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The interactions between selenium and iodine deficiencies in man and animals

  • John R Arthur (a1), Geoffrey J Beckett (a2) and Julie H Mitchell (a1)
  • DOI: http://dx.doi.org/10.1079/095442299108728910
  • Published online: 24 October 2008
Abstract
Abstract

Up to one billion people live in areas where they may be at risk from I deficiency. Many of the debilitating effects of the deficiency may be irreversible, consequently it is essential to understand the mechanisms whereby lack of I can cause disease through decreased thyroxine and 3, 3',5-triiodothyronine (T3) synthesis. Since Se has an essential role in thyroid hormone metabolism, it has the potential to play a major part in the outcome of I deficiency. These effects of Se derive from two aspects of its biological function. First, three Se-containing deiodinases regulate the synthesis and degradation of the biologically active thyroid hormone, T3. Second, selenoperoxidases and possibly thioredoxin reductase (EC 1.6.4.5) protect the thyroid gland from H2O2 produced during the synthesis of thyroid hormones. The mechanisms whereby Se deficiency exacerbates the hypothyroidism due to I deficiency have been elucidated in animals. In contrast to these adverse effects, concurrent Se deficiency may also cause changes in deiodinase activities which can protect the brain from low T3 concentrations in I deficiency. Animals with Se and I deficiency have changes in serum thyroid hormone concentrations that are similar to those observed in patients with I deficiency disease. However such animal models show no thyroid involution, a feature which is characteristic of myxoedematous cretinism in man. These observations imply that if Se deficiency is involved in the outcome of I deficiency in human populations it is likely that other interacting factors such as goitrogens are also implicated. Nevertheless the protection of the thyroid gland from H2O2 and the regulation of tissue T3 levels are the functions of Se that are most likely to underlie the interactions of Se and I.

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Corresponding author
*Corresponding author: Dr John Arthur, fax +44 (0)1224 716622, email jra@rri.sari.ac.uk
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JR Arthur , G Bermano , JH Mitchell & JE Hesketh (1996) Regulation of selenoprotein gene expression and thyroid hormone metabolism. Biochemical Society Transactions 24, 384388.

JR Arthur , F Nicol & GJ Beckett (1990 a) Hepatic iodothyronine deiodinase: The role of selenium. Biochemical Journal 272, 537540.

JR Arthur , F Nicol , GJ Beckett & P Trayhurn (1991) Impairment of iodothyronine 5′-deiodinase activity in brown adipose tissue and its acute stimulation by cold in selenium deficiency. Canadian Journal of Physiology and Pharmacology 69, 782785.

JR Arthur , F Nicol , AR Hutchinson & GJ Beckett (1990 b) The effects of selenium depletion and repletion on the metabolism of thyroid hormones in the rat. Journal of Inorganic Biochemistry 39, 101108.

MA Beck , Q Shi , VC Morris & OA Levander (1995) Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nature-Medicine 1, 433436.

GJ Beckett & JR Arthur (1994) The iodothyronine deiodinases and 5′-deiodination. Baillieres Clinical Endocrinology and Metabolism 8, 285304.

GJ Beckett , SE Beddows , PC Morrice , F Nicol & JR Arthur (1987) Inhibition of hepatic deiodination of thyroxine caused by selenium deficiency in rats. Biochemical Journal 248, 443447.

GJ Beckett , DA MacDougall , F Nicol & JR Arthur (1989) Inhibition of type I and type II iodothyronine deiodinase activity in rat liver, kidney and brain produced by selenium deficiency. Biochemical Journal 259, 887892.

SG Beech , SW Walker , GJ Beckett , JR Arthur , F Nicol & D Lee (1995) Effect of selenium depletion on thyroidal type-I iodothyronine deiodinase activity in isolated human thyrocytes and rat thyroid and liver. Analyst 120, 827831.

SG Beech , SW Walker , AM Dorrance , JR Arthur , F Nicol , D Lee & GJ Beckett (1993) The role of thyroidal type-I iodothyronine deiodinase in tri-iodothyronine production by human and sheep thyrocytes in primary culture. Journal of Endocrinology 136, 361370.

D Behne , H Hilmert , S Scheid , H Gessner & W Elger (1988) Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochimica et Biophysica Acta 966, 1221.

D Behne , A Kyriakopoulos , C Weissnowak , M Kalckloesch , C Westphal & H Gessner (1996) Newly found selenium-containing proteins in the tissues of the rat. Biological Trace Element Research 55, 99110.

G Bermano , F Nicol , JA Dyer , RA Sunde , GJ Beckett , JR Arthur & JE Hesketh (1995) Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. Biochemical Journal 311, 425430.

MJ Berry , L Banu , Y Chen , SJ Mandel , JD Kieffer , JW Harney & PR Larsen (1991 a) Recognition of UGA as a selenocysteine codon in type-I deiodinase requires sequences in the 3′ untranslated region. Nature 353, 273276.

MJ Berry , L Banu & PR Larsen (1991 b) Type-I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349, 438440.

U Bjorkman & R Ekholm (1992) Hydrogen peroxide generation and its regulation in FRTL5 and porcine thyroid cells. Endocrinology 130, 393399.

U Bjorkman & R Ekholm (1995) Hydrogen peroxide degradation and glutathione peroxidase activity in cultures of thyroid cells. Molecular and Cellular Endocrinology 111, 99107.

M Bjornstedt , M Hamberg , S Kumar , J Xue & A Holmgren (1995) Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. Journal of Biological Chemistry 270, 1176111764.

RF Burk & KE Hill (1992) Some properties of selenoprotein-P. Biological Trace Element Research 33, 151153.

RF Burk , KE Hill , JA Awad , JD Morrow , T Kato , KA Cockell & PR Lyons (1995) Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: Assessment of the roles of lipid peroxidation and selenoprotein P. Hepatology 21, 561569.

MR Calomme , JB Vanderpas , B Francois , M Vancailliebertrand , A Herchuelz , N Vanovervelt , C Vanhoorebeke & DAV Berghe (1995) Thyroid function parameters during a selenium repletion depletion study in phenylketonuric subjects. Experimentia 51, 12081215.

A Campos-Barros , H Meinhold , B Walzog & D Behne (1997) Effects of selenium and iodine deficiency on thyroid hormone concentrations in the central nervous system of the rat. European Journal of Endocrinology 136, 316323.

JP Chanoine , LE Braverman , AP Farwell , M Safran , S Alex , S Dubord & JL Leonard (1993) The thyroid gland is a major source of circulating-T(3) in the rat. Journal of Clinical Investigation 91, 27092713.

JP Chanoine , M Safran , AP Farwell , P Tranter , DM Ekenbarger , S Dubord , S Alex , JR Arthur , GJ Beckett , LE Braverman & JL Leonard (1992) Selenium deficiency and type-II 5′-deiodinase regulation in the euthyroid and hypothyroid rat - evidence of a direct effect of thyroxine. Endocrinology 131, 479484.

B Contempre , JF Denef , JE Dumont & MC Many (1993) Selenium deficiency aggravates the necrotizing effects of a high iodide dose in iodine deficient rats. Endocrinology 132, 18661868.

B Contempre , NL Duale , JE Dumont , B Ngo , AT Diplock & JB Vanderpas (1992) Effect of selenium supplementation on thyroid hormone metabolism in an iodine and selenium deficient population. Clinical Endocrinology 36, 579583.

B Contempre , JE Dumont , JF Denef & MC Many (1995) Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: A possible role in myxoedematous cretinism. European Journal of Endocrinology 133, 99109.

B Contempre , JE Dumont , B Ngo , CH Thilly , AT Diplock & JB Vanderpas (1991) Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area – the possible danger of indiscriminate supplementation of I-deficient subjects with selenium. Journal of Clinical Endocrinology and Metabolism 73, 213215.

B Contempre , O LeMoine , JE Dumont , JF Denef & MC Many (1996) Selenium deficiency and thyroid fibrosis. A key role for macrophages and transforming growth factor beta (TGF-beta). Molecular and Cellular Endocrinology 124, 715.

W Croteau , JC Davey , VA Galton & DL St Germain (1996) Cloning of the mammalian type II iodothyronine deiodinase – A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. Journal of Clinical Investigation 98, 405417.

W Croteau , SL Whittemore , MJ Schneider & DL St Germain (1995) Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase. Journal of Biological Chemistry 270, 1656916575.

G Dai , O Levy & N Carrasco (1996) Cloning and characterization of the thyroid iodide transporter. Nature 379, 458460.

GE Donald , JP Langlands , JE Bowles & AJ Smith (1993) Subclinical selenium insufficiency. 4. Effects of|selenium, I, and thiocyanate supplementation of grazing ewes on their selenium and iodine status, and on the status and growth of their lambs. Australian Journal of Experimental Agriculture 33, 411416.

GE Donald , JP Langlands , JE Bowles & AJ Smith (1994) Subclinical selenium insufficiency. 6. Thermoregulatory ability of perinatal lambs born to ewes supplemented with selenium and I. Australian Journal of Experimental Agriculture 34, 1924.

JE Dumont (1971) The action of thyrotropin on thyroid metabolism. Vitamins and Hormones 29, 287412.

JK Evenson & RA Sunde (1988) Selenium incorporation into selenoproteins in the Se-adequate and Se- deficient rat. Proceedings of the Society for Experimental Biology and Medicine 187, 169180.

A Geloen , JR Arthur , GJ Beckett & P Trayhurn (1990) Effect of selenium and iodine deficiency on the level of uncoupling protein in brown adipose tissue of rats. Biochemical Society Transactions 18, 12691270.

VN Gladyshev , KT Jeang & TC Stadtman (1996) Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin|reductase, corresponds to TGA in the human placental gene. Proceedings of the National Academy of Sciences USA 93, 61466151.

QP Gu , YM Xia , PC Ha , JA Butler & PD Whanger (1998) Distribution of selenium between plasma fractions in guinea pigs and humans with various intakes of dietary selenium. Journal of Trace Elements in Medicine and Biology 12, 815.

A Holmgren & M Bjornstedt (1995) Thioredoxin and thioredoxin reductase. Methods in Enzymology 252, 199208.

AF Howie , JR Arthur , F Nicol , SW Walker , SG Beech & GJ Beckett (1998) Identification of a 57-kilodalton selenoprotein in human thyrocytes as thioredoxin reductase and evidence that its expression is regulated through the calcium-phosphoinositol signalling pathway. Journal of Clinical Endocrinology and Metabolism 83, 20522058.

AF Howie , SW Walker , B Akesson , JR Arthur & GJ Beckett (1995) Thyroidal extracellular glutathione peroxidase: A potential regulator of thyroid-hormone synthesis. Biochemical Journal 308, 713717.

J Kohrle (1994) Thyroid hormone deiodination in target tissues - A regulatory role for the trace element selenium? Experimental and Clinical Endocrinology 102, 6389.

JM KoopdonkKool , JJM deVijlder , GJM Veenboer , C RisStalpers , JH Kok , T Vulsma , K Boer & TJ Visser (1996) Type II and type III deiodinase activity in human placenta as a function of gestational age. Journal of Clinical Endocrinology and Metabolism 81, 21542158.

PR Larsen (1996) Mammalian type 2 deiodinase sequences: Finally, the end of the beginning. Journal of Clinical Investigation 98, 242.

PR Larsen & MJ Berry (1995) Nutritional and hormonal regulation of thyroid hormone deiodinases. Annual Review of Nutrition 15, 323352.

OA Levander & MA Beck (1996) Viral evolution as driven by host nutritional selective factors: Influence of dietary oxidative stress. Food Chemistry 57, 4749.

OA Levander & MA Beck (1997) Interacting nutritional and infectious etiologies of Keshan disease – Insights from Coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. Biological Trace Element Research 56, 521.

MA McCoy , JA Smyth , WA Ellis , JR Arthur & DG Kennedy (1997) Experimental reproduction of iodine deficiency in cattle. Veterinary Record 141, 544547.

H Meinhold , A Campos-Barros , B Walzog , R Kohler , F Muller & D Behne (1993) Effects of selenium and iodine deficiency on type-I, type-II and type-III iodothyronine deiodinases and circulating thyroid hormones in the rat. Experimental and Clinical Endocrinology 101, 8793.

JH Mitchell , F Nicol , GJ Beckett & JR Arthur (1996) Selnoenzyme expression in thyroid and liver of second generation selenium- and I-deficient rats. Journal of Molecular Endocrinology 16, 259267.

JH Mitchell , F Nicol , GJ Beckett & JR Arthur (1997) Selenium and iodine deficiencies: effects on brain and brown adipose tissue selenoenzyme activity and expression. Journal of Endocrinology 155, 255263.

JH Mitchell , F Nicol , GJ Beckett & JR Arthur (1998) Selenoprotein expression and brain development in preweanling selenium- and I-deficient rats. Journal of Molecular Endocrinology 20, 203210.

MJ Obregon , C Ruiz de Ona , R Calvo , F Escobar del Rey & G Morreale de Escobar (1991) Outer ring iodothyronine deiodinases and thyroid hormone economy: responses to iodine deficiency in the rat fetus. Endocrinology 129, 26632673.

A Perez-Castillo , J Bernal , B Ferreiro & T Pans (1985) The early ontogenesis of thyroid hormone receptor in the rat foetus. Endocrinology 117, 24572461.

K Richard , R Hume , E Kaptein , JP Sanders , H VanToor , WW Deherder , JC DenHollander , EP Krenning & TJ Visser (1998) Ontogeny of iodothyronine deiodinases in human liver. Journal of Clinical Energy and Metabolism 83, 28682874.

D Salvatore , SC Low , M Berry , AL Maia , JW Harney , W Croteau , DL St Germain & PR Larsen (1995) Type 3 iodothyronine deiodinase: Cloning, in vitro expression, and functional analysis of the placental selenoenzyme. Journal of Clinical Investigation 96, 24212430.

D Salvatore , H Tu , JW Harney & PR Larsen (1996) Type 2 iodothyronine deiodinase is highly expressed in human thyroid. Journal of Clinical Investigation 98, 962968.

A Selrrano-Lozano , M Montiel , M Morell & P Morata (1993) 5′ Deiodinase activity in brain regions of adult rats – Modifications in different situations of experimental hypothyroidism. Brain Research Bulletin 30, 611616.

DL St Germain & VA Galton (1997) The deiodinase family of selenoproteins. Thyroid 7, 655668.

RA Sunde (1990) Molecular biology of selenoproteins. Annual Review of Nutrition 10, 451474.

JJ Wichtel , KG Thompson , AL Craigie & NB Williamson (1996) Effects of selenium and iodine supplementation on the growth rate, mohair production, and thyroid status of Angora goat kids. New Zealand Journal of Agricultural Research 39, 111115.

L Wu , L Mcgarry , J Lanfear & PR Harrison (1995) Altered selenium-binding protein levels associated with selenium resistance. Carcinogenesis 16, 28192824.

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