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Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review

Published online by Cambridge University Press:  07 December 2009

N. MEJRI ,
A. HEMPHILL  and
B. GOTTSTEIN
N. MEJRI
Affiliation:
Institute of Parasitology, University of Bern, Laenggass-Strasse 122, CH-3001Bern, Switzerland
A. HEMPHILL
Affiliation:
Institute of Parasitology, University of Bern, Laenggass-Strasse 122, CH-3001Bern, Switzerland
B. GOTTSTEIN*
Affiliation:
Institute of Parasitology, University of Bern, Laenggass-Strasse 122, CH-3001Bern, Switzerland
*
*Corresponding author: Institute of Parasitology, University of Bern, Laenggass-Strasse 122, CH-3001, Bern, Switzerland. Tel: +41 31 631 24 18. Fax: +41 31 631 24 77. E-mail: bruno.gottstein@ipa.unibe.ch
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Summary

As more facts emerge regarding the ways in which E. multilocularis-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cells of both the innate and adaptive arms of the immune response, E. multilocularis can orchestrate a range of outcomes that are beneficial not only to the parasite, in terms of facilitating its intrahepatic proliferation and maturation, and thus life cycle over all, but also to its intermediate host, in limiting pathology. The present review deals with the role of metacestode surface molecules as well as excretory/secretory (E/S) metabolic products of the parasite in the modulation of the host responses such as to optimize its own survival.

Keywords

Echinococcus multilocularisalveolar echinococcosisimmunologymetabolitesimmune modulation
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 3: Development and applications of cestode and trematode laboratory models , March 2010 , pp. 557 - 568
Copyright
Copyright © Cambridge University Press 2009

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