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The development of resistance to glycarbylamide and 2-chloro-4-nitrobenzamide in Eimeria tenella in chicks *

Published online by Cambridge University Press:  06 April 2009

S. J. Ball
S. J. Ball
Affiliation:
Veterinary Research Station, May and Baker, Ltd., Ongar, Essex
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Extract

A twofold increase in resistance to glycarbylamide was induced in a strain of Eimeria tenella in chicks. This strain remained susceptible to amprolium, nicarbazin, nitrofurazone, zoalene, 3,5-dinitrobenzamide, 2-chloro-4-nitrobenzamide (M & B 5921) and spiramycin.

At least an eightfold resistance to 2-chloro-4-nitrobenzamide (M & B 5921) was developed in another strain of E. tenella. This strain was also resistant to nitrofurazone, zoalene and 3,5-dinitrobenzamide, but not to glycarbylamide, amprolium, nicarbazin and spiramycin.

A single test showed no transfer of drug-resistance when the two resistant strains were given simultaneously to the same birds.

When a small number of parasites of a glycarbylamide-resistant strain of E. tenella was introduced into a larger inoculum of the normal parent strain, the resistant individuals appeared to diminish in number during passages through untreated chicks.

I wish to thank Mrs B. M. Mitchell, Miss C. A. Hitchcock and Miss J. Watkins for technical assistance at various stages of the work.

Type
Research Article
Information
Parasitology , Volume 56 , Issue 1 , February 1966 , pp. 25 - 37
Copyright
Copyright © Cambridge University Press 1966

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References

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