Hostname: page-component-7dd5485656-tbj44 Total loading time: 0 Render date: 2025-10-31T13:56:42.514Z Has data issue: false hasContentIssue false
  • English
  • Français

Experiments on the mode of action of hexyl resorcinol as an anthelmintic

Published online by Cambridge University Press:  06 April 2009

A. R. Trim
A. R. Trim
Affiliation:
Biochemical Laboratory, Cambridge
Get access Rights & Permissions [Opens in a new window]

Extract

1. Hexyl resorcinol penetrates readily into Ascaris lumbricoides var. suis through the cuticle.

2. The rate of penetration is roughly proportional to the concentration of the drug in the medium, and is not significantly affected by changes of pH. or oxygen tension and the presence of a number of other substances, including other drugs and certain nutrient substances.

3. The rate of penetration is greatly decreased by gastric mucin and certain concentrations of bile salts and soaps.

4. The rate of penetration of the drug is increased by certain concentrations of sodium oleate.

Information

Type
Research Article
Information
Parasitology , Volume 35 , Issue 4 , March 1944 , pp. 209 - 219
Copyright
Copyright © Cambridge University Press 1944

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Baldwin, E. (1943). Parasitology, 35, 89.CrossRefGoogle Scholar
Dangerfield, W. G., Gaunt, W. E. & Wormall, A. (1938). Biochem. J. 32, 59.CrossRefGoogle Scholar
Hurst, H. (1940). Nature, Lond., 145, 462.CrossRefGoogle Scholar
Lamson, P. D., Brown, H. W. & Ward, C. B. (1935). J. Pharmacol. 53, 198.Google Scholar
Lamson, P. D., Brown, H. W., Stoughton, R. W., Harwood, P. D., Baltzly, R. & Bass, A. (1935). J. Pharmacol. 53, 218.Google Scholar
Lamson, P. D. & Brown, H. W. (1935). J. Pharmacol 53, 227.Google Scholar
Lamson, P. D., Brown, H. W., Stoughton, R. W., Harwood, P. D., Baltzly, R. & Bass, A. (1935). J. Pharmacol. 53, 234, 239.Google Scholar
Rheinboldt, H. (1925). Die Methoden Organischen Chemie (ed. Houben, J.), 1, 1146.Google Scholar
Sobotka, H. & Goldberg, H. (1932). Biochem. J. 26, 555.CrossRefGoogle Scholar
Wieland, H. & Sorge, H. (1916). Hoppe-Seyl. Z. 97, 1.CrossRefGoogle Scholar