Skip to main content
×
Home
    • Aa
    • Aa

Ruminant and industrial sources of trans-fat and cardiovascular and diabetic diseases

  • Anne-Laure Tardy (a1) (a2) (a3), Béatrice Morio (a1) (a2) (a3), Jean-Michel Chardigny (a1) (a2) (a3) and Corinne Malpuech-Brugère (a1) (a2) (a3)
Abstract

The various positional isomers of oleic acid (18 : 1Δ9c or 9c-18 : 1) may have distinct biological effects. Detrimental effects of consumption of industrial trans-fatty acids (TFA) (elaidic acid; 18 : 1Δ9t) from partially hydrogenated vegetable oils on CVD risk factors are well documented. In addition, epidemiological data suggest that chronic consumption of industrial sources of TFA could alter insulin sensitivity and predispose for type 2 diabetes. However, intervention studies on this issue have remained inconclusive. Moreover, very little information is available on the effect of natural sources of TFA (vaccenic acid; 18 : 1Δ11t) coming from dairy products and ruminant meat on the development of CVD and type 2 diabetes. The review focuses on the impact of the consumption of ruminant TFA in relation to cardiovascular risk factors, inflammation and type 2 diabetes.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Ruminant and industrial sources of trans-fat and cardiovascular and diabetic diseases
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Ruminant and industrial sources of trans-fat and cardiovascular and diabetic diseases
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Ruminant and industrial sources of trans-fat and cardiovascular and diabetic diseases
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Béatrice Morio, fax +33 4 73 60 82 55, email morio@clermont.inra.fr
References
Hide All
1Scientific Panel on Dietetic Products NaA (2004) Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the presence of trans fatty acids in foods and the effect on human health of the consumption of trans fatty acids (Request no. EFSA-Q-2003-022). In EFSA Journal, vol. 81, pp. 149. Parma, Italy: European Food Safety Authority.
2Bauman DE, Mather IH, Wall RJ, et al. . (2006) Major advances associated with the biosynthesis of milk. J Dairy Sci 89, 12351243.
3Wolff RL & Sebedio JL (1991) Geometrical isomers of linolenic acids in low-caloric spreads marketed in France. J Am Oil Chem Soc 68, 719725.
4Ratnayake WM (2004) Overview of methods for the determination of trans fatty acids by gas chromatography, silver-ion thin-layer chromatography, silver-ion liquid chromatography, and gas chromatography/mass spectrometry. J AOAC Int 87, 523539.
5Leger C-L & Razanamahefa L (2005) Risques et bénéfices pour la santé des acides gras trans apportés par les aliments. Recommandations (Risks and Benefits of Food Trans Fatty Acids for Human Health. Recommendations). Maison-Alfort: AFSSA.
6Jensen RG (2002) The composition of bovine milk lipids: January 1995 to December 2000. J Dairy Sci 85, 295350.
7Bauman DE & Griinari JM (2003) Nutritional regulation of milk fat synthesis. Annu Rev Nutr 23, 203227.
8Hulshof KF, van Erp-Baart MA, Anttolainen M, et al. . (1999) Intake of fatty acids in western Europe with emphasis on trans fatty acids: the TRANSFAIR Study. Eur J Clin Nutr 53, 143157.
9Chilliard Y, Ferlay A, Mansbridge RM, et al. . (2000) Ruminant milk fat plasticity: nutritional control of saturated, polyunsaurated, trans and conjugated fatty acids. Ann Zootech 49, 181205.
10Chilliard Y & Ferlay A (2004) Dietary lipids and forages interactions on cow and goat milk fatty acid composition and sensory properties. Reprod Nutr Dev 44, 467492.
11Jakobsen MU, Bysted A, Andersen NL, et al. . (2006) Intake of ruminant trans fatty acids in the Danish population aged 1–80 years. Eur J Clin Nutr 60, 312318.
12Micha R & Mozaffarian D (2009) Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes. Nat Rev Endocrinol 5, 335344.
13Micha R & Mozaffarian D (2008) Trans fatty acids: effects on cardiometabolic health and implications for policy. Prostaglandins Leukot Essent Fatty Acids 79, 147152.
14Willett WC, Stampfer MJ, Manson JE, et al. . (1993) Intake of trans fatty acids and risk of coronary heart disease among women. Lancet 341, 581585.
15Ascherio A, Hennekens CH, Buring JE, et al. . (1994) Trans-fatty acids intake and risk of myocardial infarction. Circulation 89, 94101.
16Jakobsen MU, Overvad K, Dyerberg J, et al. . (2008) Intake of ruminant trans fatty acids and risk of coronary heart disease. Int J Epidemiol 37, 173182.
17Oomen CM, Ocke MC, Feskens EJ, et al. . (2001) Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study. Lancet 357, 746751.
18Pietinen P, Ascherio A, Korhonen P, et al. . (1997) Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Epidemiol 145, 876887.
19Bolton-Smith C, Woodward M, Fenton S, et al. . (1996) Does dietary trans fatty acid intake relate to the prevalence of coronary heart disease in Scotland? Eur Heart J 17, 837845.
20Chardigny JM, Destaillats F, Malpuech-Brugere C, et al. . (2008) Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the Trans Fatty Acids Collaboration (TRANSFACT) study. Am J Clin Nutr 87, 558566.
21Motard-Bélanger A, Charest A, Grenier G, et al. . (2008) Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am J Clin Nutr 87, 593599.
22Tholstrup T, Raff M, Basu S, et al. . (2006) Effects of butter high in ruminant trans and monounsaturated fatty acids on lipoproteins, incorporation of fatty acids into lipid classes, plasma C-reactive protein, oxidative stress, hemostatic variables, and insulin in healthy young men. Am J Clin Nutr 83, 237243.
23Raff M, Tholstrup T, Sejrsen K, et al. . (2006) Diets rich in conjugated linoleic acid and vaccenic acid have no effect on blood pressure and isobaric arterial elasticity in healthy young men. J Nutr 136, 992997.
24Kuhnt K, Kraft J, Vogelsang H, et al. . (2007) Dietary supplementation with trans-11- and trans-12-18[thinsp]: 1 increases cis-9, trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation. Br J Nutr 97, 11961205.
25Libby P (2002) Inflammation in atherosclerosis. Nature 420, 868874.
26Tardy AL, Lambert-Porcheron S, Malpuech-Brugere C, et al. . (2009) Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women. Am J Clin Nutr 90, 8894.
27Weggemans RM, Rudrum M & Trautwein EA (2004) Intake of ruminant versus industrial trans fatty acids and risk of coronary heart disease – what is the evidence? Eur J Lipid Sci Technol 106, 390397.
28Salmeron J, Hu FB, Manson JE, et al. . (2001) Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 73, 10191026.
29Clandinin MT & Wilke MS (2001) Do trans fatty acids increase the incidence of type 2 diabetes? Am J Clin Nutr 73, 10011002.
30Tardy A-L, Giraudet C, Rousset P, et al. . (2008) Effects of trans MUFA from dairy and industrial sources on muscle mitochondrial function and insulin sensitivity. J Lipid Res 49, 14451455.
31Wang Y, Lu J, Ruth MR, et al. . (2008) Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR:LA-cp rats. J Nutr 138, 21172122.
32Alstrup KK, Gregersen S, Jensen HM, et al. . (1999) Differential effects of cis and trans fatty acids on insulin release from isolated mouse islets. Metabolism 48, 2229.
33Alstrup KK, Brock B & Hermansen K (2004) Long-term exposure of INS-1 cells to cis and trans fatty acids influences insulin release and fatty acid oxidation differentially. Metabolism 53, 11581165.
34Hommelberg PP, Langen RC, Schols AM, et al. . (2010) Trans fatty acid-induced NF-κB activation does not induce insulin resistance in cultured murine skeletal muscle cells. Lipids 45, 285290.
35Booker CS & Mann JI (2008) Trans fatty acids and cardiovascular health: translation of the evidence base. Nutr Metab Cardiovasc Dis 18, 448456.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 20
Total number of PDF views: 128 *
Loading metrics...

Abstract views

Total abstract views: 319 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st October 2017. This data will be updated every 24 hours.