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Electrophysiology of Ascaris muscle and anti-nematodal drug action

Published online by Cambridge University Press:  06 April 2009

R. J. Martin ,
M. A. Valkanov ,
V. M. E. Dale ,
A. P. Robertson  and
I. Murray
R. J. Martin
Affiliation:
Department of Preclinical Veterinary Sciences, R.(D.)S.V.S., Summerhall, University of Edinburgh, Edinburgh, EH9 1QH, UK
M. A. Valkanov
Affiliation:
Department of Preclinical Veterinary Sciences, R.(D.)S.V.S., Summerhall, University of Edinburgh, Edinburgh, EH9 1QH, UK
V. M. E. Dale
Affiliation:
Department of Preclinical Veterinary Sciences, R.(D.)S.V.S., Summerhall, University of Edinburgh, Edinburgh, EH9 1QH, UK
A. P. Robertson
Affiliation:
Department of Preclinical Veterinary Sciences, R.(D.)S.V.S., Summerhall, University of Edinburgh, Edinburgh, EH9 1QH, UK
I. Murray
Affiliation:
Department of Preclinical Veterinary Sciences, R.(D.)S.V.S., Summerhall, University of Edinburgh, Edinburgh, EH9 1QH, UK
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Summary

Three groups of anthelmintic drugs act directly and selectively on muscle membrane receptors of parasitic nematodes. These groups of anthelmintics are: (1) The Nicotinic Agonists(levamisole, pyrantel, morantel and oxantel) that act on acetylcholine receptors of nematode somatic muscle; (2) The GAB A Agonist, piperazine, that acts on nematode muscle GABA receptors; and (3) The Avermectins that open glutamate gated Cl- channels on nematode pharyngeal muscle. The electrophysiology and pharmacology of muscle and neuromuscular transmission the nematode parasite, Ascaris suum, is outlined and effects of anthelmintics that interfere with transmission described. Resistance to anthelmintics has appeared in some parasitic nematodes but the mechanisms of this resistance remain to be determined

Keywords

ElectrophysiologyAscaris suummusclepharynxlevamisolepyrantelmoranteloxantelpiperazinemilbemycinavermectins
Type
Research Article
Information
Parasitology , Volume 113 , supplement S1: Molecular biochemistry and physiology of helminth neuromuscular systems , January 1996 , pp. S137 - S156
Copyright
Copyright © Cambridge University Press 1996

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