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Malaria, quinine and red cell lysis

Published online by Cambridge University Press:  06 April 2009

Hans Laser ,
Patrick Kemp ,
Nigel Miller ,
David Lander  and
Roger Klein
Hans Laser
Affiliation:
Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge, England.
Patrick Kemp
Affiliation:
Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge, England.
Nigel Miller
Affiliation:
Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge, England.
David Lander
Affiliation:
Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge, England.
Roger Klein
Affiliation:
Medical Research Council, Biochemical Parasitology Unit, Molteno Institute, University of Cambridge, Cambridge, England.
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Extract

An hypothesis is presented to explain the red cell lysis which accompanies an acute malarial infection, as well as the mode of action of certain schizonticidal drugs in the quinoline and acridine series. Quinine and a number of other antimalarial drugs have been found to counteract the inhibition by protein of fatty acid-induced lysis, when tested in an in vitro system. It is suggested that these schizonticides exert their chemotherapeutic effect by inducing the premature lysis of the parasitized red cell, as a result of relieving the inhibition by protein of haemolysis.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 2 , October 1975 , pp. 167 - 181
Copyright
Copyright © Cambridge University Press 1975

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