In 1926 two of us published the results of a long series of experiments on the toxic action of the alkaloids of ipecacuanha in cultures of several species of entozoic amoebae. These experiments led us to definite conclusions regarding the differential susceptibility of the various species of amoebae studied, and the relative potency of several alkaloids employed. They also showed clearly that the full specific action of emetine, on susceptible amoebae, is only disclosed if the alkaloid is allowed to act for a sufficient time (two or three days.)
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