Skip to main content
    • Aa
    • Aa

On the invasion of the central nervous system by nematodes I. The Incidence and pathological significance of nematodes in the central nervous system

  • J. F. A. Sprent (a1)

A wide variety of nematode species have been observed to invade the central nervous system. They may be located in the meningeal spaces or may penetrate into the tissues of the brain and spinal cord.

The pathological changes resulting from invasion of the central nervous system are influenced by the route of entry, the size and the mobility of the parasite. They may be diffuse or focal and may include haemorrhage, degenerative changes, cellular infiltration and glial proliferation. Such changes may or may not be observed in close association with the parasite.

Symptoms indicating involvement of the central nervous system have long been associated with nematode infections outside the central nervous system. The pathogenesis of these symptoms is obscure, but they may possibly be of allergic origin.

The direct pathological effects on the central nervous system are mainly the result of trauma and are directly proportional to the size and activity of the parasite. The possibility that nematodes may transport viruses into the central nervous system is briefly discussed.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

W. Beautyman & A. L. Woolf (1951). An ascaris larva in the brain in association with acute anterior poliomyelitis. J. Path. Bact. 63, 635–47.

G. Borell (1875). Virchow's Arch. 65, 399400.

G. B. Hassin & I. B. Diamond (1926). Arch. Neural. Psychiat., Chicago, 15, 3447.

R. J. C. Hoeppli (1923). Virchow's Arch. 244, 159–82.

J. R. M. Innes & C. Shoho (1952). Nematodes, nervous disease and neurotropic virus infection. Brit. Med. J. 16 Aug. pp. 366–8.

M. J. Mackerras & D. F. Sandars (1953). Nature, Lond., 173, 956.

H. Most & M. M. Abeles (1937). Arch. Neurol. Psychiat., Chicago, 37, 589616.

J. Salan & B Schwartz . (1928). J. Amer. Med. Ass. 90, 611.

R. E. Shope (1941). J. Exp. Med. 74, 4968.

R. E. Shope (1943 b). J. Exp. Med. 77, 127–38.

J. F. A. Sprent (1949). J. Infect. Dis. 84, 221–9.

J. F. A. Sprent (1950). J. Infect. Dis. 86, 146–58.

J. F. A. Sprent (1951). On the toxic and allergic manifestations produced by the tissues and fluids of ascaris. III. Hypersensitivity through infection in the guinea pig. J. Infect. Dis. 88, 168–77.

J. F. A. Sprent (1953). On the migratory behaviour of the larvae of various ascaris species in white mice. II. Longevity of encapsulated larvae, their resistance to freezing and putrefaction. J. Infect. Dis. 92, 114–17.

J. T. Syverton , O. R. McCoy , J. Koomen (1947). J. Exp. Med. 85, 759–69.

J. D. Tiner (1953 a). The migration, distribution in the brain, and growth of ascarid larvae in Rodents. J. Infect. Dis. 92, 105–13.

J. D. Tiner (1953 b). Fatalities in Rodents caused by larval Ascaris in the central nervous system. J. Mammal. 34, 153–67.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

  • ISSN: 0031-1820
  • EISSN: 1469-8161
  • URL: /core/journals/parasitology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 5 *
Loading metrics...

Abstract views

Total abstract views: 107 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th September 2017. This data will be updated every 24 hours.