Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 39
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Anderson, RM Turner, HC Farrell, SH Yang, Jie and Truscott, JE 2015. What is required in terms of mass drug administration to interrupt the transmission of schistosome parasites in regions of endemic infection?. Parasites & Vectors, Vol. 8, Issue. 1,


    Gurarie, David Yoon, Nara Li, Emily Ndeffo-Mbah, Martial Durham, David Phillips, Anna E. Aurelio, H. Osvaldo Ferro, Josefo Galvani, Alison P. and King, Charles H. 2015. Modelling control of Schistosoma haematobium infection: predictions of the long-term impact of mass drug administration in Africa. Parasites & Vectors, Vol. 8, Issue. 1,


    Medley, Graham F and Hollingsworth, T Deirdre 2015. MDA helminth control: more questions than answers. The Lancet Global Health, Vol. 3, Issue. 10, p. e583.


    Kariuki, Henry C Madsen, Henry Ouma, John H Butterworth, Anthony E Dunne, David W Booth, Mark Kimani, Gachuhi Mwatha, Joseph K Muchiri, Eric and Vennervald, Birgitte J 2013. Long term study on the effect of mollusciciding with niclosamide in stream habitats on the transmission of schistosomiasis mansoni after community-based chemotherapy in Makueni District, Kenya. Parasites & Vectors, Vol. 6, Issue. 1, p. 107.


    Pearson, Richard D. Weller, Peter F. and Guerrant, Richard L. 2011. Tropical Infectious Diseases: Principles, Pathogens and Practice.


    Anderson, Roy M. 2010. Topley & Wilson's Microbiology and Microbial Infections.


    Esmat, Gamal and Raziky, Maissa El 2009. Antischistosomal therapy: Current status and recent developments. Arab Journal of Gastroenterology, Vol. 10, Issue. 1, p. 1.


    Hall, Andrew Hewitt, Gillian Tuffrey, Veronica and de Silva, Nilanthi 2008. A review and meta-analysis of the impact of intestinal worms on child growth and nutrition. Maternal & Child Nutrition, Vol. 4, Issue. s1, p. 118.


    Midzi, N. Sangweme, D. Zinyowera, S. Mapingure, M.P. Brouwer, K.C. Kumar, N. Mutapi, F. Woelk, G. and Mduluza, T. 2008. Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 102, Issue. 8, p. 759.


    Kjetland, Eyrun F. Mduluza, Takafira Ndhlovu, Patricia D. Gomo, Exenevia Gwanzura, Lovemore Midzi, Nicholas Mason, Peter R. Friis, Henrik and Gundersen, Svein Gunnar 2006. Genital schistosomiasis in women: a clinical 12-month in vivo study following treatment with praziquantel. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 100, Issue. 8, p. 740.


    Vennervald, Birgitte J. Booth, Mark Butterworth, Anthony E. Kariuki, H. Curtis Kadzo, Hilda Ireri, Edmund Amaganga, Clifford Kimani, Gachuhi Kenty, LeeCarol Mwatha, Joseph Ouma, John H. and Dunne, David W. 2005. Regression of hepatosplenomegaly in Kenyan school-aged children after praziquantel treatment and three years of greatly reduced exposure to Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 99, Issue. 2, p. 150.


    Miguel, Edward and Kremer, Michael 2004. Worms: Identifying Impacts on Education and Health in the Presence of Treatment Externalities. Econometrica, Vol. 72, Issue. 1, p. 159.


    Doenhoff, M. J. Wheeler, J. G. Tricker, K. Hamilton, J. V. Sturrock, R. F. Butterworth, A. E. Ouma, J. H. Mbugua, G. G. Kariuki, C. and Koech, D. 2003. The detection of antibodies againstSchistosoma mansonisoluble egg antigens (SEA) and CEF6 in ELISA, before and after chemotherapy. Annals of Tropical Medicine & Parasitology, Vol. 97, Issue. 7, p. 697.


    Magnussen, Pascal 2003. Treatment and re-treatment strategies for schistosomiasis control in different epidemiological settings: a review of 10 years’ experiences. Acta Tropica, Vol. 86, Issue. 2-3, p. 243.


    Rabarijaona, L. P. Boisier, P. Ravaoalimalala, V. E. Jeanne, I. Roux, J. F. Jutand, M. A. and Salamon, R. 2003. Lot quality assurance sampling for screening communities hyperendemic for Schistosoma mansoni. Tropical Medicine and International Health, Vol. 8, Issue. 4, p. 322.


    Sow, Seydou Vlas, Sake J. Mbaye, Amadou Polman, Katja and Gryseels, Bruno 2003. Low awareness of intestinal schistosomiasis in northern Senegal after 7 years of health education as part of intense control and research activities. Tropical Medicine and International Health, Vol. 8, Issue. 8, p. 744.


    Doenhoff, Michael J. Kusel, John R. Coles, Gerald C. and Cioli, Donato 2002. Resistance of Schistosoma mansoni to praziquantel: is there a problem?. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 96, Issue. 5, p. 465.


    Bundy, Don Drake, Lesley and Hall, Andrew 2000. Nutritional Anemias.


    Saconato, Humberto Atallah, Álvaro N and Saconato, Humberto 1999. Cochrane Database of Systematic Reviews.


    Fulford, A.J.C. Webster, M. Ouma, J.H. Kimani, G. and Dunne, D.W. 1998. Puberty and Age-related Changes in Susceptibility to Schistosome Infection. Parasitology Today, Vol. 14, Issue. 1, p. 23.


    ×

Comparison of different chemotherapy strategies against Schistosoma mansoni in Machakos District, Kenya: effects on human infection and morbidity

  • A. E. Butterworth (a1), R. F. Sturrock (a2), J. H. Ouma (a3), G. G. Mbugua (a4), A. J. C. Fulford (a1), H. C. Kariuki (a3) and D. Koech (a4)
  • DOI: http://dx.doi.org/10.1017/S0031182000059850
  • Published online: 01 April 2009
Abstract

A comparison was made of the long-term impact of different methods of administration of chemotherapy (oxamniquine, 30 mg/kg in divided doses; or praziquantel, 40 mg/kg) on prevalence and intensity of Schistosoma mansoni infection in four areas in Kangundo Location, Machakos District, Kenya. In Area A, treatment was offered in October 1983 and again in April 1985 to all infected individuals. In Area H, treatment was offered in April 1985 to individuals excreting ≥ 100 eggs per gram (epg) of faeces. In Area H, treatment was offered in April 1985 to all infected school children, within the framework of the primary schools. In the witness area, Area W, treatment was given in April 1985, for ethical reasons, to a small number of individuals excreting ≥ 800 epg. Prevalence and intensities of infection were subsequently monitored at yearly intervals for three complete post-treatment years. In the Area S schools, clinical examination was also carried out at yearly intervals. Treatment of all infected individuals on two occasions (Area A) was the most effective and long-lasting way of reducing prevalence and intensity of infection. In this area, however, some earlier interventions had been carried out and pre-treatment intensities were lower than in the other areas. Treatment only of infected schoolchildren (Area S) also had a marked and prolonged effect, comparable to or better than treatment of individuals with heavy infections (Area H). Treatment of infected schoolchildren also caused a persistent reduction in the prevalence of hepatomegaly, and there was suggestive evidence from intensities of infection in community stool surveys (but not from incidence rates) of an effect on transmission. In all study areas, reinfection was most rapid and most intense among children. These findings are discussed in the light of theoretical considerations and of results from other studies, both on schistosomiasis and on intestinal helminths. We conclude that, in areas of low morbidity such as Kangundo, chemotherapy of schoolchildren only, at intervals of up to 3 years, is a satisfactory way of producing a long-term reduction in both intensity of infection and morbidity.

Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

R. M. Anderson & R. M. May (1982). Population dynamics of human helminth infections: control by chemotherapy. Nature, London297, 557–63.

R. M. Anderson & R. M. May (1985 a). Herd immunity to helminth infection and implications for parasite control. Nature, London315, 493–6.

R. M. Anderson & R. M. May (1985 b). Helminth infections of humans: mathematical models, population dynamics and control. Advances in Parasitology 24, 1101.

R. Bensted-Smith , R. M. Anderson , A. E. Butterworth , P. R. Dalton , H. C. Kariuki , D. Koech , M. Mugambi , J. H. Ouma , Siongok, T. K. Arap & R. F. Sturrock (1987). Evidence for predisposition of individual patients to reinfection with Schistosoma mansoni after treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 651–4.

M. K. Bulsara , T. Y. Sukwa & F. K. Wurapa (1985). Risks of liver and spleen enlargement in schistosomiasis mansoni infection in a rural Zambian community. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 535–6.

D. A. P. Bundy , M. S. Wong , L. L. Lewis & J. Horton (1990). Control of geohelminths by delivery of targeted chemotherapy through schools. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 115–20.

A. E. Butterworth , P. R. Dalton , D. W. Dunne , M. Mugambi , J. H. Ouma , B. A. Richardson , Siongok, T. K. Arap & R. F. Sturrock (1984). Immunity after treatment of human schistosomiasis mansoni. I. Study design, pretreatment observations and the results of treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 108–23.

A. E. Butterworth , M. Capron , J. S. Cordingley , P. R. Dalton , D. W. Dunne , H. C. Kariuki , D. Koech , M. Mugambi , J. H. Ouma , M. A. Prentice , B. A. Richardson , T. K. Siongok , R. F. Sturrock & D. W. Taylor (1985). Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune responses. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 393408.

A. E. Butterworth , A. J. C. Fulford , D. W. Dunne , J. H. Ouma & R. F. Sturrock (1988). Longitudinal studies on human schistosomiasis. Philosophical Transactions of the Royal Society of London, B321, 495511.

D. B. Elkins , M. Haswell-Elkins & R. M. Anderson (1986). The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. Study design and pre- and post-treatment observations on Ascaris lumbricoides infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 774–92.

J. E. Forrester , M. E. Scott , D. A. P. Bundy & M. H. N. Golden (1990). Predisposition of individuals and families in Mexico to heavy infection with Ascaris lumbricoides and Trichuris trichiura. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 272–6.

A. J. C. Fulford , G. G. Mbugua , J. H. Ouma , H. C. Kariuki , R. F. Sturrock & A. E. Butterworth (1991). Differences in the rate of hepatomegaly due to Schistosoma mansoni infection between two areas in Machakos District, Kenya. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press.)

B. Gryseels (1988). The morbidity of schistosomiasis mansoni in the Rusizi Plain (Burundi). Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 582–7.

B. Gryseels & A. M. Polderman (1987). The morbidity of schistosomiasis mansoni in Maniema (Zaire). Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 202–9.

K. Kloetzel & N. H. Schuster (1987). Repeated mass treatment of schistosomiasis mansoni: experience in hyperendemic areas of Brazil. I. Parasitological effects and morbidity. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 365–70.

B. Liese (1986). The organization of schistosomiasis control programmes. Parasitology Today 2, 339–45.

A. M. Polderman (1984). Cost-effectiveness of different ways of controlling intestinal schistosomiasis: a case study. Social Science and Medicine 19, 1073–80.

A. C. Sleigh , K. E. Mott , Silva, J. T. Franca , T. M. Muniz , E. A. Mota , M. L. Barreto , R. Hoff , J. H. Maguire , J. S. Lehman & I. Sherlock (1981). A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene, 75, 234–8.

R. F. Sturrock , R. Kimani , B. J. Cottrell , A. E. Butterworth , H. M. Seitz , T. A. Siongok & V. Houba (1983). Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 363–71.

R. F. Sturrock , R. Bensted-Smith , A. E. Butterworth , P. R. Dalton , H. C. Kariuki , D. Koech , M. Mugambi , J. H. Ouma & T. K. Arap Siongok (1987). Immunity after treatment of human schistosomiasis mansoni. III. Long-term effects of treatment and retreatment. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 303–14.

T. Y. Sukwa , M. K. Bulsara & F. K. Wurapa (1986). The relationship between morbidity and intensity of Schistosoma mansoni infection in a rural Zambian community. International Journal of Epidemiology 15, 248–51.

T. Y. Sukwa , B. A. Boatin & F. K. Wurapa (1988). A three year follow-up of chemotherapy with praziquantel in rural Zambian community endemic for schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 258–60.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: