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Toxoplasma gondii seropositivity and cognitive functions in school-aged children

Published online by Cambridge University Press:  20 May 2015

A. MENDY ,
E. R. VIEIRA ,
A. N. ALBATINEH  and
J. GASANA
A. MENDY*
Affiliation:
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA
E. R. VIEIRA
Affiliation:
Department of Physical Therapy, Florida International University, Miami, Florida, USA
A. N. ALBATINEH
Affiliation:
Department of Biostatistics, Florida International University, Miami, Florida, USA
J. GASANA
Affiliation:
Department of Occupational and Environmental Health, Florida International University, Miami, FL/South Florida Asthma Consortium, Ft. Lauderdale, Florida, USA
*
* Corresponding author. The University of Iowa, College of Public Health, S161 CPHB 105 River Street, Iowa City, Iowa 52242, USA. E-mail: angelico-mendy@uiowa.edu
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Summary

Toxoplasma gondii (T. gondii) infects one-third of the world population, but its association with cognitive functions in school-aged children is unclear. We examined the relationship between Toxoplasma seropositivity and neuropsychological tests scores (including math, reading, visuospatial reasoning and verbal memory) in 1755 school-aged children 12–16 years old who participated to the Third National Health and Nutrition Examination Survey, using multiple linear regressions adjusted for covariates. Toxoplasma seroprevalence was 7·7% and seropositivity to the parasite was associated with lower reading skills (regression coefficient [β] = −5·86, 95% confidence interval [CI]: −11·11, −0·61, P = 0·029) and memory capacities (β = −0·86, 95% CI: −1·58, −0·15, P = 0·017). The interaction between T. gondii seropositivity and vitamin E significantly correlated with memory scores. In subgroup analysis, Toxoplasma-associated memory impairment was worse in children with lower serum vitamin E concentrations (β = −1·61, 95% CI: −2·44, −0·77, P < 0·001) than in those with higher values (β = −0·12, 95% CI: −1·23, 0·99, P = 0·83). In conclusion, Toxoplasma seropositivity may be associated with reading and memory impairments in school-aged children. Serum vitamin E seems to modify the relationship between the parasitic infection and memory deficiency.

Keywords

Toxoplasma gondiiinfectionparasitescognitioncognitive functionintelligencememoryreadingmathschool-aged childrenvitaminsVitamin E

Information

Type
Research Article
Information
Parasitology , Volume 142 , Issue 9 , August 2015 , pp. 1221 - 1227
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Copyright © Cambridge University Press 2015 

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