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Control of schistosomiasis in sub-Saharan Africa: progress made, new opportunities and remaining challenges

  • J. R. STOTHARD (a1), L. CHITSULO (a2), T. K. KRISTENSEN (a3) and J. UTZINGER (a4)
Abstract
SUMMARY

Several other journal supplements have documented progress made in the control of schistosomiasis in Egypt, China and Brazil, however, with more than 97% of the schistosome infections now estimated to occur in Africa, the relevance of this special issue in Parasitology cannot be overemphasized. In total, 18 articles are presented, inclusive of a lead-editorial from the WHO highlighting a seminal resolution at the 54th World Health Assembly in 2001 that advocated de-worming. Facilitated by a US$ 30 million grant from the Bill and Melinda Gates Foundation in 2002, the Schistosomiasis Control Initiative subsequently fostered implementation of large-scale schistosomiasis (and soil-transmitted helminthiasis) control programmes in six selected African countries. From 2005, CONTRAST, a European union-funded consortium, was formed to conduct multi-disciplinary research pertaining to optimisation of schistosomiasis control. Progress made in schistosomiasis control across sub-Saharan Africa since the turn of the new millennium is reviewed, shedding light on the latest findings stemming from clinical, epidemiological, molecular and social sciences research, inclusive of public health interventions with monitoring and evaluation activities. New opportunities for integrating the control of schistosomiasis and other so-called neglected tropical diseases are highlighted, but more importantly, several opportune questions that arise from it frame the remaining challenges ahead for an enduring solution.

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Corresponding author
*Corresponding author: J. Russell Stothard, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, UK. Tel.: +44 207 942-5490; Fax: +44 207 942-5518; E-mail: r.stothard@nhm.ac.uk
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Anonymous (2004). Thinking beyond deworming. Lancet 364, 19931994.

R. Bergquist (2008). A century of schistosomiasis research. Acta Tropica 108, 6568.

M. Berriman , B. J. Haas , P. T. LoVerde , R. A. Wilson , G. P. Dillon , G. C. Cerqueira , S. T. Mashiyama , B. Al-Lazikani , L. F. Andrade , P. D. Ashton , M. A. Aslett , D. C. Bartholomeu , G. Blandin , C. R. Caffrey , A. Coghlan , R. Coulson , T. A. Day , A. Delcher , R. DeMarco , A. Djikeng , T. Eyre , J. A. Gamble , E. Ghedin , Y. Gu , C. Hertz-Fowler , H. Hirai , Y. Hirai , R. Houston , A. Ivens , D. A. Johnston , D. Lacerda , C. D. Macedo , P. McVeigh , Z. Ning , G. Oliveira , J. P. Overington , J. Parkhill , M. Pertea , R. J. Pierce , A. V. Protasio , M. A. Quail , M. A. Rajandream , J. Rogers , M. Sajid , S. L. Salzberg , M. Stanke , A. R. Tivey , O. White , D. L. Williams , J. Wortman , W. Wu , M. Zamanian , A. Zerlotini , C. M. Fraser-Liggett , B. G. Barrell and N. M. El-Sayed (2009). The genome of the blood fluke Schistosoma mansoni. Nature 460, 352358.

M. A. Brady , P. J. Hooper and E. A. Ottesen (2006). Projected benefits from integrating NTD programs in sub-Saharan Africa. Trends in Parasitology 22, 285291.

C. R. Caffrey (2007). Chemotherapy of schistosomiasis: present and future. Current Opinion in Chemical Biology 11, 433439.

D. G. Colley , P. T. LoVerde and L. Savioli (2001). Medical helminthology in the 21st century. Science 293, 14371438.

M. J. Doenhoff , D. Cioli and J. Utzinger (2008). Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Current Opinion in Infectious Diseases 21, 659667.

D. Engels , L. Chitsulo , A. Montresor and L. Savioli (2002). The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Tropica 82, 139146.

A. Fenwick (2006). New initiatives against Africa's worms. Transactions of the Royal Society of Tropical Medicine and Hygiene 100, 200207.

A. Fenwick , L. Savioli , D. Engels , N. R. Bergquist and M. H. Todd (2003). Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends in Parasitology 19, 509515.

J. C. Holveck , J. P. Ehrenberg , S. K. Ault , R. Rojas , J. Vasquez , M. T. Cerqueira , J. Ippolito-Shepherd , M. A. Genovese and M. R. Periago (2007). Prevention, control, and elimination of neglected diseases in the Americas: pathways to integrated, inter-programmatic, inter-sectoral action for health and development. BMC Public Health 7, 6.

P. J. Hotez , A. Fenwick , L. Savioli and D. H. Molyneux (2009). Rescuing the bottom billion through control of neglected tropical diseases. Lancet 373, 15701575.

P. J. Hotez , D. H. Molyneux , A. Fenwick , J. Kumaresan , S. Ehrlich Sachs , J. D. Sachs and L. Savioli (2007). Control of neglected tropical diseases. New England Journal of Medicine 357, 10181027.

P. J. Hotez , D. H. Molyneux , A. Fenwick , E. Ottesen , S. Ehrlich Sachs and J. D. Sachs (2006). Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Medicine 3, e102.

P. Jordan (2000). From Katayama to the Dakhla Oasis: the beginning of epidemiology and control of bilharzia. Acta Tropica 77, 940.

R. A. Kane , J. R. Stothard , A. M. Emery and D. Rollinson (2008). Molecular characterization of freshwater snails in the genus Bulinus: a role for barcodes? Parasites and Vectors 1, 15.

N. Katz (2008). The discovery of schistosomiasis mansoni in Brazil. Acta Tropica 108, 6971.

J. Keiser , J. Utzinger , M. Tanner and B. H. Singer (2004). Representation of authors and editors from countries with different human development indexes in the leading literature on tropical medicine: survey of current evidence. British Medical Journal 328, 12291232.

J. H. Kolaczinski , N. B. Kabatereine , A. W. Onapa , R. Ndyomugyenyi , A. S. Kakembo and S. Brooker (2007). Neglected tropical diseases in Uganda: the prospect and challenge of integrated control. Trends in Parasitology 23, 485493.

P. J. Lammie , A. Fenwick and J. Utzinger (2006). A blueprint for success: integration of neglected tropical disease control programmes. Trends in Parasitology 22, 313321.

D. H. Molyneux , P. J. Hotez and A. Fenwick (2005). “Rapid-impact interventions”: how a policy of integrated control for Africa's neglected tropical diseases could benefit the poor. PLoS Medicine 2, e336.

F. O. Richards Jr., A. Eigege , E. S. Miri , M. Y. Jinadu and D. R. Hopkins (2006). Integration of mass drug administration programmes in Nigeria: the challenge of schistosomiasis. Bulletin of the World Health Organization 84, 673676.

D. Rollinson , J. P. Webster , B. Webster , S. Nyakaana , A. Jorgensen and J. R. Stothard (2009). Genetic diversity of schistosomes and snails: implications for control. Parasitology 136, (in press).

J. Rumunu , S. Brooker , A. Hopkins , F. Chane , P. Emerson and J. Kolaczinski (2009). Southern Sudan: an opportunity for NTD control and elimination? Trends in Parasitology 25, 301307.

J. Seubert , R. Pohlke and F. Loebich (1977). Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against schistosomes and cestodes. Experientia 33, 10361037.

B. H. Singer and M. C. Castro (2007). Bridges to sustainable tropical health. Proceedings of the National Academy of Sciences of the United States of America 104, 1603816043.

P. Steinmann , J. Keiser , R. Bos , M. Tanner and J. Utzinger (2006). Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infectious Diseases 6, 411425.

A. S. Stensgaard , C. F. L. Saarnak , J. Utzinger , P. Vounatsou , C. Simoonga , G. Mushinge , C. Rahbek , F. Mohlenberg and T. K. Kristensen (2009). Virtual globes and geospatial health: the potential of new tools in the management and control of vector-borne diseases. Geospatial Health 3, 127141.

J. R. Stothard , B. L. Webster , T. Weber , S. Nyakaana , J. P. Webster , F. Kazibwe , N. B. Kabatereine and D. Rollinson (2009). Molecular epidemiology of Schistosoma mansoni in Uganda: DNA barcoding reveals substantial genetic diversity within Lake Albert and Lake Victoria populations. Parasitology 136, (in press).

The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium (2009). The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 460, 345351.

J. Utzinger , R. Bergquist , S. H. Xiao , B. H. Singer and M. Tanner (2003). Sustainable schistosomiasis control – the way forward. Lancet 362, 19321934.

J. Utzinger and D. de Savigny (2006). Control of neglected tropical diseases: integrated chemotherapy and beyond. PLoS Medicine 3, e112.

L. Wang , J. Utzinger and X. N. Zhou (2008). Schistosomiasis control: experiences and lessons from China. Lancet 372, 17931795.

X. N. Zhou , L. Y. Wang , M. G. Chen , X. H. Wu , Q. W. Jiang , X. Y. Chen , J. Zheng and J. Utzinger (2005). The public health significance and control of schistosomiasis in China – then and now. Acta Tropica 96, 97105.

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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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