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The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health

  • Elisa Tripoli (a1), Marco Giammanco (a1), Garden Tabacchi (a1), Danila Di Majo (a1), Santo Giammanco (a1) and Maurizio La Guardia (a1)...
Abstract
Abstract

The Mediterranean diet is rich in vegetables, cereals, fruit, fish, milk, wine and olive oil and has salutary biological functions. Epidemiological studies have shown a lower incidence of atherosclerosis, cardiovascular diseases and certain kinds of cancer in the Mediterranean area. Olive oil is the main source of fat, and the Mediterranean diet's healthy effects can in particular be attributed not only to the high relationship between unsaturated and saturated fatty acids in olive oil but also to the antioxidant property of its phenolic compounds. The main phenolic compounds, hydroxytyrosol and oleuropein, which give extra-virgin olive oil its bitter, pungent taste, have powerful antioxidant activity both in vivo and in vitro. The present review focuses on recent works analysing the relationship between the structure of olive oil polyphenolic compounds and their antioxidant activity. These compounds' possible beneficial effects are due to their antioxidant activity, which is related to the development of atherosclerosis and cancer, and to anti-inflammatory and antimicrobial activity.

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Corresponding author
*Corresponding author: Professor M. Giammanco, fax +39 091 6236407, email giammanco@unipa.it
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H Adlercreutz , C Bannwart , K Wähälä , T Makela , G Brunow , T Hase , PJ Arosemena , JT Kellis Jr & LE Vickery (1993) Inhibition of human aromatase by mammalian lignans and isoflavoid phytooestrogens. Journal of Steroid Biochemistry and Molecular Biology 44, 147153.

H Adlercreutz , Y Mousavi , J Clark , K Hockerstedt , E Hamalainen , K Wähälä , T Makela & T Hase (1992) Dietary phytoestrogens and cancer: in vitro and in vivo studies. Journal of Steroid Biochemistry and Molecular Biology 41, 331337.

R Aeschbach , J Loliger , BC Scott , A Murcia , J Butler , B Halliwell & OI Aurome . (1994) Antioxidant actions of tymol, carvacrol, 6-gingerolo, zingerone and hydroxytyrosol. Food and Chemical Toxicology 32, 3136.

C Alarcon de la Lastra , MD Barranco , V Motilova & JM Herrerias (2001) Mediterranean diet and health: biological importance of olive oil. Current Pharmaceutical Design 7, 933950.

MJ Amiot , A Fleuriet & JJ Macheix (1986) Importance and evolution of phenolic compounds in olive during growth and maturation. Journal of Agricultural and Food Chemistry 34, 823826.

MJ Amiot , A Fleuriet & JJ Macheix (1989) Accumulation of oleuropein derivatives during olive maturation. Phytochemistry 28, 6769.

F Angerosa , N D'Alessandro , P Konstantinou & L Di Giacinto (1995) GC–MS evaluation of phenolic compounds in virgin olive oil. Journal of Agricultural and Food Chemistry 43, 18021807.

OI Aruoma (1994) Nutrition and health aspects of free radicals and antioxidants. Food and Chemical Toxicology 32, 671683.

OI Aruoma , M Deiana , A Jenner , B Halliwell , K Harparkash , S Banni , FF Corongiu , MA Dessì & R Aeschbach (1998) Effect of hydroxytyrosol found in extra virgin olive oil on DNA damage and on low-density lipoprotein oxidation. Journal of Agricultural and Food Chemistry 46, 51815187.

C Bai , X Yan , M Takenake , K Sekiya & T Nagata (1998) Determination of synthetic hydroxytyrosol in rat plasma by GC-MS. Journal of Agricultural and Food Chemistry 46, 39984001.

F Benkhalti , J Prost , E Paz , F Perez-Jimenez , C El Modafar & E El Boustani (2002) Effects of feeding virgin olive oil or their polyphenols on lipid of rat liver. Nutrition Research 22, 10671075.

A Bianco , R Lo Scalzo & ML Scarpati (1993) Isolation of cornoside from Olea europaea and its transformation into halleridone. Phytochemistry 32, 455457.

A Bianco & N Uccella (2000) Biophenolic components of olives. Food Research International 33, 475485.

AD Bianco , RA Mazzei , C Melchioni , G Romeo , ML Scarpati & N Uccella (1998 a) Microcomponents of olive oil. Part 2: digalactosyldiacylglycerols from Olea europaea. Food Chemistry 62, 343346.

AD Bianco , RA Mazzei , C Melchioni , G Romeo , ML Scarpati & N Uccella (1998 b) Microcomponents of olive oil-3. Glucosides of 2 (3, 4-dihydroxy-phenyl)ethanol. Food Chemistry 63, 461464.

G Bisignano , A Tomaino , R Lo Cascio , G Crisafi , N Uccella & A Saija (1999) On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. Journal of Pharmacy and Pharmacology 51, 971974.

A Bonanome , A Pagnan , S Biffanti , A Opportuno , F Sorgato , M Dorella , M Maiorino & F Ursini (1992) Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. Arteriosclerosis and Thrombosis 12, 529533.

LC Bourne , CA Rice-Evans (1998) Urinary detection of hydroxycinnamates and flavonoids in humans after high dietary intake of fruit. Free Radical Research 28, 429438.

M Brenes , A Garcia , P Garcia , JJ Rios & A Garrido (1999) Phenolic compounds in Spanish olive oils. Journal of Agricultural and Food Chemistry 47, 35353540.

MS Brown & JL Goldstein (1983) Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annual Review of Biochemistry 52, 223.

G Cao , E Sofic & RL Prior (1997) Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radical Biology and Medicine 22, 749760.

R Capasso , G Cristinzio , A Evidente & F Scognamiglio (1992) Isolation, spectroscopy and selective phytotoxic effects of polyphenols from vegetable waste waters. Phytochemistry 31, 41254128.

R Capasso , A Evidente , S Avolio & F Solla (1999) A highly convenient synthesis of hydroxytyrosol and its recovery from agricultural waste waters. Journal of Agricultural and Food Chemistry 47, 17451748.

R Capasso , A Evidente , L Schivo , G Orru , MA Marcialis & G Cristinzio (1995) Antibacterial polyphenols from olive oil mill waste waters. Journal of Applied Bacteriology 79, 393398.

D Caruso , R Colombo , R Patelli , F Giavarini & G Galli (2000) Rapid evaluation of phenolic component profile and analysis of oleuropein aglycon in olive oil by atmospheric pressure chemical ionization-mass spectrometry (APCI-MS). Journal of Agricultural and Food Chemistry 48, 11821185.

D Caruso , F Visioli , R Patelli , C Galli & G Galli (2001) Urinary excretion of olive oil phenols and their metabolites in humans. Metabolism Clinical and Experimental 50, 14261428.

J Chen , P Blanc , CA Stoddart , M Bogan , EJ Rozhon , N Parkinson , Z Ye , R Cooper , M Balick , W Nanakorn , MR Kernan , JL Chen & ZJ Ye (1998) New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus. Journal of Natural Products 61, 12951297.

L Cinquanta , M Esti & E La Notte (1997) Evolution of phenolic compounds in virgin olive oil during storage. Journal of the American Oil Chemists Society 74, 12591264.

GA Colditz (1993) Epidemiology of breast cancer. Findings from the Nurses' Health Study. Cancer 71, 14801489.

L Cominacini , U Garbin , B Cenci & A Davoli (1991) Predisposition to LDL oxidation during copper-catalyzed oxidative modification and its relation to α-tocopherol content in humans. Clinica Chimica Acta 204, 5768.

BD Davin , DL Bedgar , T Katayama & NG Lewis (1992) On the stereoselective synthesis of (+)-pinoresinol in Forsythia suspensa from its achiral precursor, coniferyl alcohol. Phytochemistry 31, 38693874.

M Deiana , OI Aruoma , MDLP Bianchi , JPE Spencer , H Kaur , B Halliwell , R Aeschbach , S Banni , MA Dessi & FP Corongiu (1999) Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol. Free Radical Biology and Medicine 26, 762769.

R De la Puerta , V Ruiz Gutierrez , J Robin &S Hoult (1999) Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. Biochemical Pharmacology 57, 445449.

T de Rojas-Walker , S Tamir , H Ji , J Wishnock & SR Tennanbaum (1995) Nitric oxide induces oxidative damage in addition to deamination in macrophages DNA. Chemical Research in Toxicology 8, 473477.

H Esterbauer , J Gebicki , H Puhl & G Jurgens (1992) The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radical Biology and Medicine 13, 341.

M Esti , L Cinquanta , EI Notte & E La Notte (1998) Phenolic compounds in different olive varieties. Journal of Agricultural and Food Chemistry 46, 3235.

E Finotti & D Di Majo (2003) Influence of solvents on the antioxidant property of flavonoids. Nahrung/Food 47, 186187.

A Garrido Fernández , MJ Fernández Díez & MR Adams (1997) Table Olives: Production and Processing, pp 67109. London: Chapman & Hall.

F Gutierrez , B Jimenez , A Ruiz & MA Albi (1999) Effect of olive ripeness on the oxidative stability of virgin olive oil extracted from the varieties picual and hojiblanca and on the different components involved. Journal of Agricultural and Food Chemistry 47, 121127.

B Halliwell (1997) Antioxidants and human disease: a general introduction. Nutrition Reviews 55, 4452.

B Halliwell , R Aeschbach , J Loliger & OI Aruoma (1995) The characterization of antioxidants. Food and Chemical Toxicology 33, 601617.

B Halliwell & MC Gutterige (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods in Enzymology 186, 185.

SE Hankinson , WC Willett , JE Manson , DJ Hunter , GA Colditz , MJ Stampfer , C Longcope & FE Speizer (1995) Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women. Journal of the National Cancer Institute 87, 12971302.

MLG Hertog , EJM Feskens , MB Katan & D Kromhout (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007.

T Hirano , F Fukuoka , K Oka , T Naito , K Hosaka , H Mitsuhashi & Y Matsumoto (1990) Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR–75–1. Cancer Investigation 8, 592602.

I Jialal , CJ Fuller & BA Huet (1995) The effect of α-tocopherol supplementation on LDL oxidation. A dose-response study. Arteriosclerosis, Thrombosis, and Vascular Biology 15, 190198.

B Juven , Y Henis & B Jacoby (1972) Studies on the mechanism of the antimicrobial action of oleuropein. Journal of Applied Bacteriology 35, 559567.

S Kane , M Seatter & G Gould (1997) Functional studies of human Glut5: effect of pH on substrate selection and an analysis of substrate interactions. Biochemical and Biophysical Research Communications 238, 503505.

LB Kardono , S Tsauri , JM Pezzuto & AD Kinghorn (1990) Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia. Journal of Natural Products 53, 14471455.

MJ Kato , A Chu , LB Davin & NG Lewis (1998) Biosynthesis of antioxidant lignans in Sesamum indicum seeds. Phytochemistry 47, 583591.

T Keceli & MH Gordon (2001) The antioxidant activity and stability of the phenolic fraction of green olives and extra virgin olive oil. Journal of the Science of Food and Agriculture 81, 13911396.

MR Kernan , A Amarquaye , J Chen , J Chan , DF Sesin , N Parkinson , Z Ye , M Barrett , C Bales , CA Stoddart , B Sloan , P Blanc , C Limbach , S Mrisho , EJ Rozhon , JL Chen & ZJ Ye (1998) Antiviral phenylpropanoid glycosides from the medicinal plant Markhamia lutea. Journal of Natural Products 61, 564570.

N Kohyama , T Nagata , S Fujimoto & K Sekiya (1997) Inhibition of arachidonate lipoxygenase activities by 2- (3, 4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Bioscience, Biotechnology, and Biochemistry 61, 347350.

JA Laranjinha , LM Almeida & VM Madeira (1994) Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation. Biochemical Pharmacology 48, 487494.

R Leenen , AJ Roodenburg , MN Vissers , JA Schuurbiers , KP van Putte , SA Wiseman & FH van de Put (2002) Supplementation of plasma with olive oil phenols and extracts: influence on LDL oxidation. Journal of Agricultural and Food Chemistry 50, 12901297.

R Limiroli , R Consonni , A Ranalli , G Bianchi & L Zetta (1996) 1H NMR study of phenolics in the vegetation water of three cultivars of Olea europaea: similarities and differences. Journal of Agricultural and Food Chemistry 44, 20402048.

L Lipworth , ME Martinez , J Angell , CC Hsien & D Trichopoulos (1997) Olive oil and human cancer an assessment of evidence. Preventive Medicine 26, 181190.

R Lo Scalzo , ML Scarpati & RI Scalzo (1993) A new secoiridoid from olive wastewaters. Journal of Natural Products 56, 621623.

C Manna , P Galletti , V Cucciolla , GF Montedoro & V Zappia (1999) Olive oil hydroxytirosol protects human erythrocytes against oxidative damages. Journal of Nutritional Biochemistry 10, 159165.

C Manna , P Galletti , G Misto , V Cucciolla , S D'Angelo & V Zappia (2000) Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells. FEBS Letters 470, 341344.

R Masella , A Cantafora , D Modesti , A Cardilli , L Gennnaro , A Bocca & E Coni (1999) Antioxidant activity of 3, 4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. Redox Report 4, 113121.

E Miró Casas , MI Covas , M Farre , M Fito , J Ortuno , T Weinbrenner , P Roset & R de la Torre (2003) Hydroxytyrosol disposition in humans. Clinical Chemistry 49, 945952.

O Mirochnitchenko , O Prokopenko , U Palnitkar , I Kister , WS Powell & M Inouye (2000) Endotoxemia in transgenic mice overexpressing human glutathione peroxidases. Circulation Research 87, 289295.

GF Montedoro (1972) I costituenti fenolici presenti negli oli vergini di oliva. Nota 1: identificazione di alcuni acidi fenolici e loro potere antiossidante (Phenolic constituents present in virgin olive oils. Part 1: identification of some phenolic acids and their antioxidant ability). STA 3, 177186.

G Montedoro , M Servili , M Baldioli & E Miniati (1992) Simple and hydrolyzable phenolic compounds in virgin olive oil. 1. Their extraction, separation, and quantitative and semiquantitative evaluation by HPLC. Journal of Agricultural and Food Chemistry 40, 15711576.

E Monteleone , G Caporale , A Carlucci & E Pagliarini (1998) Optimisation of extra virgin olive oil quality. Journal of the Science of Food and Agriculture 77, 3137.

JJ Moreno & MT Mitjavilab (2003) The degree of unsaturation of dietary fatty acids and the development of atherosclerosis (Review). Journal of Nutritional Biochemistry 14, 182195.

L Mosca , C De Marco , F Visioli , C Cannella (2000) Enzymatic assay for the determination of olive oil polyphenol content: assay conditions and validation of the method. Journal of Agricultural and Food Chemistry 48, 297301.

Y Mousavi & H Adlercreutz (1992) Enterolactone and estradiol inhibit each others proliferative effect on MCF-7 breast cancer cells in culture. Journal of Steroid Biochemistry and Molecular Biology 41, 615619.

N Mulinacci , A Romani , C Galardi , P Pinelli , C Giaccherini & FF Vincieri (2001) Polyphenolic content in olive oil waste waters and related olive samples. Journal of Agricultural and Food Chemistry 49, 35093514.

M Nardini , M D'aquino , G Tomassi , V Gentili , M Di Felice & C Scaccini (1995) Inhibition of human low-density lipoprotein oxidation by caffeic acid and other idroxycinnamic acid derivatives. Free Radical Biology and Medicine 19, 541552.

M Nomoto , K Yamada , M Haga & M Hayashi (1998) Improvement of intestinal absorption of peptide drugs by glycosylation: transport of tetrapeptide by the sodium ion-dependent D-glucose transporter. Journal of Pharmaceutical Sciences 87, 326332.

RW Owen , A Giacosa , WE Hull , R Haubner , B Spiegelhalder & H Bartsch (2000 a) The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. European Journal of Cancer 36, 12351247.

RW Owen , A Giacosa , WE Hull , R Haubner , G Wurtele , B Spiegelhalder & H Bartsch (2000 b) Olive-oil consumption and health: the possible role of antioxidants. Lancet Oncology 1, 107112.

G Papadopoulos & D Boskou (1991) Antioxidant effect of natural phenols on olive oil. Journal of the American Oil Chemists Society 68, 669671.

F Pardo , F Perich , L Villarroel & R Torres (1993) Isolation of verbascoside, an antimicrobial constituent of Buddleja globosa leaves. Journal of Ethnopharmacology 39, 221222.

S Parthasarathy (1991) Novel atherogenic oxidative modification of low density lipoprotein. Diabetes/Metabolism Reviews 7, 163.

A Petroni , M Blasevich , M Salami , N Papini , GF Montedoro & C Galli (1995) Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thrombosis Research 78, 151160.

JM Pezzuto (1997) Plant-derived anticancer agents. Biochemical Pharmacology 53, 121133.

K Prasad (1997) Hydroxyl radical-scavenging property of secoisolar-iciresinol diglucoside (SDG) isolated from flax-seed. Molecular and Cellular Biochemistry 168, 117123.

HMG Princen , G van Poppel , C Vogelazang , R Buytenhek , FJ Kok (1992) Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Arteriosclerosis and Thrombosis 12, 554.

A Ranalli , G De Mattia , ML Ferrante (1997) Comparative evaluation of the olive oil given by a new processing system. International Journal of Food Science and Technology 32, 289297.

A Ranalli , G De Mattia & ML Ferrante (1998) The characteristics of percolation olive oils produced with a new processing enzyme aid. International Journal of Food Science and Technology 33, 247258.

A Ranalli , ML Ferrante , G De Mattia & N Costantini (1999) Analytical evaluation of virgin olive oil of first and second extraction. Journal of Agricultural and Food Chemistry 47, 417424.

PD Reaven , A Khouw , WF Beltz , S Parthasarathy & J Witztum (1993) Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by β-carotene. Arteriosclerosis and Thrombosis 13, 590.

CA Rice-Evans , NJ Miller & G Paganga (1996) Structure-antioxidant activity relationship of flavonoids and phenolic acids. Free Radical Biology and Medicine 20, 933956.

TT Rohn , TR Hinds & FF Vincenzi (1993) Ion transport ATPases as targets for free radical damage. Protection by an aminosteroid of the Ca21 pump ATPase and Na1/K1 pump ATPase of human red blood cell membranes. Biochemical Pharmacology 46, 525534.

D Ryan , H Lawrence , PD Prenzler & M Antolovic (2001) Recovery of phenolic compounds from Olea europeae. Analytica Chimica Acta 445, 6777.

M Salami , C Galli , L De Angelis & F Visioli (1995) Formation of F2-isoprostanes in oxidized low density lipoprotein. Inhibitory effects of hydroxytyrosol. Pharmacological Research 31, 275279.

DV Schapira , NB Kumar & GH Lyman (1991) Obesity, body fat distribution, and sex hormones in breast cancer patients. Cancer 67, 22152218.

M Serraino & LU Thompson (1991) The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Letters 60, 135142.

M Serraino & LU Thompson (1992) The effect of flaxseed consumption on the initiation and promotional stages of mammary carcinogenesis. Nutrition and Cancer 17, 153159.

M Servili , M Baldioli , R Selvaggini , A Macchioni & GF Montedoro (1999 a) Phenolic compounds of olive fruit: one- and two-dimensional nuclear magnetic resonance characterization of nüzhenide and its distribution in the constitutive parts of fruit. Journal of Agricultural and Food Chemistry 47, 1218.

M Servili , M Baldioli , R Selvaggini , E Miniati , A Macchioni & GF Montedoro (1999 b) HPLC evaluation of phenols in olive fruit, virgin olive oil, vegetation waters and pomace and 1D and 2D-NMR characterization. Journal of the American Oil Chemists Society 76, 873882.

C Soler-Rivas , JC Espin , HJ Wichers (2000) Oleuropein and related compounds. Journal of the Science of Food and Agriculture 80, 10131023.

E Speroni , MC Guerra , A Minghetti , N Crespi-Perellino P Pasini F Piazza A Roda (1998) Oleuropein evaluated in vitro and in vivo as an antioxidant. Phytotherapy Research 12, 98100.

G Stretch , R Nation , A Evans & R Milne (1999) Organ perfusion techniques in drug development. Drug Development Research 46, 292301.

K Takata (1995) Glucose transporters in the transepithelial transport of glucose. Journal of Electron Microscopy 45, 275284.

T Tanaka , H Makita , T Kawamori , K Kawabata , H Mori , A Murakami , K Satoh , A Hara , H Ohigashi & K Koshimizu (1997) A xanthine oxidase inhibitor 10 acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Carcinogenesis 18, 11131118.

CC Tassou & GJE Nychas (1995) Inhibition of Salmonella enteritidis by oleuropein in broth and in a model food system. Letters in Applied Microbiology 20, 120124.

LU Thompson , MM Seidl , SE Rickard , LJ Orcheson & HH Fong (1996) Antitumorigenic effect of a mammalian lignan precursor from flaxseed. Nutrition and Cancer 26, 159165.

HS Tranter , SC Tassou & GJ Nychas (1993) The effect of the olive phenolic compound, oleuropein, on growth and enterotoxin B production by Staphylococcus aureus. Journal of Applied Bacteriology 74, 253259.

A Trichopoulou (1995) Olive oil and breast cancer. Cancer Causes Control 6, 475476.

M Tsimidou , M Lytridou , D Boskou , A Paooa-Lousi , F Kotsifaki & C Petrakis (1996) On the determination of minor phenolic acids of virgin olive oil by RP-HPLC. Grasas y Aceites en la Nutrición Humana 47, 151157.

H Tsukamoto , S Hisada & S Nishibe (1984) Lignans from bark of the Olea plants, 1. Chemical and Pharmaceutical Bulletin 32, 27302735.

H Tsukamoto , S Hisada & S Nishibe (1985) Lignans from bark of the Olea plants, 2. Chemical and Pharmaceutical Bulletin 33, 12321241.

KL Tuck & PJ Hayball (2002) Major phenolic compounds in olive oil: metabolism and health effects. Journal of Nutritional Biochemistry 13, 636644.

BR van Dyke & P Saltman (1996) Hemoglobin: a mechanism for the generation of hydroxyl radicals. Free Radical Biology and Medicine 20, 985989.

P Venkatasubbaiah & WS Chilton (1990) Phytotoxins of Botryosphaeria obtusa. Journal of Natural Products 53, 16281630.

O Vieira , J Laranjinha , V Madeira & L Almeida (1998) Cholesteryl ester hydroperoxide formation in myoglobin-catalyzed low density lipoprotein oxidation: concerted antioxidant activity of caffeic and p-coumaric acids with ascorbate. Biochemical Pharmacology 55, 333340.

F Visioli (2000) Antioxidants in Mediterranean diets. World Review of Nutrition and Dietetics 87, 4355.

F Visioli , G Bellomo , GF Montedoro & C Galli (1995 a) Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents. Atherosclerosis 117, 2532.

F Visioli , GF Bellomo & C Galli (1998) Free radical scavenging properties of olive oil polyphenols. Biochemical and Biophysical Research Communications 247, 6064.

F Visioli , R Bordone , C Perugini , M Bagnati , C Cau & G Bellomo (2000 a) The kinetics of copper-induced LDL oxidation depend upon its lipid composition and antioxidant content. Biochemical and Biophysical Research Communications 268, 818822.

F Visioli , L Borsani & C Galli (2000 b) Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovascular Research 47, 419425.

F Visioli & C Galli (1998 a) Olive oil phenols and their potential effects on human health. Journal of Agricultural and Food Chemistry 46, 42924296.

F Visioli & C Galli (1998 b) The effect of minor constituents of olive oil on cardiovascular disease: new findings. Nutrition Reviews 56, 142147.

F Visioli & C Galli (2001) Antiatherogenic components of olive/olive oil. Current Atherosclerosis Reports 3, 6467.

F Visioli , C Galli , F Bornet , A Mattei , R Patelli , G Galli & D Caruso (2000 c) Olive oil phenolics are dose-dependently absorbed in humans. FEBS Letters 468, 159160.

F Visioli , A Poli & C Galli (2002) Antioxidant and other biological activities of phenols from olives and olive oil. Medicinal Research Reviews 22, 6575.

C Wang , T Mäkelä , T Hase , H Adlercreutz & MS Kurzer (1994) Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. Journal of Steroid Biochemistry and Molecular Biology 50, 205212.

SA Wiseman , JNNJ Mathot , NJ De Fouw & LBM Tijburg (1996) Dietary non-tocopherol antioxidants present in extra virgin olive oil increase the resistance of low density lipoproteins to oxidation in rabbits. Atherosclerosis 120, 1523.

N Yamanaka , O Oda & S Nagao (1997) Green tea catechins such as (-)-epicatechin and (-)-epigallocatechin accelerate Cu2+ -induced low-density lipoprotein oxidation in propagation phase. FEBS Letters 401, 230234.

V Yermilov , J Rubio & H Ohshima (1995) Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination. FEBS Letters 376, 207210.

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