nutr 56, 961–966.
539Dinelli G, Marotti I, Bosi S, et al. . (2007) Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses. Electrophoresis 28, 4212–4219.
540Milder IEJ, Feskens EJM, Arts ICW, et al. . (2005) Intake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in Dutch men and women. J Nutr 135, 1202–1207.
541Andersson AAM, Kamal-Eldin A, Fraś A, et al. . (2008) Alkylresorcinols in wheat varieties in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 9722–9725.
543Hakala P, Lampi A-M, Ollilainen V, et al. . (2002) Steryl phenolic acid esters in cereals and their milling fractions. J Agric Food Chem 50, 5300–5307.
544Iafelice G, Verardo V, Marconi E, et al. . (2009) Characterization of total, free and esterified phytosterols in tetraploid and hexaploid wheats. J Agric Food Chem 57, 2267–2273.
545Nurmi T, Nyström L, Edelmann M, et al. . (2008) Phytosterols in wheat genotypes in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 9710–9715.
546Piironen V, Toivo J & Lampi AM (2002) Plant sterols in cereals and cereal products. Cereal Chem 79, 148–154.
547Irmak S & Dunford NT (2005) Policosanol contents and compositions of wheat varieties. J Agric Food Chem 53, 5583–5586.
548Trautwein EA (2001) n-3 Fatty acids – physiological and technical aspects for their use in food. Eur J Lipid Sci Technol 103, 45–55.
549Every D, Morrison SC, Simmons LD, et al. . (2006) Distribution of glutathione in millstreams and relationships to chemical and baking properties of flour. Cereal Chem 83, 57–61.
550Fraser JR & Holmes DC (1959) Proximate analysis of wheat flour carbohydrates. IV. – analysis of wholemeal flour and some of its fractions. J Sci Food Agric 10, 506–512.
551Saunders RM & Walker HG (1969) Sugars of wheat bran. Cereal Chem 46, 85.
552Chen H, Haack V, Janecky C, et al. . (1998) Mechanisms by which wheat bran and oat bran increase stool weight in humans. Am J Clin Nutr 68, 711–719.
553Lehrfeld J & Wu YV (1991) Distribution of phytic acid in milled fractions of Scout-66 hard red winter-wheat. J Agric Food Chem 39, 1820–1824.
554Maes C, Vangeneugden B & Delcour JA (2004) Relative activity of two endoxylanases towards water-unextractable arabinoxylans in wheat bran. J Cereal Sci 39, 181–186.
555Esposito F, Arlotti G, Bonifati AM, et al. . (2005) Antioxidant activity and dietary fibre in durum wheat bran by-products. Food Res Int 38, 1167–1173.
556Gordon DT & Chao LS (1984) Relationship of components in wheat bran and spinach to iron bioavailability in the anemic rat. J Nutr 114, 526–535.
557Morris ER & Ellis R (1980) Bioavailability to rats of iron and zinc in wheat bran – response to low-phytate bran and effect of the phytate-zinc molar ratio. J Nutr 110, 2000–2010.
558Anderson NE & Clydesdale FM (1980) An analysis of the dietary fiber content of a standard wheat bran. J Food Sci 45, 336–340.
559Bagheri SM & Gueguen L (1982) Bioavailability to rats of calcium, magnesium, phosphorus and zinc in wheat bran diets containing equal amounts of these minerals. Nutr Rep Int 25, 583–589.
560Falcao-e-Cunha L, Peres H, Freire JPB, et al. . (2004) Effects of alfalfa, wheat bran or beet pulp, with or without sunflower oil, on caecal fermentation and on digestibility in the rabbit. Anim Feed Sci Tech 117, 131–149.
561Heller S, Hackler L, Rivers J, et al. . (1980) Dietary fiber: the effect of particle size of wheat bran on colonic function in young adult men. Am J Clin Nutr 33, 1734–1744.
562Maes C & Delcour JA (2002) Structural characterisation of water-extractable and water-unextractable arabinoxylans in wheat bran. J Cereal Sci 35, 315–326.
563Dornez E, Gebruers K, Wiame S, et al. . (2006) Insight into the distribution of arabinoxylans, endoxylanases, and endoxylanase inhibitors in industrial wheat roller mill streams. J Agric Food Chem 54, 8521–8529.
564Camire AL & Clydesdale FM (1982) Analysis of phytic acid in foods by HPLC. J Food Sci 47, 575–578.
565Fretzdorff B (1989) Phytic acid in wheat bran and germ products – how to remove phytic acid from these products. Z Lebens Unters Forsch 189, 110–112.
566Jenab M & Thompson LU (2000) Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis. Carcinogenesis 21, 1547–1552.
567Liu ZH, Wang HY, Wang XE, et al. . (2008) Effect of wheat pearling on flour phytase activity, phytic acid, iron, and zinc content. LWT Food Sci Technol 41, 521–527.
568Bagheri S & Guéguen L (1985) Effect of wheat bran and pectin on the absorption and retention of phosphorus, calcium, magnesium and zinc by the growing-pig. Reprod Nutr Dev 25, 705–716.
569Shils ME, Olson JA & Shike M (editors) (1994) Modern Nutrition in Health and Disease, 8th ed.Philadelphia, PA: Lea and Febiger.
570Mullin WJ & Jui PY (1986) Folate content of bran from different wheat classes. Cereal Chem 63, 516–518.
571Zhou K, Su L & Yu LL (2004) Phytochemicals and antioxidant properties in wheat bran. J Agric Food Chem 52, 6108–6114.
572Zhou KQ, Yin JJ & Yu LL (2005) Phenolic acid, tocopherol and carotenoid compositions, and antioxidant functions of hard red winter wheat bran. J Agric Food Chem 53, 3916–3922.
573Robertson JA, Faulds CB, Smith AC, et al. . (2008) Peroxidase-mediated oxidative cross-linking and its potential to modify mechanical properties in water-soluble polysaccharide extracts and cereal grain residues. J Agric Food Chem 56, 1720–1726.
574Irmak S, Jonnala RS & MacRitchie F (2008) Effect of genetic variation on phenolic acid and policosanol contents of Pegaso wheat lines. J Cereal Sci 48, 20–26.
575Kim KH, Tsao R, Yang R, et al. . (2006) Phenolic acid profiles and antioxidant activities of wheat bran extracts and the effect of hydrolysis conditions. Food Chem 95, 466–473.
576Siebenhandl S, Grausgruber H, Pellegrini N, et al. . (2007) Phytochemical profile of main antioxidants in different fractions of purple and blue wheat, and black barley. J Agric Food Chem 55, 8541–8547.
577Apak R, Güçlü K, Ozyürek M, et al. . (2005) Total antioxidant capacity assay of human serum using copper(II)-neocuproine as chromogenic oxidant: the CUPRAC method. Free Radic Res 39, 949–961.
578Moore J, Liu JG, Zhou KQ, et al. . (2006) Effects of genotype and environment on the antioxidant properties of hard winter wheat bran. J Agric Food Chem 54, 5313–5322.
579Zhou K & Yu L (2004) Antioxidant properties of bran extracts from Trego wheat grown at different locations. J Agric Food Chem 52, 1112–1117.
580Iqbal S, Bhanger MI & Anwar F (2007) Antioxidant properties and components of bran extracts from selected wheat varieties commercially available in Pakistan. LWT Food Sci Technol 40, 361–367.
581Smeds AI, Eklund PC, Sjoholm RE, et al. . (2007) Quantification of a broad spectrum of lignans in cereals, oilseeds, and nuts. J Agric Food Chem 55, 1337–1346.
582Kulawinek M, Jaromin A, Kozubek A, et al. . (2008) Alkylresorcinols in selected Polish rye and wheat cereals and whole-grain cereal products. J Agric Food Chem 56, 7236–7242.
583Graham SF, Hollis JH, Migaud M, et al. . (2009) Analysis of betaine and choline contents of aleurone, bran, and flour fractions of wheat (Triticum aestivum L.) using 1H nuclear magnetic resonance (NMR) spectroscopy. J Agric Food Chem 57, 1948–1951.
584Slow S, Donaggio M, Cressey PJ, et al. . (2005) The betaine content of New Zealand foods and estimated intake in the New Zealand diet. J Food Comp Anal 18, 473–485.
585Nyström L, Lampi AM, Rita H, et al. . (2007) Effects of processing on availability of total plant sterols, steryl ferulates and steryl glycosides from wheat and rye bran. J Agric Food Chem 55, 9059–9065.
586Irmak S, Dunford NT & Milligan J (2006) Policosanol contents of beeswax, sugar cane and wheat extracts. Food Chem 95, 312–318.
587Moruzzi G, Viviani R, Sechi AM, et al. . (1969) Studies on compounds and individual lipids of wheat germ. J Food Sci 34, 581–584.
588Dubois M, Geddes WF & Smith F (1960) The carbohydrates of the Gramineae. X. A quantitative study of the carbohydrates of wheat germ. Cereal Chem 37, 557–567.
589Garcia WJ, Gardner HW, Cavins JF, et al. . (1972) Composition of air-classified defatted corn and wheat germ flours. Cereal Chem 49, 499–507.
590Linko P, Cheng Y-Y & Milner M (1960) Changes in the soluble carbohydrates during browning of wheat embryos. Cereal Chem 37, 548–556.
591Leenhardt F, Fardet A, Lyan B, et al. . (2008) Wheat germ supplementation of a low vitamin E diet in rats affords effective antioxidant protection in tissues. J Am Coll Nutr 27, 222–228.
592Shurpalekar SR & Rao PH (1977) Wheat germ. Adv Food Res 23, 187–304.
593Bilgicli N & Ibanoglu S (2007) Effect of wheat germ and wheat bran on the fermentation activity, phytic acid content and colour of tarhana, a wheat flour–yoghurt mixture. J Food Eng 78, 681–686.
594Garcia WJ, Inglett GE & Blessin CW (1972) Mineral constituents in corn and wheat-germ by atomic-absorption spectroscopy. Cereal Chem 49, 158–167.
595Zhu KX, Zhou HM & Qian HF (2006) Comparative study of chemical composition and physicochemical properties of defatted wheat germ flour and its protein isolate. J Food Biochem 30, 329–341.
596Dodin S, Lemay A, Jacques H, et al. . (2005) The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 90, 1390–1397.
597Ostlund RE Jr, Racette SB & Stenson WF (2003) Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ. Am J Clin Nutr 77, 1385–1389.
598Mühlum A, Ingwersen M, Schünemann C, et al. . (1989) Precaecal and postileal digestion of sucrose, lactose, stachyose and raffinose. Adv Anim Physiol Anim Nutr 19, 31–43.
599Van Dokkum W, Pikaar NA & Thissen JT (1983) Physiological effects of fibre-rich types of bread. 2. Dietary fibre from bread: digestibility by the intestinal microflora and water-holding capacity in the colon of human subjects. Br J Nutr 50, 61–74.
600McCance RA & Widdowson EM (1935) Phytin in human nutrition. Biochem J 29, 2694–2699.
601Sakamoto K, Vucenik I & Shamsuddin AM (1993) [3H]Phytic acid (inositol hexaphosphate) is absorbed and distributed to various tissues in rats. J Nutr 123, 713–720.
602McCance RA & Widdowson EM (1942) Mineral metabolism of healthy adults on white and brown bread dietaries. J Physiol 101, 44–85.
603Institute of Medicine (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press.
604Walti MK, Zimmermann MB, Walczyk T, et al. . (2003) Measurement of magnesium absorption and retention in type 2 diabetic patients with the use of stable isotopes. Am J Clin Nutr 78, 448–453.
605Sandstrom B, Arvidsson B, Cederblad A, et al. . (1980) Zinc absorption from composite meals. 1. The significance of wheat extraction rate, zinc, calcium, and protein-content in meals based on bread. Am J Clin Nutr 33, 739–745.
606Sundkvist G, Dahlin LB, Nilsson H, et al. . (2000) Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance. Diabet Med 17, 259–268.
607Saha PR, Weaver CM & Mason AC (1994) Mineral bioavailability in rats from intrinsically labeled whole wheat-flour of various phytate levels. J Agric Food Chem 42, 2531–2535.
608Fox TE, Fairweather-Tait SJ, Eagles J, et al. . (1994) Assessment of zinc bioavailability – studies in rats on zinc absorption from wheat using radio-isotopes and stable-isotopes. Br J Nutr 71, 95–101.
609Welch RM, House WA, Ortiz-Monasterio I, et al. . (2005) Potential for improving bioavailable zinc in wheat grain (Triticum species) through plant breeding. J Agric Food Chem 53, 2176–2180.
610Ahmed A, Anjum F, Ur Rehman S, et al. . (2008) Bioavailability of calcium, iron and zinc fortified whole wheat flour chapatti. Plant Foods Hum Nutr 63, 7–13.
611Johnson PE & Lykken GI (1988) Copper-65 absorption by men fed intrinsically and extrinsically labeled whole wheat bread. J Agric Food Chem 36, 537–540.
612Mutanen M, Koivistoinen P, Morris VC, et al. . (2007) Relative nutritional availability to rats of selenium in Finnish spring wheat (Triticum aestivum L.) fertilized or sprayed with sodium selenate and in an American winter bread wheat naturally high in Se. Br J Nutr 57, 319–329.
613Alexander AR, Whanger PD & Miller LT (1983) Bioavailability to rats of selenium in various tuna and wheat products. J Nutr 113, 196–204.
614Weaver CM, Heaney RP, Martin BR, et al. . (1991) Human calcium absorption from whole-wheat products. J Nutr 121, 1769–1775.
615Zempleni J, Galloway J & McCormick D (1996) Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr 63, 54–66.
616Tarr J, Tamura T & Stokstad E (1981) Availability of vitamin B6 and pantothenate in an average American diet in man. Am J Clin Nutr 34, 1328–1337.
617Kayden H & Traber M (1993) Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J Lipid Res 34, 343–358.
618Andreasen MF, Kroon PA, Williamson G, et al. . (2001) Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals. J Agric Food Chem 49, 5679–5684.
619Ross AB, Shepherd MJ, Knudsen KEB, et al. . (2003) Absorption of dietary alkylresorcinols in ileal-cannulated pigs and rats. Br J Nutr 90, 787–794.
620Nissinen M, Gylling H, Vuoristo M, et al. . (2002) Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. Am J Physiol Gastrointest Liver Physiol 282, G1009–G1015.
621Nestler JE, Jakubowicz DJ, Reamer P, et al. . (1999) Ovulatory and metabolic effects of d-chiro-inositol in the polycystic ovary syndrome. N Engl J Med 340, 1314–1320.
622Campbell WW, Haub MD, Fluckey JD, et al. . (2004) Pinitol supplementation does not affect insulin-mediated glucose metabolism and muscle insulin receptor content and phosphorylation in older humans. J Nutr 134, 2998–3003.
623Nyman M, Asp N-G, Cummings J, et al. . (1986) Fermentation of dietary fibre in the intestinal tract: comparison between man and rat. Br J Nutr 55, 487–496.
624Kahlon TS, Chow FI, Hoefer JL, et al. . (2001) Effect of wheat bran fiber and bran particle size on fat and fiber digestibility and gastrointestinal tract measurements in the rat. Cereal Chem 78, 481–484.
625Hansen I, Knudsen KEB & Eggum BO (2007) Gastrointestinal implications in the rat of wheat bran, oat bran and pea fibre. Br J Nutr 68, 451–462.
626Ehle FR, Jeraci JL, Robertson JB, et al. . (1982) The influence of dietary fiber on digestibility, rate of passage and gastrointestinal fermentation in pigs. J Anim Sci 55, 1071–1081.
627Robertson JA, Murison SD & Chesson A (1992) Particle-size distribution and solubility of dietary fiber in swede-bran (Brassica napus) based and wheat-bran-based diets during gastrointestinal transit in the pig. J Sci Food Agric 58, 197–205.
628Nyman M & Asp N-G (1985) Dietary fibre fermentation in the rat intestinal tract: effect of adaptation period, protein and fibre levels, and particle size. Br J Nutr 54, 635–643.
629Sandberg AS & Andersson H (1988) Effect of dietary phytase on the digestion of phytate in the stomach and small intestine of humans. J Nutr 118, 469–473.
630Sandberg A-S, Andersson H, Carlsson N-G, et al. . (1987) Degradation products of bran phytate formed during digestion in the human small intestine: effect of extrusion cooking on digestibility. J Nutr 117, 2061–2065.
631Brune M, Rossander-Hulten L, Hallberg L, et al. . (1992) Iron absorption from bread in humans: inhibiting effects of cereal fiber, phytate and inositol phosphates with different numbers of phosphate groups. J Nutr 122, 442–449.
632Reddy M & Cook J (1991) Assessment of dietary determinants of nonheme-iron absorption in humans and rats. Am J Clin Nutr 54, 723–728.
633Reeves PG, Gregoire BR, Garvin DF, et al. . (2007) Determination of selenium bioavailability from wheat mill fractions in rats by using the slope-ratio assay and a modified Torula yeast-based diet. J Agric Food Chem 55, 516–522.
634Carter EGA & Carpenter KJ (1982) The bioavailability for humans of bound niacin from wheat bran. Am J Clin Nutr 36, 855–861.
635Kies C, Kan S & Fox HM (1984) Vitamin B6 availability from wheat, rice and corn brans for humans. Nutr Rep Int 30, 483–491.
636Kahlon TS, Chow FI, Hoefer JL, et al. . (1986) Bioavailability of vitamin A and vitamin E as influenced by wheat bran and bran particle size. Cereal Chem 63, 490–493.
637Andreasen MF, Kroon PA, Williamson G, et al. . (2001) Intestinal release and uptake of phenolic antioxidant diferulic acids. Free Radic Biol Med 31, 304–314.
638Connor WE (2000) Importance of n-3 fatty acids in health and disease. Am J Clin Nutr 71, 171S–175S.
639Brouwer IA, Katan MB & Zock PL (2004) Dietary α-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 134, 919–922.
640Hu FB, Stampfer MJ, Manson JE, et al. . (1999) Dietary intake of α-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 69, 890–897.
641Kang JX & Leaf A (1996) Antiarrhythmic effects of polyunsaturated fatty acids: recent studies. Circulation 94, 1774–1780.
642Edwards R, Peet M, Shay J, et al. . (1998) Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord 48, 149–155.
643Yehuda S, Rabinovitz S & Mostofsky DI (2005) Mixture of essential fatty acids lowers test anxiety. Nutr Neurosci 8, 265–267.
644Djousse L, Folsom AR, Province MA, et al. . (2003) Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 77, 819–825.
645Narisawa T, Fukaura Y, Yazawa K, et al. . (1994) Colon cancer prevention with a small amount of dietary perilla oil high in α-linolenic acid in an animal model. Cancer 73, 2069–2075.
646Klein V, Chajes V, Germain E, et al. . (2000) Low α-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. Eur J Cancer 36, 335–340.
647Hwang DH, Boudreau M & Chanmugam P (1988) Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. J Nutr 118, 427–437.
648Chapkin RS, McMurray DN, Davidson LA, et al. . (2008) Bioactive dietary long-chain fatty acids: emerging mechanisms of action. Br J Nutr 100, 1152–1157.
649Enke U, Seyfarth L, Schleussner E, et al. . (2008) Impact of PUFA on early immune and fetal development. Br J Nutr 100, 1158–1168.
650Townsend DM, Tew KD & Tapiero H (2003) The importance of glutathione in human disease. Biomed Pharmacother 57, 145–155.
651Higashi T, Tateishi N, Naruse A, et al. . (1977) A novel physiological role of liver glutathione as a reservoir of l-cysteine. J Biochem 82, 117–124.
652Bilzer M & Lauterburg BH (1991) Effects of hypochlorous acid and chloramines on vascular resistance, cell integrity, and biliary glutathione disulfide in the perfused rat-liver – modulation by glutathione. J Hepatol 13, 84–89.
653Troen AM, Chao W-H, Crivello NA, et al. . (2008) Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J Nutr 138, 2502–2509.
654Essien FB & Wannberg SL (1993) Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in axd mutant mice. J Nutr 123, 27–34.
655Caylak E, Aytekin M & Halifeoglu I (2008) Antioxidant effects of methionine, α-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats. Exp Toxicol Pathol 60, 289–294.
656Khumalo N, Dawber R & Ferguson D (2005) Apparent fragility of African hair is unrelated to the cystine-rich protein distribution: a cytochemical electron microscopic study. Exp Dermatol 14, 311–314.
657Sass J, Skladal D, Zelger B, et al. . (2004) Trichothiodystrophy: quantification of cysteine in human hair and nails by application of sodium azide-dependent oxidation to cysteic acid. Arch Dermatol Res 296, 188–191.
658Droge W & Holm E (1997) Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J 11, 1077–1089.
659Netto LES, de Oliveira MA, Monteiro G, et al. . (2007) Reactive cysteine in proteins: protein folding, antioxidant defense, redox signaling and more. Comp Biochem Physiol C Toxicol Pharmacol 146, 180–193.
660Marlett JA, McBurney MI & Slavin JL (2002) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 102, 993–1000.
661Tucker LA & Thomas KS (2009) Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr 139, 576–581.
662Salmeron J, Ascherio A, Rimm EB, et al. . (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Diabetes Care 277, 472–477.
663Slavin JL, Jacobs D, Marquart L, et al. . (2001) The role of whole grains in disease prevention. J Am Diet Assoc 101, 780–785.
664Glei M, Hofmann T, Kuster K, et al. . (2006) Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. J Agric Food Chem 54, 2088–2095.
665Eastwood M & Mowbray L (1976) The binding of the components of mixed micelle to dietary fiber. Am J Clin Nutr 29, 1461–1467.
666Pomare EW & Heaton KW (1973) Alteration of bile salt metabolism by dietary fibre (bran). Gut 14, 826.
667Eastwood MA (1975) Vegetable dietary fiber – potent pith. J R Soc Health 95, 188–190.
668Kaur N & Gupta AK (2002) Applications of inulin and oligofructose in health and nutrition. J Biosci 27, 703–714.
669Roberfroid MB & Delzenne NM (1998) Dietary fructans. Annu Rev Nutr 18, 117–143.
670Rozan P, Nejdi A, Hidalgo S, et al. . (2008) Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan. Br J Nutr 100, 1192–1199.
671Gibson GR, Beatty ER, Wang X, et al. . (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975–982.
672Femia AP, Luceri C, Dolara P, et al. . (2002) Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23, 1953–1960.
673Archer SY, Meng S, Shei A, et al. . (1998) p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci U S A 95, 6791–6796.
674Avivi-Green C, Polak-Charcon S, Madar Z, et al. . (2002) Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr 132, 1812–1818.
675Brighenti F, Casiraghi MC, Canzi E, et al. . (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr 53, 726–733.
676Williams CM (1999) Effects of inulin on lipid parameters in humans. J Nutr 129, 1471S–1473S.
677Beylot M (2005) Effects of inulin-type fructans on lipid metabolism in man and in animal models. Br J Nutr 93, S163–S168.
678Pai R, Tarnawski AS & Tran T (2004) Deoxycholic acid activates β-catenin signaling pathway and increases colon cell cancer growth and invasiveness. Mol Biol Cell 15, 2156–2163.
679McMillan L, Butcher S, Wallis Y, et al. . (2000) Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. Biochem Biophys Res Commun 273, 45–49.
680Braaten JT, Wood PJ, Scott FW, et al. . (1991) Oat gum lowers glucose and insulin after an oral glucose load. Am J Clin Nutr 53, 1425–1430.
681Ostman E, Rossi E, Larsson H, et al. . (2006) Glucose and insulin responses in healthy men to barley bread with different levels of (1 → 3;1 → 4)-β-glucans; predictions using fluidity measurements of in vitro enzyme digests. J Cereal Sci 43, 230–235.
682Tappy L, Gugolz E & Wursch P (1996) Effects of breakfast cereals containing various amounts of β-glucan fibers on plasma glucose and insulin responses in NIDDM subjects. Diabetes Care 19, 831–834.
683Maki KC, Shinnick F, Seeley MA, et al. . (2003) Food products containing free tall oil-based phytosterols and oat β-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults. J Nutr 133, 808–813.
684Wright RS, Anderson JW & Bridges SR (1990) Propionate inhibits hepatocyte lipid synthesis. Proc Soc Exp Biol Med 195, 26–29.
685Demir G, Klein HO, Mandel-Molinas N, et al. . (2007) β Glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int Immunopharmacol 7, 113–116.
686Vucenik I & Shamsuddin AM (2003) Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr 133, 3778S–3784S.
687Muraoka S & Miura T (2004) Inhibition of xanthine oxidase by phytic acid and its antioxidative action. Life Sci 74, 1691–1700.
688Lee SH, Park HJ, Chun HK, et al. . (2006) Dietary phytic acid lowers the blood glucose level in diabetic KK mice. Nutr Res 26, 474–479.
689Lee S-H, Park H-J, Chun H-K, et al. . (2007) Dietary phytic acid improves serum and hepatic lipid levels in aged ICR mice fed a high-cholesterol diet. Nutr Res 27, 505–510.
690Onomi S, Okazaki Y & Katayama T (2004) Effect of dietary level of phytic acid on hepatic and serum lipid status in rats fed a high-sucrose diet. Biosci Biotechnol Biochem 68, 1379–1381.
691Lee SH, Park HJ, Cho SY, et al. . (2005) Effects of dietary phytic acid on serum and hepatic lipid levels in diabetic KK mice. Nutr Res 25, 869–876.
692Singh A, Prakash Singh S & Bamezai R (1997) Modulatory influence of arecoline on the phytic acid-altered hepatic biotransformation system enzymes, sulfhydryl content and lipid peroxidation in a murine system. Cancer Lett 117, 1–6.
693Grases F, Simonet BM, March JG, et al. . (2000) Inositol hexakisphosphate in urine: the relationship between oral intake and urinary excretion. BJU Int 85, 138–142.
694Grases F, Sanchis P, Perello J, et al. . (2008) Phytate reduces age-related cardiovascular calcification. Front Biosci 13, 7115–7122.
695Shen XT, Xiao H, Ranallo R, et al. . (2003) Modulation of ATP-dependent chromatin remodeling complexes by inositol polyphosphates. Science 299, 112–114.
696Steger DJ, Haswell ES, Miller AL, et al. . (2003) Regulation of chromatin remodeling by inositol polyphosphates. Science 299, 114–116.
697Sajilata MG, Singhal RS & Kulkarni PR (2006) Resistant starch: a review. Compr Rev Food Sci Food Saf 5, 1–17.
698Malhotra SL (1968) Epidemiological study of cholelithiasis among railroad workers in India with special reference to causation. Gut 9, 290–295.
699Beard JL & Connor JR (2003) Iron status and neural functioning. Annu Rev Nutr 23, 41–58.
700Institute of Medicine (2001) Dietary Reference Intake for Vitamin A, Vitamin K, Arsenic, Baron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press.
701Uehara M, Chiba H, Mogi H, et al. . (1997) Induction of increased phosphatidylcholine hydroperoxide by an iron-deficient diet in rats. J Nutr Biochem 8, 385–391.
702Rosenzweig P & Volpe S (1999) Iron, thermoregulation, and metabolic rate. Crit Rev Food Sci Nutr 39, 131–148.
703Oexle H, Gnaiger E & Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413, 99–107.
704Ramdath DD & Golden MHN (1989) Non-haematological aspects of iron nutrition. Nutr Res Rev 2, 29–49.
705Lozoff B, Jimenez E, Hagen J, et al. . (2000) Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 105, E51.
706Oski FA, Honig AS, Helu B, et al. . (1983) Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics 71, 877–880.
707Prockop DJ (1971) Role of iron in synthesis of collagen in connective tissue. Fed Proc 30, 984–990.
708Katsumata S, Katsumata-Tsuboi R, Uehara M, et al. . (2009) Severe iron deficiency decreases both bone formation and bone resorption in rats. J Nutr 139, 238–243.
709Willis WT, Dallman PR & Brooks GA (1988) Physiological and biochemical correlates of increased work in trained iron-deficient rats. J Appl Physiol 65, 256–263.
710Cook J & Lynch S (1986) The liabilities of iron deficiency. Blood 68, 803–809.
711Rosales FJ, Jang J-T, Pinero DJ, et al. . (1999) Iron deficiency in young rats alters the distribution of vitamin A between plasma and liver and between hepatic retinol and retinyl esters. J Nutr 129, 1223–1228.
712McClung JP & Karl JP (2009) Iron deficiency and obesity: the contribution of inflammation and diminished iron absorption. Nutr Rev 67, 100–104.
713Clancaglini P, Plzauro JM, Curti C, et al. . (1990) Effect of membrane moiety and magnesium ions on the inhibition of matrix-induced alkaline phosphatase by zinc ions. Int J Biochem 22, 747–751.
714Bussiere FI, Gueux E, Rock E, et al. . (2002) Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration. Br J Nutr 87, 107–113.
715Olatunji LA & Soladoye AO (2007) Increased magnesium intake prevents hyperlipidemia and insulin resistance and reduces lipid peroxidation in fructose-fed rats. Pathophysiology 14, 11–15.
716Kisters K, Spieker C, Tepel M, et al. . (1993) New data about the effects of oral physiological magnesium supplementation on several cardiovascular risk factors (lipids and blood pressure). Magnes Res 6, 355–360.
717Barbagallo M & Dominguez LJ (2007) Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys 458, 40–47.
718Colditz G, Manson J, Stampfer M, et al. . (1992) Diet and risk of clinical diabetes in women. Am J Clin Nutr 55, 1018–1023.
719Nadler JL, Balon TW & Rude R (1997) Fiber intake and risk of developing non-insulin-dependent diabetes mellitus. JAMA 277, 1761–1762.
720Paolisso G, Scheen A, D'Onofrio F, et al. . (1990) Magnesium and glucose homeostasis. Diabetologia 33, 511–514.
721Schulze MB, Schulz M, Heidemann C, et al. . (2007) Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 167, 956–965.
722van Dam RM, Hu FB, Rosenberg L, et al. . (2006) Dietary calcium and magnesium, major food sources, and risk of type 2 diabetes in U.S. black women. Diabetes Care 29, 2238–2243.
723Paolisso G, Dimaro G, Cozzolino D, et al. . (1992) Chronic magnesium administration enhances oxidative glucose metabolism in thiazide treated hypertensive patients. Am J Hypertens 5, 681–686.
724Nadler J, Buchanan T, Natarajan R, et al. . (1993) Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 21, 1024–1029.
725Ascherio A, Rimm E, Giovannucci E, et al. . (1992) A prospective study of nutritional factors and hypertension among US men. Circulation 86, 1475–1484.
726Rubenowitz E, Axelsson G & Rylander R (1996) Magnesium in drinking water and death from acute myocardial infarction. Am J Epidemiol 143, 456–462.
727Cohen L (1988) Recent data on magnesium and osteoporosis. Magnes Res 1, 85–87.
728Bernardini D, Nasulewicz A, Mazur A, et al. . (2005) Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis. Front Biosci 10, 1177–1182.
729Reungjui S, Prasongwatana V, Premgamone A, et al. . (2002) Magnesium status of patients with renal stones and its effect on urinary citrate excretion. BJU Int 90, 635–639.
730Bray TM & Bettger WJ (1990) The physiological role of zinc as an antioxidant. Free Radic Biol Med 8, 281–291.
731Zago MP & Oteiza PI (2001) The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radic Biol Med 31, 266–274.
732Beattie JH & Avenell A (1992) Trace element nutrition and bone metabolism. Nutr Res Rev 5, 167–188.
733Ding W-Q, Yu H-J & Lind SE (2008) Zinc-binding compounds induce cancer cell death via distinct modes of action. Cancer Lett 271, 251–259.
734Guo W, Zhao Y-P, Jiang Y-G, et al. . (2008) Restoring the metabolic disturbance of zinc: may not only contribute to the prevention of esophageal squamous cell cancer. Med Hypotheses 71, 957–959.
735Hershfinkel M, Silverman WF & Sekler I (2007) The zinc sensing receptor, a link between zinc and cell signaling. Mol Med 13, 331–336.
736Bogden J, Oleske J, Munves E, et al. . (1987) Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am J Clin Nutr 46, 101–109.
737Shen H, Oesterling E, Stromberg A, et al. . (2008) Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-κB and PPAR signaling. J Am Coll Nutr 27, 577–587.
738Mocchegiani E, Giacconi R & Malavolta M (2008) Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes. Trends Mol Med 14, 419–428.
739Ohinata K, Takemoto M, Kawanago M, et al. . (2009) Orally administered zinc increases food intake via vagal stimulation in rats. J Nutr 139, 611–616.
740Robinson BH (1998) The role of manganese superoxide dismutase in health and disease. J Inher Metab Dis 21, 598–603.
741Freeland-Graves JH & Turnlund JR (1996) Deliberations and evaluations of the approaches, endpoints and paradigms for manganese and molybdenum dietary recommendations. J Nutr 126, 2435S–2440S.
742Cho SJ, Park JW, Kang JS, et al. . (2008) Nuclear factor-κB dependency of doxorubicin sensitivity in gastric cancer cells is determined by manganese superoxide dismutase expression. Cancer Sci 99, 1117–1124.
743Kattan Z, Minig V, Dauça M, et al. . (2007) Role of manganese superoxide dismutase on growth and invasive properties of human estrogen-independent breast cancer cells. Eur J Cancer Suppl 5, 76–77.
744Johnson MA, Fischer JG & Kays SE (1992) Is copper an antioxidant nutrient? Crit Rev Food Sci Nutr 32, 1–31.
745Baker A, Harvey L, Majask-Newman G, et al. . (1999) Effect of dietary copper intakes on biochemical markers of bone metabolism in healthy adult males. Eur J Clin Nutr 53, 408–412.
746Lukaski HC, Klevay LM & Milne DB (1988) Effects of dietary copper on human autonomic cardiovascular function. EurJ Appl Physiol 58, 74–80.
747Milne D (1998) Copper intake and assessment of copper status. Am J Clin Nutr 67, 1041S–1045S.
748Klevay LM (2006) Heart failure improvement from a supplement containing copper. Eur Heart J 27, 117–118.
749Zhou Y, Jiang Y & Kang YJ (2008) Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size. J Mol Cell Cardiol 45, 106–117.
750Hammud HH, Nemer G, Sawma W, et al. . (2008) Copper–adenine complex, a compound, with multi-biochemical targets and potential anti-cancer effect. Chem Biol Interact 173, 84–96.
751Klevay L (1975) Coronary heart disease: the zinc/copper hypothesis. Am J Clin Nutr 28, 764–774.
752Klevay LM (1977) Hypo-cholesterolemia due to sodium phytate. Nutr Rep Int 15, 587–595.
753Tapiero H, Townsend DM & Tew KD (2003) The antioxidant role of selenium and seleno-compounds. Biomed Pharmacother 57, 134–144.
754Levander OA (1992) Selenium and sulfur in antioxidant protective systems – relationships with vitamin E and malaria. Proc Soc Exp Biol Med 200, 255–259.
755Burk RF (1990) Protection against free-radical injury by selenoenzymes. Pharmacol Ther 45, 383–385.
756Jacobs MM (1977) Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol colon carcinogenesis. Correlative studies on selenium effects on the mutagenicity and sister chromatid exchange rates of selected carcinogens. Cancer 40, 2557–2564.
757Jacobs MM, Forst CF & Beams FA (1981) Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats. Cancer Res 41, 4458–4465.
758Jariwalla RJ, Gangapurkar B & Nakamura D (2009) Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium. Br J Nutr 101, 182–189.
759Gromadzinska J, Reszka E, Bruzelius K, et al. . (2008) Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements. Eur J Nutr 47, 29–50.
760Levander O & Morris V (1984) Dietary selenium levels needed to maintain balance in North American adults consuming self-selected diets. Am J Clin Nutr 39, 809–815.
761Arvilommi H, Poikonen K, Jokinen I, et al. . (1983) Selenium and immune functions in humans. Infect Immun 41, 185–189.
762Boyne R & Arthur JR (1986) The response of selenium-deficient mice to Candida albicans infection. J Nutr 116, 816–822.
763Ciappellano S, Testolin G & Porrini M (1989) Effects of durum wheat dietary selenium on glutathione peroxidase activity and Se content in long-term-fed rats. Ann Nutr Metab 33, 22–30.
764Douillet C, Bost M, Accominotti M, et al. . (1998) Effect of selenium and vitamin E supplementation on lipid abnormalities in plasma, aorta, and adipose tissue of Zucker rats. Biol Trace Elem Res 65, 221–236.
765Stapleton SR (2000) Selenium: an insulin mimetic. Cell Mol Life Sci 57, 1874–1879.
766Uribarri J (2007) Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake. Semin Dial 20, 295–301.
767Loghman-Adham M (1997) Adaptation to changes in dietary phosphorus intake in health and in renal failure. J Lab Clin Med 129, 176–188.
768Kesse E, Boutron-Ruault M-C, Norat T, et al. . (2005) Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study. Int J Cancer 117, 137–144.
769Arnold WH & Gaengler P (2007) Quantitative analysis of the calcium and phosphorus content of developing and permanent human teeth. Ann Anat 189, 183–190.
770Bostick RM, Potter JD, Fosdick L, et al. . (1993) Calcium and colorectal epithelial cell proliferation: a preliminary randomized, double-blinded, placebo-controlled clinical trial. J Natl Cancer Inst 85, 132–141.
771Ishihara J, Inoue M, Iwasaki M, et al. . (2008) Dietary calcium, vitamin D, and the risk of colorectal cancer. Am J Clin Nutr 88, 1576–1583.
772Mariot P, Vanoverberghe K, Lalevee N, et al. . (2002) Overexpression of an α 1H (Cav3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells. J Biol Chem 277, 10824–10833.
773Taylor JT, Zeng XB, Pottle JE, et al. . (2008) Calcium signaling and T-type calcium channels in cancer cell cycling. World J Gastroenterol 14, 4984–4991.
774Ciapa B, Pesando D, Wilding M, et al. . (1994) Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels. Nature 368, 875–878.
775Bucher HC, Cook RJ, Guyatt GH, et al. . (1996) Effects of dietary calcium supplementation on blood pressure. A meta-analysis of randomized controlled trials. JAMA 275, 1016–1022.
776Gillman MW, Hood MY, Moore LL, et al. . (1995) Effect of calcium supplementation on blood pressure in children. J Pediatr 127, 186–192.
777Umesawa M, Iso H, Ishihara J, et al. . (2008) Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: The JPHC Study Cohort. Stroke 39, 2449–2456.
778Astrup A (2008) The role of calcium in energy balance and obesity: the search for mechanisms. Am J Clin Nutr 88, 873–874.
779Major GC, Chaput JP, Ledoux M, et al. . (2008) Recent developments in calcium-related obesity research. Obes Rev 9, 428–445.
780Sharp RL (2006) Role of sodium in fluid homeostasis with exercise. J Am Coll Nutr 25, 231S–239S.
781Hollenberg NK (2006) The influence of dietary sodium on blood pressure. J Am Coll Nutr 25, 240S–246S.
782Alderman MH (2006) Evidence relating dietary sodium to cardiovascular disease. J Am Coll Nutr 25, 256S–261S.
783Heaney RP (2006) Role of dietary sodium in osteoporosis. J Am Coll Nutr 25, 271S–276S.
784Demigne C, Sabboh H, Remesy C, et al. . (2004) Protective effects of high dietary potassium: nutritional and metabolic aspects. J Nutr 134, 2903–2906.
785He FJ & MacGregor GA (2008) Beneficial effects of potassium on human health. Physiologia Plantarum 133, 725–735.
786Sjogren A, Floren CH & Nilsson A (1988) Oral administration of magnesium hydroxide to subjects with insulin-dependent diabetes mellitus – effects on magnesium and potassium levels and on insulin requirements. Magnesium 7, 117–122.
787Appel LJ, Moore TJ, Obarzanek E, et al. . (1997) A clinical trial of the ef