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Coevolution of hosts and parasites

  • R. M. Anderson (a1) and R. M. May (a2)


The coevolution of parasites and their hosts has both general biological interest and practical implications in agricultural, veterinary and medical fields. Surprisingly, most medical, parasitological and ecological texts dismiss the subject with unsupported statements to the effect that ‘successful’ parasite species evolve to be harmless to their hosts. Recently, however, several people have explored theoretical aspects of the population genetics of host-parasite associations; these authors conclude that such associations may be responsible for much of the genetic diversity found within natural populations, from blood group polymorphisms (Haldane, 1949) to protein polymorphisms in general (Clarke, 1975, 1976) and to histocompatibility systems (Duncan, Wakeland & Klein, 1980). It has also been argued that pathogens may constitute the selective force responsible for the evolution and maintenance of sexual reproduction in animal and plant species (Jaenike, 1978; Hamilton, 1980, 1981, 1982; Bremermann, 1980).



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Anderson, R. M. & May, R. M. (1979). Population biology of infectious diseases: Part I. Nature, London 280, 361–7.
Anderson, R. M. & May, R. M. (1981). The population dynamics of microparasites and their invertebrate hosts. Philosophical Transactions of the Royal Society, B, 291, 451524.
Anderson, R. M. & May, R. M. (1982 a). Frequency and density dependent effects in the coevolution of hosts and parasites (in preparation).
Anderson, R. M. & May, R. M. (1982 b). Directly transmitted infectious diseases: control by vaccination. Science, 215, 10531060.
Anderson, R. M., Jackson, H., May, R. M. & Smith, T. (1981). The population dynamics of fox rabies in Europe. Nature, London 289, 765–71.
Bailey, N. J. T.The Mathematical Theory of Infectious Diseases. New York: Macmillan.
Berry, R. J. (1980). The great mouse festival. Nature, London 283, 15.
Bremermann, H. J. (1980). Sex and polymorphism as strategies in host-pathogen interactions. Journal of Theoretical Biology 87, 671702.
Burnet, M. & White, D. O. (1972). Natural History of Infectious Disease. Cambridge: Cambridge University Press.
Clarke, B. C. (1975). The causes of biological diversity. Scientific American, 233, (2) 5060.
Clarke, B. C. (1976). The ecological genetics of host–parasite relationships. In Genetic Aspects of Host–Parasite Relationships (ed. Taylor, A. E. R. and Muller, R.), pp. 87103. Oxford: Blackwell.
Day, P. R. (1974). Genetics of Host-Parasite Interactions. San Francisco: W. H. Freeman.
Dietz, K. (1975). Transmission and control of arbovirus diseases. In Epidemiology (ed. Ludwig, D. and Cooke, K. L.), pp. 104121. Philadelphia: Society for Industrial and Applied Mathematics.
Dietz, K. (1976). The incidence of infectious diseases under the influence of seasonal fluctuations. In Mathematical Models in Medicine: Lecture Notes in Biomathematics, vol. 11 (ed. Berger, J.Buhler, W.Repges, R. and Tautu, P.), pp. 115. Berlin: Springer Verlag.
Duncan, W. R., Wakeland, E. K. & Klein, J. (1980). Heterozygosity of H-2 loci in wild mice. Nature, London 281, 603–5.
Fenner, F. & Ratcliffe, F. N. (1965). Myxomatosis. Cambridge: Cambridge University Press.
Fenner, F. & Myers, K. (1978). Myxoma virus and myxomatosis in retrospect: the first quarter century of a new disease. In Viruses and Environment, pp. 539570. London: Academic Press.
Gillespie, J. H. (1975). Natural selection for resistance to epidemics. Ecology 56, 493–5.
Greenwood, M., Bradford Hill, A., Topley, W. W. C. & Wilson, J. (1936). Experimental Epidemiology. Special Report Series, No. 209, Medical Research Council. HMSO; London.
Haldane, J. B. S. (1949). Disease and evolution. La Ricerca Scientific Supplement 19, 6876.
Hamilton, W. D. (1980). Sex versus non-sex versus parasite. Oikos 35, 282–90.
Hamilton, W. D. (1981). Sex versus non-sex versus parasite. In The Mathematical Theory of the Dynamics of Biological Populations II (ed. Hiorns, R. W. and Cooke, D.), pp. 139155. London: Academic Press.
Hamilton, W. D. (1982). Pathogens as causes of genetic diversity in their host populations. In Population Biology of Infectious Diseases (ed. Anderson, R. M. and May, R. M.). Berlin: Springer-Verlag.
Hamilton, W. D. & Zuk, M. (1982). Heritable true fitness and bright birds: a role for parasites ? Science (in the Press).
Jaenike, J. (1978). An hypothesis to account for the maintenance of sex within populations. Evolutionary Theory 3, 191–4.
Kemper, J. T. (1982). The evolutionary effect of endemic infectious disease: continuous models for an invariant pathogen. Mathematical Biosciences (in the Press).
Kendall, D. G. (1956). Deterministic and stochastic epidemics in closed populations. Proceedings of the 3rd Berkeley Symposium on Mathematical Statistics and Probability 4, 149–65.
Kermack, W. O. & McKendrick, A. G. (1927). A contribution to the mathematical theory of epidemics. Proceedings of the Royal Society, A 115, 700–21.
Leonard, K. J. (1977). Selection pressures and plant pathogens. Annals of the New York Academy of Science 287, 207–22.
Lewis, J. W. (1981 a). On the coevolution of pathogen and host: I. general theory of discrete time coevolution. Journal of Theoretical Biology 93, 927–51.
Lewis, J. W. (1981 b). On the coevolution of pathogen and host: II. selfing hosts and haploid pathogens. Journal of Theoretical Biology 93, 953–85.
Levin, B. R., Allison, A. C., Bremermann, H. J., Cavalli-Sforza, L. L., Clarke, B. C., Fretzel-Beyme, R., Hamilton, W. D., Levin, S. A., May, R. M.Thieme, H. R. (1982). Evolution of hosts and parasites. In Population Biology of Infectious Disease (ed. Anderson, R. M. and May, R. M.). Berlin: Springer-Verlag.
Levin, S. A. & Pimental, D. (1981). Selection of intermediate rates of increase in parasite-hosts systems. American Naturalist 117, 308–15.
Marmorosch, K. & Shope, R. E. (1975). Invertebrate Immunity. New York: Academic Press.
May, R. M. (1976). Estimating r: a pedagogical note. American Naturalist 110, 496–9.
May, R. M. (1979). Bifurcations and dynamic complexity in ecological systems. Annals of the New York Academy of Science 316, 517–29.
May, R. M. & Anderson, R. M. (1979). Population biology of infectious diseases: II. Nature, London 280, 455–61.
Maynard, Smith J. (1978). The Evolution of Sex. Cambridge: Cambridge University Press.
Maynard, Smith J. & Price, G. R. (1973). The logic of animal conflicts. Nature, London 246, 1518.
Mead-Briggs, A. R. & Vaughan, J. A. (1975). The differential transmissability of myxoma virus strains of differing virulence grades by the rabbit flea Spilopsyllus cuniculi (Dale) Journal of Hygiene 75, 237–47.
Mode, C. J. (1958). A mathematical model for the co-evolution of obligate parasites and their hosts. Evolution 12, 158–65.
Oster, G. F., Ipaktchi, A. & Rocklin, S. (1976). Phenotypic structure and bifurcation behaviour of population models. Theoretical Population Biology 10, 365–82.
Person, C. (1966). Genetic polymorphism in parasite systems. Nature, London 212, 266–7.
Pimentel, D. (1968). Population regulation and genetic feedback. Science, 159, 1432–7.
Ross, J. (1982). Myxomatosis: the natural evolution of the disease. In Animal Disease in Relation to Animal Conservation.Symposium of the Zoological Society of London,26th–27th November, 1981 (in the Press).
Saunders, I. W. (1980). A model for myxomatosis. Mathematical Biosciences 48, 116.
Van der Plank, J. E. (1975). Principles of Plant Infection. New York: Academic Press.
Williams, G. C. (1975). Sex and Evolution. Princeton, New Jersey: Princeton University Press.
Yorke, J. A., Hethcote, H. W. & Nold, A. (1978). Dynamics and control of the transmission of gonorrhea. Journal of Sexually Transmitted Diseases 5, 51–6.
Yorke, J. A., Nathanson, N., Pianigiani, G. & Martin, J. (1979). Seasonality and the requirements for perpetuation and eradication of viruses in populations. American Journal of Epidemiology 109, 103–23.
Yu, P. (1972). Some host-parasite genetic interaction models. Theoretical Population Biology 3, 347–57.

Coevolution of hosts and parasites

  • R. M. Anderson (a1) and R. M. May (a2)


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