Gilabert, Aude Curran, David M. Harvey, Simon C. and Wasmuth, James D. 2017. Expanding the view on the evolution of the nematode dauer signalling pathways: refinement through gene gain and pathway co-option. BMC Genomics, Vol. 17, Issue. 1,
Johnston, Chris J.C. Smyth, Danielle J. Dresser, David W. and Maizels, Rick M. 2017. TGF-β in tolerance, development and regulation of immunity. Cellular Immunology, Vol. 299, p. 14.
Lok, James B. 2017. Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival. Current Clinical Microbiology Reports, Vol. 3, Issue. 4, p. 186.
Japa, Ornampai Hodgkinson, Jane E Emes, Richard D and Flynn, Robin J 2017. TGF-β superfamily members from the helminth Fasciola hepatica show intrinsic effects on viability and development. Veterinary Research, Vol. 46, Issue. 1, p. 29.
Rehman, Z. U. Knight, J. S. Koolaard, J. Simpson, H. V. and Pernthaner, A. 2017. Immunomodulatory effects of adultHaemonchus contortusexcretory/secretory products on human monocyte-derived dendritic cells. Parasite Immunology, Vol. 37, Issue. 12, p. 657.
Crook, Matt 2017. The dauer hypothesis and the evolution of parasitism: 20years on and still going strong. International Journal for Parasitology, Vol. 44, Issue. 1, p. 1.
Grainger, John R. Askenase, Michael H. Guimont-Desrochers, Fanny Fonseca, Denise Morais da and Belkaid, Yasmine 2017. Contextual functions of antigen-presenting cells in the gastrointestinal tract. Immunological Reviews, Vol. 259, Issue. 1, p. 75.
Hewitson, James P. Rückerl, Dominik Harcus, Yvonne Murray, Janice Webb, Lauren M. Babayan, Simon A. Allen, Judith E. Kurniawan, Agnes Maizels, Rick M. and Mitre, Edward 2017. The Secreted Triose Phosphate Isomerase of Brugia malayi Is Required to Sustain Microfilaria Production In Vivo. PLoS Pathogens, Vol. 10, Issue. 2, p. e1003930.
McNeilly, Tom N. and Nisbet, Alasdair J. 2017. Immune modulation by helminth parasites of ruminants: implications for vaccine development and host immune competence. Parasite, Vol. 21, p. 51.
Stoltzfus, Jonathan D. Bart, Stephen M. Lok, James B. and Davies, Stephen John 2017. cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis. PLoS Pathogens, Vol. 10, Issue. 7, p. e1004235.
Hewitson, James P. Ivens, Al C. Harcus, Yvonne Filbey, Kara J. McSorley, Henry J. Murray, Janice Bridgett, Stephen Ashford, David Dowle, Adam A. Maizels, Rick M. and Nutman, Thomas B. 2017. Secretion of Protective Antigens by Tissue-Stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-Induced Sterile Immunity. PLoS Pathogens, Vol. 9, Issue. 8, p. e1003492.
Nisbet, Alasdair J. McNeilly, Tom N. Wildblood, Louise A. Morrison, Alison A. Bartley, David J. Bartley, Yvonne Longhi, Cassandra McKendrick, Iain J. Palarea-Albaladejo, Javier and Matthews, Jacqueline B. 2017. Successful immunization against a parasitic nematode by vaccination with recombinant proteins. Vaccine, Vol. 31, Issue. 37, p. 4017.
Thivierge, Karine Cotton, Sophie Schaefer, Deborah A. Riggs, Michael W. To, Joyce Lund, Maria E. Robinson, Mark W. Dalton, John P. Donnelly, Sheila M. and Mitre, Edward 2017. Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation. PLoS Neglected Tropical Diseases, Vol. 7, Issue. 7, p. e2307.
Zhao, Lilin Zhang, Shuai Wei, Wei Hao, Haijun Zhang, Bin Butcher, Rebecca A. and Sun, Jianghua 2017. Chemical Signals Synchronize the Life Cycles of a Plant-Parasitic Nematode and Its Vector Beetle. Current Biology, Vol. 23, Issue. 20, p. 2038.
Maizels, Rick M. Hewitson, James P. Murray, Janice Harcus, Yvonne M. Dayer, Blaise Filbey, Kara J. Grainger, John R. McSorley, Henry J. Reynolds, Lisa A. and Smith, Katherine A. 2017. Immune modulation and modulators in Heligmosomoides polygyrus infection. Experimental Parasitology, Vol. 132, Issue. 1, p. 76.
McSorley, Henry J. O'Gorman, Mary T. Blair, Natalie Sutherland, Tara E. Filbey, Kara J. and Maizels, Rick M. 2017. Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. European Journal of Immunology, Vol. 42, Issue. 10, p. 2667.
Nono, Justin Komguep Pletinckx, Katrien Lutz, Manfred B. Brehm, Klaus and MacDonald, Andrew Scott 2017. Excretory/Secretory-Products of Echinococcus multilocularis Larvae Induce Apoptosis and Tolerogenic Properties in Dendritic Cells In Vitro. PLoS Neglected Tropical Diseases, Vol. 6, Issue. 2, p. e1516.
Reynolds, Lisa A. Filbey, Kara J. and Maizels, Rick M. 2017. Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus. Seminars in Immunopathology, Vol. 34, Issue. 6, p. 829.
Stoltzfus, Jonathan D. Minot, Samuel Berriman, Matthew Nolan, Thomas J. Lok, James B. and Jex, Aaron R. 2017. RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways. PLoS Neglected Tropical Diseases, Vol. 6, Issue. 10, p. e1854.
Hewitson, James P. Harcus, Yvonne Murray, Janice van Agtmaal, Maaike Filbey, Kara J. Grainger, John R. Bridgett, Stephen Blaxter, Mark L. Ashton, Peter D. Ashford, David A. Curwen, Rachel S. Wilson, R. Alan Dowle, Adam A. and Maizels, Rick M. 2017. Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of Venom Allergen-Like (VAL) proteins. Journal of Proteomics, Vol. 74, Issue. 9, p. 1573.
The transforming growth factor-β (TGF-β) gene family regulates critical processes in animal development, and plays a crucial role in regulating the mammalian immune response. We aimed to identify TGF-β homologues from 2 laboratory model nematodes (Heligmosomoides polygyrus and Nippostrongylus brasiliensis) and 2 major parasites of ruminant livestock (Haemonchus contortus and Teladorsagia circumcincta). Parasite cDNA was used as a template for gene-specific PCR and RACE. Homologues of the TGH-2 subfamily were isolated, and found to differ in length (301, 152, 349 and 305 amino acids respectively), with variably truncated N-terminal pre-proteins. All contained conserved C-terminal active domains (>85% identical over 115 amino acids) containing 9 cysteine residues, as in C. elegans DAF-7, Brugia malayi TGH-2 and mammalian TGF-β. Surprisingly, only the H. contortus homologue retained a conventional signal sequence, absent from shorter proteins of other species. RT-PCR assays of transcription showed that in H. contortus and N. brasiliensis expression was maximal in the infective larval stage, and very low in adult worms. In contrast, in H. polygyrus and T. circumcincta, tgh-2 transcription is higher in adults than infective larvae. The molecular evolution of this gene family in parasitic nematodes has diversified the pre-protein and life-cycle expression patterns of TGF-β homologues while conserving the structure of the active domain.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.
Full text views reflects the number of PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.
* Views captured on Cambridge Core between September 2016 - 23rd September 2017. This data will be updated every 24 hours.