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Acquired immunity to Trichuris muris in the albino laboratory mouse

  • D. Wakelin (a1)
  • DOI:
  • Published online: 01 April 2009

After infection with the nematode Trichuris muris 70–75% of mice of the Schofield strain developed an immunity to the parasite and eliminated the worms between the 16th and 19th days after infection. In these mice the acquired immunity persisted for at least 3 months and prevented the establishment of subsequent infections.

In 25–30% of the mice immunity was not produced and infections developed into mature worms. These non-resistant mice remained susceptible to further infection.

The development and action of the immune response were suppressed completely by the administration of cortisone acetate.

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W. C. Campbell (1963). Spontaneous cure in Trichuris muris infections in albino mice and its suppression by cortisone. J. Parasit. 49, 628–32.

W. C. Campbell & J. V. Collette (1962). Effect of cortisone upon infection with Trichuris muris in albino mice. J. Parasit. 48, 933–4.

J. E. D. Keeling (1961). Experimental trichuriasis. I. Antagonism between Trichuris muris and Aspiculuris tetraptera in the albino mouse. J. Parasit. 47, 641–6.

J. E. Larsh (1963). Experimental trichiniasis. Adv. Parasit. 1, 213–86.

D. E. Worley , J. E. Meisenhelder , H. G. Sheffield & P. E. Thompson (1962). Experimental studies on Trichuris muris in mice with an appraisal of its use for evaluating anthelmintics. J. Parasit. 48, 433–7.

P. Whur (1966). Relationship of globule leucocytes to gastrointestinal nematodes in the sheep, and Nippostrongylus brasiliensis and Hymenolepis nana infections in rats. J. comp. Path. Ther. 76, 5765.

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