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Detection of high levels of congenital transmission of Toxoplasma gondii in natural urban populations of Mus domesticus

  • P. A. MARSHALL (a1), J. M. HUGHES (a2), R. H. WILLIAMS (a2), J. E. SMITH (a3), R. G. MURPHY (a1) and G. HIDE (a2)...

The relative importance of different transmission routes of Toxoplasma gondii has been a matter for debate. This ubiquitous parasite is generally thought to be transmitted by infective oocysts excreted by the definitive host, the cat. Ingestion of undercooked meat has also been considered an important route of transmission in many mammals while congenital transmission has generally been considered relatively rare. Experimental studies demonstrate the ability of T. gondii to be transmitted congenitally, but few studies have investigated the frequency of this transmission route in natural populations. We use PCR amplification of the SAG1 gene to investigate the frequency of congenital transmission in a wild population of mice (Mus domesticus) and show that congenital transmission is occurring in 75% of pregnancies in this population. Furthermore, for infected pregnant mice, transmission occurs to at least one foetus in 100% of cases while variable penetrance of congenital infection is observed. These high levels of congenital transmission in this wild population of mice, taken together with other recent data on congenital transmission in sheep, suggests that this phenomenon might be more widespread than previously thought.

Corresponding author
Biosciences Research Institute, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, UK. Fax: +0161 295 5015. E-mail:
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BARBER, J. S. & TREES, A. J. (1998). Naturally occurring vertical transmission of Neospora caninum in dogs. International Journal for Parasitology28, 5764.

BLEWETT, D. A. & TREES, A. J. (1987). The epidemiology of ovine toxoplasmosis with especial respect to control. British Veterinary Journal143, 128135.

COLE, R. A., LINDSAY, D. S., BLAGBURN, B. L. & DUBEY, J. P. (1995). Vertical transmission of Neospora caninum in mice. Journal of Parasitology81, 730732.

DUNCANSON, P., TERRY, R. S., SMITH, J. E. & HIDE, G. (2001). High levels of congenital transmission of Toxoplasma gondii in a commercial sheep flock. International Journal for Parasitology31, 16991703.

ELSAID, M. M. A., MARTINS, M. S., FREZARD, F., BRAGA, E. M., & VITOR, R. W. A. (2001). Vertical toxoplasmosis in a murine model, protection after immunization with antigens of Toxoplasma gondii incorporated into liposomes. Memorias do Instituto Oswaldo Cruz96, 99104.

JOHNSON, A. M. (1997). Speculation on possible life cycles for the clonal lineages in the genus Toxoplasma. Parasitology Today13, 393397.

OWEN, M. R. & TREES, A. J. (1998). Vertical transmission of Toxoplasma gondii from chronically infected house (Mus musculus) and field (Apodemus sylvaticus) mice determined by polymerase chain reaction. Parasitology116, 299304.

SAVVA, D., MORRIS, J. C., JOHNSON, J. D. & HOLLIMAN, R. E. (1990). Polymerase chain reaction for detection of Toxoplasma gondii. Journal of Medical Microbiology32, 2531.

SCHARES, G., WENZEL, U., MULLER, T. & CONRATHS, F. J. (2001). Serological evidence for naturally occurring transmission of Neospora caninum among foxes (Vulpes vulpes). International Journal for Parasitology31, 418423.

STAHL, W., SEKIGUCHI, M. & KANEDA, Y. (2002). Cerebellar anomalies in congenital murine toxoplasmosis. Parasitology Research88, 507512.

TENTER, A. M., HECKEROTH, A. R. & WEISS, L. M. (2000). Toxoplasma gondii: from animals to humans. International Journal for Parasitology30, 12171258.

TERRY, R. S., SMITH, J. E., DUNCANSON, P. & HIDE, G. (2001). MGE-PCR: a novel approach to the analysis of Toxoplasma gondii strain differentiation using mobile genetic elements. International Journal for Parasitology31, 155161.

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  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
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