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The role of added feed enzymes in promoting gut health in swine and poultry

  • Elijah Kiarie (a1), Luis F. Romero (a1) and Charles M. Nyachoti (a2)

Abstract

The value of added feed enzymes (FE) in promoting growth and efficiency of nutrient utilisation is well recognised in single-stomached animal production. However, the effects of FE on the microbiome of the gastrointestinal tract (GIT) are largely unrecognised. A critical role in host nutrition, health, performance and quality of the products produced is played by the intestinal microbiota. FE can make an impact on GIT microbial ecology by reducing undigested substrates and anti-nutritive factors and producing oligosaccharides in situ from dietary NSP with potential prebiotic effects. Investigations with molecular microbiology techniques have demonstrated FE-mediated responses on energy utilisation in broiler chickens that were associated with certain clusters of GIT bacteria. Furthermore, investigations using specific enteric pathogen challenge models have demonstrated the efficacy of FE in modulating gut health. Because FE probably change the substrate characteristics along the GIT, subsequent microbiota responses will vary according to the populations present at the time of administration and their reaction to such changes. Therefore, the microbiota responses to FE administration, rather than being absolute, are a continuum or a population of responses. However, recognition that FE can make an impact on the gut microbiota and thus gut health will probably stimulate development of FE capable of modulating gut microbiota to the benefit of host health under specific production conditions. The present review brings to light opportunities and challenges for the role of major FE (carbohydrases and phytase) on the gut health of poultry and swine species with a specific focus on the impact on GIT microbiota.

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Corresponding author

*Corresponding author: Dr Elijah Kiarie, fax +44 1672 517778, email elijah.kiarie@dupont.com

References

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1Bailey, JE & Olis, DF (1986) Biochemical Engineering Fundamentals, 2nd ed. NY: McGraw Hill Publishing Company.
2Mitchell, DA & Lonsane, BK (1992) Definition, characteristics and potential. In Solid Substrate Cultivation, pp. 113 [Doelle, HW, Mitchell, DA and Rolz, CE, editors]. New York: Elsevier Applied Biotechnology Series.
3Adeola, O & Cowieson, AJ (2011) Opportunities and challenges in using exogenous enzymes to improve non-ruminant animal production. J Anim Sci 89, 31893218.
4Barletta, A (2010) Introduction: current markets and expected development. In Enzymes in Farm Animal Nutrition, 2nd ed., pp. 111 [Bedford, MR and Partridge, GG, editors]. Wallingford, UK: CAB International.
5Bedford, MR & Schulze, H (1998) Exogenous enzymes for pigs and poultry. Nutr Res Rev 11, 91114.
6Woyengo, TA & Nyachoti, CM (2011) Review: Supplementation of phytase and carbohydrases to diets for poultry. Can J Anim Sci 91, 177192.
7Slominski, BA (2011) Recent advances in research on enzymes for poultry diets. Poult Sci 90, 20132023.
8Kiarie, E & Nyachoti, CM (2009) Alternative feed ingredients in swine diets. In Proceedings of the 32nd Saskatchewan Pork Industry Symposium, pp. 2938. Saskatoon: Saskatchewan Pork Development Board.
9Bach Knudsen, KE (2011) Effects of polymeric carbohydrates on growth and development in pigs. J Anim Sci 89, 19651980.
10Bedford, MR & Partridge, GG (2010) Feed enzymes, the future: bright hope or regulatory mine field? In Enzymes in Farm Animal Nutrition, 2nd ed., pp. 304312 [Bedford, MR and Partridge, GG, editors]. Wallingford, UK: CAB International.
11Savage, DC (1977) Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31, 107133.
12Jensen, BB (1998) The impact of feed additives on the microbial ecology of the gut in young pigs. J Anim Feed Sci 7, 4564.
13Gaskins, HR (2001) Intestinal bacteria and their influence on swine growth. In Swine Nutrition, 2nd ed., pp. 585608 [Lewis, AJ and Southern, LL, editors]. Boca Roca, FL: Taylor and Francis Inc.
14Gong, J, Si, W, Forster, RJ, et al. (2007) 16S rRNA gene-based analysis of mucosa-associated bacterial community and phylogeny in the chicken gastrointestinal tracts; from crops to ceca. FEMS Microbiol Ecol 59, 147157.
15Pluske, JR, Pethick, DW, Hopwood, DE, et al. (2002) Nutritional influences on some major enteric bacterial diseases of pigs. Nutr Res Rev 15, 333371.
16Zoetendal, EG, Collier, CT, Koike, S, et al. (2004) Molecular ecological analysis of the gastrointestinal microbiota: a review. J Nutr 134, 465472.
17Torok, VA, Hughes, RJ, Mikkelsen, LL, et al. (2011) Identification and characterization of potential performance-related gut microbiota in broiler chickens across various feeding trials. Appl Environ Microbiol 77, 58685878.
18Danzeisen, JL, Kim, HB, Isaacson, RE, et al. (2011) Modulations of the chicken cecal microbiome and metagenome in response to anticoccidial and growth promoter treatment. PLOS One 6, e27949.
19Kim, HB, Borewicz, K, White, BA, et al. (2011) Longitudinal investigation of the age-related bacterial diversity in the feces of commercial pigs. Vet Microbiol 153, 124133.
20Stanley, D, Geier, MS, Hughes, RJ, et al. (2012) The role of gastrointestinal tract microbiota in chicken productivity. Proc Aust Poult Sci Symp 23, 262265.
21Klasing, KC (2007) Nutrition and the immune system. Br Poult Sci 8, 525537.
22Niba, AT, Beal, JD, Kudi, AC, et al. (2009) Bacterial fermentation in the gastrointestinal tract of non-ruminants: influence of fermented feeds and fermentable carbohydrates. Trop Anim Health Prod 41, 13931407.
23Fairbrother, JM, Nadeau, É & Gyles, GL (2005) Escherichia coli in post-weaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Anim Health Res Rev 6, 1739.
24Hillman, K (2004) An analysis of gut microbes. Pig Int 34, 2729.
25Mackie, RI & White, BA (1997) Gastrointestinal Microbiology. New York: Chapman and Hall.
26de Lange, CFM, Pluske, J, Gong, J, et al. (2010) Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs. Livest Sci 134, 124134.
27Heo, JM, Opapeju, FO, Pluske, JR, et al. (2013) Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhea without using in-feed antimicrobial compounds. J Anim Physiol Anim Nutr (Berl) 97, 207237.
28Adjiri-Awere, A & Van Lunen, TA (2005) Subtherapeutic use of antibiotics in pork production: risks and alternatives. Can J Anim Sci 85, 117130.
29Riddell, C & Kong, XM (1992) The influence of diet on necrotic enteritis in broiler chickens. Avian Dis 36, 499503.
30Kaldhusdal, M & Skjerve, E (1996) Association between cereal contents in the diet and incidence of necrotic enteritis in broiler chickens in Norway. Prev Vet Med 28, 116.
31Jia, W, Slominski, BA, Bruce, HL, et al. (2009) Effect of diet type and enzyme addition on growth performance and gut health of broiler chickens during subclinical Clostridium perfringens challenge. Poult Sci 88, 132140.
32Timbermont, L, Haesebrouck, F, Ducatelle, R, et al. (2011) Necrotic enteritis in broilers: an updated review on the pathogenesis. Avian Pathol 40, 341347.
33McDonald, DE, Pethick, DW, Pluske, JR, et al. (1999) Adverse effects of soluble non-starch polysaccharide (guar gum) on piglet growth and experimental colibacillosis immediately after weaning. Res Vet Sci 67, 245250.
34McDonald, DE, Pethick, DW, Mullan, BP, et al. (2001) Increasing viscosity of the intestinal contents alters small intestinal structure and intestinal growth, and stimulates proliferation of enterotoxigenic Escherichia coli in newly-weaned pigs. Br J Nutr 86, 487498.
35Hopwood, DE, Pethick, DE, Pluske, JR, et al. (2004) Addition of pearl barley to a rice-based diet increases the viscosity of the intestinal contents, reduces starch digestibility and exacerbates post-weaning colibacillosis in piglets. Br J Nutr 92, 419427.
36Montagne, L, Cavaney, FS, Hampson, DJ, et al. (2004) Effect of diet composition on postweaning colibacillosis in piglets. J Anim Sci 82, 23642374.
37Durmic, Z, Pethick, DW, Pluske, JR, et al. (1998) Influence of dietary fibre sources and levels of inclusion on the colonic microbiota of pigs, and on the development of swine dysentery in experimentally-infected pigs. J Appl Microbiol 85, 574582.
38Durmic, Z, Pethick, DW, Mullan, BP, et al (1997) The effects of extrusion and arabinoxylanase in wheat based diets on fermentation in the large intestine and expression of swine dysentery. In Manipulating Pig Production VI, p. 180 [Cranwell, PD, editor]. Canberra: Australasian Pig Science Association.
39Pluske, JR, Siba, PM, Pethick, DW, et al. (1996) The incidence of swine dysentery in pigs can be reduced by feeding diets that limit the amount of fermentable substrate entering the large intestine. J Nutr 126, 29202933.
40Pluske, JR, Durmic, Z, Pethick, DW, et al. (1998) Confirmation of the role of rapidly fermentable carbohydrates in the expression of swine dysentery in pigs after experimental infection. J Nutr 128, 17371744.
41Smulders, ACJM, Veldman, A & Enting, H (1999) Effect of anti-microbial growth promoter in feeds with different levels of indigestible protein on broiler performance. In Proceedings of the 12th European Symposium on Poultry Nutrition, pp. 177182. Veldhaven, The Netherlands: World Poultry Science Association (Dutch Branch).
42Cone, JW, Jongbloed, AW, Van Gelder, AH, et al. (2005) Estimation of protein fermentation in the large intestine of pigs using a gas production technique. Anim Feed Sci Technol 124, 463472.
43Marquardt, RR, Ward, AT & Misir, R (1979) The retention of nutrients by chicks fed rye diets supplemented with amino acids and penicillin. Poult Sci 58, 631640.
44Antoniou, TC & Marquardt, RR (1982) Utilization of rye diets by chicks as affected by lipid type and level and penicillin supplementation. Poult Sci 61, 107116.
45Choct, M, Hughes, RJ, Wang, J, et al. (1996) Increased small intestinal fermentation is partly responsible for the anti-nutritive activity of non-starch polysaccharides in chickens. Br Poult Sci 37, 609621.
46Almirall, M, Francesch, M, Perez-Vendrell, AM, et al. (1995) The differences in intestinal viscosity produced by barley and β-glucanase after digesta enzyme activities and ileal nutrient digestibility more in broiler chicks than in cocks. J Nutr 125, 947955.
47Gee, JM, Lee-Finglas, W, Wortley, GW, et al. (1996) Fermentable carbohydrates elevate plasma enteroglucagon but high viscosity is also necessary to stimulate small bowel mucosal cell proliferation in rats. J Nutr 126, 373379.
48Teirlynck, E, Bjerrum, L, Eeckhaut, V, et al. (2009) The cereal type in feed influences gut wall morphology and intestinal immune cell infiltration in broiler chickens. Br J Nutr 102, 14531461.
49Daenicke, S, Bottcher, W, Jeroch, H, et al. (2000) Replacement of soybean oil with tallow in rye-based diets without xylanase increases protein synthesis in small intestine of broilers. J Nutr 130, 827834.
50Fernandez, F, Sharma, R, Hinton, M, et al. (2000) Diet influences the colonization of Campylobacter jejuni and distribution of mucin carbohydrates in the chick intestinal tract. Cell Mol Life Sci 5, 17931801.
51Jørgensen, H, Zhao, X-Q & Eggum, BO (1996) The influence of dietary fibre and environmental temperature on the development of the gastrointestinal tract digestibility degree of fermentation in the hind-gut and energy metabolism in pigs. Br J Nutr 75, 365378.
52Hübener, K, Vahjen, W & Simon, O (2002) Bacterial responses to different dietary cereal types and xylanase supplementation in the intestine of broiler chicken. Arch Anim Nutr 56, 167187.
53Torok, VA, Ophel-Keller, K, Loo, M, et al. (2008) Application of methods for identifying broiler chicken gut bacterial species linked with increased energy metabolism. Appl Environ Microbiol 74, 783791.
54Zhang, C, Zhang, M, Wang, S, et al. (2010) Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 4, 232241.
55Chen, KT, Malo, MS, Moss, AK, et al. (2010) Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol 299, G467G475.
56Lallés, J-P (2010) Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet. Nutr Rev 68, 323332.
57Visek, WJ (1978) The mode of growth promotion by antibiotics. J Anim Sci 46, 14471469.
58Niewold, TA (2007) The non-antibiotic anti-inflammatory effect of antimicrobial growth promoters, the real mode of action? A hypothesis. Poult Sci 86, 605609.
59Apajalahti, J, Kettunnen, A & Graham, H (2004) Characteristics of the gastrointestinal microbial communities, with special reference to the chicken. World Poult Sci J 60, 223232.
60Drew, MD, Van Kessel, AG, Estrada, AE, et al. (2002) Effect of dietary cereal on intestinal bacterial populations in weaned pigs. Can J Anim Sci 82, 607609.
61Bird, AR, Vuaran, M, Brown, I, et al. (2007) Two high-amylose maize starches with different amounts of resistant starch vary in their effects on fermentation, tissue and digesta mass accretion, and bacterial populations in the large bowel of pigs. Br J Nutr 97, 134144.
62Regmi, PR, Metzler-Zebeli, BU, Gänzle, MG, et al. (2011) Starch with high amylose content and low in vitro digestibility increases intestinal nutrient flow and microbial fermentation and selectively promotes bifidobacteria in pigs. J Nutr 141, 12731280.
63Ferrell, CL (1988) Contribution of visceral organs to animal energy expenditures. J Anim Sci 66, 2334.
64Agyekum, AK, Slominski, BA & Nyachoti, CM (2012) Organ weight, intestinal morphology, and fasting whole-body oxygen consumption in growing pigs fed diets containing distillers dried grains with solubles alone or in combination with a multi-enzyme supplement. J Anim Sci 90, 30323040.
65Kiarie, E & Nyachoti, CM (2009) Bioavailability of calcium and phosphorous in feedstuffs for farm animals. In Phosphorous and Calcium Utilization and Requirements in Farm Animals, pp. 7683 [Vitti, DMSS and Kebreab, E, editors]. Wallingford: CAB International.
66Selle, PH & Ravindran, V (2007) Microbial phytase in poultry nutrition. Anim Feed Sci Technol 135, 141.
67Selle, PH & Ravindran, V (2008) Phytate-degrading enzymes in pig nutrition. Livest Sci 113, 99122.
68Selle, PH, Cowieson, AJ, Cowieson, NP, et al. (2012) Protein-phytate interactions in pig and poultry nutrition: a reappraisal. Nutr Res Rev 25, 117.
69Cowieson, AJ, Acamovic, T & Bedford, MR (2004) The effects of phytase and phytic acid on the loss of endogenous amino acids and minerals from broiler chickens. Br Poult Sci 45, 101108.
70Adedokun, SA, Adeola, O, Parsons, CM, et al. (2011) Factors affecting endogenous amino acid flow in chickens and the need for consistency in methodology. Poult Sci 90, 17371748.
71Onyango, EM, Asem, KE & Adeola, O (2009) Phytic acid increases mucin and endogenous amino acid losses from the gastrointestinal tract of chickens. Br J Nutr 101, 836842.
72Yu, S, Cowieson, AJ, Gilbert, C, et al. (2012) Interactions of phytate and myo-inositol phosphate esters (IP1-5) including IP5 isomers with dietary protein and iron and inhibition of pepsin. J Anim Sci 90, 18241832.
73Lumpkins, BS, Humphrey, B, Mathis, G, et al. (2009) Performance, nutrient digestibility and expression of intestinal mucin RNA of 21 day old broiler chickens supplemented with 5000 FTU of phytase. Poult Sci 88, Suppl. 1, 59(abstract).
74Cooper, KK & Songer, J (2009) Necrotic enteritis in chickens: a paradigm of enteric infection by Clostridium perfringens type A. Anaerobe 15, 5560.
75Smulikowska, S, Czerwinski, J & Mieczkowska, A (2010) Effect of an organic acid blend and phytase added to a rapeseed cake containing diet on performance, intestinal morphology, caecal microfloral activity and thyroid status of broiler chickens. J Anim Physiol Anim Nutr 94, 1523.
76Metzler-Zebeli, BU, Vahjen, W, Baumgartel, T, et al. (2010) Ileal microbiota of growing pigs fed different calcium phosphate levels and phytase content and subjected to ileal pectin infusion. J Anim Sci 88, 147158.
77Wang, L & Lei, XG (2011) Supplemental dietary phytase alters gut microbiota of weanling pigs. J Anim Sci 89, E-Suppl. 1, 187(abstract).
78Rostagno MH, Ferrel J, Radcliffe JS, et al. (2012) Dietary supplementation with alkaline phosphatase affects intestinal microbial populations of nursery pigs. In Proccedings of the XII International Symposium on Digestive Physiology of Pigs, Keystone Resort and Conference Center, Keystone, CO, pp. 45–46.
79Doerrler, WT (2006) Lipid trafficking to the outer membrane of Gram-negative bacteria. Mol Microbiol 60, 542552.
80Malo, MS, Alam, SN, Mostafa, G, et al. (2010) Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut 59, 14761484.
81Romero, LF & Plumstead, PW (2011) Starch, protein and fat digestibility as predictors of enzyme responses in broiler diets. AFMA Matrix 20, 1217.
82Romero, LF, Plumstead, PW & Ravindran, V (2011) Energy contribution of digestible starch, fat, and protein in response to combinations of exogenous xylanase, amylase, and protease in corn-based broiler diets. Poult Sci 90, E-Suppl. 1, 20, (abstract).
83Hampson, DJ, Phillips, ND & Pluske, JR (2002) Dietary enzyme and zinc bacitracin reduce colonisation of layer hens by the intestinal spirochaete Brachyspira intermedia. Vet Microbiol 86, 351360.
84Simon, O (1998) The mode of action of NSP hydrolyzing enzymes in the gastrointestinal tract. J Anim Feed Sci 7, 115123.
85Castanon, JIR, Flores, MP & Pattersson, D (1997) Mode of degradation of non-starch polysaccharides by feed enzyme preparations. Anim Feed Sci Technol 68, 361365.
86Meng X (2005) Improved nutrient utilization and growth performance of broiler chickens fed diets supplemented with multi-carbohydrase enzyme preparations. PhD thesis, University of Manitoba.
87Voragen, AGJ (1998) Technological aspects of functional food-related carbohydrates. Food Sci Technol 9, 328335.
88Vázquez, MJ, Alonso, JL, Domínguez, H, et al. (2000) Xylooligosaccharides: manufacture and applications. Trends in Food Sci Technol 11, 387393.
89Chesson, A & Stewart, CS (2001) Modulation of the gut microflora by enzyme addition. In Gut Environment of Pigs, pp. 165179 [Piva, A, Bach Knudsen, KE and Lindberg, J-E, editors]. Loughborough: Nottingham University Press.
90Sunna, A & Antranikian, G (1997) Xylanolytic enzymes from fungi and bacteria. Crit Rev Biotechnol 17, 3967.
91Hespell, RB, O'Bryan, PJ, Moniruzzaman, M, et al. (1997) Hydrolysis by commercial enzyme mixtures of AFEX-treated corn fiber and isolated xylans. Appl Biochem Biotechnol 62, 8797.
92Li, K, Azadi, P, Collins, R, et al. (2000) Relationships between activities of xylanases and xylan structure. Enzyme Microbiol Technol 27, 8994.
93Austin, SC, Wiseman, J & Chesson, A (1999) Influence of non-starch polysaccharide structure on the metabolizable energy of UK wheat fed to poultry. J Cereal Sci 29, 7788.
94Apajalahti, J & Bedford, M (1998) Nutrition effects on the microflora of the GI tract. In Proceedings of the 19th Western Nutrition Conference, pp. 6068. Saskatoon: University of Saskachewan.
95Kiarie E (2008) Dietary means for enhanced gastrointestinal health and function in weaned pigs: an evaluation of carbohydrase enzymes targeting non-starch polysaccharides. PhD thesis, University of Manitoba.
96Diebold, G, Mosenthin, R, Piepho, HP, et al. (2004) Effect of supplementation of xylanase and phospholipase to a wheatbased diet for weanling pigs on nutrient digestibility and concentrations of microbial metabolites in ileal digesta and feces. J Anim Sci 82, 26472656.
97Osswald, T, Vahjen, W & Simon, O (2006) Influence of different non starch polysaccharide degrading feed enzymes on the intestinal microbiota in piglets. Slovak J Anim Sci 39, 5558.
98Kiarie, E, Nyachoti, CM, Slominski, BA, et al. (2007) Growth performance, gastrointestinal microbial activity, and nutrient digestibility in early-weaned pigs fed diets containing flaxseed and carbohydrase enzyme. J Anim Sci 85, 29822993.
99Rosin, EA, Blank, G, Slominski, BA, et al. (2007) Enzyme supplements in broiler chicken diets: in vitro and in vivo effects on bacterial growth. J Sci Food Agric 87, 10091020.
100Jòzefiak, DA, Rutkowski, S, Kaczmarek, BB, et al. (2010) Effect of β-glucanase and xylanase supplementation of barley- and rye-based diets on cecal microbiota of broiler chickens. Br Poult Sci 51, 546557.
101Choct, M, Hughes, RJ & Bedford, MR (1999) Effects of a xylanase on individual bird variation, starch digestion throughout the intestine, and ileal and cecal volatile fatty acid production in chickens fed wheat. Br Poult Sci 40, 419422.
102Courtin, CM, Broekaert, WF, Swennen, K, et al. (2008) Dietary inclusion of wheat bran arabinoxylooligosaccharides induces beneficial nutritional effects in chickens. Cereal Chem 85, 607613.
103Bach Knudsen, KE (1997) Carbohydrate and lignin contents of plant materials used in animal feeding. Anim Feed Sci Technol 67, 319338.
104Van Loo, JAE (2004) Prebiotics promote good health. The basis, the potential, and the emerging evidence. J Clin Gastroenterol 38, S70S75.
105Guilloteau, P, Martin, L, Eeckhaut, V, et al. (2010) From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev 23, 366384.
106Damen, B, Verspreet, J, Pollet, A, et al. (2011) Prebiotic effects and intestinal fermentation of cereal arabinoxylans and arabinoxylan oligosaccharides in rats depend strongly on their structural properties and joint presence. Mol Nutr Food Res 55, 18621874.
107Anderson, DB, McCracken, VJ, Aminov, RI, et al. (2000) Gut microbiology and growth-promoting antibiotics in swine. Nutr Abstr Rev Series B: Livest Feeds and Feeding 70, 101108.
108Lo, LL & Pickersgill, RW (1999) Xylanase-oligosaccharide interactions studied by a competitive enzyme assay. Enzyme Microbiol Technol 25, 701709.
109Van Craeyveld, V, Swennen, K, Dornez, E, et al. (2008) Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats. J Nutr 138, 23482355.
110Choct, M, Sinlae, M, Al-Jassim, RAM, et al. (2006) Effects of xylanase supplementation on between-bird variation in energy metabolism and the number of Clostridium perfringens in broilers fed a wheat-based diet. Aust J Agric Res 57, 10171021.
111Nian, F, Guo, YM, Ru, YJ, et al. (2011) Effect of xylanase supplementation on the net energy for production, performance and gut microflora of broilers fed corn/soy-based diet. Asian-Aust J Anim Sci 24, 12821287.
112Inborr, J & Ogle, RB (1988) Effect of enzyme treatment of piglet feeds on performance and post weaning diarrhea. Swedish J Agric Res 8, 129133.
113Turlington, WH, Allee, GL & Nelssen, JL (1989) Effects of protein and carbohydrate sources on digestibility and digesta flow rate in weaned pigs fed a high-fat, dry diet. J Anim Sci 67, 23332340.
114Kiarie, E, Slominski, BA, Krause, DO, et al. (2008) Non-starch polysaccharide hydrolysis products of soybean and canola meal protect against enterotoxigenic Escherichia coli in piglets. J Nutr 138, 502508.
115Kiarie, E, Slominski, BA & Nyachoti, CM (2010) Effect of products derived from hydrolysis of wheat and flaxseed non starch polysaccharides by carbohydrase enzymes on net absorption in enterotoxigenic Escherichia coli (K88) challenged piglet jejunal segments. Anim Sci J 81, 6371.
116Jensen, GS, Patterson, KM & Yoon, I (2008) Yeast culture has anti-inflammatory effects and specifically activates NK cells. Comp Immunol Microbiol Infect Dis 31, 487500.
117Nabuurs, MJ, Hoogendoorn, A, van Zijderveld, FG, et al. (1993) A long-term perfusion test to measure net absorption in the small intestine of weaned pigs. Res Vet Sci 55, 108114.
118Alam, N, Sarker, SA, Molla, AM, et al. (1987) Hydrolyzed wheat based oral rehydration solution for acute diarrhea. Arch Dis Child 62, 440444.
119Kiers, JL, Meijer, JC, Nout, MJR, et al. (2003) Effect of fermented soybeans on diarrhea and feed efficiency in weaned piglets. J Appl Microbiol 95, 545552.
120Kiers, JL, Nout, MJR, Rombouts, FM, et al. (2006) Effect of processed and fermented soybeans on net absorption in enterotoxigenic Escherichia coli-infected piglet small intestine. Br J Nutr 95, 11931198.
121Kiers, JL, Nout, MJR, Rombouts, FM, et al. (2007) A high molecular weight soluble fraction of tempeh protects against fluid losses in Escherichia coli-infected piglet small intestine. Br J Nutr 98, 320325.
122Kiarie, E, Slominski, BA, Krause, DO, et al. (2009) Gastrointestinal ecology response of piglets diets containing non-starch polysaccharide hydrolysis products and egg yolk antibodies following an oral challenge with Escherichia coli (k88). Can J Anim Sci 89, 341352.
123Kiarie, E, Slominski, BA, Krause, DO, et al. (2009) Acute phase response of piglets fed diets containing non-starch polysaccharide hydrolysis products and egg yolk antibodies following an oral challenge with Escherichia coli (k88). Can J Anim Sci 89, 353360.
124Harris, DL, Hampson, DJ & Glock, RD (1999) Swine dysentery. In Diseases of Swine, 8th ed., pp. 579600 [Straw, BE, D'Allaire, S, Mengeling, WL and Taylor, DJ, editors]. Oxford: Blackwell Science.
125Schwartz, K (2011) New (and old) tools for dysentery diagnostics. In Proceeding of the American Association of Swine Veterinarians 42nd Annual Meeting, pp. 453458. Phoenix, AZ: American Association of Swine Veterinarians.
126Siba, PB, Pethick, DW & Hampson, DJ (1996) Pigs experimentally infected with Serpulina hyodysenteriae can be protected from developing swine dysentery by feeding them a highly digestible diet. Epidemiol Infect 116, 207216.
127Kennedy, MJ, Rosnick, DK, Ulrich, RG, et al. (1988) Association of Treponema hyodysenteriae with porcine intestinal mucosa. J Gen Microbiol 134, 15651574.
128Zhang, P, Duhamel, GE, Mysore, JV, et al. (1995) Prophylactic effect of dietary zinc in a laboratory mouse model of swine dysentery. Am J Vet Res 56, 334339.
129Gast, RK (2010) Pre-harvest control of Salmonella. WATT Poultry U S A 11, 1618.
130Van Immerseel, F, Eeckhaut, V, Teirlynck, E, et al. (2007) Mechanisms of action of nutritional tools to control intestinal zoonotic pathogens. In Proceedings of the 16th European Nutrition Symposium, pp. 243250. Strasbourg: World Poultry Science Association.
131Eeckhaut, V, Van Immerseel, F, DeWulf, J, et al. (2008) Arabinoxylooligosaccharides from wheat bran inhibit Salmonella colonization in broiler chickens. Poult Sci 87, 23292334.
132Vandeplas, S, Dauphin, RD, Thiry, C, et al. (2009) Efficiency of a Lactobacillus plantarum-xylanase combination on growth performances, microflora populations, and nutrient digestibilities of broilers infected with Salmonella Typhimurium. Poult Sci 88, 16431654.
133Amerah, AM, Mathis, G & Hofacre, CL (2012) Effect of xylanase and a blend of essential oils on performance and Salmonella colonization of broiler chickens challenged with Salmonella Heidelberg. Poult Sci 91, 943947.
134Ducatelle, R & Van Immerseel, F (2010) Necrotic enteritis: emerging problem in broilers. WATT Poultry U S A 11, 2224.
135Williams, RB (2005) Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity. Avian Pathol 34, 159180.
136Collier, CT, Hofacre, CL, Payne, AM, et al. (2008) Coccidia-induced mucogenesis promotes the onset of necrotic enteritis by supporting Clostridium perfringens growth. Vet Immunol Immunopathol 122, 104115.
137Jackson, ME, Anderson, DM, Hsiao, HY, et al. (2003) Beneficial effect of beta-mannanase feed enzyme on performance of chicks challenged with Eimeria sp. and Clostridium perfringens. Avian Dis 47, 759763.
138Parker, J, Oviedo-Rondon, EO, Clack, BA, et al. (2007) Enzymes as feed additive to aid in responses against Eimeria species in coccidia-vaccinated broilers fed corn-soybean meal diets with different protein levels. Poult Sci 86, 643653.
139Bedford, MR & Cowieson, AJ (2011) Exogenous enzymes and their effects on intestinal microbiology. Anim Feed Sci Technol 173, 7684.
140Garcia, V, Gomez, J, Mignon-Grasteau, S, et al. (2007) Effects of xylanase and antibiotic supplementations on the nutritional utilization of a wheat diet in growing chicks from genetic D+ and D −  lines selected for divergent digestion efficiency. Animal 1, 14351442.
141Aphalajalati, D, Geier, MS, Hughes, RJ, et al. (2012) Does the composition of intestinal microbiota determine or reflect feed conversion efficiency? Proc Aust Poult Sci Symp 23, 3239.
142Turnbaugh, PJ, Hamady, M, Yatsunenko, T, et al. (2009) A core gut microbiome in obese and lean twins. Nature 457, 480484.
143Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1021.
144Marsh, T (2005) Culture-independent microbial community analysis with terminal restriction fragment length polymorphism. Methods Enzymol 397, 308329.
145Highlander, SK (2012) High throughput sequencing methods for microbiome profiling: application to food animal systems. Anim Health Res Rev 13, 4053.

Keywords

The role of added feed enzymes in promoting gut health in swine and poultry

  • Elijah Kiarie (a1), Luis F. Romero (a1) and Charles M. Nyachoti (a2)

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