Skip to main content Accessibility help
×
×
Home

Summary and meta-analysis of prospective studies of animal fat intake and breast cancer

  • Dominik D. Alexander (a1), Libby M. Morimoto (a2), Pamela J. Mink (a3) (a4) and Kimberly A. Lowe (a5)
Abstract

The objective of the present review was to examine the potential association between animal fat intake and breast cancer. We conducted a meta-analysis and review of epidemiological cohort studies, including data reported in the Pooling Project publication of Prospective Studies of Diet and Cancer. Random- and fixed-effects models were utilised to generate summary relative risk estimates (SRRE), and sensitivity and influence analyses were conducted. In the meta-analysis that included data reported in the Pooling Project publication of prospective cohorts (n 8) and subsequent publications of cohort studies (n 3), no significant association was observed comparing the highest category of animal fat intake with the lowest (SRRE 1·03; 95 % CI: 0·76, 1·40). Similarly, no significant association between a 5 % increment of energy from animal fat intake and breast cancer (SRRE 1·02; 95 % CI 0·97, 1·07) was observed in the meta-analysis of these studies. In conclusion, the results of the present quantitative assessment are not supportive of a positive independent association between consumption of animal fat and breast cancer, although findings may be sensitive to the type of dietary instrument used in cohort studies.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Summary and meta-analysis of prospective studies of animal fat intake and breast cancer
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Summary and meta-analysis of prospective studies of animal fat intake and breast cancer
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Summary and meta-analysis of prospective studies of animal fat intake and breast cancer
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Dominik D. Alexander, fax +1 630 274 3299, email dalexander@exponent.com
References
Hide All
1Armstrong, B & Doll, R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 15, 617631.
2Lea, AJ (1966) Dietary factors associated with death-rates from certain neoplasms in man. Lancet ii, 332333.
3Rose, DP, Boyar, AP & Wynder, EL (1986) International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 58, 23632371.
4Hursting, SD, Thornquist, M & Henderson, MM (1990) Types of dietary fat and the incidence of cancer at five sites. Prev Med 19, 242253.
5Carroll, KK & Khor, HT (1975) Dietary fat in relation to tumorigenesis. Prog Biochem Pharmacol 10, 308353.
6Freedman, LS, Clifford, C & Messina, M (1990) Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review. Cancer Res 50, 57105719.
7Smith-Warner, SA & Stampfer, MJ (2007) Fat intake and breast cancer revisited. J Natl Cancer Inst 99, 418419.
8Howe, GR, Hirohata, T, Hislop, TG, et al. . (1990) Dietary factors and risk of breast cancer: combined analysis of 12 case–control studies. J Natl Cancer Inst 82, 561569.
9Boyd, NF, Martin, LJ, Noffel, M, et al. . (1993) A meta-analysis of studies of dietary fat and breast cancer risk. Br J Cancer 68, 627636.
10Boyd, NF, Stone, J, Vogt, KN, et al. . (2003) Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer 89, 16721685.
11Smith-Warner, SA, Spiegelman, D, Adami, HO, et al. . (2001) Types of dietary fat and breast cancer: a pooled analysis of cohort studies. Int J Cancer 92, 767774.
12Prentice, RL, Caan, B, Chlebowski, RT, et al. . (2006) Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 295, 629642.
13Cho, E, Spiegelman, D, Hunter, DJ, et al. . (2003) Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst 95, 10791085.
14World Cancer Research Fund & American Institute for Cancer Research (2007) Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, DC: AICR.
15Hunter, DJ, Spiegelman, D, Adami, HO, et al. . (1996) Cohort studies of fat intake and the risk of breast cancer – a pooled analysis. N Engl J Med 334, 356361.
16Kim, EH, Willett, WC, Colditz, GA, et al. . (2006) Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up. Am J Epidemiol 164, 990997.
17Wakai, K, Tamakoshi, K, Date, C, et al. . (2005) Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Cancer Sci 96, 590599.
18Sieri, S, Krogh, V, Muti, P, et al. . (2002) Fat and protein intake and subsequent breast cancer risk in postmenopausal women. Nutr Cancer 42, 1017.
19Thiébaut, AC, Kipnis, V, Chang, SC, et al. . (2007) Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health–AARP Diet and Health Study cohort. J Natl Cancer Inst 99, 451462.
20Michels, KB, Rosner, BA, Chumlea, WC, et al. . (2006) Preschool diet and adult risk of breast cancer. Int J Cancer 118, 749754.
21Frazier, AL, Li, L, Cho, E, et al. . (2004) Adolescent diet and risk of breast cancer. Cancer Causes Control 15, 7382.
22Howe, GR, Friedenreich, CM, Jain, M, et al. . (1991) A cohort study of fat intake and risk of breast cancer. J Natl Cancer Inst 83, 336340.
23Voorrips, LE, Brants, HA, Kardinaal, AF, et al. . (2002) Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. Am J Clin Nutr 76, 873882.
24Mills, PK, Beeson, WL, Phillips, RL, et al. . (1989) Dietary habits and breast cancer incidence among Seventh-Day Adventists. Cancer 64, 582590.
25Graham, S, Zielezny, M, Marshall, J, et al. . (1992) Diet in the epidemiology of postmenopausal breast cancer in the New York State Cohort. Am J Epidemiol 136, 13271337.
26Holmes, MD, Hunter, DJ, Colditz, GA, et al. . (1999) Association of dietary intake of fat and fatty acids with risk of breast cancer. JAMA 281, 914920.
27Greenland, S & Longnecker, MP (1992) Methods for trend estimation from summarized dose–response data, with applications to meta-analysis. Am J Epidemiol 135, 13011309.
28Rothstein, H, Sutton, A & Borenstein, M (2005) Publication Bias in Meta-Analysis: Prevention, Assessments, and Adjustments. Chichester, UK: John Wiley and Sons, Ltd.
29Hermann, S, Linseisen, J & Chang-Claude, J (2002) Nutrition and breast cancer risk by age 50: a population-based case–control study in Germany. Nutr Cancer 44, 2334.
30Richardson, S, Gerber, M & Cenee, S (1991) The role of fat, animal protein and some vitamin consumption in breast cancer: a case control study in southern France. Int J Cancer 48, 19.
31Iscovich, JM, Iscovich, RB, Howe, G, et al. . (1989) A case–control study of diet and breast cancer in Argentina. Int J Cancer 44, 770776.
32Hirohata, T, Shigematsu, T, Nomura, AM, et al. . (1985) Occurrence of breast cancer in relation to diet and reproductive history: a case–control study in Fukuoka, Japan. Natl Cancer Inst Monogr 69, 187190.
33Ferraroni, M, Decarli, A, Willett, WC, et al. . (1991) Alcohol and breast cancer risk: a case–control study from northern Italy. Int J Epidemiol 20, 859864.
34Potischman, N, Coates, RJ, Swanson, CA, et al. . (2002) Increased risk of early-stage breast cancer related to consumption of sweet foods among women less than age 45 in the United States. Cancer Causes Control 13, 937946.
35Ceber, E, Sogukpinar, N, Mermer, G, et al. . (2005) Nutrition, lifestyle, and breast cancer risk among Turkish women. Nutr Cancer 53, 152159.
36Graham, S, Marshall, J, Mettlin, C, et al. . (1982) Diet in the epidemiology of breast cancer. Am J Epidemiol 116, 6875.
37Willett, W (2008) Nutritional epidemiology. In Modern Epidemiology, pp. 580598 [Rothman, KJ, Greenland, S and Lash, TL, editors]. Philadelphia: Lippincott Williams & Wilkins.
38United States Department of Agriculture Agricultural Research Service (2007) USDA Nutrient Database for Standard Reference, Release 20. Nutrient Data Laboratory homepage. http://www.nal.usda.gov/fnic/foodcomp.
39Terry, PD, Rohan, TE & Wolk, A (2003) Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. Am J Clin Nutr 77, 532543.
40Ip, C, Dong, Y, Ip, MM, et al. . (2002) Conjugated linoleic acid isomers and mammary cancer prevention. Nutr Cancer 43, 5258.
41Larsson, SC, Bergkvist, L & Wolk, A (2009) Conjugated linoleic acid intake and breast cancer risk in a prospective cohort of Swedish Women. Am J Clin Nutr 90, 556560.
42Willett, W (1998) Nutritional Epidemiology, 2nd ed. New York: Oxford University Press.
43Bingham, SA, Luben, R, Welch, A, et al. . (2003) Are imprecise methods obscuring a relation between fat and breast cancer? Lancet 362, 212214.
44Freedman, LS, Potischman, N, Kipnis, V, et al. . (2006) A comparison of two dietary instruments for evaluating the fat–breast cancer relationship. Int J Epidemiol 35, 10111021.
45Freedman, LS, Kipnis, V, Schatzkin, A, et al. . (2008) Methods of epidemiology: evaluating the fat–breast cancer hypothesis – comparing dietary instruments and other developments. Cancer J 14, 6974.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
  • URL: /core/journals/nutrition-research-reviews
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed