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Adults acquire filarial infection more rapidly than children: a study in Indonesian transmigrants

Published online by Cambridge University Press:  12 July 2001

A. J. TERHELL ,
M. HAARBRINK ,
K. ABADI ,
SYAFRUDDIN ,
R. M. MAIZELS ,
M. YAZDANBAKHSH  and
E. SARTONO
A. J. TERHELL
Affiliation:
Department of Parasitology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands
M. HAARBRINK
Affiliation:
Department of Parasitology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands
K. ABADI
Affiliation:
Department of Parasitology, Hasanuddin University, Kampus Tamalanrea, Jl. Perintis Kemerdekaan, Ujung Pandang, Sulawesi, Indonesia
SYAFRUDDIN
Affiliation:
Department of Parasitology, Hasanuddin University, Kampus Tamalanrea, Jl. Perintis Kemerdekaan, Ujung Pandang, Sulawesi, Indonesia
R. M. MAIZELS
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
M. YAZDANBAKHSH
Affiliation:
Department of Parasitology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands
E. SARTONO
Affiliation:
Department of Parasitology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands
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Abstract

To dissociate the influence of host age from length of exposure on acquisition of filarial infection, we examined the development of microfilaraemia and anti-filarial IgG4 in all ages of a naive population that became suddenly exposed to Brugia malayi as a result of transmigration. Responses in 247 transmigrants, who had settled for periods of several months up to 6 years in their new homesteads, were compared with those of 133 life-long residents. As shown in earlier studies, anti-filarial IgG4 increased with age in the indigenous population, whose age is equivalent to length of exposure. However, by examining transmigrants, it became clear that development of specific IgG4 was influenced by age, since levels of this antibody were consistently higher in transmigrant adults than in transmigrant children, despite an equal length of exposure to filarial infection. Examining microfilaraemia, it was confirmed that infection establishes more rapidly in adults than in children.

Keywords

lymphatic filariasisIgG4ageexposuretransmigrants
Type
Research Article
Information
Parasitology , Volume 122 , Issue 6 , June 2001 , pp. 633 - 640
Copyright
© 2001 Cambridge University Press

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