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Physiological changes in the gastrointestinal tract and host protective immunity: learning from the mouse-Trichinella spiralis model

Published online by Cambridge University Press:  23 May 2008

W. I. Khan
W. I. Khan*
Affiliation:
Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
*
*Corresponding author: Department of Medicine, Room 3N5D, Health Science Center, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. E-mail: khanwal@mcmaster.ca
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Summary

Infection and inflammation in the gastrointestinal (GI) tract induces a number of changes in the GI physiology of the host. Experimental infections with parasites represent valuable models to study the structural and physiological changes in the GI tract. This review addresses research on the interface between the immune system and GI physiology, dealing specifically with 2 major components of intestinal physiology, namely mucin production and muscle function in relation to host defence, primarily based on studies using the mouse-Trichinella spiralis system. These studies demonstrate that the infection-induced T helper 2 type immune response is critical in generating the alterations of infection-induced mucin production and muscle function, and that this immune-mediated alteration in gut physiology is associated with host defence mechanisms. In addition, by manipulating the host immune response, it is possible to modulate the accompanying physiological changes, which may have clinical relevance. In addition to enhancing our understanding of immunological control of GI physiological changes in the context of host defence against enteric infections, the data acquired using the mouse-T. spiralis model provide a basis for understanding the pathophysiology of a wide range of GI disorders associated with altered gut physiology.

Keywords

Trichinella spiralisimmunophysiologyinfectionimmunitymucinmuscle
Type
Review Article
Information
Parasitology , Volume 135 , Issue 6 , May 2008 , pp. 671 - 682
Copyright
Copyright © 2008 Cambridge University Press

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